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Malignant plasmacytoid myoepithelioma of the palate: histological observations compared to benign predominant plasmacytoid myoepithelial cells in pleomorphic adenoma of the palate.

Predominant benign plasmacytoid myoepithelial cells in pleomorphic adenoma and malignant plasmacytoid myoepithelioma cells were investigated morphologically. The cells of both tumors were plasmacytoid in appearance and sheet-like. Immunohistochemically, they were positive for keratin, vimentin, and S-100 protein, and negative for alpha-smooth muscle actin. In the malignant cells, large nuclei with irregular nuclear membranes and distinct nucleoi and occasional intranuclear inclusions and nuclear grooves were seen. Ultrastructural findings showed that the benign cells were richer in intermediate filaments and had fewer mitochondria. The intranuclear inclusions and nuclear grooves of the malignant cells were caused by invagination of the irregular nuclear membranes. Taken in their entirety, the above light microscopical nuclear findings may be useful as an adjunct for distinguishing malignant from benign plasmacytoid neoplastic myoepithelial cells of the salivary gland.

Adenoma, Pleomorphic↗
PubMed1987

Concomitant developmental anomalies of the face in patients with clefts of lip (alveolus, and palate) or cleft palates.

Out of 2,829 cleft patients of Nordwestdeutsche Kieferklinik Hamburg 356 were found to have additional pathologic findings in the head and neck area. It was noted that the greater the dimension of the cleft, the greater the number of concomitant anomalies. However, the severity of the additional malformation could not be correlated to the severity of clefting. All additional pathologic findings were classified according to Pfeifer's morphogenetic classification of craniofacial anomalies. In cleft patients the region most often affected was found to be the lateral (and posterior) parts of the head. However, in unilateral clefts it was not possible to correlate the location of the cleft to the location of the concomitant malformation.

Cleft Lip↗