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The immunogenetics and pathogenesis of gastric cancer. Highlights of the First Sino-European Workshop on the Immunogenetics and Pathogenesis of Gastric Cancer.

Clinical scientists from eight European countries and China gathered in the ancient Chinese capital of Xi'an on April 26-28, 2001 to discuss collaboration on a modern approach to gastric cancer prevention. Participants at the First Sino-European Workshop on Immunogenetics and Pathogenesis of Gastric Cancer presented their most up-to-date research results on topics ranging from epidemiology and immune mechanisms to Helicobacter pylori and vaccine development. Researchers then formed groups with their Chinese or European counterparts to plan future research endeavors which will benefit Chinese and European populations alike. After 3 years of organization between the Institute of Digestive Diseases of the Fourth Medical University in Xi'an, China and the Laboratory of Immunogenetics, VU University Medical Center in Amsterdam, the first workshop came into being under the joint sponsorship of the Commission of the European Union, National Natural Science Foundation of China and the Institute of Digestive Diseases, Xi'an, China. As gastric cancer is the most prevalent malignant tumor in China, the workshop was of special significance to the Chinese researchers and to the Chinese population in general. During the workshop, presentations on the epidemiology of gastric cancer showed that this disease is in fact common the world over: it is the second most common cancer next to lung cancer and about 1 million new cases were diagnosed in 2000. Three-quarters of the cases of gastric cancer occur in Asia, and approximately 80% of these cases are in China and Japan. Genetic factors and environmental factors such as diet and H. pylori infection play a role in gastric carcinogenesis. As a recognized cause of gastric cancer, H. pylori was the subject of various presentations ranging from immunological studies, molecular analysis of strains and pathogenesis to vaccine development. Specific areas of discussion included bacterial-epithelial interactions in H. pylori infection, epidemiology in China, global distribution of vacA and cagA genotypes, new evidence for host factors, nonsteroidal antiinflammatory drugs and H. pylori as independent risk factor for gastric cancer, new diagnostic techniques for H. pylori using serum levels of pepsinogen I, and autoimmune processes in corpus atrophy. Vaccine development using a variety of strategies against H. pylori was the subject of an entire session of talks. Oral immunization with urease with Escherichia coli heat labile enterotoxin was shown to be safe and immunogenic in humans as a mucosal adjuvant. Results of a study using attenuated Salmonella typhimurium as a vehicle for DNA-mediated immunization in mice were also presented. A final presentation discussed an ongoing trial comparing strain variability in the vacA and cagA gene sequences and disease expression between H. pylori infection in Europe and China. Researchers also discussed the role of IL1 gene family and TNF gene polymorphisms in gastric pathology and various immune mechanisms involved in gastric cancer, such as down-regulation of NF kappa B, IL-1 and IL-1RA, cyclooxygenase signalling, and identification of MGAg antibodies. An interactive discussion followed each presentation and ideas and suggestions were provided. According to specialty, the presenters were then assigned to groups of four or five to make plans for joint research projects. A number of international and Chinese observers were present, including representatives from the European Commission, the World Health Organization and the Chinese National Center for Biotechnology Development, and offered input on the financial feasibility of such projects.

China↗

Spirometry in primary care practice: the importance of quality assurance and the impact of spirometry workshops.

OBJECTIVE: To determine the quality of spirometry performed in primary care practice and to assess the impact of formal training. DESIGN: Randomized, controlled prospective interventional study. SETTING: Primary care practice, Auckland City, New Zealand. PARTICIPANTS: Thirty randomly selected primary care practices randomized to "trained" or "usual" groups. One doctor and one practice nurse were nominated to participate from each practice. INTERVENTIONS: "Trained" was defined as participation in an "initial" spirometry workshop at week 0 and a "maintenance of standards" workshop at week 12. "Usual" was defined as no formal training until week 12, when participants they attended the same "initial" workshop provided for the trained group. The study duration was 16 weeks. Each practice was provided with a spirometer to be used at their clinical discretion. MEASUREMENTS AND RESULTS: Spirometry data were uploaded weekly and analyzed using American Thoracic Society (ATS) criteria for acceptability and reproducibility. The workshops were assessed objectively with practical and written assessments, confirming a significant training effect. However, analysis of spirometry performed in clinical practice by the trained practitioners revealed three acceptable blows in only 18.9% of patient tests. In comparison, 5.1% of patient tests performed by the usual practitioners had three acceptable blows (p<0.0001). Only 13.5% of patient tests in the trained group and 3.4% in the usual group (p<0.0001) satisfied full acceptability and reproducibility criteria. However, 33.1% and 12.5% of patient tests in the trained and usual groups, respectively (p<0.0001), achieved at least two acceptable blows, the minimum requirement. Nonacceptability was largely ascribable to failure to satisfy end-of-test criteria; a blow of at least 6 s. Visual inspection of the results of these blows as registered on the spirometer for the presence of a plateau on the volume-time curve suggests that < 15% were acceptable. CONCLUSIONS: Although a significant training effect was demonstrated, the quality of the spirometry performed in clinical practice did not generally satisfy full ATS criteria for acceptability and reproducibility. Further study would be required to determine the clinical impact. However, the ATS guidelines allow for the use of data from unacceptable or nonreproducible maneuvers at the discretion of the interpreter. Since most of the failures were end-of-test related, the FEV1 levels are likely to be valid. Our results serve to emphasize the importance of effective training and quality assurance programs to the provision of successful spirometry in primary care practice.

Adolescent↗

7th International Workshop on Clinical Pharmacology of HIV Therapy 20-22 April 2006, Lisbon, Portugal.

The 7th International Workshop on Clinical Pharmacology of HIV Therapy was held at the Alfa Corinthia Hotel in Lisbon, Portugal. Approximately 200 pharmacologists and other scientists interested in antiretroviral pharmacology were in attendance this year. The workshop invited five lecturers to speak on topics including priorities for HIV pharmacology research in developing countries, the role of modelling and simulation in antiviral drug development, hepatotoxic side effects of antiretrovirals, peptide CCR5 antagonists, and HIV pharmacoepidemiology. The workshop also convened round table discussions on the use of therapeutic drug monitoring including updated recommendations, penetration of antiretrovirals into the CNS and genital tract, and drug labelling for antiretroviral drugs under the new FDA format. In total, 87 abstracts were accepted for presentation at the meeting: 29 oral and 58 poster presentations. This article highlights select presentations from the workshop.

Anti-Retroviral Agents↗

[Workshop: "Woman--a trip through her body"].

Morbidity due to cervical and breast cancer in Brazilian woman is high, despite the fact that these pathologies are preventable when detected early. The coverage of public health in this disease is unsatisfactory specially if one takes into account the fact that the techniques used for early detection and prevention of those types of cancer are simple and inexpensive. We observed that not many activities have been developed aiming at the education of women with regard to self-knowledge of their bodies. As a result, we prepared in 1993 a workshop entitled "Woman, a trip through her body" comprising 6 group dynamics where there is an intense participation of every woman as it is a very exciting process. The workshop is carried on by one member of the faculty staff, three nurses and nursing students of Federal University of Espírito Santo. There are 30 participants per workshop each one receiving a name tag. This workshop is composed of the following group dynamics which are developed in a cosy and informal atmosphere: Dynamic 1-Pocket History; Dynamic 2-Hands Touch; Dynamic 3-Drawing/ Modelling; Dynamic 4-Trip through the Body; Dynamic 5-Self-examination; Dynamic 6-Body Feeling.

Breast Neoplasms↗

Interdisciplinary workshop yields new entomological data for forensic sciences: Chrysomya rufifacies (Diptera: Calliphoridae) established in North Carolina.

ABSTRACT Workshops are used for educating law enforcement personnel on the application of entomological, anthropological, and botanical techniques to gather forensically important information from a body recovery site. From 8 to 11 June 2004, such a workshop was conducted in the metropolitan area of Charlotte, NC, by the American Academy of Applied Forensics at Central Piedmont Community College. For this workshop, three pig carcasses weighing individually between 40 and 60 kg were placed in the field 4 June, whereas three pigs similar in size were placed in the field 7 June. During the afternoon session on 11 June, workshop participants collected three Chrysomya rufifacies (Macquart) (Diptera: Calliphoridae) third instar larvae from a pig carcass placed in the field on 7 June. These data represent the first records of this forensically important insect in North Carolina; furthermore, these data provide evidence of this species expansion into new geographic regions of the United States. This finding is an example of the benefits derived from an experiential and interdisciplinary approach to educating death scene investigators. Learners acquired new knowledge, put it into practice through the "body" recovery exercise, and ultimately contributed to science by way of the discovery and first documentation of a forensically important insect previously not known to inhabit North Carolina.

Animals↗

Report on an interagency workshop on the radiobiology of nuclear terrorism. Molecular and cellular biology dose (1-10 Sv) radiation and potential mechanisms of radiation protection (Bethesda, Maryland, December 17-18, 2001).

The events of September 11, 2001 have focused attention on the possibility of nuclear terrorism, and 1-10 Sv is arguably the dose range of biological interest, since doses in this range both pose a risk of acute effects and are potentially survivable. Because of this interest, a coalition of U.S. government agencies (NCI, DOD, DOE) and the Radiation Research Society convened a workshop in December 2001 "to focus on molecular, cellular and tissue changes that occur [at doses of 1-10 Sv] and potential mechanisms of radioprotection". A draft report of this workshop was posted on the NCI website in February 2002. According to the draft, the workshop was also intended to "determine the research opportunities and resources required [and] develop a research-action plan for further discussion and implementation." Injuries after exposure to ionizing radiation are important to patients with cancer and to populations potentially subject to accidental or intentional exposure. In these populations, partial- or whole-body exposures in the range of 1-10 Sv are possible. The consequences of exposure of limited tissue volumes to doses above 10 Sv have been researched because of their applicability to cancer therapy, while exposure to doses below 1 Sv has been researched because of nuclear fallout and space exploration issues. Except for research aimed at protection of members of the armed forces, the intervening dose range has received relatively little attention. The workshop participants concluded that although we currently have only a limited ability to deal with the consequences of radiation exposures in this range, focused research would have the potential of rapidly expanding such capabilities.

Biomarkers↗

Consensus statements from the Second International Lung Cancer Molecular Biomarkers Workshop: a European strategy for developing lung cancer molecular diagnostics in high risk populations.

The Second Molecular Biomarkers Workshop was held at the Roy Castle International Centre for Lung Cancer Research in Liverpool, in June 2001 and it brought together experts in the clinical, epidemiological and molecular-pathology of lung cancer from Europe and the USA, to address issues surrounding the development of a European strategy for early lung cancer detection. The 2001 Workshop Breakout Groups concentrated on the current challenges in the early detection of lung cancer which need to be addressed in the light of the recent surge in interest in many countries for mounting new clinical trials to evaluate the utility of Spiral CT in early lung cancer detection. If population-based trials of CT screening are mounted it will also be a favorable clinical environment in which to evaluate efficiently recent advances in molecular screening and genotyping. The Workshop focused specifically on: a) clinical and molecular biomarkers, b) sputum as an early detection and diagnostic tool, c) validation of molecular markers prior to their use in early detection trials and d) ethical issues that have to be considered in early lung cancer detection trials. A distillation of the Workshop discussions is given in this article.

Biomarkers, Tumor↗

["Evaluating health workshops": the experience of health education committees in the Pays de la Loire region].

The five health promotion and education committees (CODES) from the Pays de la Loire region are carrying out health promotion projects involving socially disadvantaged people. These projects are referred to as ateliers santé (literally meaning "health workshops"). These interventions are conducted over a series of participatory sessions, which creates a more supportive structure to guide people with difficulties assisting them to better recognise and formulate their health needs, as they are normally part of a population group which is neither accustomed to expressing their health needs nor to being heard on this subject. At present little is known about these projects; therefore the Inter-regional and departmental health education committee from Nantes chose to carry out an evaluation of 7 of the 47 existing "workshops". Each one of the seven interventions required an average of 31 hours of preparation. Overall, there were 9 sessions organised with 8 to 9 participants, each lasting for the duration of 2.5 hours, held over a period of 32 weeks. At the end of each session, 85% of the participants claimed that there were satisfied. When questioned six months after the end of their "workshop", half of the 37 participants reported that their perceived health status was a little or much better after having taken part in the process. The evaluation demonstrates that a more clear definition of the operational objectives is necessary in order to promote increased input from the participants and to clarify the intentions of the project team towards a population group which needs a means by which it can enter into this critical debate. The process appears to be in accordance with the criteria and goals of health promotion: negotiation of the content, participation of members of the target audience throughout various stages of the project, and adjustment of the size and scale of the project being to involve a small total number of participants in order to favour effective follow up. Although evaluating the effectiveness and impact of such interventions is difficult and complicated by complex methodological questions, these "workshops" seem to have been greatly appreciated both by those who requested them and those who participated in them, with encouraging results having been witnessed in the lives of certain participants, which all serves as an incentive to pursue this kind of project.

Education↗

Degree of comfort in providing care to PWAs: effect of a workshop for baccalaureate nursing students.

A low-incidence area of HIV/AIDS was the site for this study, which examined baccalaureate nursing students' degree of comfort in providing basic nursing care to people with AIDS (PWAs), and determined the effect of a National Institutes of Health (NIH)-sponsored one-day workshop on HIV/AIDS on this degree of comfort. The pretest-posttest study revealed no statistically significant decrease after the workshop in the amount of discomfort associated with providing basic nursing care to PWAs. However, there were changes in the ranking of nursing procedures following the workshop. Included is a discussion of the workshop's effect on students' comfort level and implications for nurse educators. Ideas for related studies in the area of HIV health care are explored.

Acquired Immunodeficiency Syndrome↗

Interpretive pedagogy in action: design and delivery of a violence and health workshop for baccalaureate nursing students.

This article presents the planning and implementation of a Violence and Health Immersion Workshop for undergraduate nursing students. Given the enormous personal and economic costs of violence, the central importance of addressing violence issues in nursing curricula is emphasized. The application of three key interpretive pedagogical strategies is described: choosing critical social science as a conceptual framework for the workshop; placing specific emphasis on the decentering of content; and creating space for learners to explore this difficult issue. Formative and summative evaluations of the workshop indicated that the majority of students found the workshop to be helpful in providing the opportunity to examine and shift their own values, attitudes, and beliefs regarding violence and health. Recommendations for future research include the need for increased knowledge regarding barriers to the implementation of interpretive pedagogies, and for greater insight regarding the process of attending to differences in the participants and the facilitators.

Attitude of Health Personnel↗

Evaluating the effectiveness of occupational therapy faculty development workshops.

OBJECTIVE: The purpose of this study was to evaluate, from the participants' perspective, the effectiveness over time of 10 occupational therapy faculty development workshops conducted between 1994 and 1998. METHOD: Surveys were mailed to 179 occupational therapy faculty participants to gather demographic data and perceptions of the following aspects of the workshops: benefits over time of the instructional content, changes made in current teaching practices, progress as a faculty member, and future needs for faculty development. RESULTS: The response rate was 63% (n = 106). The majority (72%) of respondents had less than 5 years of teaching experience. Respondents were women in their early 40s with approximately 12 years of clinical experience and a master's degree. Respondents perceived the most effective aspect of the faculty development workshops as the opportunity to participate in a face-to-face environment in which they observed the skills of a master teacher demonstrating instructional principles. Further, respondents reported that the greatest changes in their current teaching practices occurred in their ability to design, implement, and evaluate a course of instruction, thus increasing their perceptions of progress as a faculty member. CONCLUSION: The 10 faculty development workshops conducted between 1994 and 1998 were judged effective by occupational therapy faculty members who perceived that their participation resulted in benefits over time to their current teaching practices.

Faculty↗

Piloting short workshops on the critical appraisal of reviews.

This paper describes a pilot programme of short workshops on the critical appraisal of review articles. The twelve workshops, which ran in various parts of the United Kingdom during 1992 and 1993, lasted either one or two half-days, and consisted of a mixture of large-group sessions and critical appraisal in small groups of a systematic review. The 274 participants came from varied backgrounds, though chiefly in public health and purchasing. The workshops were well received and were oversubscribed. Participants reported that they found them useful and that they raised their awareness of the place of evidence about effectiveness in decision-making. The challenge now is to evaluate the impact of such workshops more rigorously.

Health Personnel↗

Workshop helps nurses develop pain management techniques.

Recognizing that nurses' attitudes, their knowledge of medications, and their communication practices can influence pain management effectiveness, health care professionals at St. John's Hospital, Springfield, IL, developed a workshop to educate registered nurses and licensed practical nurses on the pharmacology and uses of analgesics. The eight-hour workshop incorporated lectures, role playing, audiovisuals, and case study applications. To evaluate the program, a questionnaire was distributed to participants three months after the workshop. Responses indicated that nurses believed they had improved their pain management skills, and project coordinators' observations on the subacute and acute care nursing units confirmed this. For example, nurses communicated pain assessments and medication follow-ups more frequently. A pain intensity scale and a pain relief worksheet were designed to assist nurses in charting patients' medication needs. The nurses also developed confidence in discussing patients' needs with physicians. If an analgesic failed to control a patient's pain, the nurses became more assertive in asking for a more effective medication. The workshops, which helped promote cooperation among physicians, nurses, pharmacists, and other health care professionals, now are presented regularly to new nursing staff as an ongoing part of St. Joseph's pain management education program.

Hospital Bed Capacity, 500 and over↗

The first Australian workshop on bedside ultrasound in the Emergency Department.

AIMS: Bedside ultrasound is not widely practised by emergency physicians in Australasia despite its use in Europe, Asia and North America, and an extensive medical literature on the subject. A workshop was organised at Auckland Hospital, aiming to introduce emergency physicians to the basics of emergency ultrasound. This article summarises the content of the programme, the responses from the participants and the principles that emerged at this workshop. METHODS: A standardised, 16-hour, emergency ultrasound curriculum was offered to 23 participants. Lectures with syllabus material were used to cover the following topics: basic ultrasound physics, pelvis, right upper quadrant, renal, aorta, trauma and echocardiography. Each participant received eight hours of hands-on ultrasound instruction. On completion of the course participants responded anonymously to a course appraisal questionnaire. RESULTS: Twenty-one participants responded to the questionnaire (91% response rate). Delegates found the course informative and the material was considered relevant. Workshop objectives were met and the venue was appropriate. Most participants thought the practical sessions could be improved by decreasing the ratio of delegates to human models. CONCLUSIONS: The first Australasian workshop on bedside ultrasound in the Emergency Department held in Auckland (February 1998) was successful in achieving its objectives. Focused emergency ultrasound can be taught to detect free intraperitoneal or pericardial fluid in trauma patients. There is a need for appropriate quality assurance and credentialling guidelines as more Australasian emergency departments consider the application of focused ultrasound.

Attitude of Health Personnel↗

Evaluation of a workshop to teach clinical bioethics in the clinical setting.

That the teaching of medical ethics must extend into the clinical years in order for medical students to effectively acquire the knowledge and skills required for dealing with clinical bioethical issues has been widely recognized. A limiting factor has been the lack of physicians able to teach bioethics in the clinical setting. This paper describes the structure and evaluation of a workshop for teaching clinicians how to teach bioethics in the clinical setting. 80 physicians participated in 4 workshops in which they were provided with the ethical principles needed to deal with clinical bioethical issues and appropriate teaching methods. Methods such as paper cases, videotaped standardized patient interactions and live standardized patients were presented. The workshops have been highly evaluated. Post workshop evaluation showed that a significant number of physicians taught ethical issues during rounds and seminars. The frequency of teaching ranged from once per month to one or more times per week.

Attitude of Health Personnel↗

Evaluation of an osteoporosis workshop for women.

Osteoporosis is a serious health problem that has reached epidemic proportions among Canadian women. This disease, and its concomitant fractures, places a heavy burden on society in terms of human suffering, loss of productivity, death, and health care costs. In keeping with these concerns, a Canadian community health agency has developed a series of workshops that are designed, in part, to educate women about this disease and to encourage them to take appropriate steps to prevent it or to make informed decisions about its treatment. The present study was designed to evaluate the outcome of one of these workshops. A semi-experimental design was used to measure any changes in the participants' knowledge about osteoporosis and their prevention and treatment practices regarding this disease. The results were compared to those of a control group that consisted of members of various branches of the Women's Institute who volunteered to participate in the study. The findings indicate that the workshop was effective in increasing the participants' level of knowledge on osteoporosis, an increase that was still evident 6 months following the session. The effect of the workshop on the actual preventive and treatment practices of women who attended, however, was limited to a slight increase in the use of hormone replacement therapy (HRT) and calcium intake.

Aged↗

Survey and workshop initiative on community nurses' knowledge of the Internet.

Information technology in the nursing profession has been in existence for years, but only now with the growing presence of the Internet is it viewed as a possible platform to help meet the need for nurses' continuing educational development. For this to happen, it is important to know qualified nurses' experience with the Internet. In the United Kingdom, there is little understanding of whether community nurses have experience in using the Internet and if they do, how they use it. This article reports the findings of a survey questionnaire, taken in 1998, that was designed to target a random sample of 100 community nurses in Aberdeen, Scotland, to gauge awareness and attitudes toward the use of electronic sources of information for continuing education purposes. The response rate for the questionnaire was 83% (n = 83). A series of workshops was also undertaken, exploring the potential of the Internet and its access. A total of 52 people attended the workshops. One of the main aims of the workshops was to demystify the image of the computer, breaking down barriers for those with little or no experience in this field. The major findings of the survey and workshops indicate that although many respondents were interested in the potential benefits of the Internet to access information, there was little use made of and limited access to computer equipment.

Adult↗

Reading research: a review of a research critical appraisal workshop.

Evidence-based practice requires that nurses possess the skills to critically evaluate and apply research findings. Unfortunately, many nurses have had no formal training in research appraisal. A five-hour workshop was offered to nurses working within nephrology settings, to assist nurses to develop research appraisal skills. This article provides an outline of the workshop agenda and reviews the session evaluations made by participants and group facilitators. Based upon the feedback from the five-hour workshop, a model for a future research appraisal workshop is presented.

Canada↗