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At least 415 records · Page 23Linked to original sources
PubMed1988

Synthesis of a biological active tumor growth factor from the predicted DNA sequence of Shope fibroma virus.

A 55-residue peptide comprising the carboxyl portion (residues 26-80) of the Shope fibroma virus growth factor (SFGF), a predicted 80-residue DNA virus gene product that encoded a homologous sequence with the epidermal growth factor transforming growth factor alpha family, was synthesized by a stepwise solid-phase method. The synthetic SFGF (26-80) purified to homogeneity by reverse-phase HPLC was characterized by fission ionization mass spectrometry and amino acid analysis. The disulfide pairings were established by enzymatic digestion and mass spectrometry and were found to be similar to those of EGF and TGF alpha. Synthetic SFGF (26-80) was found to share about 10% of the activities as EGF in the radioreceptor binding to A431 cells, stimulation of [3H]thymidine uptake in NRK cells, and induction of colony formation in soft-agar assay. Our results therefore confirmed that SFGF contained the putative biological activities of the EGF-TGF alpha family and that production of SFGF by Shope fibroma virus infected cells may account for the proliferative diseases associated with this particular virus.

Amino Acid Sequence↗
PubMed2000

Juvenile ossifying fibroma. An analysis of eight cases and a comparison with other fibro-osseous lesions.

Juvenile ossifying fibroma (JOF) is a well-defined clinical and histological entity that has recently been separated from other fibro-osseous lesions, including cemento-ossifying fibromas. Its biological behaviour is well defined, but unexplained. Its behaviour, clinical and histological appearance, however, bears resemblance to osteofibrous dysplasia of long bones, a lesion that in some cases has been reported to be part of a spectrum of diseases associated with adamantinoma, thus accounting for its variable biological behaviour. Eight cases of JOF were examined for islands of epithelium or single epithelial cells using immunocytochemistry. While these cases of JOF could clearly be separated from other fibro-osseous lesions, and were histologically similar to osteofibrous dysplasia, the absence of cytokeratin-positive cells in all cases suggests that another reason for its biological behaviour has still to be found.

Adolescent↗
PubMed1997

Cemento-ossifying fibroma of the mandible.

Cemento-ossifying fibromas are normally slow-growing, benign lesions. A cemento-ossifying fibroma occurring in a 25 year old female is presented with clinical features of a rapidly enlarging tumour within a period of less than three years. Radiolucent areas with a short history of rapid enlargement should be subjected to pathological investigation prior to definitive surgery so that the appropriate treatment may be undertaken.

Adult↗
PubMed1997

An ossifying fibroma presenting as Stafne's idiopathic bone cavity.

The purpose of this paper is to present a case of a fibro-osseous lesion which was diagnosed as an ossifying fibroma rather than a cemento-ossifying fibroma because of its location away from the tooth bearing parts of the jaw and the absence of cemental tissue in the excised specimen. Its location and features on a panoramic radiographic made Stafne's idiopathic bone cavity a possible diagnosis.

Biopsy↗
PubMed1997

Sclerotic lipoma: lipomas simulating sclerotic fibroma.

AIMS: We report a series of five unusual subcutaneous lipomas characterized by prominent stromal sclerosis in a storiform arrangement. METHODS AND RESULTS: All lesions occurred in young male adults (23.0 +/- 9.5 years), three lesions were on the scalp and two on the hands. Clinically, lipoma, chondroma or some form of cyst were suspected. In contrast to sclerotic fibroma ('circumscribed storiform collagenoma') a variable number of adipocytes were interspersed within the fibrosclerotic background. These cells also showed immunoreactivity for S100 protein as well as intracytoplasmic lipid deposits ultrastructurally. None of the lesions recurred within a follow-up period of between 0.5 and 9 years. CONCLUSIONS: Our series suggests that sclerotic lipomas should be classified with fibro- and myxolipomas, angiolipomas, spindle cell and pleomorphic lipomas, as an additional characteristic subtype of lipoma. Sclerotic lipomas are often misdiagnosed as a sclerotic fibroma, but are essentially fatty tumours and are, at least in our small series, not associated with Cowden's disease.

Adolescent↗
PubMed1999

Desmoplastic fibroma of the mandible: report of a case.

This paper describes a case of desmoplastic fibroma in a 4-year-old patient with a history of a small slowly growing swelling at the right angle of the mandible over a 3-month period. Desmoplastic fibroma was diagnosed on histological and immunohistochemical bases. The lesion responded well to thorough curettage and has not shown signs of recurrence 3 years after the surgical intervention. The clinical picture, the pathology and the management of the case are described, and the differential diagnosis and treatment are discussed.

Child, Preschool↗
PubMed2001

Fibroma of the left ventricle in a patient with Sotos syndrome.

Primary tumors of the heart are rare, with an incidence between 0.001% and 0.33% in autopsy findings, and with fibromas representing about 4% of benign cardiac tumors. We report the case of a cardiac fibroma in a 5-year-old child affected by Sotos syndrome. The mean sign was a ventricular tachycardia.

Anti-Arrhythmia Agents↗
PubMed2003

Juvenile ossifying fibroma of the mandible.

Juvenile ossifying fibroma is a benign, but potentially aggressive, fibro-osseous tumor of the craniofacial bones. The authors describe a case of a mandibular juvenile ossifying fibroma presenting in a 14-year-old boy in conjunction with congenitally missing teeth and review the histology, clinical behavior, and management of these uncommon but disfiguring lesions.

Adolescent↗
PubMed1976

[Intrapulmonary fibromas (author's transl)].

Based on 5 individual cases over a period of 8 years (1 fibroma, 1 angiofibroma, 2 adenofibromas, 1 xanthous neurofibroma) the characteristics of the rare intrapulmonary fibroma and the therapeutic consequences are discussed. Any suspicious tumor demands a thoracotomy with careful preoperative treatment and the subsegment or segment resection depending on the histological diagnosis reported during the procedure.

Adenofibroma↗
PubMed1977

[The differential diagnosis of aneurysmal bones cysts and non-ossifying fibromas (author's transl)].

With the help of intraosseous angiography, and bearing in mind the plain films and histopathological basis of the lesions, it is now possible to differentiate with certainty between a non-ossifying fibroma and an aneurysmal bone cyst. Since 20% of aneurysmal bone cysts recur after curretage or excision and most non-ossifying fibromas disappear spontaneously, intraosseous angiography has a valuable place in diagnosis.

Adolescent↗
PubMed1993

[The psammo-osteoid fibroma of the maxilla].

A case of a rare subtype of midfacial ossifying fibroma in a 5-year old child is presented. Fibro-osseous lesions represent a variety of bone proliferations each characterised by different morphological patterns of osteoid production. Psammomatoid ossifying fibroma is characterised histologically by numerous small round ossicles resembling psammoma bodies and is a locally invasive lesion of facial and cranial bones. The histopathology is described. The surgical treatment includes complete resection of the tumour as well as involved bones by means of midfacial degloving. Two years after surgical treatment the child is free from symptoms and tumour recurrence.

Child, Preschool↗
PubMed1984

[Ossifying fibroma of the bone].

In the spectrum of the fibroosseous bone tumours the ossifying fibroma of the bone (OF) is situated as a not yet clearly defined entity with many names. The present paper deals with the question wether a term innovation brings elucidation to clinical management. Therefore 811 previously published and 16 additional cases have been analysed with respect to their clinical and radiological behavior. In addition a simplificated histological reclassification was performed on 284 well documented literature cases. It was found that there are no great differences between these tumours according to their localisation, their clinical behavior, and their prognosis. All tumours of this group are suitable to different categories of histological maturation of the same tumour best called "ossifying fibroma".

Adolescent↗
PubMed1997

Infantile digital fibroma--report on eleven cases.

Infantile digital fibroma is a benign lesion, but it is sometimes a locally aggressive proliferative lesion. After having examined the literature, we analysed 11 cases of infantile digital fibroma among children between 1 to 16 years, with a long-term follow-up (14 years). We had 4 recurrences. Treatment was surgical. The histological diagnosis has required special stains to put in evidence the typical cytoplasmic eosinophil elements. Surgery usually involved excision and grafting. We also discuss therapeutic measures.

Adolescent↗
PubMed1989

Trichoblastic fibroma. A clinicopathologic study of three cases.

Three cases of trichoblastic fibroma, a rare benign skin tumor of hair follicle origin, are reported. On clinical examination, solitary, mobile, subcutaneous nodules with normal overlying skin were found on the vulva (one case) and scalp (two cases) in women aged 57, 46, and 19 years, respectively. On microscopic examination, the tumors were composed of complex nests and strands of basaloid, focally keratinized epithelium arranged in a moderately cellular fibroblastic stroma. No connection with the overlying epithelium or adjacent adnexal structures was observed. Immunohistochemical staining supported a trichogenic origin for these tumors. Trichoblastic fibromas are histologically distinctive lesions that should be distinguished from other tumors of follicular origin and from keratotic basal cell carcinoma.

Adult↗
PubMed1996

Trichoblastic fibroma. A case report and an immunohistochemical study of cytokeratin expression.

A 47-year-old woman noticed a nodule on her right shoulder that had been gradually increasing in size without symptoms. Histologic features of the biopsied nodule included round to irregularly shaped epithelial lobules demarcated by abundant sclerotic stroma located within the lower dermis and extending to the subcutis. The epithelial lobules consisted of cuboidal to columnar basaloid cells and were frequently arranged in narrow strands with many bifurcations and branching. Cystic structures containing lamellar keratinous material were occasionally found in connection with the lobules. The histologic findings were interpreted as trichoblastic fibroma. Immunohistochemical studies with antibodies directed against cytokeratins (CK) and involucrin revealed positive staining in most of the tumor cells with RCK102 and 34 beta E12 antikeratin antibodies, whereas the epithelial cords and the peripheral cells of the cystic structures stained with 170.2.14, 4.1.18, and CAM 5.2 antikeratin antibodies. However, CK1 or simple epithelial cytokeratins were not detected in any neoplastic elements. Based on comparative immunohistochemical findings in normal hair follicles, we propose that trichoblastic fibroma may first differentiate toward the outermost cell layer of the outer root sheath between the lower permanent portion and the upper transient portion and then into various other parts of the hair follicle.

Epithelium↗
PubMed1996

Solitary sclerotic fibroma of the skin: a sclerotic dermatofibroma?

Two cases of solitary tumors showing well-demarcated hypocellular, dermal fibrocollagenous proliferations are reported. The lesions were composed of hyalinized eosinophilic collagen bundles arranged in the characteristic interwoven pattern with prominent clefts, as described in sclerotic fibroma of the skin. This pattern, although predominant, was not uniform. Some areas showed a more cellular pattern with histopathologic features suggestive of dermatofibroma. In those areas, multiple spindle-shaped cells and occasional multinucleated cells were observed. The collagen bundles did not adopt a whorled pattern, and the overlying epidermis showed mild acanthosis and elongation of the rete ridges. The sclerotic changes were present mainly at the periphery and in the deep areas of the tumor. Our observations confirm the possibility that solitary sclerotic fibroma of the skin may represent, at least in some instances, the later and sclerotic stage of other more cellular neoplasms (specifically dermatofibromas) rather than an individualized neoplasm, as has been recently proposed.

Adult↗
PubMed1999

Recurrent sclerotic fibroma of the skin.

The pathologic findings of a sclerotic fibroma of the skin may resemble those of other benign cutaneous lesions. In this report, the sequential pathologic changes of a recurrent sclerotic fibroma of the skin during a period of 7 years are documented. As the lesion became older, there was not only a decrease in cellularity, but also a progressive organization of the collagen bundles toward a "plywood-like" appearance.

Adult↗