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At least 415 records · Page 23Linked to original sources
PubMed1975

[Course of coronary disease. Evaluation of prognosis and progression of coronary insufficiency with atrial pacing and ergometry].

Significant reduction of angina threshold (145 Imp./min to 134 Imp./min) and increase of ST-segment depression (0.13 to 0.17 mV) indicating progression of coronary artery disease was seen in 34 subjects studied by atrial pacing at intervals betion (0.22 mV to 0.12 mV) during exercise, which correlated significantly with decrease of heart rate (121 to 110 beats/min), is interpreted as consequence of diminished sympathetic activity and myocardial O(2)-demand. The change of hemodynamic parameters during controlled exercise does not allow evaluation concerning the progress of coronary artery disease, whereas cardiac stress test with atrial pacing is reproducible. There was no difference in relation to reduction of angina threshold between the group after combined longterm medication with nitrate and ss-blocking agent and the control group. Plasma lipid abnormalities were predictive of subsequent reduction of angina threshold. Severe 2 and 3 vessel obstruction was seen more frequently in patients exhibiting reduction of angina threshold. Level of uric acid, obesity, hypertension, age, combination of risk factors, the initially studied myocardial lactate production and angina threshold during exercise and atrial pacing had no predictive value concerning reduction of angina threshold.

Adult↗
PubMed2003

[Exploration of exercise intolerance by 31P NMR spectroscopy of calf muscles coupled with MRI and ergometry].

One hundred patients presenting with exercise intolerance or rhabdomyolysis episodes have been examined successively by 31P Nuclear Magnetic Resonance Spectroscopy (MRS) of leg plantar flexor muscles with exercise test. In all cases a muscle biopsy was performed. At the end of investigations, diagnosis of a metabolic myopathy was made in 33 patients: glycogenolysis or glycolysis deficiency in 8 cases, mitochondrial myopathy in 24 cases and CPT II deficiency in one case. Muscular dystrophy or congenital myopathy were diagnosed in 6 cases. No precise etiology could be found in 30 patients with either high CK levels or muscle biopsy abnormalities. Seven patients had rhabdomyolysis related to excessive physical activities. Twenty-four patients had functional symptoms. The principal MRS parameters used for diagnosis were the values of intracellular pH at the end of exercise and the time constant of phosphocreatine resynthesis during recovery. Lack of acidosis after exercise was observed in all patients with blockade of glycogenolysis or glycolysis. A slowing in phosphocreatine resynthesis was found in 66 p.cent of patients with definite mitochondrial myopathy. The specificity of these parameters were respectively 92.4 p.cent and 85.5 p.cent for the two groups. In conclusion (31)P MRS allows the detection of muscular glycogenoses with a sensitivity close to 100 p.cent. However, its sensitivity was lower for the detection of mitochondrial myopathies, as is also known for the other in vivo metabolic investigations, reflecting the heterogeneity of expression of mitochondrial abnormalities in a given muscle. The integration of imaging in the examination protocol may help to orientate towards the diagnostic of a dystrophy in some patients.

Adolescent↗
PubMed2003

Effects of submaximal intensity cycle ergometry for one hour on substrate utilisation in trained prepubertal boys versus trained adults.

AIM: Substrate utilisation during exercise might be different in trained prepubertal boys compared to trained adults, so dietary advice usually given to endurance trained adults may need to be adapted for endurance trained children. METHODS EXPERIMENTAL DESIGN: subjects pedalled for 1 hour on an ergocycle at 40% or 60% of Wmax (maximal aerobic power). PARTICIPANTS: 14 boys and 13 adults active in endurance sport (swimming). MEASURES: pulmonary respiratory gas-exchange ratio [RER = VCO(2)/VO(2)], used as the equivalent of the non protein respiratory quotient (RQ), was measured at rest, at the 15(th), 30(th), 45(thv and 60(th) min of exercise in order to calculate energy expenditure. RESULTS: Relative resting energy expenditure was significantly higher in boys than in adults. During exercise, energy expenditure (EE) was significantly lower in children than in adults (p<0.001), whereas fat-free mass relative EE was only influenced by intensity. Relative EE from carbohydrates (EE(CHO)) was lower in children compared to adults, even if the highest intensity involves a higher EE(CHO) in both groups (p<0.05). Boys oxidised more lipid at 40% of Wmax than 60% of Wmax or adults at either intensity. CHO utilisation was significantly increased at 60% vs 40% of Wmax, yet lower in boys than in men (p<0.01). Lipids' use, in g x min(-1) x kg-1)FFM, was significantly higher in boys than in men at 40% of Wmax (p<0.01). CONCLUSION: Trained children, at rest, had greater fat-free mass energy expenditure than adults, which may be linked to growth processes that remain unclear. During exercise, in boys, the main observation was the increase in CHO dependence relative with the intensity. Thus, it appears that CHO feeding is as important in endurance-trained boys as in endurance-trained adults, especially when exercise intensity approaches that of competition or training sessions.

Adult↗
PubMed1992

[Captopril in the treatment of patients with congestive heart failure. Its bicycle ergometry evaluation].

PURPOSE: To analyze the physical performance of the patients with congestive heart failure (CHF), grades I and II of the New York Heart Association (NYHA), submitted to ergometric test: 1) under conventional treatment with digitalis and diuretic; 2) with an angiotensin converting enzyme inhibitor, captopril, associate with conventional treatment; 3) using captopril associated with digitalis or diuretic. METHODS: A randomized double blind study was performed in 20 patients with CHF (I and II-NYHA) submitted to ergometric test in different therapeutic phases. The initial workload was 5 watts and load was increased until the appearance of limiting symptoms. RESULTS: The introduction of captopril to the conventional treatment for CHF or associated with digitalis or diuretic promotes significant increase in the duration of the physical exercise, in the oxygen consumption and in the total workload during the ergometric test. CONCLUSION: In the initial forms of CHF, captopril provides better physical performance when compared with conventional treatment and the diuretic treatment can be changed for the angiotensin converting enzyme inhibitor with equal efficacy.

Analysis of Variance↗
PubMed1991

[Ergometry testing in the past and today].

Exercise testing on bicycle-ergometer or treadmill represents a simple and relatively cheap medical procedure. It may be managed in any level of medical evaluation and especially for discovering persons with low or high cardiac risk, beside the asymptomatic or symptomatic status during the testing. The cumulated experience gave the proof than the exercise testing is superior to coronarography and ventriculography. Test protocol and conclusions must be together with the recommendations of the cardiology association and the author gives some of his own remarks and practical recommends. In personal everyday practice someone can find improvements too.

Exercise Test↗
PubMed1992

[The antianginal effects of a new delayed-release formulation of diltiazem in patients with stable angina pectoris: its evaluation by the ergometry test and dynamic electrocardiogram].

The antianginal efficacy and duration of action of slow-release (SR) diltiazem were evaluated in 12 patients with stable angina. Patients underwent maximal symptom limited bicycle exercise testing and 24-hour Holter monitoring at the end of 1-week placebo run-in phase and after 1-month therapy with either placebo or SR-diltiazem (120 mgs bid) using a placebo controlled, double-blind, randomized cross-over trial. No concomitant antianginal therapy, except sublingual nitroglycerin, was allowed during the trial. Exercise testing was performed 3 and 12 hours after drug administration. Blood samples were obtained for the determination of diltiazem plasma concentrations. After diltiazem administration, peak exercise duration increased significantly in comparison both with placebo and the run-in phase: from 292 +/- 48 to 378 +/- 113 s at 3 hours and from 286 +/- 59 to 366 +/- 109 s 12 hours after drug administration. Similarly, ST depression time increased from 240 +/- 59 to 374 +/- 123 s at 3 hours and from 231 +/- 57 to 332 +/- 123 s 12 hours after diltiazem. No significant changes of heart rate, blood pressure and double product were detected. Diltiazem plasma concentrations averaged, respectively, 175 +/- 86 pg/ml and 109 +/- 43 pg/ml 3 and 12 hours after its administration. No correlation was found between plasma concentrations and antianginal effects of diltiazem. At 24 hours Holter monitoring, SR-diltiazem induced a significant decrease of mean heart rate with a reduction in the number and duration of ischemic episodes.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMed1992

[Prognostic significance of bicycle ergometry test in patients with myocarditis].

A total of 42 patients with rheumatic carditis were examined in the acute-subacute period and following 3-5 years. Seventeen patients were diagnosed as having primary rheumatic carditis, 9 presented with tonsillogenic rheumatic carditis, and 16 had viral rheumatic carditis. The diagnosis of myocarditis was established on the basis of clinical, immunological, and virological findings. The study involved ECG, PhCG, PCG, and bicycle ergometer testing recordings. Groups of patients with good and poor prognosis were identified. Low threshold exercise, exercise-inadequate tachycardia, complex cardiac arrhythmias, phasic myocardial hypodynamic syndrome and volume exercise syndrome that are formed during performance are prognostically poor indicators. More profound electric and mechanic dysfunctions were observed in patients with tonsillogenic or viral myocarditis.

Adolescent↗
PubMed2003

[Parameters of heart rate variability during bicycle ergometry test].

Short-term (5 min) heart rate variability (HRV) was studied before and during submaximal bicycle exercise tests in 27 patients with ischemic heart disease, 23 patients with hypertension and 9 healthy subjects. Low-frequency (0.04 to 0.15 Hz) and high-frequency (0.15 to 0.40 Hz) power components of HRV were significantly decreased during submaximal exercise. The level of load at which abrupt decrease of low-frequency components below 40 ms(2) occurred possibly reflected individual exercise tolerance. Episodes of myocardial ischemia were associated with pronounced decreases of low - frequency HRV components.

Adolescent↗
PubMed1992

[Clinical outcome of silent myocardial ischemia detected by bicycle ergometry study].

Seventeen patients with positive maximal or submaximal bicycle-exercise test accompanied by painlessness and 14 patients with susceptible coronary heart disease with negative exercise test were studied and traced for 36 months. The patients underwent repeated bicycle-exercise test of the same stress and compared with those before 36 months. The results showed that 7/17 patients (41.2%) had an increase in the depressed level of ischemic type ST segment induced by exercise test. 3 of them developed effort angina pectoris: 1 suffered from myocardial infarction, 1 had recurrent atrial flutter and left heart failure, and 1 suddenly died from cardiac disease. The cardiac event rate was 3/17 (17.6%) in this group. While 14 patients with negative exercise test had no cardiac events. It seems to mean that silent myocardial ischemia detected by exercise test might have potential danger of cardiac events.

Adult↗