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At least 415 records · Page 23Linked to original sources
PubMed2004

[The study of status and advances on tetramine poisoning].

Tetramethylenedisulphotetramine(TETS) is virulent rodenticides which was strictly forbidden to use in China. Poison dose of TETS is very little, LD50 in rats in 0.1 mg/kg. Manifestations and signs of TETS poisoning are showed in 5 min. The long dated effect of poisoning is extremely strict. Mamy studys on TETS are restricted on the treatment of TETS poisoning, while that of poisoning mechanism is very few. This paper reviewed TETS poisoning mechanism, pathological changes and research advances.

Brain↗
PubMed1979

Diabetes mellitus and neuropathy following Vacor ingestion in man.

Two patients ingested Vacor, a rodenticide containing the active ingredient N-3 pyridylmethyl-N'-p-nitrophenyl urea. Both patients developed ketosis-prone diabetes mellitus and severe autonomic neuropathy. Niacinamide therapy given nine hours after Vacor ingestion in one patient and 14 hours after ingestion in the other was not successful in preventing these sequelae. Physicians need to be aware of the toxicity of Vacor, and the potential therapeutic benefit of early niacinamide therapy.

Adult↗
PubMed2006

Effect of bromadiolone on haematology, liver and kidney in Mus musculus.

Bromadiolone, a second generation anticoagulant rodenticide was tested on Mus musculus to evaluate its effects on blood, liver and kidney at varied time intervals of 6, 12, 24 and 48 hrs. Groups of six animals each were selected for experiment. Animals were administered with bromadiolone in the form of bait at 6, 12, 24 and 48 hrs time intervals. Control animals were maintained for each time interval. After each time interval the experiment and the control animals were sacrificed and the effect of bromadiolone on blood, liver and kidney were studied.

4-Hydroxycoumarins↗
PubMed1999

Epidemiological study of the claimed zinc phosphide intoxication in Kom Ombo district April 1996.

INTRODUCTION: In April 1996, in Aswan Governorate, Egypt, an outbreak of vomiting without diarrhea, abdominal and leg pain was reported. METHODS: A case-control study was conducted to determine the cause of the outbreak. 25 cases who had vomiting without diarrhea, abdominal and leg pain. Controls were randomly chosen from adjacent houses to cases and another village. RESULTS: No occupational exposure was associated with the disease, 84% of cases lived in households where chemical rodenticide had been used for rat infestations compared to 22% of controls. Laboratory analysis and field investigation identified zinc phosphide intoxication as the probable cause of this outbreak.

Abdominal Pain↗
PubMedDate not supplied

[Acute poisoning by scilliroside].

A 43-year-old man, with no history of cardiac disease, deliberately ingested 4 tablets of a rodenticide containing 12 mg of scilliroside. Vomiting appeared a few minutes later and persisted for 48 hours. At the 20th hour, when he was admitted, EKG revealed a complete atrio-ventricular block which disappeared only on the 4th day. The repolarization abnormalities characteristic of digitalization persisted still further until the 12th day.

Adult↗
PubMed1991

Electroencephalographic changes associated with bromethalin toxicosis in the dog.

Electroencephalogram (EEG) recordings were obtained before and during the clinical syndrome induced by a bromethalin rodenticide given to dogs. Nine dogs given 6.25 mg bromethalin/kg po developed clinical signs and EEG abnormalities 15 to 58 h postdosing. Predominant abnormal EEG changes included spike and spike-and-wave EEG patterns (66%), high voltage slow wave (HVSA, 50-150 microV, 1-6 Hz) activity (44%) photoconvulsive or photoparoxysmal irritative responses (44%), and marked voltage depression (dominant activity less than 10 microV) in all leads (33%).

Aniline Compounds↗
PubMed1990

[Derivative spectroscopy and its use in sanitary hygiene control].

An analytical method is developed for defining the residual quantities of rodenticide "Brodifacoum" (talon) used in the control of harmful field rodents and especially for species Microtus. The method is based on extracting the pesticide with chloroform and making use of spectrophotometry in the ultraviolet field in intervals 340-240 nm. The second derivative of the absorption is utilized as well as the band with maximum 288 nm and minimum 228 nm. The peak height in this interval is in proportion to the concentration of the brodifacoum. When analysing residual waters, reservoirs, and soil the elimination of impeding substances is performed by thin-layer chromatography. The "cis" and "trans" form of brodifacoum is jointly determined by spectrophotometry. At thin-layer chromatography processing the two forms are separated. Sensitivity of the method 0.5 microgram/cm3 (in chloroform solution). Reproduction (as coefficient of variation) 5%. A thin-layer chromatographic method is recommended for semiquantitative determination of brodifacoum.

4-Hydroxycoumarins↗
PubMed1990

Accidental poisoning with a superwarfarin compound (brodifacoum) in a child.

The "superwarfarin" compounds are 4-hydroxy derivatives of coumarin that have increased activity and a longer duration of action than the parent compound. The superwarfarins are used widely in the United States as rodenticides and are effective against warfarin-resistant strains of rats. A chronic accidental ingestion of one of these products, brodifacoum, by a 7-year-old child who had bleeding and laboratory evidence suggestive of a vitamin K-related coagulopathy is reported. The bleeding manifestations were severe and prolonged, requiring 13 months for normalization of coagulation times. With a negative history of ingestion and despite clinical suspicion, documentation of superwarfarin poisoning was hampered by the lack of readily available assays for these compounds, even from the manufacturers. Brodifacoum was also identified in rat feces from the family home. This finding raises the concern of poisoning not only from ingestion of brodifacoum particles themselves, but also from a fecal-oral route. A review of the literature is presented and the implications of this case for the practicing physician are discussed.

4-Hydroxycoumarins↗
PubMed1989

[Skin lesions caused by exposure to a pesticide norbormid].

Norbormid used as zoocide (rodenticide) can produce an irritating and allergenic effect when acting on the skin. A case of contact dermatitis is described on a woman who poured over pesticide solution in order to make poisonous pesticides for rodents. The solution got on the skin of her hands, right crus and left forearm. There the signs of acute skin inflammation appeared along with the clinical picture of chronic dermatosis caused by the solution irritating characteristics. The degree of pesticide sensitivity was determined by means of a drop test, 1%-norbormid alcohol solution being used. Preventive measures should involve workers' obligatory instructions on norbomid zoocide noxious impact on human skin and strict observance of industrial safety rules.

Accidents, Occupational↗
PubMed1989

Zinc phosphide ingestion: a case report and review.

We present the case of a patient who attempted suicide by ingestion of the rodenticide zinc phosphide. Zinc phosphide manifests its immediate toxicity through production of phosphine gas. Signs and symptoms of toxicity include nausea, vomiting, dyspnea, and changes in mental status; immediate death results from pulmonary edema. Delayed effects are secondary to the absorption of phosphide, affecting primarily the liver, heart and kidneys. Delayed deaths are related to a direct cardiotoxicity. Treatment is mainly symptomatic and supportive; aggressive airway management and circulatory support are critical to a successful outcome.

Adult↗
PubMed1989

Determination of brodifacoum and bromadiolone residues in rodent and canine liver.

A method to determine residue concentrations of anti-coagulant rodenticides, brodifacoum (BF) and bromadiolone (BD) in liver was developed, using gas chromatography/mass spectrometry. Nine dogs were given 1.1 mg of BF/kg of body weight, PO, in polyethylene glycol 400, one time. Rats were fed BF or BD (via commercial baits) in amounts from 0.28 to 11.25 mg/kg over 1- to 4-day periods. Fresh liver samples were collected at necropsy from all rats and 3 dogs, ground with Na2SO4, and extracted with CHCl3:MeOH (9:1). After evaporation and silica cartridge purification were performed, residues were oxidized with a 0.16M chromic acid solution, and an oxidation product (4-bromobenzoic acid) was partitioned into CHCl3. The methylated derivative (port derivatization with trimethylanilinium hydroxide) was assayed, using gas chromatography/mass spectrometry. Bromadiolone was detected in livers from rats given greater than 6 mg of BD/kg of body weight, but not in livers of rats given 1.25 mg of BD/kg. In contrast, BF was detected (with one exception) in livers from dogs (given 1.1 mg of BF/kg) and from rats given high (11.25 mg of BF/kg) and low (0.28 mg of BF/kg) doses. This protocol, which does not differentiate between BF and BD because of the formation of a common product after chromic acid oxidation, was used to diagnose anticoagulant toxicosis in 3 dogs, 1 human being and 1 llama naturally poisoned.

4-Hydroxycoumarins↗
PubMed1989

Superwarfarin poisoning in children: a prospective study.

This prospective study was undertaken to determine the incidence, severity, time of onset, and duration of coagulopathy in children following accidental ingestion of long-acting anticoagulant rodenticides, often called "superwarfarins." Of 110 children, who ingested superwarfarins and in whom one or more prothrombin time values were obtained, 8 had a prothrombin time ratio (patient to control) of greater than or equal to 1.2, indicative of anticoagulation. Prothrombin time values obtained 48 hours after ingestion were more likely to be prolonged (6/34, 17.6%) than values obtained 24 hours after ingestion (2/104, 1.9%) (P less than .005). The occurrence of an abnormal prothrombin time could not be predicted based on the history of amount ingested or on the presence of the characteristic green-blue product dye in or around the child's mouth. Acute toxicity was evidenced by transient abdominal pain, vomiting, and heme positive stools in 2 patients. The duration of prothrombin time prolongation could not be determined because of the few values obtained after 48 hours. To detect all possible abnormal prothrombin time values, 24- and 48-hour determinations are recommended after a child has ingested a superwarfarin.

4-Hydroxycoumarins↗
PubMed1984

Practical toxicologic diagnosis.

Strychnine toxicosis is characterized by inducible tetanic seizures and metaldehyde poisoning by fine fasciculations progressing to generalized tremors and seizures. Intoxication with 1080 causes seizures, random running movements, vomiting, defecation, urination, acidosis and hyperglycemia. Intoxication with rodenticides causing coagulopathy is characterized by hemorrhage into body cavities but not necessarily external hemorrhage. Anticholinesterase insecticides cause salivation, urination and defecation, while chlorinated hydrocarbon insecticides cause CNS disturbances. Ethylene glycol intoxication results in ataxia, depression, coma, vomiting and tachypnea, followed by acute renal failure. Urea poisoning causes bloat and CNS signs in cattle. Monensin intoxication in horses lasts several days and causes stiffness, colic, uneasiness and recumbency. Salt poisoning results in depression, seizures and hypernatremia. Lead poisoning is associated with central and peripheral nervous system signs, as well as increased numbers of nucleated RBC and basophilic stippling of RBC. Arsenic poisoning results in GI pain, diarrhea, weakness and death. Copper toxicosis in sheep is manifested by hemolytic anemia, hemoglobinemia and hemoglobinuria. Plants that may intoxicate domestic animals include sorghum, greasewood, halogeton, water hemlock, Japanese yew, larkspur, lupine, milk-weed, philodendron, oleander, castor bean and precatory bean.

Animals↗
PubMedDate not supplied

[Preliminary report on the demonstration of resistance to coumafene in Rattus rattus in Marseilles].

An abnormal proliferation of Rattus rattus in an important food-products warehouse in Marseille's periportuary zone has been recorded in spite of preventative measures put in place and aimed at testing these rodents resistance to basic anticoagulants, especially to coumafene. The laboratory experiments on animals taken from the invaded area have enabled us to prove for the first time on metropolitan ground a Rattus rattus resistance to coumafene. The colony of rodents responsible is giving proof of its resistance in already large proportions, since the survival beyond 10 days of treatment is established in 74% of the tested subjects, whereas 30% of them survive treatments prolonged by 4 to 10 weeks. The recorded results allow us to confirm the variable degrees of the state of resistance which appear to be developed locally, the origin of which cannot be defined. Taking into account the size of the affected zone and the numerous food-products storage establishments found there and usually infected with Rattus rattus, one is forced to fear a rapid progress of the territorial resistance. It is therefore opportune to take the necessary measures to destroy the resistant colony on the spot, to follow the ultimate progress in the area and to follow up in the laboratory the methods of evaluation of the efficiency of new rodenticides.

Animals↗
PubMed1995

Laboratory evaluation of bait base for the control of Indian field mouse, Mus booduga (Gray).

Species specific bait evaluation is important for the successful control of rodent populations through rodenticides. Experiments were conducted on the bait preference of Indian field mouse, M. booduga. Results reveal that rice normal grain, rice cracked grain, rice +4% coconut oil and millet +2% coconut oil may be used as effective poison carriers for the Indian field mouse. Additives like oil, sugar and salt did not improve the palatability of bait materials.

Animals↗
PubMed1994

Laboratory diagnosis of zinc phosphide poisoning.

Zinc phosphide, a readily-available rodenticide, poses a significant risk for intoxication in animals. Animals have been poisoned by ingesting treated bait or the carcasses of poisoned rodents. Toxicity is due to the liberation of phosphine gas in the stomach. Clinical signs include central nervous system excitation, depression and vomition. Similarities of clinical signs with other central nervous system toxicants make the diagnosis difficult without a specific diagnostic test. The procedure outlined in this paper detects phosphine liberated from zinc phosphide by the addition of hydrochloric acid as well as the phosphine previously generated by contact with stomach acid.

Animals↗
PubMed1993

Case management and plasma half-life in a case of brodifacoum poisoning.

Brodifacoum is a readily available, second-generation anticoagulant rodenticide (superwarfarin) that causes extended depletion of vitamin K1-dependent clotting factors. Brodifacoum ingestions are being reported with increasing frequency. For the first time, we compare plasma brodifacoum concentration to prothrombin levels over time in a case of brodifacoum poisoning. Brodifacoum was eliminated according to a two-compartment model, with an initial half-life of 0.75 days and a terminal half-life of 24.2 days. On admission, the brodifacoum level was 731 micrograms/L and the patient suffered severe urinary tract hemorrhage, requiring transfusion of blood products. Persistently increased prothrombin times necessitated treatment with phytonadione up to 80 mg/d for 4 months, until the brodifacoum level reached 10 micrograms/L. These data may help project the duration of phytonadione treatment required in future cases of brodifacoum poisoning. Superwarfarin exposure must be suspected in an otherwise unexplained vitamin K1-deficient coagulopathy.

4-Hydroxycoumarins↗
PubMedDate not supplied

Basic toxicology of pesticides.

This chapter reviews basic aspects of the health effects and mechanisms of action of the major classes of pesticides: insecticides, herbicides, rodenticides, and fungicides. Specific pesticides in each class are described, with historical detail and depictions of chemical structure.

Animals↗