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PubMed1981

[Insensitivity of some rats to intraperitoneal injections of collagenase and trypsin].

In the rat peritoneal injections of collagenase or trypsin give rise to severe lesions. In our experience 20% of the animals remain intact. The frequency of lesions increases with older and heavier subjects. Moreover 25% of the rats who remained free of lesions after a first injection of collagenase resist to a second one. This shows that they are strongly protected against the enzyme. The exact nature and location of this protective mechanism are not known.

Animals↗
PubMed1984

Mercury concentration in the blood and organs of normal and acatalasemic mice after intraperitoneal injection of metallic mercury (203Hg0).

The total amount of mercury exhaled from acatalasemic mice in ten minutes after injection of metallic mercury was about 1.6 times higher than that of normal mice. The level of metallic mercury in the blood of acatalasemic mice was significantly higher than that of normal mice. The levels of mercury in the brain and liver in acatalasemic mice in ten minutes after injection of metallic mercury, and the brain/blood ratio or liver/blood ratio of mercury in acatalasemic mice were significantly higher than those of normal mice. These results suggest that metallic mercury in the blood readily passes through the blood-brain or blood-liver barrier.

Acatalasia↗
PubMedDate not supplied

Effect of intraperitoneally injected lysine vasopressin on noradrenaline turnover in certain brain regions of the rat.

In the first part of the study penetration of blood-brain barrier by lysine vasopressin (LVP) was studied. After i.p. injection 125J-LVP or its large fragments appeared in the hypothalamus, hippocampus, tuberculum olfactorium and brain stem. In these structures the effect of i.p. injected LVP on noradrenaline level and turnover rate was studied. LVP produced an increase of noradrenaline level in the hypothalamus, hippocampus and tuberculum olfactorium. In the brain stem no marked changes in noradrenaline content were found. In all the examined brain structures LVP slowed down turnover rate of noradrenaline.

Animals↗
PubMed1982

Dna synthesis in the urinary-tract epithelium of the rat induced by laparotomy and by intraperitoneal injection of distilled water, physiological saline and lycopodium spores.

The tritiated thymidine labelling index (LI) of the epithelium of the ureters and urinary bladder of young male Wistar rats is substantially increased 18 h after a simple laparotomy incision. A similar highly significant increase (P less than 0.001) has been observed after a single i.p. injection of various materials, including (a) distilled water, (b) 0.5% glycogen in physiological saline, and (c) 1% suspension of lycopodium spores in physiological saline. In each instance an aseptic inflammatory response develops in the peritoneal cavity. Reasons are given supporting the concept that a mitogen is produced from a constituent of the inflammatory exudate in the peritoneal cavity and that the factor reaches the affected epithelium by direct diffusion.

Animals↗
PubMed1980

Localization and quantitation of lithium in rat tissue following intraperitoneal injections of lithium chloride. II. Brain.

The distribution of lithium in the rat brain following chronic i.p. injections of lithium chloride has been determined by a radiographic dielectric track registration technique. The study indicated significant differences in lithium distribution in various areas of the brain. Consistently high levels were observed in the neocortex and putamen, and low concentrations in the cerebellum and white matter structures such as the corpus callosum and basis pedunculi. Intermediate levels were found in the thalamus, hypothalamus, septal nuclei, dentate gyrus, hippocampus and substantia grisea centralis.

Animals↗