The natural history of chronic non-leukaemic myelosis.
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The paper deals with the results obtained by investigating the function of phagocytes (ingestion and bactericidity) in germs of a stem of staphylococcus aureus 209 and escherichia coli 0-III of mature neutrophilic granulocytes in 30 patients with chronic, not-lymphocytic leukaemia. The ingestion corresponded to the norm. Bactericidity towards the germs of staphylococcus aureus was statistically significant decreased, viz. it was retarded as well as diminished. In certain patients this deviation from the norm found a particularly strong expression, which became evident in clinical appearances. As it was to be expected, no interconnection could be detected between the activity of alkaline granulocytic phosphatase and the function of phagocytosis.
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A survey is given on the present state of the standard therapy of chronic myeloleucosis as well as on some newer tendencies of treatment. Since in the therapy of the chronic phase of the disease and also of the blast crisis despite application of combinations of cytostatics no decisive success is to be recorded, some newer techniques--the splenectomy as well as the various kinds of the transplantation of bone marrow (autologous, syngenic, allogenic)--and their chances for success are briefly discussed.
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