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Results for “Peromyscus”

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At least 415 records · Page 23Linked to original sources
PubMed1990

Melatonin receptors and signal transduction in melatonin-sensitive and melatonin-insensitive populations of white-footed mice (Peromyscus leucopus).

The pineal hormone melatonin times seasonal alterations in reproductive function in photoperiodic mammals. In white-footed mice, there is variation in responsiveness to the reproductive effects of melatonin between populations originating in different locations; mice from Connecticut (CT) respond normally to melatonin, while mice from Georgia (GA) appear insensitive to melatonin. In the present paper, we compare melatonin receptor distribution and a second messenger response to melatonin in white-footed mice from CT and GA. Specific binding of 125I-labeled melatonin (I-MEL) was observed in a variety of brain regions in each population, but there were no consistent differences in the distribution or intensity of I-MEL binding between the populations. Furthermore, melatonin inhibited forskolin-stimulated cAMP accumulation in median eminence/pars tuberalis explants from both populations. These results suggest that insensitivity to melatonin in GA mice is not due to a gross defect in melatonin receptors or receptor-effector coupling.

Animals↗
PubMed1985

Studies of pericopulatory pregnancy blockage and the gestation period in deer mice (Peromyscus maniculatus).

It has previously been shown that female deer mice in cycling estrus that copulate with or are exposed to more than one male at the time of mating have a lower probability of delivering a litter than when mating with and being exposed to just one male. In the present research the effect of post-mating exposure to the bedding of a strange versus a familiar male was studied in females in postpartum estrus. In four experiments females in postpartum estrus were protected from pericopulatory pregnancy blockage, presumably by suckling-induced elevated prolactin levels. Varying female experience, number of ejaculations, and the presence of suckling pups had no effect on this protection. Thus, both the pericopulatory block and the Bruce effect (a more delayed type of pregnancy blockage) occur in cycling, but not suckling, females. This suggests that the two may have a common mechanism and leads to a new perspective in the search for adaptive significance. In addition, the subsequent gestation periods were prolonged in females nursing young; the length was affected by the number of pups weaned from the previous litter and the number of pups being carried.

Adaptation, Physiological↗