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PubMed1982

Vacuolar myopathy with type 2 A fiber atrophy and type 2 B fiber deficiency. A case of childhood form acid alpha-1,4-glucosidase deficiency.

This report describes a female patient with childhood form of acid maltase deficiency who survived till fifteen years old. Although acid alpha-1,4-glucosidase was deficient in the liver, kidney, skeletal and cardiac muscles, neutral alpha-1,4-glucosidase was present in normal concentrations in those organs. On light microscopic examination, numerous intracytoplasmic vacuoles containing acid phosphatase positive granules and PAS positive materials were present in both type 1 and 2 A fibers, predominantly in the latter. The striking finding in the present case was a selective type 2 fiber atrophy with type 2 B fiber deficiency believed to result from type 2 motor neuron dysfunction in the spinal cord. Electron microscopic study revealed extensive glycogen particle accumulation, autophagic vacuoles and myelin figures in the muscle fibers.

Adolescent↗

PubMed2003

Man-made mineral fiber hazardous properties assessment using transgenic rodents: example of glass fiber testing.

Transgenic BigBlue rats were exposed to CM 44 glass fibers (6.3 mg/m3) by nose only, 6 h/day for 5 days. Two endpoints were examined 1, 3, 14, 28, and 90 days following exposure: fiber biopersistence and mutations in lung DNA. The half-time of the fibers >20 microm was 12.8 days, and mutant frequencies of control and exposed rats were similar across all time points. The mutation spectra of both series were similar after 28 days of fixation time. These results showed that a glass fiber with a high clearance in the lung seems to not present any significant effect on mutagenesis on lung DNA and are in marked contrast to results for asbestos, which caused a twofold mutant frequency increase as described in a previous study.

Animals↗

PubMed1965

Correlated morphological and physiological studies on isolated single muscle fibers. I. Fine structure of the crayfish muscle fiber.

Single fibers isolated from walking leg muscles of crayfish have 8- to 10-micro sarcomeres which are divided into A, I, and Z bands. The H zone is poorly defined and no M band is distinguishable. Changes in the width of the I band, accompanied by change in the overlap between thick and thin myofilaments, occur when the length of the sarcomere is changed by stretching or by shortening the fiber. The thick myofilaments (ca. 200 A in diameter) are confined to the A band. The thin myofilaments (ca. 50 A in diameter) are difficult to resolve except in swollen fibers, when they clearly lie between the thick filaments and run to the Z disc. The sarcolemma invaginates at 50 to 200 sites in each sarcomere. The sarcolemmal invaginations (SI) form tubes about 0.2 micro in diameter which run radially into the fiber and have longitudinal side branches. Tubules about 150 A in diameter arise from the SI and from the sarcolemma. The invaginations and tubules are all derived from and are continuous with the plasma membrane, forming the transverse tubular system (TTS), which is analogous with the T system of vertebrate muscle. In the A band region each myofibril is enveloped by a fenestrated membranous covering of sarcoplasmic reticulum (SR). Sacculations of the SR extend over the A-I junctions of the myofibrils, where they make specialized contacts (diads) with the TTS. At the diads the opposing membranes of the TTS and SR are spaced 150 A apart, with a 35-A plate centrally located in the gap. It appears likely that the anion-permselective membrane of the TTS which was described previously is located at the diads, and that this property of the diadic structures therefore may function in excitation-contraction coupling.

Animals↗

PubMed1989

A component of the side tail fiber of Escherichia coli bacteriophage lambda can functionally replace the receptor-recognizing part of a long tail fiber protein of the unrelated bacteriophage T4.

The distal part of the long tail fiber of Escherichia coli bacteriophage T4 consists of a dimer of protein 37. Dimerization requires the catalytic action of protein 38, which is encoded by T4 and is not present in the virion. It had previously been shown that gene tfa of the otherwise entirely unrelated phage lambda can functionally replace gene 38. Open reading frame (ORF) 314, which encodes a protein that exhibits homology to a COOH-terminal area of protein 37, is located immediately upstream of tfa. The gene was cloned and expressed in E. coli. An antiserum against the corresponding polypeptide showed that it was present in phage lambda. The serum also reacted with the long tail fibers of phage T4 near their free ends. An area of the gene encoding a COOH-terminal region of ORF 314 was recombined, together with tfa, into the genome of T4, thus replacing gene 38 and a part of gene 37 that codes for a COOH-terminal part of protein 37. Such T4-lambda hybrids, unlike T4, required the presence of outer membrane protein OmpC for infection of E. coli B. An ompC missense mutant of E. coli K-12, which was still sensitive to T4, was resistant to these hybrids. We conclude that the ORF 314 protein represents a subunit of the side tail fibers of phage lambda which probably recognize the OmpC protein. ORF 314 was designated stf (side tail fiber). The results also offer an explanation for the very unusual fact that, despite identical genomic organizations, T4 and T2 produce totally different proteins 38. An ancestor of T4 from the T2 lineage may have picked up tfa and stf from a lambdoid phase, thus possibly demonstrating horizontal gene transfer between unrelated phage species.

Bacteriophage lambda↗

PubMed2003

Micro-optical 1 x 4 fiber switch for multimode fibers with 600-microm core diameters.

The design, manufacture, and test of a 1 x 4 micro-optical fiber switch for multimode fibers with 600-microm core diameters are described. Microlens array telescopes allow for variable and fast beam deflection when the positions of the cylindrical microlens arrays relative to each another are altered by specially designed piezomechanical actuators. Standard achromats are used for collimation of light emitted by the input multimode fiber and for focusing of the deflected light onto a linear array of output multimode fibers. Design and assembly of micro-optical as well as of optomechanical components are discussed. Insertion loss and cross talk are measured, and the results are compared with those of numerical optical simulations. Measurements of switching time and long-term stability, as well as of thermal behavior, are also presented.

Journal Article↗

PubMed2005

Versatile in-fiber sensing by use of core-replaced D-fiber.

We present a method of replacing a section of the core of a D-shaped optical fiber with sensing materials as a platform for various extrinsic fiber sensors. In this configuration light guides within the sensing material allow for strong interaction between the sensing material and the optical field. Initial experimental results indicate that replacing the fiber core with polymer enhances its temperature sensitivity by at least a factor of 5. The new technique is promising as a means for incorporating various sensing materials into the path of a beam traveling in an optical fiber.

Journal Article↗

PubMed2005

Microinterferometric optical phase tomography for measuring small, asymmetric refractive-index differences in the profiles of optical fibers and fiber devices.

A new technique, microinterferometric optical phase tomography, is introduced for use in measuring small, asymmetric refractive-index differences in the profiles of optical fibers and fiber devices. The method combines microscopy-based fringe-field interferometry with parallel projection-based computed tomography to characterize fiber index profiles. The theory relating interference measurements to the projection set required for tomographic reconstruction is given, and discrete numerical simulations are presented for three test index profiles that establish the technique's ability to characterize fiber with small, asymmetric index differences. An experimental measurement configuration and specific interferometry and tomography practices employed in the technique are discussed.

Journal Article↗

PubMed2005

Dynamic evolution of the spectrum of long-period fiber Bragg gratings fabricated from hydrogen-loaded optical fiber by ultraviolet laser irradiation.

Long-period fiber Bragg gratings fabricated by exposure of hydrogen-loaded fiber to UV laser light exhibit large-scale dynamic evolution for approximately two weeks at room temperature. During this time two distinct features show up in their spectrum: a large upswing in wavelength and a substantial deepening of the transmission minimum. The dynamic evolution of the transmission spectrum is explained quantitatively by use of Malo's theory of UV-induced quenching [Electron. Lett. 30, 442 (1994)] followed by refilling of hydrogen in the fiber core and the theory of hydrogen diffusion in the fiber material. The amount of hydrogen quenched by the UV irradiation is 6% of the loaded hydrogen.

Journal Article↗

PubMed2003

Short-pulse, all-fiber, Raman laser with dispersion compensation in a holey fiber.

The use of Raman gain in conventional fiber followed by dispersion compensation in a holey fiber in a synchronously pumped laser configuration allowed compression by a factor of 8.5 of output pulses at a selected wavelength with respect to the pump pulses. We obtained 2-ps output pulses at 1.14 microm from a totally fiber-integrated laser pumped with 17-ps pulses at 1 microm. Higher pulse compression should be possible with nonlinear chirp compensation. Ultrashort-pulse, all-fiber Raman lasers at wavelengths shorter than 1.3 microm are feasible.

Journal Article↗

PubMed2004

High-power supercontinuum generation in highly nonlinear, dispersion-shifted fibers by use of a continuous-wave Raman fiber laser.

High-power supercontinua are demonstrated in highly nonlinear, dispersion-shifted fibers with a continuous-wave Raman fiber laser. Supercontinuum growth is experimentally studied under different combinations of fiber length and launch power to show output powers as high as 3.2 W and bandwidths greater than 544 nm. Modulation instability (MI) is observed to seed spectral broadening at low launch powers, and the interplay between MI and stimulated Raman scattering plays an important role in the growth of the continuum at high launch powers. The effect on continuum generation of parametric four-wave mixing coupled with the higher-order dispersion properties of the fiber is investigated.

Journal Article↗

PubMed2005

20-kW peak power all-fiber 1.57-microm source based on compression in air-core photonic bandgap fiber, its frequency doubling, and broadband generation from 430 to 1450 nm.

We demonstrate an ultrashort all-fiber-integrated chirped-pulse amplification system yielding 1-ps pulses with 20 kW of peak power. 40-ps initial pulses generated by an externally modulated laser diode are chirped by self-phase modulation in a conventional fiber, amplified, and compressed in 110 m of air-core photonic bandgap fiber. The compressed pulses are frequency doubled in a periodically poled KTP crystal with up to 48% efficiency and applied to supercontinuum generation in a holey fiber, resulting in a high-power uniform continuum that stretches from 430 to 1450 nm.

Journal Article↗

PubMed2005

Continuous-wave supercontinuum laser based on an erbium-doped fiber ring cavity incorporating a highly nonlinear optical fiber.

We experimentally demonstrate a novel erbium-doped fiber based continuous-wave (cw) supercontinuum laser. The laser has a simple ring-cavity structure incorporating an erbium-doped fiber and a highly nonlinear dispersion-shifted fiber (HNL-DSF). Differently from previously demonstrated cw supercontinuum sources based on single propagation of a strong Raman pump laser beam through a highly nonlinear fiber, erbium gain inside the cavity generates a seed light oscillation, and the oscillated light subsequently evolves into a supercontinuum by nonlinear effects such as modulation instability and stimulated Raman scattering in the HNL-DSF. High quality of the depolarized supercontinuum laser output with a spectral bandwidth larger than 250 nm is readily achieved.

Journal Article↗

PubMed2006

Self-Q-switched Er-Brillouin fiber source with extra-cavity generation of a Raman supercontinuum in a dispersion-shifted fiber.

Brillouin mirrors based on a single-mode optical fiber provide the simplest, completely passive, and most universal way to produce nanosecond pulses with extensive wavelength tunability. We propose an all-fiber solution, where a passively Q-switched Er-doped Briilouin fiber laser pumped by a low-power laser diode produces pulses with a peak/average power contrast of 500 W/25 mW and, in association with a conventional dispersion-shifted fiber employed as an extracavity nonlinear medium, causes the generation of a nanosecond supercontinuum extending from 900 to over 1800 nm. Expanding evolution of the spectrum kicked off by the multicascade Brillouin process is reported.

Journal Article↗

PubMed2006

Erbium fiber laser based on intracore femtosecond-written fiber Bragg grating.

We report the inscription of fiber Bragg gratings (FBGs) into a nonphotosensitive Er-doped fiber by using a phase-mask scanning technique with near IR femtosecond laser pulses. A grating of 40 mm length with a period of 1.075 microm was realized. We measured transmission losses of -18.9 dB at lambda=1554.5 nm with a FWHM bandwidth of 0.15 nm. By pumping the fiber containing the fabricated FBG, it was possible to realize a fiber laser with an output power of 38 mW, a slope efficiency of 21.1%, and low noise (SNR=60 dB).

Journal Article↗

PubMed2006

Coupling characteristics between single-core fiber and multicore fiber.

A simple method for coupling between a single-core single-mode fiber and a multicore single-mode fiber is proposed and demonstrated. An effective coupling approach is based on a process of standard splicing and tapering between the single-core single-mode fiber and the multicore single-mode fiber.

Journal Article↗

PubMedDate not supplied

The effect of placement of glass fibers and aramid fibers on the fracture resistance of provisional restorative materials.

The fracture resistance of provisional restorations is an important concern for the restorative dentist. The fracture resistance of a material is directly related to its transverse strength. Six specimens of similar dimensions were prepared from three resins (PMMA, PEMA and BIS acryl-composite). The resins were reinforced with glass and aramid fibers. The samples were tested immediately after the material set, following seven days of wet storage using three-point compression loading. The results were analyzed with an analysis of variance (ANOVA). Fracture resistance of the specimens was statistically different (p < 0.001) among the materials. Specimens reinforced with glass fibers showed higher transverse strength (149.82 MPa). The fiber reinforcement of resin materials increased the strength values (20-50%). Within the limitations of this study, the transverse strengths of PMMA, PEMA and BIS acryl-resin composites were improved after reinforcement with glass and aramid fibers.

Acrylic Resins↗

PubMed1989

[Fiber emissions from weathered asbestos cement products. 2. Physical-chemical properties of liberated asbestos fibers].

It could be already shown that fibrous particulates can be emitted from weathered and corroded surfaces of asbestos-cement-(AC)-products and that these fibers increase the total ambient air concentration after having been dispersed in the atmosphere. In this investigation we studied the influence of the polluted atmosphere on physical and chemical properties of asbestos fibers in the corroded surface layer. It was found, that in a part of these asbestos fibers the magnesium was partly leached and that the fibers were strongly contaminated by deposited air pollutants.

Air Pollutants↗

PubMed1986

Past exposures to airborne fibers and other potential risk factors in the European man-made mineral fiber production industry.

A historical environmental investigation was undertaken in European man-made mineral fiber factories (MMMF). The aim was to assess past exposures to MMMF and other environmental risk factors (asbestos, polycyclic aromatic hydrocarbons, polychlorinated biphenyls, formaldehyde, and arsenic). A self-administered questionnaire completed by each plant management and an interview of the respondents were used. Addition of oil to the MMMF, change in the nominal fiber size of the bulk MMMF, and elimination of early discontinuous production techniques were identified as principal changes. The absence of oil, small nominal size, and labor-intensive production have been judged to be associated with higher airborne fiber levels. It was concluded that for epidemiologic purposes the subdivision of the history of each plant into an early, intermediate, and late technological phase based on the aforementioned changes would be appropriate. Corresponding time periods were identified for asbestos usage, use of bitumen as a binder, and production of slag wool. Two factories were singled out for specific attention: one where asbestos was used in calcium silicate brick production and one where olivine, used as a raw material, may have been contaminated with natural mineral fibers and where the production process would have exposed workers to coal-tar pitch volatiles.

Air Pollutants, Occupational↗