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PubMed1997

Coaggregation of Candida albicans with oral Fusobacterium species.

Nine strains of oral Fusobacterium were examined for their ability to coaggregate in vitro with four strains of the oral yeast. Candida albicans. All of the Fusobacterium nucleatum strains and Fusobacterium periodontium and Fusobacterium sulci coaggregated to various degrees with all of the Candida strains. Fusobacterium alocis, Fusobacterium mortiferum and Fusobactrium simiae strains did not coaggregate with any of the Candida strains. Exposure of the coaggregating Fusobacterium strains but not the Candida strains to heat, trypsin, and proteinase K eliminated coaggregation. Amphotericin B or trichodermin treatment of the yeast species had no effect. The reactions were inhibited by addition of 0.1 M mannose, glucosamine and alpha-methyl mannoside. All coaggregating pairs were disaggregated by the addition of sodium dodecyl sulfate, but nonionic detergents had no effect. The addition of 2.0 M urea completely reversed coaggregation. Candida strains were sensitive to periodate oxidation, whereas the Fusobacterium strains were stable to this treatment. All coaggregations occurred in the presence of saliva and appeared stronger than in buffer. These data suggest that the coaggregations involve either a protein or glycoprotein on the Fusobacterium surface, which may interact with carbohydrates or carbohydrate-containing molecules on the surface of the Candida. These observations expand the known range of intergeneric coaggregations occurring between human oral microbes and indicate that coaggregation of C. albicans and Fusobacterium species may be an important factor in oral colonization by this yeast. The authors believe this to be the first description of coaggregation concerning a carbohydrate component on the yeast cell and a protein component on the oral bacterial cell.

Bacterial Adhesion↗
PubMed2004

Cross-generational effects on gender differences in psychoactive drug abuse and dependence.

BACKGROUND: Studies of patients with cocaine and heroin use disorders have shown gender differences in prevalence, course, and outcome. These differences may be decreasing in successive generations. Less is known about gender differences in course and symptomatology for other illicit drug use disorders, especially in community samples. METHOD: Participants (1323 men and 1384 women) who were biological or step-parents of twins and born in the 1940-1960s, from the Minnesota Twin-Family Study (MTFS) were divided into two cohorts based on the median birth year. A structured interview was used to assess DSM-III-R cannabis, amphetamine, cocaine and hallucinogen use disorders. RESULTS: There was a higher prevalence of each of these drug disorders and earlier onset of cannabis and amphetamine use disorders in later-born participants. For most drug use disorder categories, men and women were similar with respect to age of onset and severity of disorder but women had a shorter course of drug use disorders. Women with amphetamine disorders were atypical with respect to having a higher frequency of use but similar number of lifetime uses compared to men, and more emotional effects of amphetamine intoxication than men. In addition, women with amphetamine disorders were more likely to have anorexia nervosa than those without amphetamine disorders. CONCLUSIONS: These results have several implications for prevention, etiology and treatment.

Adult↗
PubMed2000

The grandmother role as experienced by lesbian women.

This study explores the grandmother role as experienced by a nonrandom sample of nine lesbian women. It examines how they define the grandmother role, and the behaviors and actions through which they enact the role. During individual interviews each woman was asked to talk about what makes a woman a good grandmother, memories of her own grandmothers, and the relationship she has with one or more of her grandchildren. The effect of her sexual orientation on the relationship was not explored. These women define the grandmother role as providing emotional support to their grandchildren, providing varied experiences for their grandchildren, and providing support for the parents of their grandchildren.

Adult↗
PubMed2006

First- and third-person perceptions of images of older people in advertising: an inter-generational evaluation.

With the baby boomers increasing in age, the number of older Americans is projected to increase to 82 million by 2050, an increase of 225% from the year 2000. But despite their growing numbers, older individuals continue to face negative attitudes toward them, their way of thinking, and their abilities. These negative attitudes result from the assumption that older people have diminished physical and mental abilities, when in fact, today's older adults are more active and in better physical and mental health than those in any previous generation. This study examines the relationship between first- and third-person perceptions and positive and negative images by determining how older people and younger people perceive each other. More specifically, when older and younger individuals look at positive and negative images of older people in advertisements, what is their perception of the effects those images will have on the other generation? Our findings show that both first- and third-person effects exist and that their perceptions depend on whether the images in the advertisements are positive or negative. The results also indicate that young people rely on the stereotypes they hold of older people when making their perceptions.

Adolescent↗
PubMed1994

Psychiatric genetics: research challenges and pathways forward.

Lessons from past psychiatric genetic research, together with key issues in psychiatry requiring genetic investigation, are reviewed in order to consider the implications for the ways forward. It is argued that traditional quantitative genetics needs to use a combination of twin, adoptee, and family strategies, to examine continuities and discontinuities in psychopathology between childhood and adult life, to compare dimensions and categories, to employ adequate conceptualization and measurement of disorders, to use statistical techniques based on latent constructs, to use biological trait indicators where possible, to examine risk factors as well as diseases, to include good measures of postulated environmental risk variables, to study the interplay between genes and environment, and to study the key assumptions underlying genetic strategies. Molecular cytogenetics needs to consider both the general and specific psychopathological risks associated with chromosome abnormalities and to examine the mechanism involved, to examine the role of submicroscopic chromosomal deletions and of mitochondrial disorders, and to investigate the mechanisms involved in trinucleotide repeat amplifications that take place during intergenerational transmission. Molecular genetics needs to make greater use of smaller pedigrees in view of the concerns over phenotypic definition and genetic heterogeneity in very large extended dense pedigrees, to use sib-pair designs in view of the likelihood that most psychiatric disorder will prove to be multifactorial, to combine association strategies with linkage analyses, to pay careful attention to the definition of phenotypes in probands, to remain in close touch with other branches of biological psychiatry, and to make effective use of collaboration between centers. To date, transgenic models have had a rather limited application in psychiatry but, despite their difficulties, they are likely to provide an underpinning for gene therapy in disorders where that seems feasible.

Genetic Heterogeneity↗
PubMed2006

The Medical College of Wisconsin Senior Mentor Program: experience of a lifetime.

The Medical College of Wisconsin (MCW) Senior Mentor Program (SMP) has been offered to a small group of first and second year medical students as a course alternative to the traditional physician mentor program. The program links students with healthy older adult mentors and includes mentor/student visits, didactic sessions, written assignments, and shadowing experiences. The goals of the course are to increase positive attitudes about aging and geriatrics and to teach basic assessment and interviewing skills in geriatric content areas. A course evaluation including questionnaires, focus groups, and content analysis found that students experienced positive attitude change about geriatric patient care, increased knowledge about geriatrics, and satisfaction with the mentor/student relationship. Students have reported gains in their knowledge of geriatric and gait assessment, ADL evaluation, and mental health screening, among other issues. Further, students report being excited, more comfortable, and less fearful caring for and interacting professionally with older adults as a result of the SMP. The SMP is an effective and meaningful method of geriatric education for preclinical students. It may be an alternative at medical schools that cannot support a large-scale multi-year senior mentor program.

Adult↗
PubMed1993

Congenital diseases and abnormalities of pigs.

Several congenital developmental anomalies are not listed in this review because they have no proposed cause. It is the author's hope that this article will serve practicing veterinarians and the swine industry by being an informative guide for stimulating independent thought toward diagnosing congenital diseases. Remember that the cause may have exerted its effects weeks or months before being observed. A detailed history of the dam as well as the rest of the herd is important. If possible, a history of neighboring herds should also be examined for similar problems. Either conduct a thorough necropsy with appropriate tissues submitted for diagnostic analysis, or send representative pigs to a diagnostic center for a complete evaluation. If chromosome evaluation is desired, contact the evaluating laboratory for submission procedures. Breeding records should be evaluated for intragenerational frequencies and intergenerational patterns typical of genetic transmission. When evaluating pedigrees, the frequent occurrence of an individual is not proof of its involvement. The frequency of occurrence in the diseased population must be significantly greater than it is in a random population of pigs. Dr. H.W. Leipold, in the pathology department at the Kansas State University College of Veterinary Medicine, maintains an extensive database of congenital anomalies in domestic animals. I recommend that he be contacted in all cases of undiagnosed or unusual cases of congenital disease. He possibly can help with a definitive diagnosis and your contact will help expand this important central database of congenital diseases.

Animals↗
PubMed2005

Widowhood and depressive symptoms among older Chinese: do gender and source of support make a difference?

In this study, we examined the effects of gender and pre-bereavement social support from three different sources (spouse, adult children, and friends) on widowhood adjustment among older adults in China. Hypotheses were developed by integrating the literature in the West and the cultural context of China. Data came from a panel survey, conducted in 1991 (baseline) and 1994 (follow-up), of a probability sample of older persons in Wuhan, China. For the present analysis, only those who were married with children at baseline were selected (N = 1,263). About 10% of the sample experienced spousal death between the two measurement points. Multiple regression analyses suggest that widowhood had a negative mental health consequence for older Chinese. Social support from adult children buffered the deleterious effect of widowhood, whereas spousal support during the marriage increased one's vulnerability. Support from friends was not found to have a significant effect. Gender difference in the effect of widowhood was also not evident. In this study, we have extended bereavement and social support research to a developing nation, with some findings similar to and some different from studies in Western developed nations.

Adaptation, Psychological↗
PubMed2002

Gender and intergenerational transmission of alcohol use patterns: an analysis of adult children in Moscow.

Based on a 1996 sample of adult children and their parents in Moscow, this study investigates the degree to which alcohol use patterns are transmitted from parents to adult children and examines the roles of gender, family status, and family interaction dynamics for transmission. Findings suggest that parents' drinking and family status/interaction patterns indeed influence adult children's alcohol consumption. Frequency and volume of alcohol use is higher among children whose mothers typically drink about 3 or more drinks daily or who drink on a weekly basis. Fathers' frequency and volume of alcohol use positively influences only sons' drinking. Mothers' drinking, however, may undermine fathers' positive effect on sons. Fathers' verbal and physical abuse significantly affects daughters' consumption.

Adolescent↗
PubMed2004

Illness, injury, and disability among Shiwiar forager-horticulturalists: implications of health-risk buffering for the evolution of human life history.

Human life history is distinguished by long lifespan, delayed reproduction, intergenerational asymmetric benefit transfers from adults to juveniles and between adults, and a large brain able to engage in unprecedented levels of learning, reasoning, and insight. The evolution of these traits depends on relatively low human mortality. Understanding why humans have low mortality is therefore critical for understanding the evolution of key human traits. One explanation is that the evolution of food provisioning during periods of health crisis reduced mortality. This hypothesis turns on health risk having posed a significant adaptive problem that could be effectively buffered by healthcare provisioning. Unfortunately, the frequency, duration, and fitness effects of temporary disability are difficult to estimate based on osteological evidence alone, and systematic ethno-biological research on these issues among extant small-scale societies with little access to Western medical care is lacking. Here I present data on 678 injuries and illnesses suffered by 40 Shiwiar forager-horticulturalists, based on physical evidence and informant reports. A subsample of 17 individuals provided data on incidence and duration of disability for 215 pathological incidents. Results indicate that injury and illness occur frequently across the lifespan. Most living individuals have suffered temporarily disabling health crises likely to have been lethal without provisioning. The fitness effects of surviving these episodes are high, suggesting that the Shiwiar population structure and lifeway are dependent on infrequent extended provisioning to temporarily disabled individuals, and that provisioning of aid during healthcare crises effectively lowers mortality in this small-scale society.

Adolescent↗
PubMed2004

The role of family systems in severe and recurrent psychiatric disorders: a developmental psychopathology view.

Family systems theory has been highly influential in the study of recurrent psychiatric disorders. This review examines two interrelated domains: research on expressed emotion (EE) attitudes among relatives (criticism, hostility, or emotionally overinvolvement) and relapses of schizophrenia or bipolar disorder, and randomized trials of family intervention in these populations. The literature is discussed in terms of contemporary systems theory and concepts from developmental psychopathology research. Several conclusions are drawn: (a) levels of EE are correlated with caregivers' attributions regarding the controllability of patients' behaviors; (b) EE attitudes are associated with bidirectional, mutually influential cycles of interaction between relatives and patients; and (c) family psychoeducational therapy, when combined with pharmacotherapy, is associated with lower rates of relapse in schizophrenia and bipolar illness. Underlying disturbances in family systems may emerge in response to illness symptoms in a family member, but also have recursive effects on the developmental course of the illness once manifest. The nature and stability of these recursive effects will depend on dynamic processes in the patient, the relative, and their relationship. Future research should elucidate mediating and moderating variables in the pathways from EE to patients' outcomes, and the conditions under which family treatments bring about favorable outcomes of psychiatric disorder.

Adult↗
PubMed1999

[Clinical and molecular genetic studies of Machado-Joseph disease].

Studies on clinical and molecular genetic aspects of Machado-Joseph disease (MJD) are reviewed. MJD is now regarded as the most common autosomal dominant form of ataxia. Analyses of haplotypes and an intragenic polymorphism in the MJD1 gene, however, ruled out the possibility that founder chromosome is present among worldwide MJD patients. The expanded CAG repeats become unstable during parent-offspring transmission and the mechanism is being studied. Two factors contributing to the intergenerational instability have sofar been identified: 1) paternal transmission and 2) a intragenic polymorphism flanking the CAG repeats. Single sperm analysis of MJD patients, however, revealed paradoxical contraction of the CAG repeat size in sperm. Correlations between the size of the CAG repeats and genetic anticipation, clinical manifestation and morphologic changes are also discussed.

Founder Effect↗
PubMed1998

Intergenerational influences affecting birth outcome. I. Birthweight for gestational age in the children of the 1958 British birth cohort.

There is considerable literature on intergenerational influences on birthweight. Few studies have been able to investigate such influences on the more basic measures of birthweight for gestational age and gestational age itself. This paper considers fetal growth. The investigations are derived from the 1958 British birth cohort followed from birth to age 33 years. Included were questions on physical and social characteristics of each parent and the grandparents, and birth details of parent and first child. In the present study, fetal growth in non-preterm babies, after adjustment for the known effects of smoking and sex of the child, is explained best by factors relating to the parent's own growth, primarily in utero, but also to adulthood. There are small additional effects of education or social class but not of parent's gestational age. Only 15% of the variability in the child's fetal growth can be explained by the mother's characteristics and approximately 7% by the father's. Parent's own fetal growth accounts for nearly half of the variability if unadjusted for other factors and nearly a third after adjustment for sex of child, smoking, parental height and weight, maternal age at menarche and paternal age at first birth. Parental fetal growth makes the greatest anthropometric contribution.

Adolescent↗
PubMed2002

The effects of kin on child mortality in rural Gambia.

We analyzed data that were collected continuously between 1950 and 1974 from a rural area of the Gambia to determine the effects of kin on child mortality. Multilevel event-history models were used to demonstrate that having a living mother, maternal grandmother, or elder sisters had a significant positive effect on the survival probabilities of children, whereas having a living father, paternal grandmother, grandfather, or elder brothers had no effect. The mother's remarriage to a new husband had a detrimental effect on child survival, but there was little difference in the mortality rates of children who were born to monogamous or polygynous fathers. The implications of these results for understanding the evolution of human life-history are discussed.

Demography↗
PubMed1993

Anticipation in bipolar affective disorder.

Anticipation refers to the increase in disease severity or decrease in age at onset in succeeding generations. This phenomenon, formerly ascribed to observation biases, correlates with the expansion of trinucleotide repeat sequences (TNRs) in some disorders. If present in bipolar affective disorder (BPAD), anticipation could provide clues to its genetic etiology. We compared age at onset and disease severity between two generations of 34 unilineal families ascertained for a genetic linkage study of BPAD. Life-table analyses showed a significant decrease in survival to first mania or depression from the first to the second generation (P < .001). Intergenerational pairwise comparisons showed both a significantly earlier age at onset (P < .001) and a significantly increased disease severity (P < .001) in the second generation. This difference was significant under each of four data-sampling schemes which excluded probands in the second generation. The second generation experienced onset 8.9-13.5 years earlier and illness 1.8-3.4 times more severe than did the first generation. In additional analyses, drug abuse, deaths of affected individuals prior to interview, decreased fertility, censoring of age at onset, and the cohort effect did not affect our results. We conclude that genetic anticipation occurs in this sample of unilineal BPAD families. These findings may implicate genes with expanding TNRs in the genetic etiology of BPAD.

Adult↗
PubMed2000

The nature of support from adult sansei (third generation) children to older nisei (second generation) parents in Japanese Canadian families.

Given the growing ethnocultural diversity of Canada's aging population and the increased research focus on the role of the family in the social support of older persons, it is important to explore the ways in which adult ethnic minority children provide assistance to older parents within the context of the family. The current study contributes to research on intergenerational support systems in later life in Japanese Canadian families by examining the factors, particularly the cultural value of oya koh koh (filial obligation), affecting the nature of support from adult children to older parents. Using data gathered from interviews with 100 older nisei (second generation) parents and 100 adult sansei (third generation) children in British Columbia, the study focuses on the frequency, quality and provision of three types of support: emotional, service, and financial. Results of logistic regression analyses indicate that oya koh koh has a significant effect on children's provision of emotional support, but no effect on financial or service support. Parent's health and socioeconomic status are found to have significant effects on children's provision of financial and service support. Child's availability is also a major determinant of financial support. Further, ordinary least squares (OLS) regression analyses results suggest that oya koh koh has a significant effect on the quality of emotional support provided by children to their parents. Findings are discussed in terms of the North American Asian "ideal" family myth and directions for future research.

Journal Article↗
PubMed2002

Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.

The mechanism of expansion of the (CTG)n repeat in myotonic dystrophy (DM1) patients and the cause of its pathobiological effects are still largely unknown. Most likely, long repeats exert toxicity at the level of nuclear RNA transport or splicing. Here, we analyse cis- and trans-acting parameters that determine repeat behaviour in novel mouse models for DM1. Our mice carry 'humanized' myotonic dystrophy protein kinase (Dmpk) allele(s) with either a (CTG)84 or a (CTG)11 repeat, inserted at the correct position into the endogenous DM locus. Unlike in the human situation, the (CTG)84 repeat in the syntenic mouse environment was relatively stable during intergenerational segregation. However, somatic tissues showed substantial repeat expansions which were progressive upon aging and prominent in kidney, and in stomach and small intestine, where it was cell-type restricted. Other tissues examined showed only marginal size changes. The (CTG)11 allele was completely stable, as anticipated. Introducing the (CTG)84 allele into an Msh3-deficient background completely blocked the somatic repeat instability. In contrast, Msh6 deficiency resulted in a significant increase in the frequency of somatic expansions. Competition of Msh3 and Msh6 for binding to Msh2 in functional complexes with different DNA mismatch-recognition specificity may explain why the somatic (CTG)n expansion rate is differentially affected by ablation of Msh3 and Msh6.

Animals↗