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PubMed1989

[Sonographic structure of the intestinal wall--significance for the diagnosis of inflammatory intestinal diseases].

Sonography can depict the transformation of the intestinal wall in Crohn's disease, esp. its layers. Besides demonstrating the transmural aspect of inflammation it also shows typical mesenteritis and complications such as fistula, abscess, inflammatory tumour, stenosis and ileus. Sonography proves invaluable in following up Crohn's disease. Differential diagnosis against other diseases of the bowel wall (ulcerous colitis, radiogenic, ischaemic, infectious and pseudomembranous colitis, as well as some types of lymphoma and carcinoma of the intestine) on a purely morphological basis is difficult, but nevertheless possible.

Colitis, Ulcerative↗
PubMed1992

Role of reactive oxygen species in intestinal diseases.

It is well known that reactive oxygen metabolites are generated during several pathologies, and that they are able to disturb many cellular processes and eventually lead to cellular injury. After intestinal ischemia, reactive oxygen species are produced when the ischemic tissue is reperfused. The enzyme xanthine oxidase is thought to play a key role in this process. As a result of this oxygen radical production, the permeability of the endothelium and the mucosa increases, allowing infiltration of inflammatory leukocytes into the ischemic area. Moreover, reactive oxygen species are also indirectly involved in leukocyte activation. In turn, these inflammatory cells respond with the production of oxygen radicals, which play an important role in the development of tissue injury. Thus, intestinal ischemia and reperfusion evokes an inflammatory response. Also during chronic intestinal inflammatory diseases, reactive oxygen metabolites are proposed to play an important role in the pathology. Scavenging of reactive oxygen species will thus be beneficial in these disorders.

Animals↗