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Lattice permutation for reducing motion artifacts in radial and spiral dynamic imaging.

Radial and spiral trajectories exhibit favorable characteristics for dynamic imaging. Nevertheless, changes in image contents during acquisition lead to inconsistencies in the k-space data, which are manifested as streaks or spiral artifacts, respectively. This work proposes the concept of lattice permutation to reorder the data segments for artifact suppression. This acts to reshuffle the alias pattern along the temporal frequency axis. The proposed approach is well suited to sliding window reconstruction, although more sophisticated methods are also possible. For typical image series where the signal energies are concentrated in the low temporal frequencies, the permutation displaces most of the aliased signals from the low temporal frequencies to the high temporal frequencies, where they are attenuated by sliding window reconstruction, while the signals in the low temporal frequencies are mostly contaminated by aliasing from the much weaker signals in the higher temporal frequencies. This results in considerably reduced artifacts without any increase in scan time. In practice, lattice permutation achieves similar artifact suppression as the bit-reversed order, but with a less stringent restriction on the number of segments. At the same time, it provides a more powerful approach to controlling the alias pattern exactly. Results from real-time cardiac imaging are demonstrated.

Artifacts↗

Selective suppression of artifact-generating echoes in cine DENSE using through-plane dephasing.

In displacement-encoded imaging with stimulated echoes (DENSE), tissue displacement is encoded in the phase of the stimulated echo. However, three echoes generally contribute to the acquired signal (the stimulated echo, the complex conjugate of the stimulated echo, and an echo due to T(1) relaxation). It is usually desirable to suppress all except the stimulated echo, since otherwise the additional echoes will cause displacement measurement errors. Ideally, suppression of the artifact-generating echoes would be independent of time, T(1), and displacement-encoding frequency, and would not require additional acquisitions. In this study through-plane gradients were used to selectively dephase artifact-generating echoes without causing significant signal loss of the stimulated echo. A cine DENSE sequence was modified to include dephasing gradients and perform complementary spatial modulation of magnetization (CSPAMM). For single-acquisition cine DENSE using dephasing alone, artifact suppression was similar to CSPAMM with two acquisitions. The use of dephasing with CSPAMM required two acquisitions, but demonstrated greater artifact suppression than CSPAMM alone or dephasing alone.

Algorithms↗

ANC schemes for the enhancement of EEG signals in the presence of EOG artifacts.

One of the most important applications of adaptive systems is in noise cancellation using adaptive filters. In this paper, we propose adaptive noise cancellation schemes for the enhancement of EEG signals in the presence of EOG artifacts. The effect of two reference inputs is studied on simulated as well as recorded EEG signals and it is found that one reference input is enough to get sufficient minimization of EOG artifacts. This has been verified through correlation analysis also. We use signal to noise ratio and linear prediction spectra, along with time plots, for comparing the performance of the proposed schemes for minimizing EOG artifacts from contaminated EEG signals. Results show that the proposed schemes are very effective (especially the one which employs Newton's method) in minimizing the EOG artifacts from contaminated EEG signals.

Algorithms↗

Artifacts in sensitivity-enhanced HSQC.

Proton-proton coupling can generate artifacts in sensitivity-enhanced HSQC spectra. These artifacts appear as cross-peaks involving remote protons. They are caused by relayed coherence transfer during the back-transfer portion of the pulse sequence. We present a product operator analysis of artifact formation and experimental results which demonstrate that the magnitude of these artifacts can exceed 10% of the main peak.

Artifacts↗

Microimaging at 14 tesla using GESEPI for removal of magnetic susceptibility artifacts in T(2)(*)-weighted image contrast.

In magnetic resonance imaging (MRI), T(2)(*)-weighted contrast is significantly enhanced by extremely high magnetic field strength, offering broad potential applications. However, the T(2)(*)-weighted image contrast distortion and signal loss artifact arising from discontinuities of magnetic susceptibility within and around the sample are also increased, limiting utilization of high field systems for T(2)(*)-weighted contrast applications. Due to the B(0) dependence of the contrast distortions and signal losses, and the heterogeneity of magnetic susceptibility in biological samples, magnetic susceptibility artifacts worsen dramatically for in vivo microimaging at higher fields. Practical applications of T(2)(*)-sensitive techniques enhanced by higher magnetic fields are therefore challenged. This report shows that magnetic susceptibility artifacts dominate T(2)(*)-weighted image contrast at 14 T, and demonstrates that the GESEPI (gradient echo slice excitation profile imaging) technique effectively reduces or eliminates these artifacts at long TE in the highest field (14 T) currently available for (1)H imaging.

Algorithms↗

Improved reduction of motion artifacts in diffusion imaging using navigator echoes and velocity compensation.

Navigator echoes provide a means with which to remove motion artifacts from diffusion-weighted images obtained using any multishot imaging technique. However, residual motion artifact is often present in the corrected images rendering the technique unreliable. It is shown that velocity-compensated diffusion sensitization when used in tandem with a navigator echo further reduces the degree of residual motion artifacts present in the corrected images and improves the reliability and clinical utility of the technique. This is demonstrated by applying a method for quantification of motion artifact to brain images of healthy volunteers scanned using both conventional (Stejskal-Tanner) and velocity-compensated gradient sensitization. Other factors affecting the efficacy of the navigator echo technique, such as brain pulsatile motion, gradient b factor, and navigator echo signal-to-noise ratio, are also discussed.

Artifacts↗

Motion artifact in magnetic resonance imaging: implications for automated analysis.

Automated measures of cerebral magnetic resonance images (MRI) often provide greater speed and reliability compared to manual techniques but can be particularly sensitive to motion artifact. This study employed an automatic MRI analysis program that quantified regional gray matter volume and created images for verification and quality control. Motion artifact was assessed on each image and assigned a rating of none, mild, moderate, or severe. Greater motion artifact was associated with smaller gray matter volumes. Severity of motion artifact is an important, but often overlooked, consideration in the interpretation of automated MRI measures.

Adolescent↗

Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI.

Artifacts generated by motion (e.g., ballistocardiac) of the head inside a high magnetic field corrupt recordings of EEG and EPs. This paper introduces a method for motion artifact cancellation. This method is based on adaptive filtering and takes advantage of piezoelectric motion sensor information to estimate the motion artifact noise. This filter estimates the mapping between motion sensor and EEG space, subtracting the motion-related noise from the raw EEG signal. Due to possible subject motion and changes in electrode impedance, a time-varying mapping of the motion versus EEG is required. We show that this filter is capable of removing both ballistocardiogram and gross motion artifacts, restoring EEG alpha waves (8-13 Hz), and visual evoked potentials (VEPs). This adaptive filter outperforms the simple band-pass filter for alpha detection because it is also capable of reducing noise within the frequency band of interest. In addition, this filter also removes the transient responses normally visible in the EEG window after echo planar image acquisition, observed during interleaved EEG/fMRI recordings. Our adaptive filter approach can be implemented in real-time to allow for continuous monitoring of EEG and fMRI during clinical and cognitive studies.

Adult↗

Removal of ocular artifacts from electro-encephalogram by adaptive filtering.

The electro-encephalogram (EEG) is useful for clinical diagnosis and in biomedical research. EEG signals, however, especially those recorded from frontal channels, often contain strong electro-oculogram (EOG) artifacts produced by eye movements. Existing regression-based methods for removing EOG artifacts require various procedures for preprocessing and calibration that are inconvenient and time-consuming. The paper describes a method for removing ocular artifacts based on adaptive filtering. The method uses separately recorded vertical EOG and horizontal EOG signals as two reference inputs. Each reference input is first processed by a finite impulse response filter of length M (M = 3 in this application) and then subtracted from the original EEG. The method is implemented by a recursive least-squares algorithm that includes a forgetting factor (lambda = 0.9999 in this application) to track the non-stationary portion of the EOG signals. Results from experimental data demonstrate that the method is easy to implement and stable, converges fast and is suitable for on-line removal of EOG artifacts. The first three coefficients (up to M = 3) were significantly larger than any remaining coefficients.

Algorithms↗

Preliminary study of correction of original metal artifacts due to 1-125 seeds in postimplant dosimetry for prostate permanent implant brachytherapy.

PURPOSE: We investigated a subtraction-based reprojection approach to reduce CT metal artifacts due to I-125 seeds and evaluated the clinical implications in postimplant dosimetry for prostate permanent implant brachytherapy. MATERIALS AND METHODS: The raw projection data were used to reduce metal artifacts due to I-125 seeds. CT images of the metal parts only were separated from the original CT images by setting the threshold for pixel value to that of the I-125 seeds. Using these images, sinograms of CT images with and without seeds were obtained by inverse Radon transform (iRT), and the sinogram of the metal image was subtracted from that of the original image. Finally, the image was reconstructed using the sinogram by Radon transform (RT). This technique was applied to a prostate phantom and to a patient undergoing prostate permanent implant brachytherapy. RESULTS: Metal artifacts from I-125 seeds were reduced in both the phantom and patient studies. This technique decreased the density of the inner region of seeds but enhanced the density of the seed edge, thereby facilitating the identification of seed number, orientation, and location. CONCLUSION: This method reduces metal artifacts from I-125 seeds, and has potential for decreasing the time required for and improving the accuracy of postimplant dosimetry.

Artifacts↗

Submicrovolt full-field cone electroretinograms: artifacts and reproducibility.

The clinical utility of submicrovolt full-field 30-Hz (cone) electroretinograms was assessed by quantifying their contamination by electrical and photoelectric artifacts from xenon-flash stimulators and their test-retest variation in patients with retinitis pigmentosa. Artifacts obtained in saline with four commonly used electrodes varied with electrode type and consisted of an early, brief electrical component and a superimposed, extended photoelectric component. Techniques for minimizing these artifacts are described. Electroretinogram recordings from patients with advanced retinitis pigmentosa or congenital rod monochromatism indicate that these artifacts can be virtually eliminated with bipolar lenses. To assess test-retest variation, narrow-band-filtered responses were obtained twice during 6 weeks from patients with amplitudes less than 1 microV; threshold criteria for significant (p < 0.05) change in amplitude with this technique were approximately 0.25 log unit for each of two different systems.

Adolescent↗

Entropy is more resistant to artifacts than bispectral index in brain-dead organ donors.

OBJECTIVE: To evaluate the usefulness of entropy and the bispectral index (BIS) in brain-dead subjects. DESIGN AND SETTING: A prospective, open, nonselective, observational study in the university hospital. PATIENTS AND PARTICIPANTS: 16 brain-dead organ donors. INTERVENTIONS: Time-domain electroencephalography (EEG), spectral entropy of the EEG, and BIS were recorded during solid organ harvest. MEASUREMENTS AND RESULTS: State entropy differed significantly from 0 (isoelectric EEG) 28%, response entropy 29%, and BIS 68% of the total recorded time. The median values during the operation were state entropy 0.0, response entropy 0.0, and BIS 3.0. In four of 16 organ donors studied the EEG was not isoelectric, and nonreactive rhythmic activity was noted in time-domain EEG. After excluding the results from subjects with persistent residual EEG activity state entropy, response entropy, and BIS values differed from zero 17%, 18%, and 62% of the recorded time, respectively. Median values were 0.0, 0.0, and 2.0 for state entropy, response entropy, and BIS, respectively. The highest index values in entropy and BIS monitoring were recorded without neuromuscular blockade. The main sources of artifacts were electrocauterization, 50-Hz artifact, handling of the donor, ballistocardiography, electromyography, and electrocardiography. CONCLUSION: Both entropy and BIS showed nonzero values due to artifacts after brain death diagnosis. BIS was more liable to artifacts than entropy. Neither of these indices are diagnostic tools, and care should be taken when interpreting EEG and EEG-derived indices in the evaluation of brain death.

Artifacts↗

Respiration artifacts in whole-body (18)F-FDG PET/CT studies with combined PET/CT tomographs employing spiral CT technology with 1 to 16 detector rows.

PURPOSE: Co-registration accuracy in combined whole-body (WB) PET/CT imaging is impaired by respiration-induced mismatches between the CT and the PET. Furthermore, PET/CT misregistration may bias the PET tracer distribution following CT-based attenuation correction (CT-AC). With the introduction of multi-row CT technology of up to 16 detector rows into PET/CT designs, we investigated the incidence of respiration artifacts in WB PET/CT examinations of patients who were unable to follow any breath-hold instructions. METHODS: A total of 80 WB studies from six international sites operating PET/CT tomographs with 1-, 2-, 4-, 6-, 8-, and 16-row spiral CT were included. PET/CT examinations were acquired with the patients breathing normally during both the CT and the PET scan, and CT-AC was performed routinely. All studies were anonymized and reviewed independently by three radiologists and three nuclear medicine specialists. We report the frequency and severity of artifacts on CT and PET for the thorax and the abdomen. RESULTS: In WB PET/CT imaging of normally breathing patients, significant gains in diagnostic image quality can be expected from employing CT technology with six or more detector rows. In our study, fewer PET images appear distorted than corresponding CT images, which is due to the limited propagation of only mild CT image artifacts after the resampling of the CT-based attenuation map during CT-AC. CONCLUSION: In whole-body PET/CT imaging of normally breathing patients, respiration-induced artifacts are reduced in both magnitude and prominence for PET/CT systems employing CT components of six or more detector rows.

Adolescent↗

Artifacts in the ascending aorta on computed tomography: another measure of aortic distensibility?

The appearance of the ascending aorta was studied in 53 patients undergoing computed tomography on a modern system capable of routine 1 second data acquisition times. Motion artifact caused a blurred aortic outline in 48 patients; the extent was objectively and subjectively assessed. The maximum and minimum cross-sectional aortic areas were measured at the margins of the blur. The area of the blur, expressed as a fraction of the minimum aortic cross-sectional area, decreased with age (P < 0.001) and was significantly smaller in the 13 patients with known cardiovascular problems (P < 0.05). These findings were substantiated by the subjective gradings which showed less marked artifacts amongst elderly patients (although this observation did not reach statistical significance). Artifacts were less prominent in 16 patients with evidence of aortic wall calcification, both on subjective grading (P < 0.05) and formal area measurements (P < 0.05). These observations lead us to believe our postulation that this artifact is an indicator of aortic distensibility and thus, indirectly, of cardiovascular status.

Adolescent↗

Pulsatile motion artifact reduction in 3D steady-state-free-precession-echo brain imaging.

An image can be made from the echo of a steady-state-free-precession and pulse sequences for this purpose have been implemented on various commercial systems under such names as "CE-FAST" and "SSFP" (herein generically termed SSFP-Echo). Such sequences can be employed to achieve strong T2-weighting with reduced T2* effects, but are limited by their sensitivity to flow and motion which produce artifacts. Simple considerations indicate that this sensitivity is primarily related to the (implementation-dependent) moments of the imaging gradients. In this work, MR imaging of the brain using a standard implementation of the sequence with large moment "crusher" gradients on the slice select axis (to dephase the FID of the SSFP) is compared to a modified implementation with reduced moment gradient pulses and different radiofrequency (RF) phase cycling. Asymmetric echo acquisition and narrowed bandwidth was used to further reduce gradient moments. The sensitivity of this sequence to flow and motion artifacts, especially for motion perpendicular to the slice, is thus expected to be significantly reduced. The modified sequence was found to have flow and motion artifacts reduced by a factor of five in the axial plane and a factor of two in the coronal plane. These modifications can thus significantly reduce the flow and motion artifacts commonly seen in conventional images of the SSFP echo with little or no penalty in scan time or signal-to-noise ratio.

Artifacts↗

Vascular access ports and catheters: ex vivo testing of ferromagnetism, heating, and artifacts associated with MR imaging.

The purpose of this study was to evaluate ferromagnetic qualities, heating, and artifacts associated with MR imaging of implantable vascular access ports (IVAPs, N = 9) and catheters (N = 8). Ferromagnetism was determined using previously described techniques. Heating was assessed for the IVAPs by measuring temperature immediately before and after performing a 3D GRASS, MTC pulse sequence for 60 min at an SAR of 2.8 W/kg. Artifacts were evaluated in association with the use of a fast GRASS pulse sequence and graded according to the severity of image distortion. None of the IVAPs or catheters were attracted by the magnetic field of the MR system. The largest temperature change measured was -0.3 degree C. Artifacts varied, depending on the component materials used for the construction of the IVAPs and catheters. The lack of ferromagnetic qualities and negligible heating indicates that MR imaging performed at 1.5 T or less may be conducted safely in patients with each of the IVAPs and catheters tested. None of the artifacts produced by the presence of the IVAPs or catheters is considered to impair the diagnostic aspects of MR imaging, especially if the device is not positioned directly in the imaging area of interest.

Artifacts↗

Artifact processing in topographic mapping of electroencephalographic activity in neuropsychopharmacology.

Mapping of the electroencephalogram (EEG) has been found to be a valuable method in clinical neuropsychopharmacology. It is evident that careful treatment of artifacts is of utmost importance for EEG data processing, as artifacts that contaminate the EEG data can lead to spurious results. The artifact-processing method described in this article splits signal analysis into a preprocessing step, yielding individual electro-oculographic (EOG) regression factors for EOG minimization, and into a processing step, yielding target variables. The combination of avoiding, minimizing, and identifying artifacts, as well as visual checking of face validity, will help remove artifactual effects from the EEG.

Aged↗

Correction of motion artifacts from cardiac cine magnetic resonance images.

RATIONALE AND OBJECTIVES: An image registration method was developed to automatically correct motion artifacts, mostly from breathing, from cardiac cine magnetic resonance (MR) images. MATERIALS AND METHODS: The location of each slice in an image stack was optimized by maximizing a similarity measure of the slice with another image slice stack. The optimization was performed iteratively and both image stacks were corrected simultaneously. Two procedures to optimize the similarity were tested: standard gradient optimization and stochastic optimization in which one slice is chosen randomly from the image stacks and its location is optimized. In this work, cine short- and long-axis images were used. In addition to visual inspection results from real data, the performance of the algorithm was evaluated quantitatively by simulating the movements in four real MR data sets. The mean error and standard deviation were defined for 50 simulated movements as each slice was randomly displaced. The error rate, defined as the percentage of non-satisfactory registration results, was evaluated. The paired t-test was used to evaluate the statistical difference between the tested optimization methods. RESULTS: The algorithm developed was successfully applied to correct motion artifacts from real and simulated data. The results, where typical motion artifacts were simulated, indicated an error rate of about 3%. Subvoxel registration accuracy was also achieved. When different optimization methods were compared, the registration accuracy of the stochastic approach proved to be superior to the standard gradient technique (P < 10(-9)). CONCLUSIONS: The novel method was capable of robustly and accurately correcting motion artifacts from cardiac cine MR images.

Adult↗