Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Contraindications”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 415 records · Page 23Linked to original sources
PubMed1975

Oral diazoxide contraindicated in severe hypertension with renal failure.

Diazoxide was given orally to nine hypertensive patients with renal failure and its effect on blood pressure and on glucose metabolism was studied. There was no long-term antihypertensive effect. During treatment insulin release and glucose assimilation after an intravenous glucose load were frankly impaired, but this impairment was reversible after stopping the treatment. Two major complications (diabetic ketoacidosis and pancreatitis) were observed. In view of these observations, the authors are of the opinion that oral diazoxide is contraindicated in the treatment of hypertension in patients with renal failure.

Acute Disease↗
PubMed1993

Laparoscopic cholecystectomy in pregnancy: contraindicated or indicated?

Laparoscopic cholecystectomy has proven to be superior to traditional open cholecystectomy in uncomplicated cases of cholecystitis. The patients experience less pain with less need for narcotics, fewer incisional complications, earlier postoperative ambulation, and a shorter hospitalization. It is our opinion that pregnancy, previously considered an absolute contraindication to laparoscopic cholecystectomy, is now an indication for laparoscopic cholecystectomy in select patients. We describe one of our cases of laparoscopic cholecystectomy during pregnancy. The patient was at 17 weeks gestation and had an unremarkable procedure and a recovery similar to that expected for a non-pregnant patient. Review of current literature has shown that this procedure can be done safely and with an excellent outcome for both the patient and her fetus.

Adult↗
PubMed1996

Clinical aspects of the Ross procedure: indications and contraindications.

In the past decade, the pulmonary autograft procedure has emerged as the operation of choice for young individuals with aortic root pathology not amenable to repair. This is due in large part to the durability of the pulmonary autograft in the aortic position. Freedom from thrombosis and long-term anticoagulation also provide support for its application, as well as the pulmonary autograft's similarity to the human aortic valve. The present indications for the Ross procedure continue to broaden. Patient age is certainly a factor, with the upper limit being 50 years. Patients who present with mechanical or bioprosthetic aortic valve dysfunction also seem to be appropriate candidates for the procedure, as do those who present with active endocarditis. Athletes also are an appropriate subset based on the absence of anticoagulation and the extreme physiological and hemodynamic consequences of their chosen field. Contraindications to the Ross procedure include multivessel coronary artery disease as well as multiple pathology in which a second valve replacement device is required. Extremes of age and severely depressed left ventricular function also contradict application of the pulmonary autograft.

Age Factors↗
PubMed1998

Paclitaxel plus vinorelbine in metastatic breast Ca patients with contraindications to receive anthracyclines.

Thirty-three metastatic breast cancer patients with prior chemotherapy (adjuvant alone, 9 patients; chemotherapy for metastatic disease alone, 13 patients; chemotherapy for both, 11 patients) received paclitaxel (Taxol) 135 mg/m2 over 1 h followed by vinorelbine (Navelbine) 30 mg/m2 over 10 minutes on day 1 every 3 weeks. All patients had contraindications to receive anthracycline therapy (primary resistance, 10 patients; dose reaching the maximum recommended dose and/or myocardiopathy, 23 patients). Twenty-eight patients had previously received anthracyclines, and the remaining 5 had received prior CMF (cyclophosphamide, methotrexate, fluorouracil). The combination of paclitaxel plus vinorelbine was given as first-line chemotherapy for metastatic disease to 9 patients and as second- or third-line to the remaining 24 patients. The mean number of metastatic sites was 2 (range 1-5). Twenty-two patients had visceral involvement. Overall, 3 complete and 13 partial responses were observed among the 33 patients (objective response rate 48.5%, 95% confidence interval 31% to 66.5%). The response rate in patients receiving the regimen as first-line chemotherapy was 67% (6/9 patients), compared to 42% (10/24) in those receiving the regimen as second- or third-line chemotherapy. Primary anthracycline-resistant patients showed a response rate of 60% (6/10), whereas the remaining patients had a response rate of 43.5% (10/23). The main toxicities were grade 3 alopecia (92%), grade 3-4 neutropenia (28%), neutropenic fever (16%), grade 1-2 peripheral neuropathy (44%), arthralgias-myalgias (32%), and hypersensitivity reactions (8%). Phlebitis was a significant clinical problem in patients receiving the drugs through a peripheral vein.

Adult↗
PubMed1998

Insulin lispro (Humalog), the first marketed insulin analogue: indications, contraindications and need for further study.

OBJECTIVE: To review the available literature on the new insulin analogue insulin lispro and provide information on its efficacy, indications for use and contraindications. DATA SOURCES: MEDLINE searches were made for articles published from 1966 to 1996 using the indexing term "lispro", "Humalog" and "insulin analogs". STUDY SELECTION: About 30 studies and review articles were selected based on their relevance to the stated objective. These were critically appraised for the purpose of writing the review article so that it would be relevant to general practitioners, internists and nurse educators. DATA SYNTHESIS: The therapeutic challenge when treating diabetic patients is to bring the blood glucose level into as normal a range as possible, with minimal hypoglycemia and hyperinsulinemia. Insulin lispro has a much faster, higher and shorter-lasting peak serum insulin level than regular human insulin, thus mimicking physiologic secretion of insulin more closely. As a result, there is improvement in postprandial blood glucose levels and decreased episodes of hypoglycemia, with no change in the hemoglobin A1c (HgbA1c) level. The ability to inject insulin lispro immediately before the meal allows greater flexibility of lifestyle. Compared with regular insulin, insulin lispro is associated with a lower risk of hypoglycemia with exercise several hours after a meal. It is therefore most useful for the motivated, compliant diabetic patient who would like to achieve a better hypoglycemia-HgbA1c ratio as well as for patients desiring further flexibility with premeal insulin injections. Use of insulin lispro has been shown to improve HgbA1c levels in patients using insulin pumps. It is well tolerated, and therapy is often continued after studies are completed. Further study is needed to establish optimal basal regimens.

Blood Glucose↗
PubMed1998

[Is surgery for portal hypertension a contraindication for liver transplantation?].

INTRODUCTION: Orthotopic liver transplantation (OLT) is the only curative treatment for hepatic cirrhosis and is the most effective in the control of portal hypertension. The aim of this study was to analyze whether greater morbi-mortality is observed in patients undergoing liver transplantation with previous surgery for portal hypertension with respect to patients not having undergone this surgery. MATERIALS AND METHODS: Different variables were analyzed in 2 groups of transplanted patients: one of 18 patients who had previously undergone surgery for portal hypertension and another group of 54 patients without this previous surgery. RESULTS: The following factors were studied: mean operative time and length of anahepatic phase, intraoperative consumption of concentrates of erythrocytes, fresh frozen plasma, units of platelets and cryoprecipitates, days of mechanical ventilation, stay in the ICU and total postoperative stay. No significant differences were observed (p < 0.05) in any of these factors or in survival. DISCUSSION: On analysis of the difficulty of surgical technique, postoperative evolution and survival and based on the variables described it may be concluded that previous surgery for portal hypertension does not only not contraindicate posterior liver transplantation, but rather may be useful in patients with an adequate hepative reserve presenting variceal hemorrhage since posterior transplantation does not present a worsened prognosis.

Adult↗
PubMed1972

Oral contraceptives contraindicated for nursing mother.

F.S. Schroeder (Eureka, Montana) asked: Is it wise or advisable for a nursing mother to take oral contraceptives? Answer (by W.N. Spellacy): It is neither wise nor advisable to prescribe oral contraceptives to nursing mothers. This is because the steroid components, as is the case with most drugs, are excreted into the milk. Their effects on the neonate are variable and dose-dependent. For example, an androgen-type progestagen may masculinize a female infant, and steroid metabolites may contribute to neonatal jaundice. Accordingly, most pharmaceutical companies include a Food and Drug Administration approved statement in their drug advertisements under warnings: A small fraction of the hormonal agents in oral contraceptives has been identified in the milk of mothers receiving these drugs. The long-range effect to the nursing infant cannot be determined at this time.

Contraception↗