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PubMed1989

A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys.

The purpose of this study was to determine whether disruption of early social attachment alters the activity of brain biogenic amine systems in rhesus monkeys (Macaca mulatta). Male rhesus monkey infants were deprived of maternal interaction, peer interaction, or both, during the first 22 months of life. Cerebrospinal fluid (CSF) was collected under rigorously controlled conditions approximately every month and assayed for levels of norepinephrine (NE), its major metabolite, and the metabolites of dopamine and serotonin. Mother-Deprived infants had lower levels of CSF NE than Mother-Reared infants. Mother-Deprived infants also failed to develop the same pattern of intercorrelations between compounds and month-to-month stability in levels of neurotransmitter and metabolites in CSF as the Mother-Reared infants. Finally, there were changes in CSF NE levels associated with social separation and social group formation. The brain NE system appears to be sensitive to changes in the social environment. Its level of activity, as reflected in levels of NE in CSF, appears to depend on both the prevailing social environment and the prior rearing environment.

3,4-Dihydroxyphenylacetic Acid↗
PubMed2006

Social environment regulates corticotropin releasing factor, corticosterone and vasopressin in juvenile prairie voles.

Stressful social conditions, such as isolation, that occur during sensitive developmental periods may alter present and future social behavior. Changes in the neuroendocrine mechanisms closely associated with affiliative behaviors and stress reactivity are likely to underlie these changes in behavior. In the present study, we assessed the effects of post-weaning social housing conditions on the neuropeptides arginine vasopressin (AVP) and oxytocin (OT), and components of the hypothalamic-pituitary-adrenal axis (corticotropin releasing factor: [CRF], and corticosterone: [CORT]) in the prairie vole (Microtus ochrogaster), a socially monogamous bi-parental rodent. Following weaning at 21 days of age, prairie voles were maintained in one of three housing conditions: social isolation (isolate), paired with a same sex sibling (sibling) or paired with a stranger (stranger) of the same sex and age. Housing conditions were maintained for either 4 or 21 days. Central CRF, AVP and OT immunoreactivity (ir) were quantified and circulating plasma CORT, AVP and OT were assayed. Isolated voles had higher CRF-ir in the paraventricular nucleus of the hypothalamus (PVN) compared with sibling and stranger housed voles. Plasma CORT was significantly higher in isolates. AVP-ir was significantly lower in the PVN of isolate females compared to either sibling females or stranger females. However, AVP-ir was significantly higher in the supraoptic nucleus (SON) of isolates compared to siblings. There were no differences in central OT-ir or plasma OT. These results identify neuroendocrine mechanisms which respond to isolation and potentially modulate behavior.

Animals↗
PubMed1986

Social visions and social control: the evolution of medical thought in postwar Hungary.

After nearly two decades of rigid adherence to the Soviet model of social and economic development, Hungary initiated a series of reforms in the 1960s that emphasize decentralization and market economic mechanisms. Internal repression and surveillance have diminished concurrently. Shaped by these broader social trends, three explanations of disease causation have successively emerged in Hungary since World War II: social medicine, a lifestyle model, and a psychosocial model. Although each model attempts to offer the best explanation for prevailing patterns of morbidity and mortality, each also reflects an underlying world view and the political priorities that derive from it. Social medicine and the lifestyle model have served largely to consolidate the power of ruling elites. The psychosocial model, on the other hand, has the potential to challenge the social order. The current popularity of the lifestyle model seems rooted in a widespread cynicism about social change which in turn is a product of contemporary social conditions in Hungary.

Hungary↗
PubMed2001

Environmental enrichment decreases intravenous self-administration of amphetamine in female and male rats.

RATIONALE: Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE: The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS: Female and male rats were raised from 21 days of age in one of three different conditions: an enriched condition (EC) containing novel objects and social partners, a social condition (SC) containing social partners only, or an isolated conditioned (IC) without objects or social partners. Beginning at 51 days of age, rats were then tested for operant responding for a sucrose reinforcer using an incremental fixed ratio (FR) requirement across four sessions. Rats were then implanted with a chronic indwelling intravenous catheter and were allowed to self-administer amphetamine (0.03 or 0.1 mg/kg per infusion) for five FR1 sessions, followed by a progressive ratio (PR) session. RESULTS: EC rats initially showed an increase in sucrose-reinforced responding relative to IC rats and this environment-induced difference was greater in females than in males. However, in both sexes, the environment-induced difference in sucrose-reinforced responding dissipated completely across repeated sessions. With amphetamine self-administration, both EC and SC rats earned fewer infusions than IC rats across repeated FRI sessions using the low dose of amphetamine (0.03 mg/kg per infusion), but not using the higher dose of amphetamine (0.1 mg/kg per infusion). EC rats also earned fewer self-infusions of the low amphetamine dose on the PR session relative to IC rats. The effects of environmental enrichment on amphetamine self-administration were similar in both females and males. CONCLUSION: These results suggest that environmental enrichment may serve as a protective factor for reducing amphetamine self-administration.

Amphetamine↗
PubMed2005

The psychological well-being of the Chinese elderly living in old urban areas of Hong Kong: a social perspective.

Using the Geriatric Depression Scale-15 (GDS-15) and the short form of the General Health Questionnaire-12 (GHQ-12), this study found that the Chinese elderly who live in old urban areas of Hong Kong are at risk of suffering from poor mental health because of their relatively deprived social conditions. It was also found that the respondent's scores in the GDS-15 correlated with their social conditions, including type of housing, availability of helpers, financial status and family support. However, Chinese elderly people often avoid seeking help because of the fear of being stigmatised. There is a need for more research in the future to study their needs and problems so that social work practitioners can be well informed and culturally competent to help this disadvantaged group.

Aged↗
PubMedDate not supplied

Infants of depressed mothers exhibit atypical frontal electrical brain activity during interactions with mother and with a familiar, nondepressed adult.

Previous studies have shown that infants of depressed mothers exhibit atypical frontal brain electrical activity when they are interacting with their mothers. Whereas typically developing infants exhibit greater left versus right frontal brain activity, infants of depressed mothers have been found to exhibit reduced relative left frontal activity. The left frontal brain region has been associated with the expression of positive emotions. In the present study, the question of whether the atypical pattern of brain activity found in infants of depressed mothers generalizes to situations not involving mother was addressed. Brain electrical activity was recorded from 13- to 15-month-old infants of depressed (N = 59) versus nondepressed (N = 40) mothers during a baseline condition, and during several social conditions that included a playful social interaction with a familiar experiments. Infants of depressed mothers exhibited reduced left relative to right frontal activity during the baseline condition, and during interactions with their mothers and with the familiar experimenter. The present results suggest that the atypical pattern of electrical brain activity found in infants of depressed mothers generalizes to a variety of situations, including positive interactions with nondepressed adults.

Adult↗
PubMed1990

[Technology development as social process: prospects and frontiers of social scientific elucidation of technological advancement].

This article provides an overview of the new developments in social scientific technology research which have changed considerably as a result of public debate and reactions to the importance of advancements in technology. The shift in emphasis, away from the effects of technology to its shaping, is described and certain hypotheses and concepts of advancement in the study of the social conditions underlying technical development processes are presented.

Culture↗
PubMed2006

Influence of flexibility and variability of working hours on health and well-being.

Flexible working hours can have several meanings and can be arranged in a number of ways to suit the worker and/or employer. Two aspects of "flexible" arrangement of working hours were considered: one more subjected to company control and decision (variability) and one more connected to individual discretion and autonomy (flexibility). The aim of the study was to analyze these two dimensions in relation to health and well-being, taking into consideration the interaction with some relevant background variables related to demographics plus working and social conditions. The dataset of the Third European Survey on working conditions, conducted in 2000 and involving 21,505 workers, was used. Nineteen health disorders and four psycho-social conditions were tested by means of multiple logistic regression analysis, in which mutually adjusted odds ratios were calculated for age, gender, marital status, number of children, occupation, mode of employment, shift work, night work, time pressure, mental and physical workload, job satisfaction, and participation in work organization. The flexibility and variability of working hours appeared inversely related to health and psycho-social well-being: the most favorable effects were associated with higher flexibility and lower variability. The analysis of the interactions with the twelve intervening variables showed that physical work, age, and flexibility are the three most important factors affecting health and well-being. Flexibility resulted as the most important factor to influence work satisfaction; the second to affect family and social commitment and the ability to do the same job when 60 years old, as well as trauma, overall fatigue, irritability, and headache; and the third to influence heart disease, stomachache, anxiety, injury, and the feeling that health being at risk because of work. Variability was the third most important factor influencing family and social commitments. Moreover, shift and night work confirmed to have a significant influence on sleep, digestive and cardiovascular troubles, as well and health and safety at work. Time pressure also showed a relevant influence, both on individual stress and social life. Therefore, suitable arrangements of flexible working time, aimed at supporting workers' coping strategies, appear to have a clear beneficial effect on worker health and well-being, with positive consequences also at the company and social level, as evidenced by the higher "feeling to be able to work until 60 years of age".

Adult↗
PubMed2002

Growth and living conditions in childhood and hypertension in adult life: a longitudinal study.

OBJECTIVES: To examine the interplay between childhood growth and living conditions in the development of hypertension. DESIGN: A longitudinal study of people whose growth between birth and 12 years, and social circumstances during childhood and adult life, were recorded. SETTING: Helsinki, Finland. PARTICIPANTS: Eight thousand seven hundred and sixty men and women born in Helsinki University Central Hospital during 1934-44, who attended child welfare clinics in the city and were still resident in Finland in 1971. MAIN OUTCOME MEASURES: Incidence of hypertension defined by prescription of medication. RESULTS: The 1404 children who later developed hypertension grew differently to other children. Low birthweight and shortness or thinness at birth were followed by rapid compensatory growth in weight and height, and an above-average body mass index (BMI, kg/m(2)) from the age of 8 years onwards. Some 25% of children with low birthweight but high BMI at 12 years subsequently developed hypertension, compared to 9% of those with high birthweight but low BMI. Growth had large effects on the risk of later hypertension in children living in poor social conditions, but only small effects in children in good living conditions. Living conditions in adult life did not affect the risk of hypertension. CONCLUSIONS: Hypertension originates in slow fetal growth followed by rapid compensatory growth in childhood. This path of growth has a greater effect on the risk of disease among children who live in poor social conditions. Living conditions in adult life do not seem to be important.

Birth Weight↗
PubMed1990

Personal construct systems of psoriatic patients.

Repertory grid techniques were employed to assess the personal construct systems of psoriatic patients (n = 35), controls with other skin conditions (n = 28) and controls with no skin condition (n = 29). A grid was designed with six supplied constructs representing previously reported subjective experiences of psoriatics, and 12 elements representing typical social conditions. Social adjustment was defined as the relationship between constructs. The results suggest that psoriatics are less well socially adjusted in highly visible situations. There was no difference in social adjustment between males and females specific to the psoriatic group, but body awareness in female psoriatics correlated positively with the severity of the condition.

Adult↗
PubMed1980

Social stress influences tumor growth.

Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated following social and physical stress exposure. Although social isolation following tumor cell transplantation enhanced tumor growth, it appeared that it was the abrupt change in social conditions, rather than the isolation per se which was responsible for the exacerbation of tumorigenicity. Moreover, it was found that the animals' behavior after social change could modify this effect. If mice engaged in persistent fighting, the tumorigenic consequences of social change were not apparent. In addition, it was observed that social conditions interacted with physical stress. Footshock enhanced tumor growth among group housed mice, but retarded tumor development among socially isolated mice.

Adaptation, Psychological↗
PubMed1985

Prenatal stress and prepuberal social rearing conditions interact to determine sexual behavior in male rats.

The two major categories of factors known to influence adult sexual behavior potentials are the relative amounts of androgen present during specific stages of perinatal ontogeny and adequate social stimulation during prepuberal development. The possible interaction between these two was evaluated by characterizing the ejaculatory and lordotic behavior potentials of prenatally stressed and control male rats that had been weaned at 16 days of age and raised either in total social isolation or with a same-age female, a control male, or a prenatally stressed male. The decrement in male sexual behavior produced by prenatal stress was attenuated by raising the male with either a female or a control male. Social isolation alone or in combination with stress resulted in severely deficient male behavior. Peripheral skin shock promoted ejaculatory behavior in many previously noncopulating prenatally stressed males raised with other stressed males, but it was ineffective in most isolated animals. The high lordosis potential characteristic of prenatally stressed male rats was slightly lower in the group with a female cagemate and was markedly decreased by social isolation. These results support and extend the finding by Dunlap, Zadina, and Gougis (1978) that prenatal hormonal events and prepuberal rearing conditions can interact to attenuate or accentuate the effects that either treatment alone has on the development of adult sexual behavior potentials.

Animals↗
PubMed2005

The influence of social environmental condition on the production of stress-induced 22 kHz calls in adult male Wistar rats.

Adult rats emit 22 kHz ultrasonic vocalizations (USVs) in response to aversive stimuli, and these sounds are suggested to have communicative information among conspecifics. It is conceivable that social environment during development of rats has relevance to the emission of 22 kHz USVs. To examine the effects of social environment after weaning on production of stress-induced USVs, we compared the amount of emission of USVs among three groups of rats reared under different conditions after weaning. One group of rats was housed individually, and the other two groups were housed in pairs, in which social hierarchy of the pair was determined by social dominance-subordination relationships. The USVs were induced by acute mild somatic stimuli on the back and neck. Individually reared rats emitted much fewer USVs than pair-reared rats. In addition, socially subordinate rats emitted more USVs compared with socially dominant ones. These results suggest that not only social interaction but also the status in social hierarchy may play an important role in the process of the development of USVs induced by somatic stimuli.

Analysis of Variance↗
PubMed1999

A systematic analysis of the influence of prior social context on aggression and self-injury within analogue analysis assessments.

Experimental analogue analyses are sometimes used to identify the operant function of aberrant behavior for individuals with developmental disabilities. These methods are proposed to be superior to other assessment techniques because they systematically control for the presence and absence of hypothesized maintaining contingencies within the analogue analysis. Analogue analyses are usually performed over a brief period of time with little reference to the broader social context within which they are conducted. Social interactions that a person experiences prior to an analogue analysis assessment might influence performance within the assessment. The authors examined the influence of prior social conditions on levels of aberrant behavior under analogue assessments with two individuals with severe developmental disabilities. Results indicated that prior social conditions significantly influenced analogue analysis results in idiosyncratic ways for both. These findings are discussed in terms of the need to examine broad contextual influences when conducting functional analyses of aberrant behavior.

Adult↗
PubMed1997

[Health status and medical care accessibility of single, homeless persons].

The homeless population in Germany is continually increasing. Featuring prominently among those on the increase are women, young persons and homeless people from East Germany. Studies of the health of homeless individuals in recent years show that indices of illness are far higher for many disorders than for comparable groups who are housed. One result from a recent study by the University of Mainz (1994) was that more than 90% of homeless people urgently need medical treatment. According this research, the main health problems of the homeless are: cardiac disease (hypertension, CAD) (52.5%), skin disease (scabies, lice, leg ulcers, abscesses, pyodermias) and acute infections (50%), lower respiratory tract (COAD) (47.5%) and trauma victims (50%), followed by liver (30%), kidney (25%) and gastrointestinal diseases (GU) (20%). The problems of alcoholism and mental disorders of various sorts are added to this picture. Violence to homeless people is increasing. A lot of homeless people are multi-morbid. The relationship between the time of homelessness and the state of illness was not linear. It was found that in the beginning of homelessness most of the homeless people were in a poor physical condition. The poor physical condition of homeless people does not stem from only one cause, but results from a combination of different factors: individual social conditions (social class; social relations; sedentary lifestyle), personal or family life crisis (life events and coping behaviour), the individual risk behaviour (for instance the bizarre sleeping accommodations, alcohol and cigarette consumption unemployment in a depressed economy, structure of the society (cutbacks in government welfare and social service programmes). As a result of bad experiences with existing medical institutions, homeless persons do not consult the doctor or too late. Many are afraid of large institutions; most are not members of a health insurance scheme (uninsured); and many are perceived in some sense to be "undesirable" as patients. Medical care offers for homeless people must be re-examined and changed appropriately in accordance with the requirements of the patients and the acceptability of the measures. Health care for the homeless is sorely needed. It is an urgent necessity to create special low-level acceptance medical care institutions. This health care service should be made available to homeless persons at the places where they gather (to set up a mobile medical service, medical streetwork, medical care ambulances). The interdisciplinary theme approach, which integrates the skills of physicians, nurses and social workers, is an invaluable strategy for establishing though and continuous care. Without good health, homeless people cannot resolve their other basic problems; and people simply cannot be healthy if they do not have a stable place to live.

Adult↗
PubMed1989

[Psychosomatic aspects of the patients with stomatognathic dysfunction. 2].

Various kinds of mind stress are prevalent in our society today. Especially, in the current society, number of patients who suffered from mind stress have been increased. And to our interest, many of them tended to show dysfunction in stomatognathic system. We have reported in the previous report that psychosomatic factors not only occlusal factors played an important role in the function of stomatognathic system. If the stomatognathic dysfunction patients were treated without the care of psychosomatic factors, effect of the treatment may sometimes be resulted in slow or uncertain cure. So we must analyze the psychosomatic condition of the patients in order to diagnose and treat them effectively. Therefore we studied the relationship between the psychosomatic factors and the social condition such as age, sex, type of job, marital status. The personality test was done among the general patients, who belonged to three different companies, using a questionnaire such as CMI test in regard to general patients. The results indicated that the difference of social condition developed different tendency in psychosomatic condition. This suggestion that psychosomatic factors must be taken care in order to diagnose and treat the patients.

Female↗
PubMed2001

Canadian Aboriginal communities: a framework for injury surveillance.

At the international level, evidence supports the position that regardless of whether a country is industrialized or less developed, vulnerable populations living in poor social conditions are at disproportionate risk of injury. The Aboriginal population of Canada is one such vulnerable population. In addition to poor social conditions and marginalization related to historical injustices, this population is faced with the challenge of working with little or no descriptive injury data relevant to the community level. It has been and continues to be a significant barrier to the adoption and implementation of injury prevention strategies and programs. Recognizing that surveillance is an intrinsic component of public health practice, this study was undertaken to address a critical data gap facing Aboriginal communities. The objective of the study was to develop the conceptual design of an injury surveillance framework that would be culturally relevant, that is 'acceptable and owned by the target population', and would meet the specific requirements for injury data and data collection methods for the study population. The methodology was undertaken with focus groups at national and community levels, and relied on the use of strategic activities such as benchmarking, guided discussions, nominal group technique exercises and critical document reviews. The process of benchmarking served to identify that injury surveillance systems described in the literature, linking data to action, are not a predominant reality. The locus of control is often removed from the population of interest and resides primarily with experts under the jurisdiction and control of designated authorities. In order for the surveillance system to have cultural relevance, the focus group identified that the locus of control must be defined by the population of interest at the community level, and that the system must be germane and flexible to consider the local environment. The Aboriginal framework proposed places the locus of control with the community, in partnership with its data sources. Surveillance activities remain largely distinct from communities of interest, leading us to consider whether structural changes can serve to promote a link between data and action. Traditional or standard surveillance systems, by virtue of their structure, promote a disassociation between information and community action. Data management under the complete jurisdiction of sources external to a community appears to obstruct potential linkages between information and action.

Benchmarking↗