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Hemophilia: the changing role of the orthopedic surgeon in the era of HIV infection.

HIV infection and AIDS have posed additional challenges to the orthopedic surgeon and they are discussed in this paper. The acute hemarthrosis. 1. Undertreatment has resulted in further joint degeneration 2. A hemarthrosis with an unusual pain pattern or an elevated temperature may be a pyarthrosis and aspiration and culture are necessary for diagnosis. This complication was very rare prior to HIV infection. Synovitis. 1. In the past we suggested factor replacement and steroids as the primary method of treatment. The use of steroids may be contraindicated in the HIV positive patient. 2. Radioactive synovectomy should be considered in the immune compromised patient. 3. The risks to the surgical team of arthroscopic synovectomy are discussed. Advanced arthropathy. 1. A late infection rate of 10.4% in HIV positive patients with total knee replacements has changed the indications for this procedure. 2. Lesser procedures such as arthrotomy and osteotomy should be considered. Pseudotumor. 1. The indications for pseudotumor surgery must include an evaluation of the risk-benefit ratio in the patient with HIV infection. 2. The orthopedic surgeon must accept the challenge of stimulating and training his students and residents in the principles of orthopedic care of the person with hemophilia.

HIV Infections↗

Imaging aspects of new techniques in orthopedic surgery.

Advances and new techniques in orthopedic surgery continue to challenge the radiologist in our attempts to maintain familiarity with imaging aspects of these procedures. This article is an attempt to review several of these new orthopedic techniques and modifications of standard procedures. In addition the use of computed radiography, a recently developed modification of digital technology, in musculoskeletal imaging was also assessed. It is our responsibility to recognize the normal radiologic appearance of these new techniques. Perhaps more importantly better understanding of these new orthopedic surgical procedures may allow detection of complications at the earliest stage, improving patient management and clinical outcome.

Diagnostic Imaging↗

[The laryngeal mask--news in orthopedic anesthesia].

The laryngeal mask airway (LMA) was first used at the Department of Orthopedics, School of Medicine, University of Zagreb on May 8, 1991. Two hundred and three patients were undergoing elective orthopedic surgery during the first year of the LMA use. A size-3 mask was used for women and children weighing over 25 kg (55 lbs) and a size-4 mask for men. Research has been undertaken in 12 patients aged between 30-73 years scheduled for total hip replacement. Blood pressure, heart rate and hemoglobin oxygen saturation were continuously monitored with a noninvasive method. No signs of cardiovascular disorders were noticed 1-min before and 3-min after insertion. Only 2 (16.6%) patients, who suffered no complications, had ventilating pressure higher than 20 cm H2O. The LMA proved to be very useful in anesthesia where endotracheal intubation was difficult or almost impossible. Of 12 examinees, 3 with severe rheumatoid arthritis and 2 with ankylosing spondylitis were successfully anesthetized with the LMA. Awakening from anesthesia was very pleasant. There were no serious complications in terms of laryngo- or bronchospasm, aspiration or insufflation of the stomach. The LMA has been found to be very helpful in solving problems of anesthesia in orthopedic patients. A set of laryngeal mask airways should be an integral part of every anesthetic equipment.

Adolescent↗

[Dual-energy X-ray absorptiometry: value in orthopedics].

We emphasize the opportunity of an in vivo bone mass measurement with an easy and accurate technique for orthopedic practice. At the present time, Dual Energy X Ray Absorptiometry (DEXA) is the most used technique, and is a safe and short examination. It can assess the quantity of mineral of any region of the body with a remarkable reproducibility (1 to 3 per cent). New machines are improved, and they permit many practical applications beyond the osteoporosis field. Thus, in orthopedics, we can distinguish several interesting topics. Peripheral risk of fracture can be evaluated because of good correlation between bone mineral content and biomechanical properties of bone. Even if a peripheral fracture occurs after a fall, low bone mineral density plays an important role, as in the case of femoral neck fractures in elderly patients. In traumatological practice, a DEXA with a specialized advice has to be requested if the traumatism cannot fully explain the occurrence of the peripheral fracture. Low bone mineral density defines an osteoporotic state, with the possibility of selecting adequate therapy. The good reproducibility of the measurement allows early estimation of bone loss following a period of immobilization. Varying models of osteosynthesis can be compared in vivo, to evaluate a decrease of "stress shielding" bone resorption. The role of stiffness of an implant on regional bone mineral content can be assessed. Likewise, periprosthetic bone mineral content can be measured in various regions, and followed over time. Specific software allows the exclusion of the region where the metallic prosthesis is projected. The reproducibility of this peripheral bone mineral content is 2 to 3 per cent, which individually allows an estimation of variations of more than 5 per cent. It will be possible to evaluate in vivo the influence of various parameters of the prosthesis on bone mineral content in controlled studies, such as the role of the shape, the position, the structure, the coating. Mineral content of biomaterials and bone grafts are taken into account. Focusing the X Ray beam allows ultrahigh resolution. Precise measurements of very small parts of bone such as rodent tibia or vertebra are possible. The good reproducibility (2 per cent) authorizes the evaluation of various parameters which modify bone remodeling, such as immobilization or activity, ovariectomy. Preventive or curative therapeutics which change bone mass can be evaluated in animal pre clinical studies. There are other methods of measurement of bone mineral content. Digitalization of radiographs is not sufficiently accurate and CT Scan generate high levels of radiation. The DEXA is actually the best compromise for an accurate and reproducible measurement of the bone mineral content in vivo. This method will certainly be an important tool in orthopedics for several clinical or animal investigations in the future.

Absorptiometry, Photon↗

Autologous blood donation plus epoetin alfa in nonanemic orthopedic surgery patients.

Intravenous (i.v.) administration of epoetin alfa facilitates the collection of autologous blood (AB) prior to elective orthopedic surgery. However, the optimum dose and dosage regimen remains to be defined. The aim of this multicenter, randomized, placebo-controlled study was to determine the optimum i.v. dose of epoetin alfa (300 IU/kg or 600 IU/kg) that would allow nonanemic patients to donate > or = 4 units of AB within 14 to 21 days of elective orthopedic surgery. All patients (n = 103) received oral iron supplementation and were treated with epoetin alfa or placebo three times during 1 week, within 3 weeks of surgery. Eighty patients were evaluable in the efficacy analysis. Compared with placebo, significantly more evaluable patients treated with epoetin alfa were able to donate > or = 4 AB units. Furthermore, epoetin alfa dose-dependently increased the preoperative reticulocyte count and attenuated the decrease in hematocrit associated with AB predonation. There was no significant difference with respect to allogeneic blood exposure between the epoetin alfa and placebo treatment groups. In addition, the 600 IU/kg dose was not significantly more effective than the 300 IU/kg dose for most efficacy parameters assessed. Several patients became iron-deficient, suggesting that oral supplementation is not an adequate source of iron in these patients. Epoetin alfa 300 IU/kg therefore appears to be the optimum i.v. dose for facilitating the collection of > or = 4 units of AB within 14 to 21 days of elective orthopedic surgery.

Blood Transfusion↗

Orthopedic surgery in the combat zone.

Experience in all major conflicts in this century has shown that orthopedic surgical/musculoskeletal care is a major component of medical support for deployed combat forces. This care consists of treatment of injuries due to both war wound trauma and non-wound trauma, which may be secondary to enemy action of "accidental". Key considerations are that most orthopedic injuries will require evacuation to echelon-IV or -V facilities out of the combat zone, and that appropriate treatment in the combat zone (echelon II or III) will reduce morbidity and facilitate evacuation. The modern experience of orthopedics in the combat zone is reviewed, with emphasis on the Persian Gulf experience and current Deployable Medical Systems, and a plan for care is promulgated.

Humans↗

Risk factors for early wound complications after orthopedic surgery for rheumatoid arthritis.

OBJECTIVE: To identify risk factors for the occurrence of early wound complications following orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS: We reviewed records of patients with RA undergoing joint surgery to identify predictors of the following early postoperative surgical outcomes: (1) prolonged drainage; (2) wound cellulitis; (3) wound dehiscence; (4) suture abscess; and (5) superficial or deep wound infection. RESULTS: During the study, 204 patients with RA underwent 119 total knee replacements, 105 total hip replacements and 143 procedures of other joints, for a total of 367 orthopedic surgeries. A total of 57 complications were observed (15.9%) of which 26 were considered major (7%). Of the 230 total arthroplasties of the hip, knee, shoulder or elbow, 3 were followed by early deep wound infections (1.3%). In univariate analysis, factors significantly related to the occurrence of complications included Hispanic ethnicity [relative risk (RR) 1.43, 95% confidence interval (CI) 1.16 to 1.78]. and preoperative use of azathioprine (RR 2.13, 95% CI 1.04 to 4.37). Complications were less frequent among patients given methotrexate, but the differences was not significant. Operative blood loss was inversely related to the occurrence of complications. In the multivariate model, the only significant predictors of complications were Hispanic ethnicity (RR 2.86, 95% CI 1.43 to 5.56) and operative blood loss (RR 0.50/liter lost, 95% CI 0.29 to 0.86). CONCLUSIONS: We were unable to demonstrate an independent effect of antirheumatic therapy at the time of surgery on the occurrence of postoperative wound complications. Our study suggests that patients with RA of Hispanic ethnicity may be at increased risk of developing postoperative wound complications following orthopedic surgery. Further study is necessary to explain the mechanism of increased complications in this population.

Adult↗

[The behavior of the fibrinolytic system during long-term orthopedic immobilization].

Our previous experimental studies on rats motionless for 7 to 60 days in special devices limiting their movements revealed a significantly increased activity of the fibrinolytic system (Groza, Artino) due to the "detention stress" rather then to the immobilization. Starting from these studies we have tried to observe the behaviour of the fibrinolytic system during long-term orthopedic immobilization (7-28 days) on patients having different injuries of the lower limb and submitted to orthopedic therapy (with or without osteosynthesis) to which an anticoagulant preventive treatment was added (heparin or low-molecular-weight substitutes such as Clivarine, Fraxiparine). We studied on 23 patients (11 male and 12 female) motionless for 14, 21, 28 days the plasma fibrinolytic activity (PFA) through euglobulin lysis time (ELT). Clinical investigation revealed that PFA did not change significantly during long-term orthopedic immobilization regardless of the duration of immobilization (14,21,28 days). Rosenfeld et al. (1994) described in healthy volunteers on bedrest for 36 hours an increase of PFA beginning at 24 hours of immobilization, this variation being capable of preventing stasis effects. Our results suggest that preventive anticoagulant therapy properly given during immobilization prevents thromboembolic events.

Adolescent↗

The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery.

STUDY OBJECTIVES: To evaluate the effect of a standard meal on bioavailability of bromfenac, and on the relative analgesic efficacy and adverse effect liability of bromfenac 25 mg, naproxen sodium 550 mg, and acetaminophen 325 mg in the treatment of pain after orthopedic surgery. DESIGN: Randomized, double-blind, single-dose, parallel-group. SETTING: Two wards of the orthopedic surgery department at the Central Hospital, Karlstad, Sweden. PATIENTS: Three hundred ten patients with steady, moderate, or severe pain within 72 hours after orthopedic surgery. INTERVENTIONS: Patients were randomly assigned both to receive a standard meal or remain in a fasted state, and to treatment with a single oral dose of bromfenac 25 mg, naproxen sodium 550 mg, or acetaminophen 325 mg, when they experienced steady, moderate, or severe pain that required an analgesic. Using a self-rating record, subjects rated their pain and its relief for up to 8 hours after medicating. Blood samples were obtained from all patients using one of two schedules. MEASUREMENTS AND MAIN RESULTS: The peak plasma bromfenac concentration for fed patients was only 28% of that of fasted patients. Disregarding food intake, bromfenac 25 mg and naproxen sodium 550 mg were significantly superior to acetaminophen 325 mg for all summary measures of analgesia. Bromfenac and naproxen were superior to acetaminophen by hour 1 and this difference persisted for 8 hours. Food reduced bromfenac's analgesic effect, but not that of naproxen or acetaminophen; treatment by meal interaction was significant for five measures of efficacy. Analgesic response for fed bromfenac recipients, compared with those who were fasted, ranged from 37-71%. The percentage of patients reporting an adverse effect was significantly higher for bromfenac (25%) and naproxen (24%) than for acetaminophen (12%). CONCLUSIONS: Results of analgesic studies not taking patients' food status into consideration might be misleading. Although bromfenac 25 mg and naproxen sodium 550 mg produced significant analgesia compared with acetaminophen 325 mg, bromfenac's efficacy was significantly reduced when patients ate a standard meal. Adverse effects were transient and consistent with the pharmacologic profiles of the drugs.

Acetaminophen↗

[The effect of anesthesiologic technique on the mental state of elderly patients submitted for orthopedic surgery of the lower limbs].

UNLABELLED: Influence of anesthetic technique on mental status in elderly patients submitted to major orthopedic procedures of lower limbs. Mental impairment is a common occurrence in elderly patients after major orthopedic surgery. Few studies have been published so far on this topic in spite of its relevant clinical and economic implications. OBJECTIVE: 1) To verify whether anesthesia has a causative role in postoperative mental confusion in elderly patients; 2) to compare the effects of General Anesthesia (GA) and Spinal Anesthesia (SA) on mental status. DESIGN: Controlled, comparative study. PATIENTS: Sixty patients aged > or = 70, ASA I-II, submitted to femoral neck repair. SETTING: Anesthesia Dept. and Orthopedic Dept. of a District Hospital in Italy. METHOD: The day before surgery the mental status of elected patients was evaluated employing a modified Organic Brain Syndrome (OBS) scale (Gustafsson). The better the mental status, the lesser the OBS score. It was possible therefore to distinguish "oriented" from "confuse" patients (38 vs 22) if they scored < or = 6 or > 6 respectively. Patients from each group were than randomly assigned to receive either GA or selective SA. Neither group was premedicated. GA was induced with propofol 1 mg/kg and maintained with O2/N2O 40/60% and isoflurane; atracurium was employed to facilitate mioresolution. Spinal anesthesia was performed with hyperbaric 1% bupivacaine. All patients were monitored in the Recovery Room (RR) for at least one hour. Occurrence of hypotension and/or hypoxia in the Operating Room (OR) or the RR was immediately treated. Mental status was reassessed on the 1st and 2nd postoperative day and results were compared with the corresponding preoperative OBS scores both in GA patients and in SA patients. RESULTS: No statistically significant differences were found between pre- and postoperative OBS scores in both GA and SA group, whether "oriented" or "confuse". CONCLUSIONS: Mental status of elderly patients submitted to femoral neck repair doesn't seem to be influenced by the anesthetic technique chosen, independent of preoperative psychic conditions.

Aged↗

Gene expression analysis of osteoblastic cells contacted by orthopedic implant particles.

Particles generated from orthopedic implants through years of wear play an essential role in the aseptic loosening of a prosthesis. We have investigated the biocompatibility of these orthopedic particles on different osteoblast-like cells representative of different stages of osteoblast maturation. We found the particles induced a caspase-dependent apoptosis of osteoblasts, with less mature osteoblasts being the most susceptible. An analysis of gene expression was performed on the less mature osteoblasts, which were in contact with the particles. We found that the particles had a profound impact on genes that code for inflammatory cytokines and genes involved in controlling the nuclear architecture. Results from this study suggest that the peri-implant osteolysis after a total joint replacement can be due in part to a decrease of bone formation and not solely to an overstimulation of bone resorption as is generally proposed. Development of new drugs that promote normal bone formation and osteoblast survival would possibly control peri-implant osteolysis, resulting in a better prognosis for patients with orthopedic implants.

Animals↗

[Occupational health studies on airport transport workers. III. Musculoskeletal complaints and orthopedic disorders of airport transport workers (author's transl)].

In an epidemiologic cross-sectional study, 366 transport workers (age-range: 19-61 years) of a big German airport who are engaged in physical heavy work in unfavorable body positions in narrow freight spaces of airplanes, were investigated with regard to their subjective musculoskeletal complaints through a standardized anamnesis in an interview questionnaire. An additional clinical orthopedic examination was performed in 104 of the transport workers. Back pains were the most frequently reported complaints: at the time of examination 66% of the transport workers reported present back complaints. 57% had experienced previous back syndromes. Increasing age and stature were associated with a higher prevalence of these complaints. Years of exposure to transport work correlated positively with the prevalence of back complaints. After back complaints, knee complaints followed in the prevalence of locomotor complaints (41% of the interviewed workers). The prevalence increased with age and body weight significantly. Neck complaints were reported by 33% of the workers, arm complaints by 41%: again, age increased the prevalence of these complaints significantly. In the standardized clinical orthopedic examination, the prevalence of the functional findings were sometimes higher than in the interview. In contrast to the subjective complaints at the interview, individual factors (age, stature, weight, and work experience in the present occupation) had very little influence on the prevalence of objective findings. The clinical, epidemiologic screening methods employed have proved efficacious in detecting orthopedic disorders in an occupational collective. This study has shown that transport workers with wide discrepancies between body length and the space available in airplane cargo bellies, considerable overweight, or a history of former back syndromes should not be employed. Means to alter cargo belly dimensions in airplanes as well as the increased use of mechanical loading aids and additional training of the workers in proper lifting and carrying of cargo should be taken in to consideration.

Adult↗

Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery.

Without prophylaxis, patients subjected to major abdominal surgery have a risk of deep vein thrombosis of approximately 30%, while the rate varies between 40% and 60% in orthopedic surgery. The reasons for this discrepancy are not completely understood. The present study was designed to compare the pre- and postoperative behavior of different coagulation and fibrinolysis parameters in patients undergoing both types of surgery, receiving low molecular weight heparin prophylaxis. Samples were taken before operation and on postoperative days 1, 3, and 7. The following parameters were assessed: prothrombin fragment 1 + 2, thrombin-antithrombin III complexes, fibrinopeptide A, tissue plasminogen activator, plasminogen activator inhibitor, plasmin-alpha 2-antiplasmin complexes, and fibrin degradation products. We found a significant increase in the clotting markers postoperatively compared with preoperative values (P < 0.05), both in abdominal and orthopedic surgery, indicating a marked hemostatic activation which remained until postoperative day 7. A significant increase in plasminogen activator inhibitor (P < 0.01) and a decrease in tissue plasminogen activator and plasmin-alpha 2-antiplasmin complexes was also observed early after operation. The plasminogen activator inhibitor activity decreased, while tissue plasminogen activator and plasmin-alpha 2-antiplasmin levels increased significantly on days 3 and 7 (P < 0.05). Fibrin degradation products significantly increased throughout the postoperative period (P < 0.01). Preoperatively, we found higher plasminogen activator inhibitor activity and lower tissue plasminogen activator and plasmin-alpha 2-antiplasmin complexes (P < 0.05) in patients undergoing hip replacement compared with abdominal surgery. Fibrin degradation products were also significantly lower on postoperative day 3 in patients undergoing hip replacement (P < 0.01). We suggest that the lower preoperative fibrinolytic activation observed in patients undergoing orthopedic surgery compared with abdominal surgery might have pathophysiological consequences. Our results also indicate that the hemostatic activation persists beyond the 7th postoperative day despite prophylaxis.

Abdomen↗

Radiological and orthopedic score in pediatric hemophilic patients with early and late prophylaxis.

In order to evaluate joint alteration, 17 patients with hemophilia A and B were investigated over a period of 4 years (1993-1997). Patients were subdivided into two groups, according to therapy regimens. In group 1 (n=10) prophylactic treatment was initiated until the third year of life. In group 2 (n=7) patients received prophylactic treatment at the age of 5 years and above. To assess alterations in knee, elbow, and ankle joints, the radiological score and the physical examination score of the Orthopedic Advisory Committee of the World Federation of Hemophilia were used. The sum of the scores of these six joints was defined as the patient-dependent score. Patients of group 1 (median age at the end of observation: 10 years) reached a median radiological score of 1.0 (range: 0-13) and an orthopedic score of 0 (range: 0-4), whereas patients of group 2 (median age: 14 years) had a radiological score of 20 (range: 2-47) and an orthopedic score of 8 (range: 0-12), which shows a significant difference (p <0.01). In both treatment groups a manifestation or progression of arthropathic alteration was seen in those children who had repeated joint bleeding (>5) prior to the onset of prophylactic treatment (r=0.90, p>0.01). Altogether, two of 60 joints in group 1 and 12 of 42 joints in group 2 had a radiological score > or = 4. Elbow joints were more often affected than knee and ankle joints. In conclusion, the number of joint bleedings before prophylactic treatment was started influenced the progression of arthropathy even in patients with early onset of prophylaxis. The aim of treatment in severe hemophilia should be early prophylaxis before repeated joint bleeding occurs in order to prevent osteoarthropathic alteration.

Adolescent↗

The maxillary orthopedic splint.

Craniomaxillary orthopedic correction of the skeletal imbalance of Class II malocclusions is often the desired method of treatment in these cases. The ability to apply a "pure" orthopedic force to the maxillary complex has so far eluded research efforts. However, the use of a maxillary splint with a high-pull extraoral traction assembly has been shown to be most effective in reducing Class II skeletal dysplasias through a combination of dentoalveolar and basal bone changes. Force delivery to the maxillary complex in Class II skeletal jaw disharmonies is through the teeth. The philosophy behind the use of the maxillary splint is that if the force delivered to the upper jaw involved the use of all the upper teeth (and hard palate) rather than only the maxillary first molars, as in conventional extraoral orthodontic therapy, the effect on the jaws would be more orthopedic than orthodontic in nature. The advantages of the use of the maxillary splint in the younger patient with a severe Class II malocclusion are that it reduces the vulnerability of the maxillary incisors to accidental fracture, while concomitantly reducing the Class II dysplasia, thereby effectively shortening the later-stage multiband corrective time and procedures. Further advantages of the maxillary splint described are ease of construction and clinical application, which makes it an attractive appliance for use in dental clinics or institutions in which patient volume, infrequent visits, and ecomomic factors are major considerations. This preliminary report on the philosophy of treatment procedure and description of the appliance design is to be followed by a further cephalometric and clinical evaluation of results achieved with its use.

Cephalometry↗

Orthopedic coordination of dentofacial development in skeletal Class II malocclusion in conjunction with edgewise therapy. Part II.

This second of two articles describes the effects of mandibular growth enhancement in a comprehensive orthopedic approach to the correction of skeletal Class II malocclusion. Clinical and experimental evidence gives support to the concept, and case histories show the clinical mode of use of the appliance system. An initial 10- to 12-month orthopedic phase is followed by a second phase of similar duration in which full edgewise therapy is used to establish a gnathologically ideal occlusion. As the essential corrections are achieved in the orthopedic phase, the second phase is much reduced in complexity and is generally confined to alignment and final detailing. This combined approach to skeletal Class II treatment offers the possibility of better harmony of dental and facial features, with continued stability through the period of facial growth.

Cephalometry↗

Paget's disease of bone: orthopedic complications.

Orthopedic complications of Paget's disease are among the most common indications for treatment of Paget's disease. These complications include severe bone pain, joint pain, skeletal deformity, pathological fracture, and rarely malignant degeneration. The use of effective pharmacological modalities has transformed the treatment of Paget's disease in the past four decades. Although few patients with Paget's disease ever require surgical therapy, successful surgical management of severe orthopedic complications has improved the quality of life for many sufferers. Selected modalities with promising results include total hip replacement for intractable pagetic arthritis of the hip, proximal tibial osteotomy for painful malalignment of the knees, total knee replacement for intractable arthritis of the knee, and internal fixation for pathological fracture. Common surgical complications of joint replacement include infection, hemorrhage, heterotopic ossification, and aseptic loosening. The medical, surgical, and rehabilitation modalities available in managing primary and secondary orthopedic complications of Paget's disease provide a wide array of options that must be carefully considered in each patient.

Arthroplasty↗

Long-term urologic, orthopedic, and psychological outcome of posterior urethral rupture in children.

OBJECTIVES: To evaluate the long-term urologic, orthopedic, and psychological outcome of children after posterior urethral rupture (PUR) due to pelvic trauma. METHODS: We retrospectively reviewed the records of 49 children with PUR from 1986 to 2000. The long-term urologic results were determined by voiding function, continence, and erectile function. The orthopedic results were determined by pelvic radiography and a questionnaire. Psychiatric diagnoses were made using the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV), criteria and the Structured Clinical Interview for DSM-IV Axis I Disorders. RESULTS: The mean follow-up was 12 years (range 4 to 17). The average age was 8 years at the time of the trauma and 20 years at the last follow-up. Urethral continuity was achieved in 97.9% of the children. Of the 49 patients, 19 had at least one urologic complication, 18 had orthopedic pathologic findings, and 21 had psychiatric diagnoses. The number of urologic procedures required (more than three), presence of long-term complications, and total number of hospitalizations (more than three) secondary to the injury significantly affected the development of a psychological disorder. CONCLUSIONS: The results of our study have shown that posttraumatic PUR in children is associated with a significant rate of long-term complications. Nonoperative treatment of pediatric pelvic fractures associated with PUR has been quite successful. Repeated operations, the presence of long-term urologic complications, and frequent and long hospital stays result in serious attendant psychological problems. Therefore, careful and prolonged follow-up of posttraumatic urethral injury with a multidisciplinary approach is necessary to provide better outcomes and a better quality of physical and social life for these children.

Adolescent↗