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PubMed1999

Neck-proprioceptive influence on auditory lateralization.

The effect of transcutaneous vibration of the posterior neck muscles on the lateralization of dichotic sound was investigated in human subjects. Two-alternative forced-choice (left/right) judgements were made on acoustic stimuli presented with different interaural level differences via headphones during neck-muscle vibration. A shift of the subjective auditory median plane toward the side contralateral of vibration was found, indicating that the sound was perceived as shifted toward the side of vibration. The mean magnitude of the vibration-induced intracranial shift was 1.5 dB. The results demonstrate a neck-proprioceptive influence on sound lateralization and suggest that this proprioceptive input is used for a central-nervous transformation of auditory spatial coordinates onto a body-centered frame of reference.

Acoustic Stimulation↗
PubMed1993

Sensory loss in stroke patients: effective training of tactile and proprioceptive discrimination.

Although somatosensory loss following stroke is common, with negative consequences for functional outcome, studies of existing somatosensory retraining programs are limited by theoretical weaknesses, poor methodology, and negative findings. We, therefore, developed a new program for stroke patients and investigated its effect on tactile discrimination in four AB, single-case quasi-experiments and its effect on tactile and proprioceptive discrimination in four multiple-baseline experiments. Training involved specific, graded discrimination tasks, attentive exploration of stimuli with vision occluded, deliberate anticipation, and quantitative feedback. Graphic and statistical interrupted time-series analyses indicated that treatment produced improvements in seven of eight tactile time series and all four proprioceptive time series. Baseline improvement in one tactile time series prevented unequivocal evaluation of treatment effect. Improvements were clinically significant, discrimination in the affected hand becoming comparable to the other hand and normal performance. Therapeutic effects were maintained at 3-month to 5-month follow-up tests.

Adult↗
PubMed1994

Eye proprioception and visual localization in humans: influence of ocular dominance and visual context.

It has been previously established that the application of low amplitude mechanical vibrations to the inferior rectus muscle of human subjects results in an illusory upward movement of a luminous spot fixated in total darkness, and in a corresponding overshooting of the target when the subject is asked to point to this spot. In the first experiment described here, we compared the effects of applying vibrations to each eye separately and to both eyes simultaneously, under monocular and binocular viewing conditions, in left- and right-eyed subjects. The results confirmed that proprioceptive signals arising from both eyes are involved in egocentric visual localization. A proprioceptive dominance was observed however since vibration of the dominant eye gave rise to larger pointing displacements. In addition, whichever eye was stimulated, the pointing shift induced by vibrating a covered eye was of smaller amplitude than that which occurred when vibrations were applied to the viewing eye. The second experiment showed that both the vibration induced illusions and the pointing shifts disappeared in a structured visual context, which suggests that the processes involved when the target is viewed in darkness might differ from those occurring in structured surroundings.

Eye Movements↗
PubMed1993

Haloperidol exaggerates proprioceptive-tactile support reflexes and diminishes vestibular dominance over them.

Rats made immobile and cataleptic by haloperidol, a dopamine receptor blocker, maintain their static stable equilibrium by employing a variety of allied postural support reflexes. Under some test conditions, competition between such reflexes occurs, and in haloperidol-treated rats, unlike undrugged controls, proprioceptive-tactile stimuli appear to be dominant over vestibular stimuli. We investigated this relationship in rats by testing their air-righting with and without simultaneous contact of the tail on a wooden platform. The rats were lightly held in a supine position by the shoulders and pelvis, with or without tail contact on a small wooden platform 47 cm above the ground. Undrugged rats showed the normal pattern of righting which involves axial rotation with cephalocaudal recruitment whether the tail is contacting the platform or not. Upon release, the haloperidol-treated rats (2.5 mg/kg) gripped the platform with their tail, which interfered with the air-righting reflex. This demonstrates that in haloperidol-treated rats, the dominance of tactile-proprioceptive postural support reflexes over those triggered vestibularly.

Animals↗
PubMed1991

Contribution of eye muscle proprioception to velocity-response characteristics of eye movements: involvement of the cerebellar flocculus.

The vestibulo-ocular reflex (VOR) and optokinetic nystagmus (OKN) were examined in alert pigmented rabbits following interruption of proprioceptive afferents from the extraocular muscles in one eye by surgical section of the ophthalmic branch of the trigeminal nerve (V1 nerve). Deficits were mainly produced in movement dynamics of the ipsilateral eye including reduction of (1) the VOR gain at a high frequency of head rotation, (2) the OKN gain and (3) the velocity of quick eye movements in the OKN. In some of the rabbits examined, the cerebellar flocculus was lesioned by local injection of kainic acid before severance of the V1 nerve. No significant additional reductions of VOR or OKN gains were produced by V1 nerve section in the flocculus-lesioned rabbits. These results suggest that proprioceptive signals from eye muscles act to improve VOR and OKN dynamics through the neuronal mechanisms involving the cerebellar flocculus.

Animals↗
PubMed1989

Neuromagnetic imaging studies discriminate proprioceptive and cutaneous cortical inputs during median nerve stimulation in man.

The localizing capabilities of the neuromagnetic imaging technique have been used to non-invasively discriminate mainly proprioceptive from cutaneous afferences to the contralateral hemisphere in human volunteers during separate median nerve stimulation at wrist and digits. The high time-resolution achieved in the localization of the equivalent sources of the early latency (15-30 ms) evoked fields permitted to follow their apparent movement as represented by an early and deep dipole (15 ms, about 5 cm deep, probably a subcortical source), a shallower one (20 ms, about 1.5 cm), and an intermediate one (23 ms, about 3 cm). These sources are supposed to be the manifestation of time-lagged parallel proprioceptive and cutaneous afferences from the thalamic ventro basal complex to different primary sensory areas in the postcentral gyrus. Both deeper and shallower dipoles could not be identified during selective stimulation of cutaneous afferents from the digital branches of the median nerve.

Cerebral Cortex↗
PubMed1982

Inhibitory actions of a novel endogenous tripeptide, methyionyl-tyrosyl-lysine, on proprioceptive neurons in the lumbar spinal cord of the cat.

The actions of a tripeptide, methionyl-tyrosyl-lysine (Met-Tyr-Lys), isolated from spinal cord and dorsal root ganglia have been investigated by iontophoretic application to single neurones in the spinal cord of the cat. Met-Tyr-Lys inhibited a group of neurons located mainly in laminae V and VI of the lumbar dorsal horn: excitation was never observed. The inhibition was rapid in onset and was not mimicked by the action of the constituent amino acids. Neurons inhibited by Met-Tyr-Lys received proprioceptive inputs as shown by their excitation or inhibition from stimulation of deep receptors and by their responses to leg or foot movement. Bicuculline and strychnine separately, at doses which antagonized responses to gamma-aminobutyric acid and glycine, respectively, had no or little effect both on responses to Met-Tyr-Lys and on the inhibition evoked in the same neurons by low-intensity (1.5-4T) stimulation of the tibial or common peroneal nerves. Thus receptors for Met-Tyr-Lys are different from those for glycine or gamma-aminobutyrate. In addition it is possible that there is a component of the inhibition evoked by peripheral nerve stimulation which is not mediated by either glycine or gamma-aminobutyrate. Met-Tyr-Lys may have an inhibitory role in relation to proprioception.

Animals↗
PubMed1991

The anatomical substrate for cat extraocular muscle proprioception.

The localization of cell bodies and of the central terminal projections of extraocular muscle afferent neurons was examined in adult cats using transport of horseradish peroxidase. The results confirm that primary afferent cell somata subserving extraocular muscle proprioception are located within the medial portion of the ipsilateral trigeminal ganglion. Occasional labeling of cell bodies in the mesencephalic nucleus of the trigeminal nerve occurred only in association with evidence of spread of tracer beyond the eye muscles. These results, taken together with work of others, make it unlikely that the trigeminal mesencephalic nucleus participates significantly in eye muscle proprioception. The central projections of extraocular muscle afferent neurons were found consistently in a restricted area in the ventral portion of the pars interpolaris of the spinal trigeminal nucleus. This corresponds exactly with their site of termination in the monkey [Porter (1986) J. comp. Neurol. 247, 133-143]. Terminal labeling was restricted to this area in cases in which there was no evidence of spread of the tracer beyond the extraocular muscles. In contrast to previous findings in the monkey, the cat did not exhibit a second muscle afferent representation in the cuneate nucleus. Though it is known that extraocular muscle afferent signals interact with both retinal and vestibular signals, and thus probably are involved in both visual processing and oculomotor control, the details of their roles in these processes are not yet clear.(ABSTRACT TRUNCATED AT 250 WORDS)

Afferent Pathways↗
PubMed2005

Proprioceptive coordination of movement sequences in humans.

OBJECTIVE: To estimate the processing time and neuromuscular delay required to extract and process sensory information from the ankle in order to coordinate an upper extremity movement sequence. METHODS: Nineteen able-bodied subjects were tested on their ability to perform a motor task that involved extension of their left index finger when their left ankle was passively plantar flexed at random velocities through a predetermined target angle. RESULTS: We found that the able-bodied subjects were able to adjust their finger responses up to ankle velocities of 70 degrees /s (300 ms). Reaction time, defined as the delay between onset of ankle rotation and how quickly the index finger could be extended, was 215 ms. The processing time and conduction delay was estimated to be approximately 85 ms. CONCLUSIONS: These results indicate that the nervous system processes kinesthetic input related to joint rotation of the ankle with the central mechanisms to execute a planned coordinated task with the upper extremity. SIGNIFICANCE: The time required to process proprioceptive information from the leg to perform a coordinated task with the upper extremity may vary throughout the lifespan. Understanding the effects of age, exercise, or injury on proprioceptive processing time may have important clinical implications.

Adult↗
PubMed2005

Development of upper limb proprioceptive accuracy in children and adolescents.

This study was designed to determine differences in the proprioceptively guided movements of children (8-10 years) and adolescents (16-18 years). Participants were blindfolded and asked to actively match passively determined target positions of the elbow joint under three matching conditions. Overall, children were less accurate than adolescents in all matching tasks and utilized different kinematic strategies for making the matching movements. Specifically, children made larger absolute errors and utilized matching movements which, compared to adolescents, were of shorter duration and less irregular in terms of their velocity profiles. An assessment of limb asymmetry was also performed revealing a non-dominant arm matching advantage but only for children and only in the task requiring interhemispheric transfer of a memory-based model of limb position. The proprioceptive differences observed in this study are likely the result of experience-driven refinement in the utilization of somatosensory feedback throughout childhood and into adolescence.

Adolescent↗
PubMed2005

Role of the inertial eigenvectors in proprioception near the limits of arm adduction range of motion.

Common everyday activities such as reaching for a cup, combing one's hair, or positioning a tool involve the accurate registration of the limb's orientation relative to the body and the environment. Past work has demonstrated that the ability of humans to perceive the spatial orientation of an occluded arm is tied to the arm's inertial eigenvectors, invariant mechanical parameters corresponding to a limb's axes of rotational symmetry. In a recent study participants pointed to visible targets while the arms' inertial eigenvectors were displaced by asymmetrically weighted splints. The lack of an effect of those splints on pointing error led them to conclude that inertial eigenvectors are not the primary invariants used for proprioception. However, their data suggested an effect of the eigenvectors, but only for conditions in which pointing did not require placing the arm near the limits of shoulder adduction range of motion. In the present study we found a significant effect of displacing the eigenvector for all tested arm angles, regardless of degree of shoulder adduction. Overall, the results supported the hypothesis that proprioception is based on sensitivity to the limb's inertial eigenvectors, with no reduction of the eigenvector effect when adducting the arm so as to reach far across the body midline.

Adolescent↗
PubMed2006

Proprioception in the ACL-ruptured knee: the contribution of the medial collateral ligament and patellar ligament. An in vivo experimental study in the cat.

In the absence of anterior cruciate ligament (ACL), secondary restraints such as menisci, ligaments, and tendons restrict anterior knee laxity. Strain detection at these sites could define the contribution of this alternative signalling system to knee proprioception after ACL injury. The hypothesis in this study questions if measurements of anterior tibial translation (ATT) from surface strain gauges on the insertions of the medial collateral ligament (MCL) and the patellar tendon (PT) are sufficiently sensitive and specific to differentiate normal, stable knees from acutely unstable knees due to ACL section. Twelve cats received miniaturized strain gauges on the surface of MCL and PT distal insertions. A purpose-made receiver transformed into measurements any voltage variation obtained during passive knee flexion-extension and anterior tibial translation manoeuvres. Variables under evaluation included first peak latency, normalized amplitude, and slope of voltage along time. Femorotibial displacements were video recorded, digitized, and used as the ATT reference. The proposed system detected significant changes in the slope of the voltage/time signal, with higher specificity and sensitivity during ATT after experimental ACL section. Changes were not significant during flexion or extension. It was found that a pattern of earlier and more intense strain in MCL and PT distal insertions was found during ATT in the ACL deficient knee. Enhanced pattern recognition learning from these structures could be a future target for proprioceptive training after ACL injury.

Animals↗
PubMed2006

The tendency to altered perception of airflow resistance in aged subjects might be due mainly to a reduction in diaphragmatic proprioception.

Elderly patients with asthma, particularly those above the age of 80 years, appear less able to detect early worsening of their airflow resistance and hence might not take 'rescue' bronchodilator medication promptly. No consistent explanation for the observation has been posited. We hypothesize that deterioration in the sensitivity and accuracy of inspiratory (mainly diaphragmatic) proprioception is a plausible mechanism. This contention is supported by observations that indicate the central role of afferent phrenic nerve fibres arising from mechanoreceptors in diaphragmatic muscle and entheses in the ability to sense changes in intrathoracic pressure and volume. Other sensory afferent sources appear less important in this context because the ability to detect intrathoracic pressure and volume changes is preserved in patients with heart-lung transplants (parenchymal and airway denervation), topically anaesthetized upper airways and spinal cord transection below C4 (intact phrenic function) but not cord transection above C2 (phrenic function absent) if the airways are simultaneously anaesthetized. Further support for the hypothesis comes from demonstration of reduced integrated proprioceptive function in older subjects, such as increased postural sway, reduced ability to judge changes in joint position and slower recovery from eye and hand perturbation. In the context of asthma, the detection of a change in airflow resistance depends mainly on the subconscious detection of a mismatch between the inspiratory effort and the volume change achieved; the resulting discrepancy between length (volume) and tension (muscular effort) is felt as a sensation of obstructed breathing, resulting in greater effort to breath and conscious actions such as self-medication. Our hypothesis proposes that a reduced ability to detect accurately the volume change during tidal breathing delays the sensing of the obstruction in older subjects.

Aged↗
PubMed2004

Proprioceptive weighting changes in persons with low back pain and elderly persons during upright standing.

The purpose of this study was to examine whether postural instability observed in persons with spinal pain and in elderly persons is due to changes in proprioception and postural control strategy. The upright posture of 20 young and 20 elderly persons, with and without spinal pain, was challenged by vibrating ankle muscles (i.e. tibialis anterior, triceps surae) or paraspinal muscles. Center of pressure displacement was recorded using a force plate. Persons with spinal pain were more sensitive to triceps surae vibration and less sensitive to paraspinal vibration than persons without spinal pain. Elderly persons were more sensitive to tibialis anterior vibration than young healthy persons. These results suggest that spinal pain and aging may lead to changes in postural control by refocusing proprioceptive sensitivity from the trunk to the ankles.

Adult↗
PubMedDate not supplied

Trunk muscle proprioceptive input assists steering of locomotion.

During locomotion, human subjects navigate in their environment and choose the direction by means of the internal representation of space that is continuously updated by sensory input. Aim of this study was to assess whether trunk proprioceptive information plays a role in the definition of the reference frame for orientation. Unilateral trunk muscle vibration was applied during locomotion along a straight path in seven subjects. Vibration was administered either from the onset or in the middle of a seven-step task, under eyes-open (EO) or blindfolded condition. The deviation of the walking trajectory was quantified by the distance of the seventh from the first foot print along the medio-lateral axis. Foot angles and stride lengths were computed for all foot-falls. Vibration produced a clear-cut deviation from the straight-ahead direction when delivered in the middle of blindfolded locomotion. With EO the deviation was much smaller. A mild deviation was obtained in blindfolded condition when vibration started at the onset of locomotion. All deviations from the straight-ahead were accompanied by coherent changes in foot orientation on the ground. Trunk proprioception plays a major role in the definition of locomotor trajectory. Trunk input seems to be weighted against vision and whole-body kinematic information.

Analysis of Variance↗
PubMed2006

Sensorimotor adaptation to inertial forces in a multi-force environment does not depend on the number of targets: indirect validation of the altered-proprioception hypothesis.

The ability of our sensorimotor system to adapt to changing and complex environmental demands has been under experimental scrutiny for more than a century. Previous works have shown that aimed arm movements adapt quickly and completely to Coriolis force, but incompletely to the combination of Coriolis and centrifugal forces without visual cues. Two hypotheses may be advanced to explain this discrepancy: the workspace-exploration hypothesis, and the degraded-proprioception hypothesis. The aim of this study was to distinguish between the above two alternatives by comparing adaptive improvement during off-axis rotation in subjects pointing at one, three or seven different targets in complete darkness. Two main results emerge: (a) off-axis rotation led initially to errors in the direction of Coriolis force and in the opposite direction of the centrifugal force; (b) the size of the visited workspace has no effect on the way the subjects adapt to a multi-force environment. The lack of a target-number effect and the persistence of lateral errors in the pointing movements performed during rotation of the platform, support the degraded-proprioception rather than the workspace-exploration hypothesis of adaptation to a multi-force environment.

Acclimatization↗
PubMed2005

Monosynaptic circuitry of trigeminal proprioceptive afferents coordinating jaw movement with visceral and laryngeal activities in rats.

Jaw movement is intimately related to various oromotor and visceral functions such as feeding, swallowing, vocalization, respiration and cardiac function. Neuronal circuitry that links jaw movement and these visceral and oromotor functions is largely unknown. The purpose of this study is to determine whether the trigeminal proprioceptive and jaw-muscle spindle afferents send axons to and synapse with the motoneurons innervating visceral organs and laryngeal muscles utilizing multiple double-labeling and physiological approaches. Double labeling of anterograde tracing combined to retrograde transport was performed by injection of biotinylated dextran amine into the mesencephalic trigeminal nucleus and cholera toxin B subunit or horseradish peroxidase into the vagus nerve and the recurrent laryngeal nerve. Mesencephalic trigeminal nucleus neuronal terminals contacted with visceral and laryngeal muscle motoneurons in the ambiguus nucleus and the nearby intermediate reticular zone. By electron microscopic observation, we confirmed that mesencephalic trigeminal nucleus terminals made asymmetric axodendritic synapses with these motoneurons. Double labeling of physiologically characterized jaw muscle spindle afferent neurons combined with anti-choline acetyltransferase immunohistochemistry showed that jaw-muscle spindle afferent boutons closely contacted choline acetyltransferase-immunoreactive motoneurons in the ambiguus nucleus and intermediate reticular zone. This report is the first to demonstrate that the trigeminal proprioceptive afferents synapsed upon visceral and laryngeal muscle motoneurons and provide neuronal networks for the jaw-visceral and jaw-laryngeal coordination.

Afferent Pathways↗
PubMed2003

Reliability and validity of ankle proprioceptive measures.

OBJECTIVE: To determine the reliability and validity of ankle proprioceptive measures. DESIGN: Reliability was assessed between test occasions. Construct validity was addressed by the ability of measures to differentiate among groups. SETTING: Laboratory of an educational institution. PARTICIPANTS: Eight healthy adults were recruited into each of 3 groups: (1) young (20-39y), (2) middle-aged (40-59y), and (3) older adults (>or=60y). Four subjects from each group (n=12) participated in retesting. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Threshold for perception of passive movement, error in active reproduction of position, error in reproduction of velocity, and error in reproduction of torque. RESULTS: Intersession reliability was excellent (intraclass correlation coefficient [ICC] range, .79 - .95) for threshold for perception of movement, error in active reproduction, error in velocity reproduction, and error in dorsiflexion torque reproduction; intersession reliability was good for error in reproduction of plantarflexion torque (ICC=.72). Threshold for perception of movement differed between groups 1 and 3 and between groups 2 and 3 (P<.05). Error in reproduction of position was greater in group 2 than in group 1 (P<.05). CONCLUSION: Differences in proprioception between the older and the 2 younger groups were best detected by using threshold for perception of passive movement.

Adult↗