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PubMed1985

Diminished internalization and action of 1,25-dihydroxyvitamin D3 in dermal fibroblasts cultured from New World primates.

We investigated the occurrence of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]-resistant osteomalacia in the New World primate colony of Saguinus imperator at the Los Angeles Zoo. The mean serum concentration of 1,25-(OH)2D3 was elevated 5-fold in the New World primates compared to that in their Old World counterparts. The specific internalization of 0.6 nM [3H]1,25-(OH)2D3 by cultured dermal fibroblasts from New World primates was reduced 75% compared to that by cells from Old World primates or man. The decrease in hormone uptake resulted from a decrease in the number of high affinity intracellular binding sites for 1,25-(OH)2D3 and apparently caused a 90-95% reduction in 1,25-(OH)2D3-induced 25-hydroxyvitamin-D3-24-hydroxylase activity. There was no alteration in the capacity or avidity of New World primate serum for 1,25-(OH)2D3 compared to that of serum from Old World primates. These data suggest that the occurrence of vitamin D-resistant osteomalacia in New World primates is the result of decreased high affinity, receptor-mediated uptake of 1,25-(OH)2D3 by the target cell.

Animals↗
PubMedDate not supplied

Fauna, flora, fowl, and fruit: effects of the Columbian Exchange on the allergic response of New and Old World inhabitants.

The Columbian Exchange has been described as "the most important event in human history since the end of the Ice Age." This interchange of many species of fauna, flora, fowl, and fruits resulted in new encounters between New and Old World inhabitants. Prominent among these were manifestations of allergic reactions to many of the new substances. Little imagination is required to reflect on what these substances, added to or detracted from both the New and Old World lifestyles, habits, and diets. The numerous peas, vegetable seeds, and grasses, such as sugarcane, introduced during Columbus' later voyages, made an enormous difference in the lives of New World inhabitants, as did the introduction of the cow and horse, not to mention substances such as coconuts and bananas, that are now intimately associated with the Caribbean and the Bahamas. This article focuses on some the more important exchange substances and emphasizes many forms of anaphylaxis: asthma, food allergy, hypersensitivity pneumonitis, chronic bronchitis, rhinitis, serum sickness, and other conditions that developed in both New and Old World inhabitants. To mention only a few examples, the Europeans introduced to the New World potential dangers such as honeybees (anaphylaxis). It also gave the New World the cow and the horse (serum sickness), which became the constant companion of Columbus' Indians and the American cowboy. It gave the Italians their thick red gravy, and the New World its pizza (food allergy). The Caribbean received bananas and coconuts and the New World embraced coffee (caffeine addiction). On the other hand, the exchange also caused Europeans to begin puffing away on tobacco.

Animals↗
PubMed2006

[Explosion of the subjective world].

PURPOSE: This text was inspired by an article in psycho-oncology: "The influence of psychotherapy on the extension of life in people with advanced cancer". I intend to show that cancer causes disintegration ("explosion") of a person's subjective world. MATERIAL AND METHODS: (philosophical discourse): Categories of the personal world and the subjective world are introduced and the reality of the subjective world is accepted. The following connotations are essential to further discussion: The mind acts on the body. The psychic state (therefore the state of the brain) is reflected in states and processes localized outside the brain. The epistemologist desires to discover the causal mechanism that explains these effects. The body may act on the mind. Overwhelming evidence has accumulated that disorders of the mind may be caused by disturbances of processes in the nervous system. I reject the view that "the brain is the cause of the mind". CONCLUSIONS: Every person lives in his or her own, private, subjective world. It is a relatively stable world of personal memories, observations and imaginations. This world extends in subjective time and space. Its content is composed of conscious psychic experiences, one after another. Experiences create the stream of consciousness. Serious illness leads to the explosion or disintegration of subjective world, destruction of one's sense of personal identity, impossibility of autoreflection, and loss of sense of living. In such cases, individualized psychotherapeutic intervention proves to be irreplaceable.

Body Image↗
PubMed1994

Epidemiology and ethics: the perspective of the Third World.

The relation of epidemiology and ethics is discussed from a Third World perspective, including the following issues: the structure and dynamics of a Third World Society; the nature of the relationship between the First World "islanders" in the Third World and their counterparts in the First World, and between the "islanders" and their fellow citizens; the inner dynamics of Third World researchers; the different knowledge systems; and the role of institutions in the Third World and the First World.

Biomedical Research↗
PubMed2002

New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor.

Alpha-dystroglycan (alpha-DG) has been identified as a major receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa virus, two Old World arenaviruses. The situation with New World arenaviruses is less clear: previous studies demonstrated that Oliveros virus also exhibited high-affinity binding to alpha-DG but that Guanarito virus did not. To extend these initial studies, several additional Old and New World arenaviruses were screened for entry into mouse embryonic stem cells possessing or lacking alpha-DG. In addition, representative viruses were further analyzed for direct binding to alpha-DG by means of a virus overlay protein blot assay technique. These studies indicate that Old World arenaviruses use alpha-DG as a major receptor, whereas, of the New World arenaviruses, only clade C viruses (i.e., Oliveros and Latino viruses) use alpha-DG as a major receptor. New World clade A and B arenaviruses, which include the highly pathogenic Machupo, Guanarito, Junin, and Sabia viruses, appear to use a different receptor or coreceptor for binding. Previous studies with LCMV have suggested the need for a small aliphatic amino acid at LCMV GP1 glycoprotein amino acid position 260 to allow high-affinity binding to alpha-DG. As reported herein, this requirement appears to be broadly applicable to the arenaviruses as determined by more extensive analysis of alpha-DG receptor usage and GP1 sequences of Old and New World arenaviruses. In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position.

Amino Acid Sequence↗
PubMed2000

The World Bank and pharmaceuticals.

Within less than a decade the World Bank has become the largest single source of finance (loans) for health in low and middle income countries as well as a major player in the field of pharmaceuticals. Often 20-50% of the recurrent government health budget in developing countries is used to procure drugs. Drugs are among the most salient and cost-effective elements of health care and often a key factor for the success of a health sector reform. However, pharmaceuticals are frequently being used irrationally, mainly due to market imperfections in health care, such as information asymmetries, leading to serious health problems and a heavy financial burden on the health system. Lending priorities set by the World Bank could be used to promote public health sector reform, leading to the rational use of affordable and available drugs of good quality in developing countries. This report provides the first analysis of World Bank activity in the pharmaceutical sector worldwide. The analysis of 77 staff appraisal reports, describing the planning phase of World Bank country projects, shows that 16% of the total World Bank health, nutrition and population budget, or approximately US$1.3 billion, has been committed to loans or credits supporting pharmaceutical activities in the programme countries between 1989-95. Roughly US$1.05 billion has been committed to procurement of drugs and medical equipment. Only 5% of the total pharmaceutical sector lending is committed to software components such as drug policy work and rational use of drugs. No more than 45% of the projects were developed in collaboration with pharmaceutical expertise. The World Bank is recommended to improve its pharmaceutical sector involvement by promoting drug policy research and development including national and international dialogue on pharmaceutical issues to ensure rational use of both drugs and loans. In this, the World Bank has an advantage given its experience from working with both the private and the public sector, its in-house expertise in health economics, and lastly its ability to be listened to by governments through its power.

Data Interpretation, Statistical↗
PubMed1987

Adrenal 11-hydroxylase activity in a hypercortisolemic New World primate: adaptive intra-adrenal changes.

The squirrel monkey, a representative New World primate, has high plasma cortisol and aldosterone concentrations when compared to Old World primates. We measured adrenal mitochondrial 11-hydroxylase (11-OHase) activity in squirrel monkeys and in two representative Old World species (cynomolgus and rhesus macaques) in an effort to explain these elevated plasma glucocorticoid and mineralocorticoid levels. The activity of 11-OHase was 5-fold higher in the squirrel monkey than in the Old World species tested. Calculated 11-OHase Vmax was different in the squirrel monkey and the cynomolgus. However, the Km values were similar in the New World primate when compared to cynomolgus. The ability of metyrapone to block 11-OHase was less in the former than in the latter. The data are consistent with the hypothesis that the squirrel monkey adrenal cortex possesses an increased number of 11-hydroxylase enzyme units compared to that of Old World primate species, and is therefore more efficient in producing cortisol. This difference in 11-OHase activity in the squirrel monkey, in addition to other previously reported adrenal steroidogenic enzyme alterations, may be adaptive in nature, favoring increased cortisol and aldosterone production in this and possibly other New World primate species.

Adaptation, Physiological↗
PubMed2005

The belief in a just world and subjective perceptions of society: a developmental perspective.

The hypothesis guiding this study stated that just world beliefs (i.e., the belief that the world is orderly and just) are primitive beliefs that lose their importance across age as they become replaced by more sophisticated forms of reasoning enabling individuals to handle a world that is neither orderly nor just. In addition, just world beliefs were thought to relate to perceptions of inequality and collectivism within society. In this study, a cross-sectional design was employed involving 235 secondary school pupils and 268 psychology students divided over six age groups with mean ages 12, 14, 16, 18, 20, and 22 years and older. They were presented with the Just World Beliefs Scale and the Individualism-Collectivism Scale. Outcomes revealed that general beliefs in a just world begin to loose their importance around the age of 12, followed by personal beliefs around the age of 16. Vertical collectivism related positively to general and personal just world beliefs showing that the experience of social 'inequality' plays an important role in the maintenance of such beliefs.

Adolescent↗
PubMed2006

Molecular phylogeny of New World Myotis (Chiroptera, Vespertilionidae) inferred from mitochondrial and nuclear DNA genes.

Recent studies have shown that species in the genus Myotis have evolved a number of convergent morphological traits, many of which are more related to their mode of food procurement than to their phylogeny. Surprisingly, the biogeographic origins of these species are a much better predictor of phylogenetic relationships, than their morphology. In particular, a monophyletic clade that includes all New World species was apparent, but only a third of the 38 species have been analysed. In order to better understand the evolution of this clade, we present phylogenetic reconstructions of 17 Nearctic and 13 Neotropical species of Myotis compared to a number of Old World congeners. These reconstructions are based on mitochondrial cytochrome b (1140 bp), and nuclear Rag 2 genes (1148 bp). Monophyly of the New World clade is strongly supported in all analyses. Two Palaearctic sister species, one from the west (M. brandtii) and one from the east (M. gracilis), are embedded within the New World clade, suggesting that they either moved across the Bering Strait, or that they descended from the same ancestor that reached the New World. An emerging feature of these phylogenetic reconstructions is that limited faunal exchanges have occurred, including between the North and South American continents, further emphasizing the importance of biogeography in the radiation of Myotis. A fossil-calibrated, relaxed molecular-clock model was used to estimate the divergence time of New World lineages to 12.2+/-2.0 MYA. Early diversification of New World Myotis coincides with the sharp global cooling of the Middle Miocene. Radiation of the temperate-adapted Myotis may have been triggered by these climatic changes. The relative paucity of species currently found in South America might result from a combination of factors including the early presence of competitors better adapted to tropical habitats.

Animals↗
PubMed2000

A conceptual framework for designing micro-worlds for complex work domains: a case study of the Cabin Air Management System.

A conceptual framework for the design of micro-worlds is presented in this paper. This is illustrated by a micro-world, called Cabin Air Management System (CAMS), that has been used in a research program to investigate human behavior during work with complex systems. Although CAMS is based on the operational context of spaceflight, its underlying principles correspond to a process control task. The authors propose a theoretical framework for micro-world design, which was used to guide the development of the CAMS micro-world. This may provide a helpful guideline for researchers wishing to develop a micro-world by using a more structured approach. A detailed technical description of CAMS is given to demonstrate the kind of real-world scenarios that may be simulated with this task environment. Finally, general aspects of the utility of micro-world research are discussed.

Air Conditioning↗
PubMed2003

Gene duplication and other evolutionary strategies: from the RNA world to the future.

Beginning with a hypothetical RNA world, it is apparent that many evolutionary transitions led to the complexity of extant species. The duplication of genetic material is rooted in the RNA world. One of two major routes of gene amplification, retroposition, originated from mechanisms that facilitated the transition to DNA as hereditary material. Even in modern genomes the process of retroposition leads to genetic novelties including the duplication of protein and RNA coding genes, as well as regulatory elements and their juxtapositon. We examine whether and to what extent known evolutionary principles can be applied to an RNA-based world. We conclude that the major basic Neo-Darwinian principles that include amplification, variation and selection already governed evolution in the RNA and RNP worlds. In this hypothetical RNA world there were few restrictions on the exchange of genetic material and principles that acted as borders at later stages, such as Weismann's Barrier, the Central Dogma of Molecular Biology, or the Darwinian Threshold were absent or rudimentary. RNA was more than a gene: it had a dual role harboring, genotypic and phenotypic capabilities, often in the same molecule. Nuons, any discrete nucleic acid sequences, were selected on an individual basis as well as in groups. The performance and success of an individual nuon was markedly dependent on the type of other nuons in a given cell. In the RNA world the transition may already have begun towards the linkage of nuons to yield a composite linear RNA genome, an arrangement necessitating the origin of RNA processing. A concatenated genome may have curbed unlimited exchange of genetic material; concomitantly, selfish nuons were more difficult to purge. A linked genome may also have constituted the beginning of the phenotype/genotype separation. This division of tasks was expanded when templated protein biosynthesis led to the RNP world, and more so when DNA took over as genetic material. The aforementioned barriers and thresholds increased and the significance and extent of horizontal gene transfer fluctuated over major evolutionary transitions. At the dawn of the most recent transformation, a fast evolutionary transition that we will be witnessing in our life times, a form of Lamarckism is raising its head.

Animals↗
PubMed2003

Midwives and women together for the family of the world: the place of research.

In this paper, I explore the place of research in the theme 'Midwives and women: together for the family of the world'. I begin by examining each of the concepts involved. What is the family of the world? Midwives: what do they contribute to the family of the world? Women: what do they contribute to the family of the world? Putting midwives and women together what is the impact on the family of the world. What is the place of research and what is its impact? I build an argument to show that midwifery research covers social, cultural and political spheres. It breaks the barriers between midwives and women and helps create a true partnership where there is interactivity rather than just one-way information giving from midwife to woman. Once midwives interact with women, they are more likely to persuade them and the world around the women to change their way of doing things. By evaluating what they do using research, midwives are able to capture the safe motherhood success stories and effect replication where needed. With research, midwives become unified, assertive, and mutually supportive in order to reinforce professional identity, accountability and autonomy in the delivery of quality care for women and their families. The family of the world therefore has a ready source of care and support, leadership, knowledge and policies that have been tried and tested to be effective in contributing to the health of women and their families.

Female↗
PubMed2003

Assessing experimentally derived interactions in a small world.

Experimentally determined networks are susceptible to errors, yet important inferences can still be drawn from them. Many real networks have also been shown to have the small-world network properties of cohesive neighborhoods and short average distances between vertices. Although much analysis has been done on small-world networks, small-world properties have not previously been used to improve our understanding of individual edges in experimentally derived graphs. Here we focus on a small-world network derived from high-throughput (and error-prone) protein-protein interaction experiments. We exploit the neighborhood cohesiveness property of small-world networks to assess confidence for individual protein-protein interactions. By ascertaining how well each protein-protein interaction (edge) fits the pattern of a small-world network, we stratify even those edges with identical experimental evidence. This result promises to improve the quality of inference from protein-protein interaction networks in particular and small-world networks in general.

Cluster Analysis↗
PubMed2004

Relationship between world-ranking and Olympic performance of swimmers.

Coaches believe world-ranking lists are a reliable tool for predicting international swimming performance. To examine the relationship between world-ranking and Olympic performance, we modelled world-ranking time and best time from the 2000 Olympic Games for 407 top-50 world-ranked swimmers. Analysis of log-transformed times yielded within-athlete and between-athlete coefficients of variation (CV) and percent changes in performance from world-rankings to Olympics. Variations and performance progressions were compared across sex, stroke, distance, nation and medal status. The within-athlete coefficient of variation of performance for all swimmers was 0.8% (95% confidence limits: 0.7 to 0.9%). Females were slightly less consistent, although not substantially different to males (ratio of female/male within-athlete CV: 1.1; 95% confidence limits: 1.0 to 1.2) and had a wider range of talent (ratio of female/male between-athlete CV: 1.2; 95% confidence limits: 1.1 to 1.4). Swimmers from Australia (AUS) were more consistent than those from the United States (USA) and other nations (OTHER) (ratio of within-athlete CV, USA/AUS: 1.5; 95% confidence limits: 1.0 to 2.2; OTHER/ AUS: 1.6; 95% confidence limits: 1.2 to 2.1). Most Olympic medallists (87%) had a top-10 world-ranking. Overall performance time at the Olympics was slower than world-ranking time by 0.3% (95% confidence limits: 0.2 to 0.4%), medallists improved by 0.6% (95% confidence limits: 0.4 to 0.9%) and non-medallists swam 0.6% slower (95% confidence limits: 0.5 to 0.7%). We conclude that a top-10 ranked swimmer who can improve performance time by 0.6%, equivalent to 0.13 s in the men's 50-m freestyle, will substantially increase their chance of an Olympic medal (the difference between first and fourth place).

Achievement↗
PubMed2006

Donor funding priorities for communicable disease control in the developing world.

Prior research has considered donor funding for developing world health by recipient and donor country but not by disease. Examining funding by disease is critical since diseases may be in competition with one another for priority and donors may be making allocation decisions in ways that do not correspond to developing world need. In this study I calculate donor funding for 20 historically high-burden communicable diseases for the years 1996 to 2003 and examine factors that may explain variance in priority levels among diseases. I consider funding for developing world health from 42 major donors, classifying grants according to the communicable disease targeted. Data show that funding does not correspond closely with burden. Acute respiratory infections comprise more than a quarter of the burden among these diseases but receive less than 3% of direct aid. Malaria also stands out as a high-burden neglected disease. The evidence indicates that neither developing world need nor industrialized world interests explain all funding patterns, and that donors may be imitating one another in ways that do not take into account problems in the developing world. There is an urgent need for a major increase in funding for communicable disease control in the developing world, and for more balanced allocation of the resources already provided.

Communicable Disease Control↗
PubMed2003

Infectious diseases, non-zero-sum thinking, and the developing world.

Despite some improvements in the health status of the world during the last few decades, major obstacles remain. Improvements in health outcomes have not been shared equally among countries and poverty is clearly the main reason. Infectious diseases, which remain the major cause of death worldwide, are an incalculable source of human misery and economic loss. In fact, 25% of all deaths and 30% of the global burden of disease are attributed to infectious diseases. Unfortunately, more than 95% of these deaths, most of which are preventable, occur in the developing world, where poverty is widespread. The 3 major infectious disease killers in these countries are HIV/AIDS, tuberculosis, and malaria. The principles of social justice and health as a human right in the developing world have been advocated as the main justification for health assistance from rich to poor countries. Although we do not disagree with this, we argue that a strategy that emphasizes the shared benefit to rich and poor countries would facilitate this process. We propose that the accomplishment of these challenging tasks should be viewed from the perspective of game theory, where the interests of the parties (in this case rich and poor countries) overlap. As the world becomes increasingly integrated, economic development in resource-poor countries will increase the opportunities for richer countries to profit from investment in the developing world. Global health has political and international security implications for the developed world, as well. In view of the current health status of the developing world, we are not playing a game but facing a matter of life and death. "When health is absent, wisdom cannot reveal itself, art cannot become manifest, strength cannot fight, wealth becomes useless, and intelligence cannot be applied" --Herophilus, 325 BCE (Physician to Alexander the Great). The purpose of this article is to address the relationship between health, poverty, and development in the context of game theory. We will focus on the link between economic inequalities and health outcomes, exclusively concentrating our analysis on the impact of infectious diseases. Subsequently, we will outline the game, the players, and the potential win-win outcomes that may potentially result.

Communicable Diseases↗
PubMed2005

Epidemic spreading and cooperation dynamics on homogeneous small-world networks.

We introduce a class of small-world networks--homogeneous small-worlds--which, in contrast with the well-known Watts-Strogatz small-worlds, exhibit a homogeneous connectivity distribution, in the sense that all nodes have the same number of connections. This feature allows the investigation of pure small-world effects, detached from any associated heterogeneity. Furthermore, we use at profit the remarkable similarity between the properties of homogeneous small worlds and the heterogeneous small-worlds of Watts-Strogatz to assess the separate roles of heterogeneity and small-world effects. We investigate the dependence on these two mechanisms of the threshold for epidemic outbreaks and also of the coevolution of cooperators and defectors under natural selection. With respect to the well-studied regular homogeneous limits, we find a subtle interplay between these mechanisms. While they both contribute to reduce the threshold for an epidemic outburst, they exhibit opposite behavior in the evolution of cooperation, such that the overall results mask the true nature of their individual contribution to this process.

Journal Article↗
PubMed1998

Human endogenous retrovirus K homologous sequences and their coding capacity in Old World primates.

The coding capacity for retroviral Gag and Env proteins has been maintained in human endogenous retroviruses of the HERV-K family. HERV-K homologous sequences have been found in all Old World primates. Here, we examined Old World primate species for the presence of full-length HERV-K gag and env genes and the presence of gag and env open reading frames as determined by the protein truncation test. Full-length HERV-K env genes were found in DNAs of all Old World primate species, whereas open reading frames for Env protein were found solely in human, chimpanzee, and gorilla DNAs. The mutational event leading to two HERV-K types was found to have occurred after the separation of hominids from lower Old World primates and before the expansion of hominids. Full-length HERV-K gag genes in hominids displayed a 96-bp deletion compared to those in lower Old World primates. The ancient gag variant has not been maintained during hominid evolution. Open reading frames for HERV-K Gag have been found in all Old World primates except chimpanzees. Our study of the HERV-K family during Old World primate evolution contributes to the understanding of their possible biological functions in the host genomes.

Animals↗