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PubMed1981

HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.

Forty-six cultured cell lines of diverse human tumor origins, including 25 melanoma cell lines, were HLA allotyped with the use of a modified eosin complement-dependent cytotoxicity test in combination with absorption and two-color fluorescence techniques. In 10 cases (1 renal cell carcinoma line and 9 melanoma cell lines), the cell line donors had been HLA typed a few years before the cell line-typing project had started and in 13 cases (1 renal cell carcinoma line and 12 melanoma cell lines), the cell line donors were currently available for comparative typing of lymphocytes. HLA-typing results suggested that most cell lines expressed genetically appropriate HLA antigens, although 1 cell line had more than two HLA antigens for one HLA locus and 2 cell lines lacked expression of one or more HLA antigens in comparison with donor typing. One hepatoma cell line, 1 of 2 of the bladder carcinoma cell lines tested, and 17 of the 25 melanoma cell lines expressed DR alloantigens in addition to their HLA-A, B, and C locus antigens. For 9 of the melanoma cell lines, comparisons with donor DR alloantigens could be made, and all these cell lines had exactly the same DR allospecificities as those found on donor B-lymphocytes. HLA typing of cell lines can be used as an adjunct to polymorphic isoenzyme marker tests to verify their patient source and lack of contamination by another cell line, and HLA typing should be used to determine the antigen composition of cells used in the preparation of reagents for immunotherapy or in studies of tumor-specific immunity.

Cell Line↗
PubMed1991

Increase of vaccination coverage by mass media and individual approach: intensified measles, mumps, and rubella prevention program in Finland.

In the 1970s, mass vaccination projects were started in various parts of the world against measles and congenital rubella, with eradication as the final goal. In many developing and industrial countries, including Finland, the elimination of measles failed because of low vaccination coverage. In Finland, a combined measles, mumps, and rubella (Virivac) vaccination program was started in 1982. Computerized recording of the vaccinated children was considered necessary and was integrated with the population registry to identify the hard-to-reach families. Several interventions improved compliance: a mass media campaign and notification of nonvaccinated children to local health professionals and parents. All successive campaigns increased vaccination coverage significantly, with the notification of parents about their nonvaccinated child being especially effective. A vaccination coverage of over 96% was achieved, which theoretically prevents measles, mumps, and rubella transmission.

Child↗
PubMed1994

The development of cimetidine: 1964-1976. A human story.

There was still controversy regarding the physiology of acid secretion in 1964 when a team at Smith Kline & French Laboratories in England started a project to prove the existence of more than one receptor for histamine and to find a substance capable of blocking the effects not blocked by the commonly used antihistamines. The team was convinced that histamine was the final mediator of acid secretion. After 8 years, James Black and his coworkers published evidence of the first histamine2-receptor antagonist, burimamide. As this substance was not suitable for oral therapy, the research continued. Metiamide was synthesized with promising clinical effects but questionable safety. The final answer was cimetidine (Tagamet), approved in England in November 1976. Cimetidine was a breakthrough in the treatment of peptic ulcers. In this article I focus on the human factors lying behind many of the decisions made during the years of research. Without personal courage under stressful conditions, the H2-receptor antagonists might never have reached the market.

Adult↗
PubMed2006

Unprotected sex with multiple partners: implications for HIV prevention among young men with a history of incarceration.

OBJECTIVES: The objectives of this study were to describe preincarceration risk behaviors of young men and identify correlates of unprotected sex with multiple partners during the 3 months before incarceration. STUDY: Data on preincarceration risk behaviors were obtained from 550 men, aged 18 to 29 years, in state prisons in California, Mississippi, Rhode Island, and Wisconsin. Correlates of unprotected sex with multiple partners were determined by logistic regression. RESULTS: Of 550 participants, 71% had multiple sex partners, 65.1% had sex with a partner they perceived as risky, and 45.3% engaged in unprotected sex with multiple partners. Men who drank heavily (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.11-2.54) or who had a risky partner (OR, 3.90; 95% CI, 2.60-5.85) were more likely to report unprotected sex with multiple partners. Men who attended religious gatherings (OR, 0.66; 95% CI, 0.46-0.96) or lived in stable housing (OR, 0.69; 95% CI, 0.48-1.00) were less likely to report unprotected sex with multiple partners. CONCLUSIONS: Most participants engaged in behaviors that could result in a sexually transmitted disease, including HIV. Prevention programs should address the relationship between heavy alcohol use and risky sexual behavior. Discharge planning should address housing needs. Faith-based community organizations may play an important role for some young men in their transition to the community.

Adolescent↗
PubMed1992

Nursing science in The Netherlands: the Utrecht contribution.

The two goals of a 5-year nursing science project at the State University of Utrecht were the establishment of graduate nursing science studies and a nursing research programme. The project formally started on 1 January 1987 and is now nearing completion. This paper builds on a paper previously published in the Journal of Advanced Nursing. It first describes the history of nursing science in The Netherlands and sets out to demonstrate how the Utrecht goals were achieved.

Curriculum↗
PubMed2007

Factors influencing the choice of the first ward: comparison between newly qualified nurses and managers.

We had given a questionnaire to a group of newly qualified nurses and nursing managers responsible for their recruitment with the purpose of understanding the factors influencing the choice of the first ward. For this study, 45 nurses and 10 nursing managers had been recruited. There are 19 factors that influence the choice of the first ward: the most important is the kind of patient, both, nursing managers and newly qualified nurses agreed about, while about the other factors there were different answers. Reflecting on the choice factors may help hospitals to better understand the expectations of the newly qualified nurses and start improving projects to make even the less requested wards more attractive; it can also help the faculty to reflect about the academic curriculum that mostly influences the professional future of the students.

Adult↗
PubMed2004

Current status of the gyro centrifugal blood pump--development of the permanently implantable centrifugal blood pump as a biventricular assist device (NEDO project).

The New Energy and Industrial Technology Development Organization (NEDO) project was started in 1995. The goal is the development of a multipurpose, totally implantable biventricular assist device (BVAD) that can be used for any patient who suffers from severe heart failure. Our C1E3 (two-week pump) centrifugal pump, called the Gyro pump, has three design characteristics: a magnetic coupling and double pivot bearing system, an eccentric inlet port, and secondary vanes on the bottom of the impeller. The pump was miniaturized. The C1E3 evolved into the NEDO PI-601, a totally implantable centrifugal pump for BVAD. The current NEDO PI-710 pump (five-year pump) system includes a centrifugal pump with pivot bearings, a hydraulically-levitated impeller, an rpm-controlled miniaturized actuator (all-in-one actuator plus controller), an emergency clamp on the left outflow, and a Frank-Starling-type flow control. The final mass production model is now finalized, and the final animal study and two-year endurance studies are ongoing.

Assisted Circulation↗
PubMed2006

Our children too: a history of the Black Caucus of the Society for Research in Child Development, 1973-1997.

The Black Caucus of the Society for Research in Child Development(SRCD) was founded in 1973 to address concerns about the portrayal of Black children in scientific research, the lack of participation of ethnic minority members in the governance structure of SRCD, and the perceived need for a mutual support system for minority scholars aspiring to productive careers in the child development field. In this monograph, early members of the Caucus describe its history through the first 25 years, in 15 chapters distributed among sections on Caucus history, teaching and mentoring, publications and research-related issues, and supportive academic institutions. Among the topics explored are the formation and goals of the Caucus, its structure and membership, Caucus members' achieving stature and influence within SRCD, mentoring through the Toddler and Infant Experiences Study (TIES), response to the Atlanta child murders,the successful Pre-Conferences, SRCD Monographs and milestone developmental publications by Caucus members, the role of African American scholars in research on African American children (including the use of an ecological approach to study family processes), linkages between theory,research, and practice in Project Head Start, the contributions of the University of Michigan and Howard University, and looking to the future for students. Appendices trace Caucus chronological history and identify early sustaining members. This volume celebrates the accomplishments of the Caucus while also revisiting challenges that have arisen both internally and through membership in the SRCD parent organization. Key thematic issues include: cultural deficit versus cultural difference; linkages between poverty, race, and empowerment; advocacy versus objectivity in scientific research; and how the cultural or racial identity of the researcher informs scientific knowledge. The collaborations of Caucus members and others in SRCD modified the lens through which children of racially and ethnically diverse backgrounds are portrayed in the scientific literature.

Adolescent↗
PubMed1985

Caries and total extraction in a medium-sized city in the Netherlands.

In 1982 a combined sociodental research project was started in the city of Groningen in order to gain insight into the dental and social reasons for total extraction. 91% of the dentists in the city participated in this study by collecting the extracted teeth, filling out a questionnaire and asking their patients to fill out another questionnaire concerning the behavioral aspects of total tooth loss. 78% of the 134 patients returned the questionnaire. In this article the caries status in relation to the social background and dental attendance pattern has been described. The mean age at the time of extraction was 44.2 yr. The patients were a good cross-section of the Dutch population as regards education level, type of health insurance and sex. The average number of teeth was 14.2. The average DEMFT value was 22.8. Although regular attenders had less D-teeth than irregular attenders they had an average of 3.5 teeth with active caries. Regular attenders had more F-teeth but less sound teeth than irregular attenders. The contribution of the dental health care system to the dental health of the population is discussed.

Adolescent↗
PubMed1985

Periodontal status and total tooth extraction in a medium-sized city in the Netherlands.

A combined sociodental research project was started in the city of Groningen in 1982 aimed at gaining insight into the reasons for total tooth extraction. Patients showing up for total tooth extraction during 1982 participated in this study by filling out a questionnaire concerning the underlying reasons for their decision to have all their teeth extracted. The dentists in this city were asked to collect all the extracted teeth and to fill out a short questionnaire for each patient about the reason (diagnosis) for the total tooth extraction. The periodontal status of the extracted teeth was established afterwards by measuring the percentage of the loss of attachment (L.A.). It appeared that most surfaces in the molar region and the front teeth in the mandible were affected by periodontal disease. Advanced generalized periodontal disease was established in 17% of the patients, accounting for 64% of all teeth with an L.A. measurement of greater than 50%. Periodontal disease could not be identified as the main clinical condition requiring tooth extraction: even in the group of 55 yr of age and older advanced periodontal disease was found in only one third of the extracted teeth. Finally, the contribution of regular dental attendance to periodontal health is discussed.

Adult↗
PubMed1983

Biochemical markers for testicular germ-cell tumors in relation to histology and stage: some experiences from the Danish testicular cancer (DATECA) Study from 1976 through 1981.

The DATECA Project was started in January 1976 and includes all patients with testicular cancer in Denmark. During the first 6 years, 1246 patients entered the joint protocol for histology, staging, management, and clinical use of tumor markers. Only 746 DATECA patients fulfilled the claims for being ideally monitored with preoperative as well as postoperative serologic marker determinations. The overall prevalence of marker positivity, that is, elevated preoperative values of alpha-fetoprotein (AFP) and/or human chorionic gonadotrophin (HCG) was 8% for patients with seminoma and 63% for patients with nonseminomatous disease. The prevalence of increased marker concentration in serum was correlated to stage (higher prevalence in higher stages) and to prognosis (marker-negative patients had a better prognosis than did marker-positive patients). An increased concentration of AFP or HCG was correlated with the presence of a primary endodermal sinus tumor and choriocarcinoma component, respectively.

Alkaline Phosphatase↗
PubMed1997

Oral health of 3-year-old children and their parents after 29 months of child-focused antiatherosclerotic dietary intervention in a prospective randomized trial.

A long-term prospective, randomized dietary intervention to prevent exposure of children to the known atherosclerosis risk factors (the STRIP baby project) was started when the age of the children was 7 months. The aim of this substudy was to analyze the oral effects of the dietary intervention in the children and their parents when the children had reached the age of 3 years. Every fifth family of the main study was invited to this substudy (n = 179). Those studied (n = 148) represented well the intervention and the control groups and both genders in terms of intake of saturated fatty acids, the dietary polyunsaturated fatty acid to saturated fatty acid (PUFA/SAFA) ration and serum cholesterol and HDL cholesterol concentrations. Though no difference was found in sucrose consumption between the intervention and the control groups, the intervention children received relatively (in E%) more energy from carbohydrates than the control children (p < 0.005), used absolutely (in g) and relatively (in E%) less fat (p < 0.05) and had a higher PUFA/SAFA ratio in their diet (p < 0.001). Of the 3-year-old children 93% were caries free, and dental decay was a prevalent in the intervention as in the control children. Control children brushed their teeth unassisted more often than the intervention children (p < 0.05). The intervention fathers also received more energy (in E%) from carbohydrates (p < 0.01), the intervention mothers used less fat (p < 0.05) and had a higher PUFA/SAFA ratio in the diet (p < 0.05) than the control fathers and mothers, respectively. Dental and periodontal health of the intervention and control parents (n = 250, 84% attending, mean +/- SD age: 34.2 +/- 54.5 years also showed no differences even though the control parents had more commonly last visited a dentist over 3 years before this examination (p < 0.05). We conclude that a 29-month period of a low-saturated-fat, low-cholesterol but high-carbohydrate diet as advocated in the STRIP baby trial does not seem to have harmful effects on the oral health of the children or their parents. Minor untoward differences had occurred in the dental health behavior of the control children and their parents.

Arteriosclerosis↗
PubMed2004

A qualitative study of substance use and sexual behavior among 18- to 29-year-old men while incarcerated in the United States.

The article describes men's perceptions of and experience with substance use and sexual behavior during incarceration. Grounded theory content analyses were performed on qualitative interviews conducted with 80 men, aged 18 to 29, in four U.S. states. Participants believed that drugs were easily available in prison. Half reported using substances, primarily marijuana or alcohol, while incarcerated. Key themes included the role of correctional personnel in the flow of substances in prison and the economic significance of substance trafficking. With regard to sexual behavior, most men acknowledged that it occurred but were hesitant to talk in-depth about it. There was a strong belief in "don't look, don't tell," and sex in prison was often associated with homosexual behavior or identity. Sex during incarceration was reported by 12 men, mostly with female partners. Participants were pessimistic about HIV/STD/hepatitis prevention efforts inside correctional facilities. These findings highlight the need for risk reduction programs for incarcerated men.

Adolescent↗
PubMed1989

Local action groups in prevention of child accidents.

Local action groups, organized by public health nurses, were formed in eight municipalities of Norway in order to prevent childhood accidents. The process of establishing such action groups and their way of operating are reported. The study revealed a potential for local activities in health promotion and yielded experience worth considering when starting similar projects. A project should be designed locally and priorities based upon locally felt needs. Formal channels for transferring knowledge from the health sector to other sectors in the municipality need to be established. An action group consisting of both lay people and professionals seems to be the most efficient means.

Accident Prevention↗
PubMed1995

[Gene expression of human eukaryotic initiation factor-4E for protein synthesis and study of its recognition mechanism of mRNA cap structure].

Being stimulated by the insights from model studies that (i) the intimate combination of hydrogen-bonding pairing and aromatic stacking interactions is important for the specific binding of guanine base by peptide and (ii) the pi-pi stacking force of Trp is significantly strengthened by the guanine N7-methylation (m7G), this research project was started, because (a) the mRNA cap structure is characterized by the existence of m7G and (b) an eukaryotic initiation factor-4E (eIF-4E), a protein which specifically recognizes the mRNA cap structure and opens the protein biosynthesis, contains 8 Trp residues irrespective of its relatively low molecular weight of about 25 kDa. In order to prepare the sufficient amount of sample for carrying out the analysis of the recognition mechanism of mRNA cap structure by eIF-4E at the atomic level, firstly, the expression of human eIF-4E gene in Escherichia coli was attempted. An artificial gene encoding for human eIF-4E was chemically synthesized and succeeded in the expression with two different forms, i.e., as a fusion protein with human growth hormone and a direct expression of soluble protein. The isolation of eIF-4E and its purification procedure using the m7GTP affinity chromatography were accomplished. It was shown by spectroscopic methods that the recombinant eIF-4E exhibits essentially the same tertiary structure as the native one and the binding ability with mRNA cap analog was identical with each other. In order to analyze the functional amino acid residues which are essential for specific recognition of mRNA cap structure, next a series of eIF-4E mutants were prepared by the site-directed mutagenesis, and His37, His200, Trp102 and Glu103 were suggested to be important for binding of mRNA cap structure, as judged from comparison of the binding abilities of respective mutants with a m7GTP affinity column. Since the crystals of recombinant eIF-4E-m7GTP complex suitable for X-ray crystallography are now in preparation, the detailed interaction mode between them will be opened in near future.

Amino Acid Sequence↗
PubMed2003

Predictors of risky sex of young men after release from prison.

A longitudinal study of demographic and behavioural characteristics associated with risky sexual behaviours of young men after release from prison. One hundred and six men were interviewed in prison and at one week and six months after release. Overall, 37% reported a previous sexually transmitted disease (STD) diagnosis. In the 30 days before incarceration, 33% had had sex with a risky partner, and 59% had had multiple female sex partners. After release, 38 (36%) men reported having had risky sex (>or=2 female sex partners and unprotected vaginal sex): 12 (13%) at one week and 31 (34%) at six months. The only factor independently associated with risky sex was the use of alcohol/drugs before sex: one-week odds ratio (OR)=6.11 (95% confidence interval [CI]: 1.42-26.40), six-month OR=3.05 (95% CI: 1.30-9.42). Behavioural intervention programmes for incarcerated men should address drug and alcohol use and its contribution to higher risk for HIV and STDs.

Adolescent↗
PubMed2005

Screening for sexually transmitted diseases and hepatitis in 18-29-year-old men recently released from prison: feasibility and acceptability.

Men entering prisons have high rates of sexually transmitted disease (STD), hepatitis, and HIV. This study sought to determine the acceptability and feasibility of screening for STD and hepatitis in young men released from prison. Participants were interviewed six months after release and offered free screening. Of 42 (56%) eligible men who participated in the qualitative interview, 33 (79%) provided at least a blood or urine specimen. Eight of 33 (24%) men tested had chlamydia, trichomoniasis, hepatitis B or C virus (HBV or HCV). Three of 32 (9%) had chlamydia, three of 32 (9%) had trichomoniasis, two of 28 (7%) had prior syphilis, and two of 28 (7%) had HCV. Of 28 tested for HBV, six (21%) were immune, two (7%) had chronic infection, and 20 (71%) were susceptible. Barriers to screening included lack of forewarning, inconvenience, and insufficient incentive. In conclusion, screening for STD and hepatitis among former inmates can be acceptable and feasible. Forewarning, reducing the time burden, and providing monetary incentives may increase screening rates.

Adolescent↗