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Alcohol with xylocaine for treatment of eyelid dystonia.

Eyelid dystonia represents a form of idiopathic torsion dystonia, and it is considered as a rare disorder. Although botulinum toxin injections into the eyelids and eyebrows are considered by many neurologists as the treatment of choice for this, its cost limit its use in our community. A study was conducted at the King Hussein Medical Center between January 1995 and January 1998 using 1-2 ml of 0.5% xylocaine added to 99.5% ethanol in one-tenth of the volume of xylocaine, made injectable into the eyelids and eyebrows muscles in patients with blepharospasm. The treatment was aimed at reducing muscle spindle afferent activity. Twenty-one patients were given this modality of treatment in at least 8-12 separate sessions, with two weeks elapsing between any two sessions. Mild to moderate improvement was observed in 47.6% of our patients. The average latency from the time of the injection to the onset of improvement was 30-60 min and the average duration of improvement was 5-7 days. The commonest encountered side-effect was bruising at the site of injection that resolved spontaneously in less than 5 days. It is obvious that the usefulness of this treatment is limited by the substantially shorter duration of benefit, thus it cannot be considered as an alternative to Botox treatment. It may be useful to investigate whether a higher alcohol concentration is more effective.

Blepharospasm↗

[Radiation dose of the radiologist and the assistant in transarterial hepatic chemoembolization--comparison with the dose limits].

PURPOSE: To determine the values of effective dose and partial body dose for the radiologist and the assistant during transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) und to compare the doses with the dose limits. MATERIALS AND METHODS: In 65 TACE of HCC cases, values of various surface doses for the radiologist and the assistant were measured. The measurements were performed with the help of thermoluminescence dosemeters (TLD) that were attached to the eyebrows, over the lobes of the thyroid gland, to the breasts, abdomen and symphysis, and to the hands and the lower legs. The measured surface dose values were used as indicators of the exposure of the organs and tissues located near the surface, i. e. eye lens, thyroid gland, breast, testes and tibia. They were also seen as conservative estimations of tissues deep inside the body and the extremities. RESULTS: The highest surface dose for the radiologist was measured at the lower leg (0.58 +/- 0.28 mSv) and the highest surface dose for the assistant was measured at the right lower leg (0.24 +/- 0.20 mSv) since it was closer to the tube than the left side, followed by the dose values at the also unprotected areas of the eyebrows, lobes of the thyroid gland and the hands. The estimated value of the effective dose was 0.06 +/- 0.03 mSv for the radiologist and 0.04 +/- 0.01 mSv for the assistant. With regard to the relationship between the dose limits according to the German X-ray regulation and the measured values and with regard to the maximum possible number of interventions per year, the partial body dose of the red bone marrow in the lower leg provided the greatest limitation, followed by the partial body dose of the muscle in the lower leg and the effective dose. CONCLUSION: In order to meet the dose limits, especially the lower leg should be protected, and the effective dose should also be reduced.

Allied Health Occupations↗

The keyhole concept in aneurysm surgery--a comparative study: keyhole versus standard craniotomy.

OBJECTIVE: The purpose of the study is to compare the results of minimally invasive keyhole craniotomy and standard larger craniotomies in the surgical treatment of patients with intracranial aneurysms. METHODS: In the past eight years 628 patients were operated by two experienced neurosurgical teams. The first group of 482 patients with 565 aneurysms were operated through a small keyhole craniotomy, using the eyebrow keyhole approach in particular. The remaining 146 patients with 167 aneurysms were operated using a standard craniotomy that included pterional/frontotemporal, frontoparietal parasagittal, and retrosigmoid suboccipital craniotomies. All operations were performed in the standard microsurgical technique using intraoperative evoked potential monitoring and endoscopic assistance in selected cases. RESULTS: Most supratentorial aneurysms and basilar tip aneurysms were successfully operated through an eyebrow keyhole craniotomy. Distal MCA aneurysms as well as aneurysms on the MCA with a long M1 segment were operated through a temporal keyhole, and aneurysms of the distal PCA (P2-P3) segment subtemporally. The frontoparietal parasagittal keyhole approach was used only for pericallosal artery aneurysms. Infratentorial aneurysms of the VA/PICA complex were operated via a retrosigmoid approach. On comparing the surgery results in patients with a keyhole craniotomy and those with standard craniotomy, similar outcomes were found for both groups, with excellent or very good outcomes (GOS 5 and 4) in 398 (82.57%) patients from the keyhole craniotomy group, and in 116 (79.45%) patients from the standard craniotomy group. The mortality rate in the keyhole group was 0.83% (4 patients) and 2.05% (3 patients) in the standard craniotomy group. CONCLUSION: Parallel treatment results in using two options--keyhole craniotomy and standard larger craniotomy--were analysed in the past eight years. Two experienced neurosurgical teams in performing both surgical approaches have reached almost similar morbidity and mortality rates, and overall surgical results. The type of craniotomy is selected according to the experience of the surgical team, and familiarity with certain approach. The authors have good experience with the minimally invasive approach for different intracranial pathology and recommend it especially in neurovascular surgery.

Adolescent↗

Endoscopic facial surgery.

The emergence of endoscopically assisted cosmetic surgery has been very rapid. Public demand has burgeoned this trend resulting in the widespread use of these techniques prior to their proven efficacy. Fortunately, the results to date are favorable. The endoscopic brow and forehead lift appear to be as reliable as the open coronal approach while inflicting less incisional morbidity and decreased postoperative recovery time. This combination of decreased morbidity and post surgical discomfort have led to increased patient acceptance of browlifting. The soft-tissue orbital complex is composed of the eyebrow, upper and lower eyelids, and the malar prominence. When used in conjunction with blepharoplasties, the endoscopic browlift and midfacial suspension dramatically improve the appearance of the eye when compared to blepharoplasty alone. The applied surgical anatomy, indications, and operative technique used in endoscopic upper facial rejuvenation are detailed. Surgeons who are not utilizing the endoscopic techniques are encouraged to do so when repositioning the eyebrow and malar prominence would improve the aesthetic result.

Endoscopy↗

The transnasal advancement flap: A technique for medial canthal area defects.

AIM. To illustrate an alternative technique for reconstructing defects in the medial canthal area following tumour removal. MATERIALS AND METHODS. Eight consecutive patients who underwent Mohs(1) micrographic surgery for removal of a basal cell carcinoma in the medial canthal area were prospectively recruited. An experienced dermatologist trained in Mohs(1) micrographic surgery removed the tumour, and subsequently an oculoplastic surgeon reconstructed the defect. An incision is made from the superior end of the defect superomedially towards the midline of the dorsum of the nose following one of the natural lines of the skin (spec name). The incision runs in arcuate fashion just medial to the eyebrow and then reaches the dorsum of the nose and extends on the contralateral aspect of the nose towards the medial canthal area. The skin is then undermined to free up the newly formed flap. The flap is advanced towards the lesion and fixed intra-dermally with Vicryl Rapide(R) sutures to ensure anchoring into the concavity of the medial canthal region. The skin is then sutured with prolene sutures. RESULTS. The defects presented were oval or round in shape with diameters ranging from 0.5 to 2 cm. In all cases the transnasal flap covered the entire area and the defect was successfully reconstructed. Mean follow-up is 10.8 months (+/-4.5 SD) (range 4-17 months); all patients had an excellent cosmetic result and were subjectively satisfied. CONCLUSIONS. The transnasal advancement flap seems to have some advantages over the usual reconstruction techniques in use to repair medium defects in the medial canthal area. These are the avoidance of vertical scars in the glabellar area, eyebrow hair is not transposed into the medial canthal area, the skin match is excellent, both in colour and thickness, and surgical scars are hidden within the natural lines of the nasal bridge. We advocate the use of this technique for all minor to medium skin defects.

Journal Article↗

Phonomyography of the corrugator supercilii muscle: signal characteristics, best recording site and comparison with acceleromyography.

BACKGROUND: This study investigated the acoustic signal characteristics and best recording site of phonomyography at the corrugator supercilii muscle and compared phonomyography with acceleromyography. METHODS: In 12 patients (group I), after induction of anaesthesia and insertion of a laryngeal mask, a microphone (frequency range 2.5 Hz to 10 kHz) was placed on six different areas on the forehead and the peak-to-peak response after single-twitch stimulation of the facial nerve was measured. The microphone was placed where the response was largest and mivacurium 0.2 mg kg(-1) was administered. Fast Fourier transformation was applied to all signals to determine peak frequencies and the power-frequency relationship at different stages of neuromuscular block. In an additional 15 patients (group II), the same microphone and an acceleromyographic probe were placed above the middle portion of the left and right eyebrows respectively. Onset and offset of neuromuscular block were determined after mivacurium 0.2 mg kg(-1). RESULTS: In all seven women and all five men in group I, the best response was obtained just above the middle portion of the eyebrow. Peak frequency was 4.1 (SD 0.9) Hz without neuromuscular block and did not change significantly during onset and offset of neuromuscular block. Ninety per cent of the total signal power was below 40 Hz. In group II, mean onset time and maximum effect measured were 104 (20) s and 76 (10)% respectively using acceleromyography and 134 (30) s and 92 (4)% using phonomyography (P<0.04). Mean time to reach 25, 75 and 90% of control was 9.5 (2.8), 14 (5.1) and 15.1 (5.3) min respectively using acceleromyography and 6.9 (2.8), 12.5 (5.9) and 13.6 (4.9) min using phonomyography (P<0.04). Bland-Altman testing revealed significant bias (precision) for onset time, maximum effect and time to reach 25% of control (acceleromyography minus phonomyography) at -30 (38) s, -16 (11)% and 2.6 (2.8) min respectively. CONCLUSIONS: Phonomyography can be used to determine neuromuscular block at the corrugator supercilii muscle. In comparison with acceleromyography, phonomyography tends to measure a longer onset with more pronounced maximum effect and shorter recovery of neuromuscular block.

Adult↗

Folded skin with lipomatous nevus in the forehead and scalp.

An 18-year old Japanese woman with folded skin in the forehead and scalp was found to have an underly Brachycephaly with peculiar hair lines, broad and sparse eyebrows, bilateral epicanthi, and decreased neck-shoulder angles were found, as well as reticular pigmentation of fingers and toes. Routine laboratory data and endocrine analyses were within normal limits. Combined longitudinal and coronal incisions in the forehead and scalp initially, followed by gull-wing incisions along the eyebrows, resulted in satisfactory improvement of the clinical appearance.

Adolescent↗

Modifications in endoscopic facelifts.

Since 1996, 72 patients (66 women and 6 men) have undergone endoscopic upper and midface rejuvenation. Sixteen of these patients had concomitant lower face rejuvenation at the same time. The patients were operated using a personal endoscopic technique, including biplanar endoscopic dissection (subgaleal and subcutaneous) at the forehead and temporal regions, excision of a galeal strip approximately 1 cm in thickness (to achieve a stable forehead lift), and a lower blepharoplasty incision for midface lifting and fixation of the malar fat pad. This approach helps to prevent midface widening-a concern of most surgeons. Regarding patient satisfaction, 51 patients had excellent results, 16 patients had good results, and 5 patients had an improved appearance of the mid and upper face. Complications included 11 incidences of temporary numbness in different regions of the upper and mid face, three incidences of temporary lower lid retraction (which did not require additional revision), three relapses of eyebrow elevation (which were reoperated), and unbalanced eyebrows in 2 patients (which were corrected during secondary revisional procedures).

Adult↗

Correction of recurrent blepharoptosis using an orbicularis oculi muscle flap and a frontalis musculofascial flap.

Thirteen patients underwent reoperation for recurrent blepharoptosis using the orbicularis oculi muscle flap or the frontalis musculofascial flap. The orbicularis oculi muscle flap and the frontalis musculofascial flap are a modification of direct transplantation of the frontalis muscle to the tarsal plate. This is based on an anatomic study showing that the frontalis muscle and its fascia are connected with the orbicularis oculi muscle at the eyebrow region. The patients' previous blepharoptosis operations were frontalis muscle suspension with autogenous or alloplastic material. Their follow-up period ranged from 6 months to 10 years. The average interval between the patient's first frontalis suspension to their reoperation was 8.09 years. The selection of the muscle flaps was based on the extent of levator function of the patient. When the eyelid excursion was moderate (>4 mm), the orbicularis oculi muscle flap was used. For patients with minimal or weak eyelid excursion (<3 mm), the frontalis musculofascial flap was used. Eleven patients (91.6%) gained levator excursion of more than 7 mm and reduced the height difference of both palpebral fissures by less than 2 mm after the reoperation. After an average follow-up of 20 months, 11 patients (14 eyelids) recorded satisfactory results. This is based on the criteria of Souther, and Jordan and Anderson. The overall results were more than satisfactory. Even though 2 patients reported poor results, there was no complete failure in this series. The authors' technique offers several advantages over conventional frontalis muscle suspension: it is a simple technique that has a good operative field, there is no donor morbidity and less complications, and asymmetrical supratarsal folding, eyelid notching, lagophthalmus, and abnormal eyebrow position that can occur after a frontalis muscle suspension can be avoided. In summary, the orbicularis oculi muscle flap or the frontalis musculofascial flap are considered for patients with recurrent blepharoptosis after frontalis muscle suspension.

Adolescent↗

Major depression: behavioral markers of depression and recovery.

The concepts of psychosocial and psychomotor inhibition characteristic of major depression are based primarily on clinical observations. It is possible to describe and define these two types of inhibition by means of a systematic, quantitative ethological (behavioral) approach, which singles out precise and significant behavior markers. This investigation focuses on the behavioral features of psychosocial and psychomotor inhibition in 11 hospitalized depressed subjects and their changes during clinical recovery. The hypothesis that major depression is characterized by a significant reduction of social interaction is tested (psycho-intellectual inhibition is not addressed). Results show significant behavioral differences between depressed and recovered subjects with depression being characterized by a significant reduction of social interaction, whereas self occupation and body mobility are reduced to a lesser degree. Behavior markers for depression include nonspecific gaze, withdrawal, no mouth movements, no eye region movements, and social inactivity. Behavior markers for recovery include socially interested, social smile, verbal social initiative, speech, nod, raised eyebrows, wrinkled eyebrows, social laughter, gesticulation, drum one's fingers, point, and help. Findings point to tendencies toward two types of major depression and two types of recovery. A companion paper (Schelde, this journal) addresses theoretical issues.

Adult↗

Measurement of facial muscle strength in normal subjects.

OBJECTIVES: Muscle strength is a fundamental measure of function for neuromuscular systems; however, mimetic facial muscle strength has never been recorded. The objective of the present feasibility project was to measure facial muscle strength. STUDY DESIGN: The study design was a prospective experimental trial in 10 normal subjects. Descriptive statistics, tests, and analysis of variance were used to summarize and compare data. METHODS: Subjects were selected by convenience following submission and approval of a prospectively designed protocol and consent form to the Human Studies Committee. Application of a force transducer to the central eyebrow and commissure during eyebrow raising, eyelid closing, smiling, and puckering was performed by two methods: surface adhesion method (n = 5) and direct probe application method (n = 5). Data were recorded in pounds. Three repetitions of each movement were made. RESULTS: Rank order of muscle strengths (in pounds) by the surface adhesion technique was as follows: brow, 0.758; eye, 0.549; pucker, 0.387; and smile, 0.307. By direct probe application the rank order of muscle strengths was as follows: eye, 0.880; brow, 0.773; and smile, 0.730. CONCLUSIONS: Objective measures of facial motion are crucial for quantitative investigations of preventative, therapeutic, reconstructive, and rehabilitative interventions for facial nerve and muscle lesions. Until the present, objective measures required cross-correlations with current standards that were subjective. This is the first time an actual physical measure of facial muscle function has been performed. The purpose of presenting this preliminary work is to stimulate advancement along this line of research.

Adult↗

Endoscope-assisted supraorbital craniotomy for lesions of the interpeduncular fossa.

OBJECTIVE: The supraorbital approach is well accepted for lesions in the anterior fossa, the sellar region, and the anterior circle of Willis. However, the usefulness of this approach has not yet been elucidated for lesions in the interpeduncular fossa. The technique of an endoscope-assisted, ipsi- and contralateral supraorbital approach to lesions within the interpeduncular fossa is described, and the initial results are reported. METHODS: A small supraorbital craniotomy, using an eyebrow incision, was performed in each of seven patients who were operated on for different types of lesions in the interpeduncular fossa, including a neuromuscular choristoma of the oculomotor nerve, a retrosellar epidermoid tumor, and five aneurysms (two of the basilar artery tip, two at the offspring of the superior cerebellar artery, and one fusiform arterial widening of the basilar artery apex). The surgical approach, its indications and limitations, and the additional value of an endoscope are outlined. RESULTS: All lesions could be easily reached and well visualized through this approach by using an endoscope as an adjunct to the operating microscope. The saccular aneurysms all could be clipped successfully, the fusiform widening was wrapped, the epidermoid tumor was removed completely, and the choristoma was removed only partially because of brain stem invasion. The patient with the neuromuscular choristoma had persistent diabetes insipidus postoperatively, most probably caused by stretching the pituitary stalk with the endoscope. The patient with the epidermoid tumor showed a postoperative transient partial oculomotor nerve paresis at the side of the approach. The cosmetic results of the eyebrow incisions for this approach were excellent in all patients. CONCLUSION: Lesions in the interpeduncular fossa can be effectively treated using a supraorbital approach, which can be ipsi- or contralateral to the side of the lesion, depending on the exact location of the lesion. The use of an endoscope is essential to visualize these lesions that lie in the shadow of the sellar and parasellar anatomic structures. The major advantage over other approaches are a nearly perpendicular surgical route (although the distance is longer, which is, on the other hand, not a disadvantage), a minimized amount of dissection and brain retraction by using an endoscope through anatomic gateways, and a small surgical incision with excellent cosmetic results.

Adult↗

Subperiosteal approach as an improved concept for correction of the aging face.

A harmonious facial appearance is determined by a balanced relationship among all tissues of the face. With advancing age, balance is lost among the bone, muscle, fat, and skin as progressive changes occur in their volume, shape, position, and consistency. Study of clinical cases and fresh cadaver dissections has led to better understanding of the superficial musculoaponeurotic system (SMAS) and its relationship with the facial muscles and their bony insertions. From these anatomic studies we have developed an improved concept of rhytidectomy with the subperiosteal detachment of all soft tissues from the orbit, upper maxilla, malar bone, and nose. Following this detachment, the soft tissues of the cheek, forehead, jowls, nasolabial folds, lateral canthus, and eyebrows can be lifted to reestablish their youthful relationship with the underlying skeleton. Our 4-year experience includes 105 patients. Sixty percent of these patients were admitted to the hospital and had their procedure under general anesthesia; forty percent, however, had their procedure in an outpatient setting requiring only local anesthesia (lidocaine hydrochloride 1% plus epinephrine) and intravenous sedation (midazolam, ketamine). Complications have been minimal except for temporary paralysis of the frontal nerve in seven patients; guidelines for prevention have subsequently been developed. The subperiosteal rhytidectomy is excellent and appears more natural for rejuvenation of the upper and central face, eyebrows, periorbita, external canthus, cheeks, and nasolabial fold.

Aged↗

Endoscopic forehead lift: an operative technique.

On the basis of over 100 endoscopic forehead lifts, we present an in-depth view of the current operative technique. The critical components are the following: (1) a subgaleal resection of muscle insertions rather than a subperiosteal approach to muscle origins, (2) a complete periosteal release along the lateral orbital rim, (3) a vertical suspension utilizing screws and staples that are removed at 1 week, and (4) a lateral temporal expansion using absorbable sutures. With this technique, a more controlled eyebrow position and eyebrow shape can be achieved.

Adult↗

Shortening of the long forehead.

A long forehead disrupts the harmony among the facial components and may contribute to the semblance of facial aging. Slight forehead length disharmony on a senescent face can be corrected by placing the incision at the hairline, elevating the eyebrows through subcutaneous or subgaleal dissection, and removing excess skin without posterior scalp immobilization. For moderate to major reduction of the forehead length, the scalp is elevated back to the occipital region through a pretrichial incision, and relaxation incisions are made at a right angle to the vector of advancement. The entire scalp is then repositioned anteriorly, advancing the hairline caudally and shortening the forehead. Retraction of the scalp or excessive elevation of the eyebrows is prevented by anchoring the galeal fascia to the cranial bone using a bone-tunneling technique in one to three rows. The number of fixation rows is commensurate to the amount of advancement and rigidity of the scalp. The more immobile the scalp preoperatively, the more relaxation incisions and fixation tunnels are necessary. Following caudal repositioning of the scalp, the non-hair-bearing skin is excised, and a meticulous repair is done. These procedures have been performed in 180 patients with a high degree of satisfaction. Temporary hair loss was experienced in one smoker who underwent the most advancement through posterior scalp elevation and continued to smoke postoperatively. Also, on three patients in the subcutaneous forehead rhytidectomy group, two of whom were smokers, delayed healing was observed in the temple area because of compromised circulation requiring secondary revision.

Forehead↗

Porous polyethylene implants in orbital floor reconstruction.

The purpose of this article is to present the authors' experience with the use of porous polyethylene ultrathin sheets for orbital floor reconstruction. Thirty-two patients with orbital floor fractures were treated with porous polyethylene ultrathin sheets. Sixteen cases corresponded to orbitozygomatic fractures, 11 cases corresponded to pure orbital floor fractures, and five corresponded to panfacial fractures. The subciliary approach was used in 15 patients and the transconjunctival approach in nine; another three patients were operated on through a preexisting eyebrow wound, two were operated on with a subtarsal approach, two were operated on through an eyebrow extension of a facial wound, and one patient was operated on through the facial wound. Intraoperatively, all patients received a prophylactic dose of intravenous antibiotics. Postoperatively, 24 patients received amoxicillin clavulanate for 5 to 7 days, two patients received clindamycin, and six patients received no antibiotics. Enophthalmos was corrected in 15 of 24 patients (62.5 percent), and hypoglobus in nine of 11 (82 percent). Diplopia was resolved in 25 of 28 patients (89.3 percent) with preoperative impairment. Extrinsic eye movement impairment was resolved in 25 of 27 patients (92.6 percent). A preoperative visual acuity deficit was present in four patients (12.5 percent) and was resolved in one (from 20/100 to 20/20). Visual acuity improved in one patient (from 20/60 to 20/30). In the other two patients, visual acuity remained altered (from 20/30 to 20/30). One patient (3.1 percent) suffered blindness induced by surgery. Nine of 26 patients (34.6 percent) had residual infraorbital nerve hypesthesia and five (19.2 percent) had residual paresthesias. Postoperatively, epiphora was present in six patients (18.8 percent) and ectropion in five (15.6 percent). Although there was no statistical significance between the surgical approach and the presence of epiphora (p = 0.211) and ectropion (p = 0.422), patients who were treated using the transconjunctival approach suffered reduced ectropion (0 percent) compared with patients treated using the subciliary approach (20 percent). However, patients treated using the transconjunctival approach suffered increased epiphora (22.2 percent) compared with those treated with the subciliary approach (13.3 percent). There were four cases (12.5 percent) of postoperative facial infections. Two of these cases were resolved with systemic antibiotics, one was resolved with bone sequestrum resection, and one patient needed removal of the implant. Orbital infections were related in all cases to titanium osteosynthesis miniplates or skull bone graft. When comparing patients who were treated with and without antibiotics, no statistical differences (p = 0.958) were found relative to the presence of infections. Correction of hypoglobus is technically easier than enophthalmos, because enophthalmic correction requires a wide, deep subperiosteal dissection and implant positioning, posterior to the equator of the globe, with the inherent risk of orbital apex injury.

Adolescent↗

Mucinous eccrine adenocarcinoma of the periocular region.

PURPOSE: To report 4 patients with mucinous eccrine adenocarcinoma of the periocular region. METHODS: Interventional case series of 4 patients with mucinous eccrine adenocarcinoma of the periocular region treated at 2 centers. RESULTS: Two patients with mucinous eccrine adenocarcinoma of the upper eyelid, 1 with mucinous eccrine adenocarcinoma of the lower eyelid, and 1 with mucinous eccrine adenocarcinoma of the eyebrow were included in this report. The lower eyelid lesion and the eyebrow lesion recurred after Mohs micrographic surgery. Both recurrent lesions were treated with Mohs micrographic surgery and postoperative adjuvant external-beam radiation therapy. The other 2 primary tumors were treated with wide local excision with frozen section control of margins and did not recur. The follow-up time after the most recent surgical procedure ranged from 8 to 17 months (median, 12 months). CONCLUSIONS: Mucinous eccrine adenocarcinoma is a rare ocular adnexal neoplasm that can involve the eyelid and periocular skin, can be locally invasive, and has a high risk of local recurrence despite Mohs surgery.

Adenocarcinoma, Mucinous↗

Pathogenesis and surgical correction of involuntary contraction of the occipitofrontalis muscle that causes forehead wrinkles.

Assuming that an agonistic function is present to maintain an adequate visual field, we hypothesized that stretching of the mechanoreceptor of Mueller muscle induces involuntary contraction of the occipitofrontalis muscle, as well as the levator muscles. In patients with aponeurotic blepharoptosis, both unilateral instillation of phenylephrine to contact Mueller smooth muscle fibers and unilateral aponeurotic fixation ipsilaterally reduced the eyebrow height during primary and upward gazing. Bilateral aponeurotic fixation bilaterally reduced the eyebrow height, with fewer forehead wrinkles. Stretching of the mechanoreceptor of Mueller muscle induces involuntary contraction of the bilateral levator muscles. Its increased stretching may induce involuntary contraction of the ipsilateral occipitofrontalis muscle via the mesencephalic trigeminal nucleus and the facial subnucleus as another stretch reflex. The involuntary contraction of the occipitofrontalis muscle that causes forehead wrinkles during primary gazing can be corrected by the aponeurotic fixation to reduce the stretching of Mueller muscle.

Facial Muscles↗