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PubMedDate not supplied

The regeneration of triturus limbs deformed by a carcinogen.

In this study the regeneration of newt limbs deformed by carcinogen treatment was investigated. Treatment of an amputated limb with the carcinogen MNNG results in a regenerate with many abnormalities. Upon reamputation proximal to the first amputation level all new limbs regenerate normally, but when the reamputation is performed through the abnormal limbs the same type of abnormal limbs was regenerated. In cases of cone-arrested regenerates, reamputation within the cone does not results in regeneration. These results suggest that the carcinogen causes permanent changes in the blastema cells.

Amputation, Surgical↗
PubMed1990

Proliferative response of the mesencephalic matrix areas in the reparation of the optic tectum of Triturus cristatus carnifex.

The localization and proliferative response of optic tectum matrix cells has been studied in adult newt following an experimental lesion on an optic lobe. The results show that 15 days after the lesion the cells in division, autoradiographically labelled, are located in the periventricular layer. Thirty days after the lesion the labelled cells are also found in the innermost grey layers; at 90 days the injured optic tectum regains the cytoarchitecture characteristic of this centre, with labelled cells, whether in the external or in the internal pyriform layers. In all the stages the labelled cells are also found in the periventricular layers of the controlateral optic tectum, in the dorsal pallium and in the striatum. The quantitative data exhibit the existence of a direct relationship between the number of proliferating cells in the injured optic lobe and the extent of the lesion. These data show the possibility of active cellular proliferation for the reconstruction of the lesioned nervous area and for restoration of the characteristic histological structure.

Animals↗
PubMed1988

Opening of blood-brain barrier in Triturus cristatus carnifex by hyperosmolar mannitol solutions.

The permeability of the newt cerebral capillaries to lanthanum ion has been studied after perfusion with mannitol solutions of increasing molarity. In the control specimens lanthanum deposits were limited to the luminal side of the capillaries and tracer did not spread to the pericapillary spaces due to the tight junctions. Treatment with hypertonic solutions of mannitol (0.25M, 0.5M, 1M) caused opening of the blood brain barrier with a progressive increase in lanthanum between the endothelial cell edges, in the basal lamina and in the extracellular spaces of the nervous parenchyma in relation to the molarity of the mannitol solution. The spread of lanthanum is probably due to opening of the tight junctions between the endothelial cells, since pinocytotic vesicles labelled with tracer were not evident.

Animals↗
PubMed1987

Newly-formed neurons in the regenerating optic tectum of Triturus cristatus carnifex.

A histochemical light and electron microscopy study of acetylcholinesterase (AChE) was carried out on the regenerating opic tectum of adult newt. A plug of optic tectum was removed and 15 days later [6-H3] thymidine was injected. Ninety days after the lesion the brain was removed, treated for histochemical AChE-detection and autoradiographic analysis. This double treatment showed the capacity of these adult amphibians to regenerate the nervous tissue through the proliferation of undifferentiated elements and their subsequent differentiation into neurons as is shown by the presence of cells both labelled by [6-H3] thymidine and by the AChE-reaction product.

Acetylcholinesterase↗