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At least 415 records · Page 23Linked to original sources
PubMed1999

Evaluation of antigen detection and antibody detection tests for Trypanosoma evansi infections of buffaloes in Indonesia.

Two Ag-ELISAs, an IgG-specific antibody detection ELISA (IgG ELISA) and a card agglutination test (CATT) for the detection of Trypanasoma evansi infections in buffaloes in Indonesia, were compared. Diagnostic sensitivity estimates were obtained by testing sera from 139 Indonesian buffaloes which had been found to be infected by parasitological tests. Diagnostic specificity was estimated by testing sera from 263 buffaloes living in Australia. Response-operating characteristic curves were constructed, and optimal ELISA cut-off values, which minimized the number of false-negative and false-positive results, were chosen. The IgG ELISA had the highest sensitivity (89%) and the CATT had the highest specificity (100%). There was a significant difference between the sensitivities (71 and 81%), but not between the specificities (75 and 78%), of the two Ag-ELISAs. The four tests were further compared by calculation of post-test probabilities of infection for positive and negative test results using a range of prevalence values, and likelihood ratios. The results suggested that the CATT was the best test to 'rule-in' infection (i.e. the highest probability of infection in test-positive animals) and the IgG ELISA was the best test to 'rule-out' infection (i.e. the lowest probability of infection in test-negative animals).

Agglutination Tests↗
PubMed2004

Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Bioactivity-directed fractionation of extracts of two Diospyros maritima bark samples from Indonesia,one collected at sea level in a beach forest in Java and the other collected at a slight elevation away from the sea shore on the island of Lombok, yielded a diverse set of secondary metabolites. The naphthoquinone plumbagin (1), although found in extracts of both specimens, constituted a much larger percentage of the former sample, which also yielded a series of plumbagin dimers, maritinone (2), chitranone (3), and zeylanone (4). The latter sample yielded a new naphthoquinone derivative, (4S)-shinanolone (5), and a new natural product coumarin, 7,8-dimethoxy-6-hydroxycoumarin (6), along with three other analogues of plumbagin, 2-methoxy-7-methyljuglone (7), 3-methoxy-7-methyljuglone (8), and 7-methyljuglone (9). The structures of compounds 5 and 6 were elaborated by physical, spectral, and chemical methods. All of the isolates were evaluated in both cytotoxicity and antimicrobial assays, and structure-activity relationships of these naphthoquinones are proposed. Plumbagin (1) and maritinone (2) were evaluated also for in vivo antitumor activity in the hollow fiber assay, but both were found to be inactive.

Aspergillus niger↗
PubMed1999

Srivastavanema cynocephali n. sp. (Nematoda, Trichostrongylina, Heligmosomoidea), a parasite of a dermopteran from Indonesia.

Srivastavanema cynocephali n. sp., a parasite of Cynocephalus variegatus (Dermoptera) from Indonesia, is described. This species is closely related to S. yapi Durette-Desset & Lim Boo Liat, 1975, in the characters of the synlophe at the mid-body and in the shape of the caudal bursa, but it is distinguished by the pattern of the synlophe in the posterior part of the body, very long, thin rays 2 and 3, a less developed genital cone, the absence of a membrane between left and right rays 6, and longer spicules. Its morphology is slightly less specialised than the four previously known species of the genus, which are all parasites of petauristines. The genus Srivastavanema (Singh, 1962) has a systematic position between the Heligmonellinae and the Brevistriatinae. Therefore, it may be a parasite of the Dermoptera which could have secondarily evolved within the Petauristinae. The Dermoptera may have played an important role in the evolution of the Heligmonellinae.

Animals↗
PubMed2002

Vitamin A intake is low among pregnant women in central Java, Indonesia.

From 1996-1998, a longitudinal study on nutritional status during pregnancy was carried out in Purworejo District, Central Java, Indonesia. Dietary intake was assessed in each trimester using six 24-hour recalls, and analyzed cross-sectionally among 493 women. The proportion of women below the Indonesian RDI for vitamin A (700 RE) ranged from 83% in the first trimester to 76% in the third. Regardless of total vitamin A intake, plant sources contributed 64-79% in all three trimesters. The contribution from animal and fortified sources was generally lower throughout pregnancy for those with low education compared to those with high education. Significant risk factors for having a low vitamin A intake (< FAO/WHO basal RDI, 370 RE) in the second and third trimesters were fewer than six years of education, low socio-economic status, a low energy intake, and a low vitamin A intake in the previous trimester. Home gardening and chicken-raising were not positively associated with vitamin A intakes. Given the large percentage of women with inadequate vitamin A intakes, further strategies are needed to increase the vitamin A intake of all pregnant women in this area.

Adult↗
PubMed2004

Archaeology and age of a new hominin from Flores in eastern Indonesia.

Excavations at Liang Bua, a large limestone cave on the island of Flores in eastern Indonesia, have yielded evidence for a population of tiny hominins, sufficiently distinct anatomically to be assigned to a new species, Homo floresiensis. The finds comprise the cranial and some post-cranial remains of one individual, as well as a premolar from another individual in older deposits. Here we describe their context, implications and the remaining archaeological uncertainties. Dating by radiocarbon (14C), luminescence, uranium-series and electron spin resonance (ESR) methods indicates that H. floresiensis existed from before 38,000 years ago (kyr) until at least 18 kyr. Associated deposits contain stone artefacts and animal remains, including Komodo dragon and an endemic, dwarfed species of Stegodon. H. floresiensis originated from an early dispersal of Homo erectus (including specimens referred to as Homo ergaster and Homo georgicus) that reached Flores, and then survived on this island refuge until relatively recently. It overlapped significantly in time with Homo sapiens in the region, but we do not know if or how the two species interacted.

Animals↗
PubMed2004

A new small-bodied hominin from the Late Pleistocene of Flores, Indonesia.

Currently, it is widely accepted that only one hominin genus, Homo, was present in Pleistocene Asia, represented by two species, Homo erectus and Homo sapiens. Both species are characterized by greater brain size, increased body height and smaller teeth relative to Pliocene Australopithecus in Africa. Here we report the discovery, from the Late Pleistocene of Flores, Indonesia, of an adult hominin with stature and endocranial volume approximating 1 m and 380 cm3, respectively--equal to the smallest-known australopithecines. The combination of primitive and derived features assigns this hominin to a new species, Homo floresiensis. The most likely explanation for its existence on Flores is long-term isolation, with subsequent endemic dwarfing, of an ancestral H. erectus population. Importantly, H. floresiensis shows that the genus Homo is morphologically more varied and flexible in its adaptive responses than previously thought.

Adult↗
PubMed2005

Further evidence for small-bodied hominins from the Late Pleistocene of Flores, Indonesia.

Homo floresiensis was recovered from Late Pleistocene deposits on the island of Flores in eastern Indonesia, but has the stature, limb proportions and endocranial volume of African Pliocene Australopithecus. The holotype of the species (LB1), excavated in 2003 from Liang Bua, consisted of a partial skeleton minus the arms. Here we describe additional H. floresiensis remains excavated from the cave in 2004. These include arm bones belonging to the holotype skeleton, a second adult mandible, and postcranial material from other individuals. We can now reconstruct the body proportions of H. floresiensis with some certainty. The finds further demonstrate that LB1 is not just an aberrant or pathological individual, but is representative of a long-term population that was present during the interval 95-74 to 12 thousand years ago. The excavation also yielded more evidence for the depositional history of the cave and for the behavioural capabilities of H. floresiensis, including the butchery of Stegodon and use of fire.

Aging↗
PubMed1999

Who has a high vitamin A intake from plant foods, but a low serum retinol concentration? Data from women in Indonesia.

OBJECTIVE: To examine whether the relationship between vitamin A intake, from plant and animal foods, and vitamin A status is the same throughout a population. DESIGN: Analysis of cross-sectional data on vitamin A intake, vitamin A status, physiological condition and socio-economic status. SETTING: Central Java, Indonesia. SUBJECTS: Women with a child < or =24 months old (n = 600). RESULTS: Mean serum retinol concentration of women with animal vitamin A intake below or above the median (50 RE/d) was 1.28 and 1.38 micromol/L, respectively (P<0.05). For those with intake above the median the distribution curve for serum retinol concentration was shifted towards the right, to higher concentrations. Serum retinol concentration of women with plant vitamin A intake below or above the median (279 RE/d) was 1.30 and 1.36 micromol/L, respectively (P<0.05). Again, the distribution curve for serum retinol was shifted towards higher concentrations for women with an intake above the median, except for the subgroup of 25% with the lowest serum retinol concentration (<1.10 micromol/L). These women did not seem to benefit from their relatively high vegetable intake. They also had the lowest socio-economic status. CONCLUSIONS: The subgroup that was most in need of vitamin A could not obtain it from plant foods. It may well be that, because of their lower socio-economic status, their hygiene conditions were worse and therefore host-related factors that affect carotene bioavailability, such as parasitic infestation, were less favourable in this group. They depended on supplements and, if affordable, on animal foods, fruits and/or fortified products.

Adult↗
PubMed2000

A developmental view of the undernourished child: background and purpose of the study in Pangalengan, Indonesia.

OBJECTIVES: This is the first of a series of reports published in this supplement of an experimental study to test the validity of a conceptual model about the intellectual delay of undernourished children. This paper describes the model and outlines its empirical and theoretical basis. The model provides a conceptual framework for the multiple relationships among growth and developmental domains presumably affected by malnutrition. It allows for a statistical statement regarding the goodness of fit between data and theory. The model also identifies particular hypotheses regarding multiple distinct pathways of human development. The following questions were addressed: (1) what are the effects of early supplementary feeding on the physical growth, motor development and activity, mental development and behavior of infants and toddlers who are nutritionally at risk? (2) What are the effects of a micronutrient supplement in the presence and absence of a high-energy supplement? (3) What are the moderating effects of developmental level and timing of the intervention. DESIGN: The study was a randomized clinical trial involving two cohorts (12 and 18 months old) of nutritionally-at-risk children living in Pangalengan, West Java, Indonesia and three types of supplements: condensed milk + micronutrients; skimmed milk + micronutrients; and skimmed milk. The children were tested every 2 months for a period of 12 months.

Child Development↗
PubMed2000

Effects of an energy and micronutrient supplement on motor development and motor activity in undernourished children in Indonesia.

OBJECTIVES: This paper reports the effects of an energy and micronutrient supplement on the motor development, motor milestones and motor activity of nutritionally at risk infants and toddlers in Pangalengan, Indonesia. DESIGN: Two cohorts of children were randomly assigned to three treatments E = 1171 kJ + 12 mg iron; M = 209 kJ + 12 mg iron; S = 104 kJ. Supplementation was given for 12 months. SETTING: The sites were six tea plantations in Pangalengan, West Java. SUBJECTS: A 12-month-old (n = 53) and an 18-month-old (n = 83) cohort were recruited from day-care-centers. Twenty children that received S belonged to the 12- and 18-month-old cohorts. Inclusion criteria were: no chronic disease; length-for-age < or = -1 standard deviation (s.d.) and weight-for-length between -1 and -2 s.d. of the median of the reference of the World Health Organization. METHODS: Evaluations of intake were made at baseline and every 2 months thereafter. Motor development was assessed with the Bayley Scale and with a custom-made scale to assess gross motor development leading to bipedal locomotion. Motor activity was assessed through 4 h continuous observations of the child's interaction with the social and physical environment. RESULTS: In the 12-month-old cohort, as compared to the M and S groups the children that received the E supplement walked at an earlier age, had higher scores in the Bayley Scale and were motorically more active. Similar intergroup differences were observed in the 18-month-old cohort in the total motor activity score.

Age Factors↗
PubMed2000

Effects of an energy and micronutrient supplement on skeletal maturation in undernourished children in Indonesia.

OBJECTIVES: This paper reports the effects of an energy and micronutrient supplement on skeletal maturation of nutritionally at risk infants and toddlers in Pangalengan, Indonesia. DESIGN: Two cohorts of children were randomly assigned to three treatments: E = 1171 kJoule + 12 mg iron; M = 12 mg iron + 209 kJ; S = 104 kJ. Supplementation was given for 12 months. SETTING: The sites were six tea plantations in Pangalengan, West Java. SUBJECTS: A 12-month-old (n = 53) and an 18-month-old (n = 83) cohort were recruited from day-care-centers. Twenty children that received S belonged to the 12- and 18-month-old cohorts. Inclusion criteria were: no chronic disease; length-for-age < or = -1 standard deviation (s.d.) and weight-for-length between -1 and -2 s.d. of the median of the reference of the World Health Organization. METHODS: Skeletal maturation was measured by X-ray of the left hand and wrist. The number of ossified centers and two different measures of skeletal age (Skel-1 and Skel-2) were the outcome variables measured. RESULTS: In the 12-month-old cohort, there were intergroup differences 6 and 12 months after baseline. First, the children in the E group were about 2 months more advanced in ossified centers than the children in the S group (P < 0.10). At 12 months, the children in the E group were about 3 months more advanced in skeletal age than the children in the M group. M group children were about 2.5 months behind the children in the S group.

Age Determination by Skeleton↗
PubMed2000

Effects of an energy and micronutrient supplement on mental development and behavior under natural conditions in undernourished children in Indonesia.

OBJECTIVES: This paper reports the effects of an energy and micronutrient supplement on mental development and on the social cognitive and emotionally regulatory behaviors of nutritionally at risk infants and toddlers in Pangalengan, Indonesia. DESIGN: Two cohorts of children were randomly assigned to three treatments: E = 1171 kJ + 12 mg iron; M = 12 mg iron + 209 kJ; S = 104 kJoule. Supplementation was given for 12 months. SETTING: The sites were six tea plantations in Pangalengan, West Java. SUBJECTS: A 12-month-old (N = 53) and an 18-month-old (N = 83) cohort were recruited from day-care-centers. Twenty children who received S belonged to the 12- and 18-month-old cohort. Inclusion criteria were: no chronic disease; length-for-age < or = -1 standard deviation (s.d.) and weight-for-length between -1 and -2 s.d. of the median of the reference of the World Health Organization. METHODS: Evaluations of intake were made at baseline and every 2 months thereafter. Motor development was assessed with the Bayley Scale and with a custom-made scale to assess gross motor development leading to bipedal locomotion. Four hours of continuous observations were made of the child's interaction with the social and physical environment. RESULTS: In the 12-month-old cohort, as compared with the M and S groups, the children who received the E supplement walked at an earlier age, had higher scores in the Bayley Scale and showed more mature social-cognitive and emotional regulatory behaviors. Similar intergroup differences were observed in the 18-month-old cohort in social cognition and regulation of emotions.

Anemia, Iron-Deficiency↗
PubMed2000

A developmental view of the effects of an energy and micronutrient supplement in undernourished children in Indonesia.

OBJECTIVES: This paper presents the results of a structural equation model testing whether the longitudinal data of the Pangalengan subjects fit the theoretical model regarding the intellectual delay of undernourished children. DESIGN: Two cohorts of children were randomly assigned to three treatments: E = 1171 kJ + 12 mg iron; M = 12 mg iron + 209 kJ; S = 104 kJ. Supplementation was given for 6 months. SETTING: The sites were six tea plantations in Indonesia. SUBJECTS: A 12-month-old (n = 53) and an 18-month-old (n = 83) cohort were recruited from day-care-centers. Inclusion criteria were: no chronic disease; length-for-age = < 1 standard deviation (s.d.) and weight-for-length between -1 and -2 s.d. of the median of the reference of the World Health Organization. METHODS: Twenty-four-hour dietary intakes were assessed using the weighted individual inventory technique. Body weight and length were obtained using standard procedures; motor development was assessed with the Bayley Scale and with a custom made scale for motor development leading to bipedal locomotion. Four-hour observations were made of the child's interactions with the environment. Carrying a child in the arms and exploratory behavior were used as indicators of caregiving and exploration. All measurements were obtained every 2 months. RESULTS: The original model did not fit the data. The model was then modified with the inclusion of two new pathways: from activity and from motor development to mental development. Following these adjustments the model fit the data for each cohort and for both cohorts combined.

Anthropometry↗
PubMed1997

Appropriateness of self-medication: method development and testing in urban Indonesia.

BACKGROUND: Most illness episodes are treated by self-medication, however, little is known about the appropriateness of this self-medication. Moreover, tools to evaluate the appropriateness of self-medication still need to be developed. In order to monitor the use of drugs by the general public, we developed methodology (for evaluation of the appropriateness of self-medication) that would be reproducible and would therefore allow comparison over time and between regions. METHOD: For each complaint, criteria for appropriate treatment were set, based on evaluation of both the efficacy and the risks of the medications used. To keep cost at a minimum and to ensure reproducibility, no use was made of expert panels. Instead, only internationally recognized printed sources were used. RESULTS: This study used data on self-medication collected in urban Indonesia in 1993. After excluding illness episodes first treated only with traditional drugs, non-drug treatments or treated by a health worker, we found that self-medication used as a first action was appropriate in 16% of the cases. Fifty-six per cent combined appropriate and unnecessary components and 8% included unnecessary components only. Sixteen per cent of treatments were considered potentially harmful. Only 4.5% of the illness episodes were not treated. Analysis of these potentially harmful treatments showed that over use of antihistamine in children under 5 years of age, use of prescription drugs and multiple intake of paracetamol or antihistamines in different medicines were the main problems. The results of this analysis enabled us to set priorities and formulate recommendations to rationalize the use of drugs in self-medication. CONCLUSION: The proposed methodology should allow international comparisons and the evaluation of the impact of future interventions.

Child, Preschool↗
PubMed2003

New species of the fleas Farhangia and Nestivalius, from endemic rodents in Sulawesi, Indonesia.

The fleas (Siphonaptera: Pygiopsyllidae) Farhangia quattuordecimdentata sp. n. and Farhangia sedecimdentata sp. n. are described from pygmy squirrels (Prosciurillus spp.), and Nestivalius sulawesiensis sp. n. from murine rodents, all from Sulawesi, Indonesia. Both new species of Farhangia were collected in Central Sulawesi (Sulawesi Tengah); F. quattuordecimdentata sp. n. was recovered mainly from P. murinus, whereas F. sedecimdentata sp. n. was recovered mainly from P. leucomus. These new species are compared with the two previously described species of Farhangia: F. celebensis (Ewing) from P. murinus in North Sulawesi (Sulawesi Utara) and F. sciuri (Ewing) from the tree squirrel Callosciurus prevosti in Sabah (Borneo). Nestivalius sulawesiensis sp. n. was collected from six species of endemic murine rodents in both North and Central Sulawesi. It is compared to the morphologically similar N. pomerantzi (Traub) from Mindanao, which parasitizes murine hosts that are endemic to the Philippines.

Animals↗
PubMed1997

Typhoid fever in Ujung Pandang, Indonesia--high-risk groups and high-risk behaviours.

We performed a hospital-based case-control study to identify high risk groups and routes of transmission of typhoid fever in the city of Ujung Pandang on the island of Sulawesi, Indonesia. The annual incidence of this disease in southern Sulawesi is estimated at 3.1/1000 and the case fatality at 5.1% Cases were 50 patients over 13 years of age admitted to Stella Maris Hospital with a diagnosis of typhoid fever between June and September 1991. Diagnosis was made on clinical grounds and in 90% of cases confirmed by a Widal test. Controls were 42 patients admitted for non-infectious disorders during the same period and individually matched by age and sex. Controls did not have a history of typhoid fever. Interviews took place in hospital. Analysis was by unconditional logistic regression. High-risk groups consisted of those who were single, unemployed and those who had a university education. Median age of cases was 22 years. Consumption of food from warungs (food stalls in the street) was strongly associated with risk (OR = 45). Both cases and controls washed hands after use of the toilet and before meals, but cases used soap significantly less often (OR = 30). The results of this study can be used to take preventive measures against this severe disease of educated and single young adults by targetting them for IEC-activities emphasizing the importance of thorough hand-washing and the need to take care in the selection of street-foods.

Adolescent↗
PubMed1999

Use of hospital data for Safe Motherhood programmes in south Kalimantan, Indonesia.

The evaluation of Safe Motherhood programmes has been hampered by difficulties in measuring the preferred outcomes of maternal mortality and morbidity. The need for adequate indicators has led researchers and programme managers alike to resort to indicators of utilization and quality of health services. In this study we assess the magnitude of four indicators of use of essential obstetric care (EOC) and one indicator of quality of care in health facilities in three districts in South Kalimantan, Indonesia. The general picture which emerges for South Kalimantan is that the use of obstetric services is low. Even in the more urban district of Banjar where facility-based coverage is highest, fewer than 14% of all deliveries take place in an EOC facility, 2% of expected births are admitted to such a facility with a major obstetric intervention (MOI), and 1% of expected births have an MOI for an absolute maternal indication. The use of facility-based EOC is consistently lower in Barito Kuala compared to the other districts, and the differences persist regardless of the indicators used. In this setting with low utilization rates, general rates of utilization of EOC facilities seem to be as satisfactory an indicator of relative access to EOC as more elaborate indicators specifying the reasons for admission. The inequalities in access to care revealed by the various indicators of use of EOC services may prove to be a more powerful stimulus for change than the widely reported and highly inaccurate accounts of the high levels of maternal mortality.

Delivery, Obstetric↗
PubMed1999

Outcome in three groups of patients with typhoid fever in Indonesia between 1948 and 1990.

The outcome in three groups of patients with bacteriologically confirmed typhoid fever caused by Salmonella typhi, treated during three episodes between 1948 and 1990 in Java, Indonesia, was compared by retrospective analysis of hospital records. The study population consisted of three groups of patients. Group I (n = 50) was treated in Batavia (the present Jakarta) from 1948 to 1950, Group II (n = 61) in Yogyakarta from 1952 to 1956, Group III (n = 105) in Semarang from 1989 to 1990. Main outcome measures were days until defervescence, early relapses during hospitalization, duration of hospital stay, complications and mortality. Group I received supportive treatment only, Group II low doses of chloramphenicol (total 12.5 g) and Group III full doses of chloramphenicol (total 27 g); occasionally other antibiotics were used. In Group I, II and III the mean number of days until defervescence was 16, 8 and 6 and the mean number of days in hospital 43, 47 and 15, respectively. Mortality was 26%, 10% and 5% and complications occurred in 38%, 18% and 13%, respectively. Between Group I and Group II the differences in mortality and complications were statistically significant (P < 0.05). Compared to Group I the proportion of early relapses was higher in Group II, but was zero in Group III. There were significantly fewer gastrointestinal complications in Group II than in Group I (P < 0.01) and even fewer in Group III. When no antibiotic against S. typhi was available, typhoid fever had a protracted course, and only 74% of patients survived. Even with low dosages of chloramphenicol, defervescence was earlier and mortality and complications decreased dramatically, but early relapses were frequent. Full doses of chloramphenicol for a sufficient period of time only slightly reduced mortality and complications further, but eliminated early relapses completely.

Adolescent↗