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At least 415 records · Page 23Linked to original sources
PubMed1986

Porous hydroxyapatite as a bone-graft substitute in metaphyseal defects. A histometric study.

Porous hydroxyapatite (Interpore 500) formed by conversion of the Porites goniopora coral exoskeleton has pores averaging 600 micrometers and pore interconnections averaging 260 micrometers in diameter. In the proximal tibial metaphysis of eight dogs, a defect one cubic centimeter in size was created unilaterally and was fitted with a block of Interpore 500. Both proximal tibial metaphyses were retrieved at two, four, six, and twelve months. Stained undecalcified sections were examined by light microscopy and quantitated by histometric methods. The implant-side specimens contained compact bone along the external surface and trabecular bone interiorly. The interior of these specimens was composed of 51.9 +/- 1.3 per cent soft tissue, 13.0 +/- 1.2 per cent bone, and 35.1 +/- 1.2 per cent Interpore 500 (mean and standard error). The interior of the normal specimens was composed of 79.7 +/- 1.4 per cent soft tissue and 20.2 +/- 1.4 per cent bone. The allocation of implant pore space between bone and soft tissue was proportional to that of bone and soft tissue in the normal tibiae. The stereological distribution of regenerated bone in the porous hydroxyapatite was also the same as in the normal tibiae. The appositional process of incorporation of the implant was confirmed by the finding that 66.5 per cent of the surface of the Interpore 500 was covered with bone ingrowth at twelve months.

Animals↗
PubMed1988

The locked Grosse-Kempf intramedullary nail in the treatment of diaphyseal and metaphyseal fractures of the femur and tibia.

The Gross-Kempf locked intramedullary nail widens the indications for the traditional Küntscher nail in the treatment of diaphyseal and metaphyseal fractures of the lower limbs. The study includes 87 patients with a total of 93 closed fractures treated between 1981 and 1987. Osteosynthesis was carried out in 85 closed fractures and in 8 Grade 1 or 2 open fractures. Possible assemblies in relation to the level and type of fracture and the protocol for weightbearing are illustrated, with emphasis on the fact that dynamization of static assemblies is not always essential. The high percentage of positive results (86%) and the relatively small incidence of complications confirm the validity of this method. The only drawback is the fairly high dose of radiation absorbed by the surgeon during the operation.

Adult↗
PubMed1987

[A new form of metaphyseal chondrodysplasia].

The authors report a new form of metaphyseal chondrodysplasia revealed in a 5 1/2 year-old boy with seizures. This disorder associated coxa vara, large terminal phalanges, bilateral cataracts and severe mental deficiency. Both parents were healthy, suggesting autosomal recessive transmission. There is no associated calcium phosphate metabolism disorder. An enzymatic abnormality might be the cause of the bone, ocular and neuronal lesions.

Bone and Bones↗
PubMed1986

The metaphyseal blanch sign of slipped capital femoral epiphysis.

In the early stage of slipping of the capital femoral epiphysis, the epiphysis slips posteriorly in relation to the neck of the femur. When this occurs, the posterior portion of the femoral head is seen on the anteroposterior radiograph as a crescent-shaped area of increased density overlying the metaphysis adjacent to the epiphyseal plate. This metaphyseal blanch sign suggests that slipping of the capital femoral epiphysis has occurred and that a lateral radiograph should be made to confirm or exclude the diagnosis.

Adolescent↗
PubMed1986

[Prolonged states of virtual recovery after atypical pubertal schizophrenic episodes with over-valuation disorders of the "metaphysical intoxication" type].

Using clinical and follow-up methods of investigation the authors studied a number of patients with juvenile slowly progressive schizophrenia in whom the disease picture in youth was characterized by over-worship disturbances of the "metaphysical intoxication" type which were attended by marked social and occupational disadaptation. A group of patients (n = 25) was identified with a state of practical cure after youth. Three most characteristic patterns of personality changes in these patients were described. The dominant role in their structure was played by manifestations of delay of mental maturation and the syndrome of psychic juvenilism of a dissociated nature. A certain relationship was found between the level and nature of the patients' occupational adaptation and the type of their personality changes. The question is discussed about the determination of the disease stage in such cases. The authors consider them as recovery states with some personality changes which can be ascribed to residual schizophrenia.

Adolescent↗
PubMed1985

Cell kinetics of growth cartilage in spondylo-metaphyseal chondrodysplasia (smc) mice.

The gene for spondylo-metaphyseal chondrodysplasia (smc) in the mouse disrupts the formation of growth plate cartilage. No cartilage columns are found in the head of the tibia and secondary centres of ossification appear very late. The number of cells labelled with tritiated thymidine is sharply reduced at 16, 18 and 21 days of age but hypertrophic cell height is normal. Cells taking up label are found scattered throughout the large cartilaginous epiphyses.

Animals↗
PubMed1985

[Sex-linked inheritance in fronto-metaphyseal dysplasia].

The author reports a family study of fronto-metaphyseal dysplasia in a 2 months-old child, in his mother and maternal grand-mother. The child is the more severely affected, while the mother and the grand-mother have less severe manifestations of the syndrome. This evidence permits to confirm the X-linked recessive inheritance of the disease, with severe manifestations in males and variable expression in female carriers.

Abnormalities, Multiple↗
PubMed1979

[Metaphyseal chondrodysplasia with atypical vertebral changes in a case of anorchism (author's transl)].

A case of metaphyseal chondrodysplasia with testicular dysgenesis, hair aplasia, hormonal and somatic features partially indicative of Noonan's syndrome, followed from 6 to 14 years, is described. The associated vertebral changes can be referred to same chondrodysplasic process; persistence of intermediate cartilage and precocious discal damage contribute in vertebral morphogenesis.

Adolescent↗
PubMed1982

[A contribution to the treatment of the proximal metaphyseal tibia fracture in children (author's transl)].

The proximal metaphyseal fracture of the tibia in children must be regarded as an important injury, which will be developing into a progressive crus valgum if it stays untreated. The cause of this misgrowth is the interposition of the Pes anserinus into the crack of the fracture. Initial the x-ray will show an exactly position of the tibia, so that the treatment seems to be conservative. The misgrowth only can be prevented by an operation with releasing the Pes anserinus out of the fracture. One case of this rare injury is demonstrated.

Child↗
PubMed1978

[Acceleration of postnatal development, hypertony, enlargement of the middle phalanges and of the distal metaphyses of the femur, peculiar facies: a case of Weaver's syndrome?].

A child is described with accelerated bone maturation, large dysplastic ears, and hypertelorism. These are features of both the Marshall-Smith and Weaver's syndrome. The child was mentally retarded and had enlargement of the middle phalanges, features only seen in Marshall-Smith syndrome. However, there was also enlargement of the metaphyses, a characteristic of Weaver's syndrome. The possiblity that these syndromes may represent different manifestations of the same entity is discussed.

Bone Development↗
PubMed1984

The anatomy of metaphyseal torus fractures.

On the basis of several human and animal specimens, torus (bone-expanding) fractures appear to be a combination of plastic deformation and complete fracture of the cortex in the transition area of woven-fibered metaphyseal bone to lamellar (osteon) diaphyseal bone. The cortex in this region of susceptibility undergoes an abrupt transition from relative porosity to increased density. The changes in the biomechanic characteristics in the transition region may predispose to local failure, while micro- and macrostructure dictate that the pattern of failure will be torus deformation rather than a complete transverse fracture.

Animals↗
PubMed1983

Leg lengthening by closed metaphyseal corticotomy.

A new method of limb lengthening is presented which can be used after closure of the epiphyses. It consists of interruption of the cortex by a closed technique at the metaphyseal level through a 1 cm incision. Fixation and progressive distraction are achieved by means of a special encircling external fixation device using crossed wires under tension. The rationale and technique are described and the results are reported and illustrated. These show that the method is more reliable, quicker and has fewer complications than the standard techniques.

Adolescent↗
PubMed1983

Intracapsular metaphyseal osteoid osteoma of the femoral neck.

The authors discuss the 20 cases of intracapsular metaphyseal osteoid osteoma of the neck of the femur found among the total 186 cases of osteoid osteoma on the files of the Tumour Centre of the Rizzoli Orthopaedic Institute. They assess the diagnostic methods that can be used to determine the precise position of the "nidus" with reference to the surgical route to be used. The operation must expose the osteoid osteoma directly by opening the joint.

Adolescent↗
PubMed1984

The ultrastructure of mandibular condylar and rib cartilage from mice carrying the spondylo-metaphyseal chondrodysplasia (smc) gene.

The ultrastructural appearance of cartilage from a new mutant spondylo-metaphyseal chondrodysplasia (smc) is described. The matrix is abnormally rich in collagen fibres which often form a sheath around the chondrocytes. Collagen balls - spherical inclusions of collagen fibres - are a unique and characteristic feature of the matrix, and the chondrocytes contain large amounts of lipid.

Achondroplasia↗
PubMed1982

Metaphyseal changes in Perthes' disease: an experimental study.

Glass microspheres were introduced into the hind-limb circulation of 6 immature Gottingen mini-pigs so as to result in ischaemia of the developing proximal femur. Radiological abnormalities similar to those seen in the metaphysis in Perthes' disease were produced in 1 animal. Histological examination shows that these resulted from arrest of a portion of necrotic growth plate within the metaphysis with a corresponding defect within the growth plate. This was associated with ischaemia of the adjacent epiphysis. These changes support the suggestion that metaphyseal change in Perthes' disease are secondary to epiphyseal ischaemia. It is possible that the growth-plate defect may be the precursor of intrinsic deformity of the femoral head.

Animals↗
PubMed1980

Epiphyseal extension of metaphyseal osteosarcoma in skeletally immature individuals.

In a restrospective macroscopic and microscopic study of twenty-six macrosections of skeletally immature individuals with metaphyseal osteosarcoma, we determined the incidence, extent, and mode of tumor extension into the epiphysis. The physis appeared to have a tendency to act as a barrier to tumor spread, but did not restrain the tumor tissue in most cases. Epiphyseal extension of the tumor tissue was massive in more than half of the cases, with tumor tissue abutting against the articular cartilage, and in one instance perforating it. Some tumors had a sizable extra-osseous component that extended around the physis beneath the perichondral ring and capsular structures into the ossific nucleus. These findings have important implications when limited surgery is performed for appendicular osteosarcoma.

Adolescent↗
PubMed1982

Communicating cartilage canals of the physis of the distal part of the ulna of growing swine and their potential role in healing of metaphyseal dysplasia of osteochondrosis.

The distal parts of ulnae of 22 pigs ranging in age from 1 day to 6 months were studied histologically. Communicating cartilage canals passing from the epiphyseal vasculature through the physis and anastomosing with the metaphyseal vasculature were identified in neonatal pigs. In older pigs, the communicating cartilage canals had become smaller, as evidence by the presence of only capillaries. Eosinophilic matrical strekas and patches containing scattered elongated nuclei and centrally located accumulations of erythrocytes within the physis became more numerous in groups of old pigs. These streaks were considered to be compressed, nonpathologic extensions of the communicating physeal cartilage canals. In abnormally thick physeal cartilage of dysplastic 3-month-old-pigs, ossification was observed around hypertrophied communicating cartilage canals in the central portion of the lesion. Presumably, with reestablishment of endochondral ossification, the physis could return to its normal thickness and laminar pattern.

Animals↗