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PubMed2000

A new desensitizing dentifrice--an 8-week clinical investigation.

An 8-week, double-blind, three-way clinical trial compared the dentinal hypersensitivity-reducing effectiveness of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength Toothpaste, Colgate-Palmolive Co.) with a commercially available desensitizing dentifrice containing 5.0% potassium nitrate and 0.243% sodium fluoride in a silica base (Sensodyne Fresh Mint Toothpaste, Block Drug Company, Inc.) and a nondesensitizing dentifrice containing 0.243% sodium fluoride in a silica base (Colgate Winterfresh Gel, Colgate-Palmolive Co.). One hundred nine subjects were stratified into three balanced groups according to gender, age, mean baseline tactile (Yeaple Probe), and thermal (air blast) scores. The test products were randomly assigned to each group with instructions to brush twice daily. Oral examinations with tactile and thermal assessments were repeated after 4 and 8 weeks. The new dentifrice group demonstrated statistically significant improvements in tactile and thermal sensitivity over the two control groups.

Adult↗

PubMed1999

Use of a whitening dentifrice for control of chlorhexidine stain.

A major drawback to clinicians prescribing and patients using chlorhexidine rinse is the development of extrinsic staining. In order to assess the effectiveness of a whitening dentifrice in controlling chlorhexidine stain, fifty-seven subjects rinsed with chlorhexidine twice daily while brushing twice daily with either fluoridated whitening or a fluoridated regular dentifrice. Stain was assessed at 1, 2, and 3 month intervals using a stain index with two components; one with parameters for color intensity and one for tooth percentage covered with stain. Facial surfaces accumulated less stain than lingual surfaces. For many, although not all surfaces, and at many, although not all time periods, the group utilizing the whitening dentifrice exhibited less staining. It is advantageous to recommend a whitening dentifrice that has demonstrated stain suppression when prescribing a chlorhexidine rinse. Improved patient satisfaction leading to increased compliance with the antimicrobial regimen is a desired outcome.

Adolescent↗

PubMed1997

Clinical efficacy of an optimized stannous fluoride dentifrice, Part 4: A 3-month calculus clinical study, northwest USA.

The objective of this 3-month, double-blind study was to investigate the efficacy of Colgate Optimized Stannous Fluoride (COSF) dentifrice for the control of supragingival dental calculus accumulation. After 3 months' use, the COSF dentifrice group exhibited a statistically significant 56.6% reduction in supragingival calculus formation, as compared to the control dentifrice group. The results of this study support the conclusion that the COSF dentifrice is efficacious for controlling the accumulation of supragingival calculus.

Adult↗

PubMed2003

Effects of a carbamide peroxide agent and desensitizing dentifrices on enamel microhardness.

PURPOSE: To evaluate the in vitro microhardness of enamel treated with a 10% carbamide peroxide agent and two desensitizing dentifrices at different bleaching times. MATERIALS AND METHODS: A 10% carbamide peroxide bleaching agent was evaluated (Rembrandt 10%) (REM). A placebo agent was used as a control group (PLA). The bleaching and the placebo agents were applied to human enamel dental fragments for 8 hours per day, followed by immersion for 5 minutes in a slurry solution of desensitizing dentifrices: Sensodyne (S) or Sensodyne Fluor (SF). During the remaining time, the enamel fragments were individually stored in 13.5 ml of artificial saliva. Knoop microhardness measurements were performed at baseline, 8 hours, 7, 14, 21, 28, 35 and 42 days of treatment and at 7 and 14 days of a post-treatment period. RESULTS: Analysis of variance and Tukey's test showed no differences in enamel microhardness for REM + SF (P=0.069) and PLA + SF (P=0.93) within each time interval. The dental fragments treated with REM + S and PLA + S showed an increase in microhardness values within each time interval (P<0.0001). There were significant differences among the treatment agents from the 28th to the 56th day. The use of 10% carbamide peroxide bleaching and a desensitizing dentifrice significantly increased the enamel microhardness values during the bleaching treatment and after 14 days after the completion of the treatment. After the post-treatment period, the enamel fragments treated with a placebo agent and with a 10% carbamide peroxide agent and with a desensitizing fluoride dentifrice maintained the baseline values.

Carbamide Peroxide↗

PubMed2003

Effect of fluoridated dentifrice and acidulated phosphate fluoride application on early artificial carious lesions.

PURPOSE: To evaluate the effect of a combination of fluoride dentifrice and acidulated phosphate fluoride (APF) on enamel with incipient caries lesions. MATERIALS AND METHODS: Bovine dental enamel blocks with artificial caries lesions were divided into four treatment groups and submitted to a pH-cycling model: (1) Placebo non-fluoridated dentifrice (PD); (2) Fluoridated dentifrice (FD), 1,100 ppm F; (3) APF (12,300 ppm F, pH 3.5) + PD; 4) APF+FD. APF was applied to enamel blocks of groups APF+PD and APF+FD before the pH-cycling regimen and all of them were exposed to dentifrice during the cycling. RESULTS: The results showed that 61-81% of the fluoride previously deposited in enamel by APF was released to the media during the pH-cycling. The final concentration of fluoride in enamel in the group APF+PD was lower than that before the cycling (P < 0.05), but in the group APF+FD the reduction was not significant (P> 0.05). FD treatment was significantly more efficient than PD in rehardening the enamel surface and increasing the hardness of the caries lesions. APF+PD treatment was not more efficient than PD in increasing enamel hardness and an additive effect of APF+FD was not observed.

Acidulated Phosphate Fluoride↗

PubMedDate not supplied

Anti-calculus effects of dentifrice containing pyrophosphate compared with control.

A 3-month, double-blind, randomized, longitudinal, parallel clinical study was conducted to compare the effects on supragingival calculus deposits of a dentifrice containing soluble pyrophosphate to a control MFP dentifrice, which did not contain pyrophosphates. During the pre-test phase, 247 teachers were examined for presence of calculus on the lingual surfaces of the 6 lower anterior teeth, using the Periodontal Probe Method of Calculus Assessment (Volpe et al. 1965). Statistical methods employed were the two-way analysis of variance as well as the paired and unpaired t tests. The level of statistical significance chosen was p less than 0.05. At the end of the 3-month pre-test phase, 88 candidates with the highest calculus index scores met the initial criteria and were stratified into two balanced groups based on their age and sex. Each group received an oral prophylaxis and participants were assigned to use either the dentifrice containing the pyrophosphate or the MFP and instructed to brush their teeth twice daily at home for the next 3 months (test phase). The results showed that the group using the pyrophosphate dentifrice experienced a 20% greater reduction in calculus formation when compared to the MFP control There was also a greater number of calculus-free subjects and tooth surface sites in the soluble pyrophosphate group. The change in the Volpe-Manhold Index revealed significant differences for both the pyrophosphate group (change = 1.7111; p = 0.0010) as well as, though less prominent, for the control group (change = 1.4186; p = 0.0313).

Adult↗

PubMed2003

Anticaries efficacy of a new dentifrice for hypersensitivity.

PURPOSE: To evaluate the expected anticaries efficacy of a new dentifrice containing stannous fluoride as the anticaries agent and potassium nitrate as the antihypersensitivity agent using a series of laboratory and animal studies. METHODS: Four surrogate studies were performed in this assessment including fluoride uptake in sound enamel, enamel solubility reduction, fluoride bioavailability and animal caries. RESULTS: Each of these studies indicated the new dentifrice for hypersensitivity (Colgate Sensitive Maximum Strength) was effective in inhibiting the caries process. The data demonstrate that this new dentifrice is predicted to be highly effective against caries and equivalent to a positive control dentifrice.

Acid Etching, Dental↗

PubMed2003

Relationship between dentifrice fluoride concentration and clinical caries reduction.

PURPOSE: To review the published literature on clinical caries trials of fluoride dentifrices and to combine their results in order to evaluate the correlation between fluoride concentration in dentifrice formulations and their anticaries efficacy, i.e., the dose-response relationship. METHODS: All available dentifrice caries clinical trials reported in the literature of products having at least two fluoride concentrations greater than 0 ppm were reviewed, graphed and statistically analyzed. RESULTS: The evaluation supported a linear correlation between the fluoride concentration of dentifrices between 0 and 5000 ppm F and clinical caries efficacy.

Cariostatic Agents↗

PubMed2004

[Effectiveness of three whitening dentifrices].

Over the past years the market share of whitening dentifrices has been increasing. The aim of this parallel, randomized, double-blind clinical trial was to assess the efficiency of three commercially available tooth whitening dentifrices. Thirty-six subjects with extrinsic tooth stain (A3 and darker) were randomly assigned to three groups (A, B, C) of twelve subjects each. Group A brushed their teeth twice daily with Durodont medical fresh and white (RDA 70), Group B with Friscodent Zahnweiss (RDA 87) and Group C with a combination of Durodont Zahnweiss intensiv (RDA 166) and Durodont medical fresh and white. At baseline and after four and eight weeks the color of the anterior teeth was evaluated using a VITAPAN classical color shade and a special colorimeter (Homeba). The colors of the shade guide were arranged and nummerized by value. After four and eight weeks of use each dentifrice showed a significant whitening effect compared to baseline (p < or = 0.05). There were, however, no significant differences between the groups. Moreover both methods showed similar results. Thus, the results support a significant "whitening" effect of all three dentifrices.

Adult↗

PubMed2003

Evaluation of total pH and soluble and ionic fluoride concentrations in dentifrices commercially available in Brazil.

PURPOSE: To verify the total (TF), soluble (SF) and ionic (IF) fluoride concentrations in the main Brazilian dentifrices for comparison and quality control according to the current Brazilian Ministry of Health Regulations, 2000. MATERIALS AND METHODS: Nineteen brands, from 2 batches, fresh or aged at 45 degrees C/48 h, had their F concentrations and pH analyzed with a specific electrode and pHmeter. To analyze the TF, 0.25 ml of 2M HCL was added to 0.25 ml of the suspension of each dentifrice. This was kept at 45 degrees C/1 h and 0.50 ml of M NaOH and 1.0 ml of TISAB II was added. To assay SF and IF, after centrifugation, the supernatant was used and the same steps described above were followed for SF. The analysis of IF was made by adding 0.25 ml of the supernatant to 1.0 ml of TISAB II, 0.5 ml of M NaOH and 0.25 ml of 2M HCL. Paired t tests were used for statistical analysis. RESULTS: The concentration of TF, SF and IF ranged from 555.7 - 1835.1; 449.3 - 1619.3 and 96.9 - 1534.6 ppm respectively. After aging, a significant reduction in the SF concentration (p = 0.00002) was observed, which did not occur for TF and IF (p > 0.05). Only the brand Colgate Baby presented pH 6.8. The other dentifrices had an alkaline pH, ranging from 7.1 - 9.9. CONCLUSION: Although the term 'soluble' was suppressed by the new regulation, the dentifrices analyzed were in accordance to the Brazilian Ministry of Health Regulations, 1989.

Brazil↗

PubMed2005

Role of dentifrices on abrasion of enamel exposed to an acidic drink.

PURPOSE: To evaluate in vitro the abrasive potential of different dentifrices on enamel previously exposed to an acidic soft drink. METHODS: 150 bovine enamel slabs measuring 6 x 3 x 2 mm were grounded flat and polished. Surface roughness was measured to obtain Ra (microm) baseline values using a profilometer. The slabs' outer surface was covered with a tape except for a 3 x 4 mm window. According to a randomized complete block design, specimens were exposed to an acidic drink or distilled water (control) for 5 minutes, and then to artificial saliva for 1 minute. Next, the experimental units were submitted to 5,000 brushing strokes using one of four dentifrices - regular (RE), baking soda (BS), tartar control (TC) or whitening (WT) - or distilled water as control (CO) (n=15). At the end of five repetitions of this erosive/abrasive cycle, the tape was removed and final readings of surface roughness were carried out. Roughness gain consisted of the subtraction of the baseline values from the post-treatment measurements. Also, the enamel wear due to erosive/abrasive challenges was profilometrically determined. RESULTS: ANOVA did not show significant interaction between enamel condition (eroded and sound) and dentifrice (P> 0.05) for both roughness gain and wear. No significant effect was found for enamel condition and dentifrice in the wear analysis. The exposure of enamel to the acidic drink provided higher roughness gain than did distilled water. Tukey's test evidenced that TC yielded significantly greater increase in surface roughness than did both CO and WT, whereas BS and RE induced an intermediate roughness gain.

Analysis of Variance↗

PubMed2005

Effect of a stannous fluoride dentifrice on the sulcular microbiota: a prospective cohort study in subjects with various levels of periodontal inflammation.

OBJECTIVES: To assess the effects of an experimental 0.454% stannous fluoride (SnF2) dentifrice on the oral sulcular microbiota in patients with various stages of oral diseases using checkerboard DNA-DNA hybridization. MATERIAL AND METHODS: In the present one-month, single center, single product, prospective cohort trial, 37 adults (mean age 37.6) were assigned to one of four oral health condition cohorts with seven to 10 subjects each: 1. mild gingivitis, 2. marked generalized gingivitis to moderate periodontitis, 3. caries-prone and 4. treated moderate to advanced chronic periodontitis in supportive periodontal care. All four groups were asked to use the test dentifrice and a power toothbrush twice a day for one minute during a four-week test period. Before and after the trial period, Plaque Indices (PII, Silness and Löe, 1964) and Gingival Indices (GI, Löe and Silness, 1963) were recorded. Subgingival plaque samples were collected from all patients at Baseline, as well as after two and four weeks. These samples were analyzed for content of 40 bacterial species using checkerboard DNA-DNA hybridization. RESULTS: As a result of the only one minute brushing with the stannous fluoride dentifrice, the mean PII at Baseline was significantly lower (p < 0.05) from the mean PII at four weeks. No statistically significant differences were found between premolar and molar mean values. Moreover, no statistically significant differences were found between the mean GI at Baseline and at four weeks. The microbiological analysis showed that at baseline subjects in groups 2 and 4 had significantly higher bacterial loads of bacteria than groups 1, and 3 (i.e. A. actinomyctemcomitans P. gingivalis, T. forsythia, and T. denticola. Over the study period, the total bacterial load did not change in groups 2, 3 and 4. In groups 1 and 3, however, an increase in the loads of Streptococci spp. were noticed (p < 0.05) including S. mitis, S. intermedius, and S. sanguis (p < 0.01) suggesting an increase in the presence of early colonizing and health associated bacteria. CONCLUSION: One minute brushing with a 0.454% stannous fluoride dentifrice did--after four weeks--not affect the subgingival microbial profiles in patients with moderate periodontitis and treated moderate to advanced periodontitis. However, the sulcular microbial profiles of mild gingivitis and caries-prone patients were affected, indicating a shift towards a gingival health associated microbiota in the sulcular region of patients not affected by attachment loss. RUNNING HEAD: Effect of stannous fluoride on sulcular microbiota.

Adult↗

PubMed2005

Clinical evaluation of dentinal hypersensitivity treatment with 5% potassium nitrate dentifrice.

AIM: To evaluate the desensitizing effect of a Bulgarian-made dentifrice containing 5% potassium nitrate in a double-blind experiment. MATERIAL AND METHODS: The study included 40 clinically healthy individuals aged 23 to 60 years, who complained of increased sensitivity to thermal, chemical and mechanical stimuli in 462 teeth. The recruited patients were allocated into two groups: 20 patients were treated with the Sensi I dentifrice, and the other 20--the Sensi II dentifrice. The outcome of treatment was evaluated by any alteration in pain sensitiveness in response to different stimuli and changes in the threshold of electrical excitability. RESULTS: The Sensi I toothpaste (containing 5% potassium nitrate) was found to have a better desensitizing effect than the Sensi II placebo toothpaste (P < 0.01). The Sensi I dentifrice caused a rise in the threshold of electrical excitability of sensitive teeth with clinically intact enamel (P < 0.01), teeth with erosions (P < 0.05) and teeth with exposed root surfaces (P < 0.001). CONCLUSION: The Sensi toothpaste, containing 5% potassium nitrate, demonstrated a pronounced anesthetizing effect; it can be used successfully for treatment of dentinal hypersensitivity of teeth with clinically intact enamel, erosions and exposed root surfaces due to gingival recessions.

Adult↗

PubMed1991

[Fluoride accumulation of the surface enamel of primary tooth after supervised brushing with a low dose-fluoridated dentifrice].

The fluoride accumulation on the surface enamel of primary incisive using a low dosed fluoridated dentifrice (0.085% F) was determined in vivo in comparison with a placebo dentifrice within a longitudinal study. After 12 months supervised brushing the superior incisive of the preschool children used the fluoridated dentifrice show a fluoride concentration of 609 ppm, after 20 months 612 ppm fluoride. The fluoride concentration of the surface enamel of the placebo group was 380 (after 12 months) and 385 ppm fluoride (after 20 months). Presume the optimal caries prevention should not reach by only using the low dosed fluoridated dentifrice.

Child, Preschool↗

PubMed1990

Clinical study of the anticaries efficacy of three fluoride dentifrices containing anticalculus ingredients: three-year (final) results.

A 3-year double blind clinical trial was conducted to compare the caries inhibition of an A.D.A.-accepted fluoride dentifrice to the caries inhibitions provided by three fluoride dentifrices containing anticalculus agents. All dentifrices used a compatible silicon dioxide abrasive system. The initial mean age of the subjects was 9.9 yrs and they resided in F-deficient (F less than 0.3 ppm) communities on Long Island, NY. Caries activity in all groups was low with the average annual increment being less than one surface. There were no statistically significant differences in any of the dental parameters tested, DMFS, DMFT, and buccolingual, mesiodistal and occlusal surface increments. It was concluded that the presence of anticalculus agents, specifically soluble pyrophosphates, zinc chloride and zinc oxide, do not interfere with the caries inhibition benefits of fluoride in a compatible dentifrice formulation.

Acidulated Phosphate Fluoride↗

PubMed1990

Over-the-counter dentifrices in the treatment of tooth hypersensitivity. Review of clinical studies.

Dentinal hypersensitivity is a common condition. Most cases, after professional diagnosis, can be treated simply and inexpensively by home use of a desensitizing dentifrice. Because the habit of toothbrushing with a dentifrice for cosmetic reasons is well established in the population, compliance with this regimen is not a problem. Dentifrices incorporating potassium nitrate, strontium chloride, and dibasic sodium citrate have all been clinically determined to be effective desensitizers, and several brands have been critically evaluated and accepted by the Council on Dental Therapeutics of the ADA. During the years, clinical methodology has evolved from monadically designed, subjective investigator reports to present-day, double-blind, placebo-controlled clinical trials employing stimuli that are quantifiable in physical units. Future development of more effective desensitizing dentifrices will depend on standardization in clinical design, especially regarding stimulus choice and mode of application.

Clinical Trials as Topic↗

PubMedDate not supplied

The comparative clinical cariostatic efficacy of sodium fluoride and sodium monofluorophosphate dentifrices: a review of trials.

This report reviews the methods and findings of published clinical studies comparing dentifrices containing sodium fluoride (NaF) and sodium monofluorophosphate (Na2PO3F) for the purpose of determining whether sodium fluoride formulations have superior cariostatic effects. Nine of ten reported trials found a numerical advantage for sodium fluoride dentifrices with highly compatible abrasive systems and the hypothesis that these two fluoride agents have equivalent cariostatic effects is rejected (p = 0.011). Therefore, the collective clinical evidence demonstrates that dentifrices containing NaF have greater cariostatic effectiveness than dentifrices containing Na2PO3F.

Calcium Pyrophosphate↗

PubMed1989

Fluoride uptake from NaF/pyrophosphate anticalculus dentifrices in vitro: effect of pyrophosphate dose.

Fluoride uptake from anticalculus dentifrices containing combinations of sodium fluoride and variable doses of soluble pyrophosphate has been evaluated in an in vitro fluoride uptake model. Artificial carious lesions were treated for 30 minutes in 25% w/w saliva slurries of dentifrices. Fluoride uptake into the partially demineralized enamel was assessed by microdrill biopsy. Results show equivalent fluoride uptake for dentifrices containing 0.243% sodium fluoride in combination with 0, 4.0 and 5.0% soluble pyrophosphate. These results, coupled with analytical measures of available fluoride, suggest no negative effects of pyrophosphate on fluoride availability or access to artificial carious lesions for soluble pyrophosphate concentrations up to 5.0% in a conventional (1,100 ppm fluoride) sodium fluoride dentifrice system.

Dentifrices↗