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Clip-induced biliary stone.

Surgical clip migration is a well-known phenomenon ever since their first use in surgery. The mechanism of clip migration is poorly understood, and can occur from days to years after laparoscopic cholecystectomy. Migration of the surgical clips may be a complex process involving necrosis, pressure exerted from intra-abdominal movement, formation of stones over the exposed clip within the bile duct, and eventual migration into the common bile duct. We report two cases, a 58-year-old man and a 54-year-old woman, of clip- induced biliary stones resulting from surgical clip migration a few years after laparoscopic cholecystectomy.

Cholecystectomy, Laparoscopic↗

Intraoperative localization of early-stage gastrointestinal tumors using a marking clip detector system.

Intraoperative Tumor site recognition is extremely difficult during laparoscopic surgical treatment of early-stage gastrointestinal carcinoma. A novel marking method that uses both metallic clips and a marking clip detector system (MCDS, Olympus Optical Co., Tokyo, Japan) modified from a metal detector system, was designed by the authors. Metallic clips were applied to the tumor site during preoperative endoscopy, and the clip site was identified intraoperatively using the MCDS. In a basic ex vivo study, three metallic clips were detected easily (100% detection). In a clinical study, the marking site was detected in all gastric cancer patients who underwent laparoscopic subtotal gastrectomy. The mean distance between detected site and clip along the longitudinal bowel axis was 6.4 +/- 2.9 mm. Mean detection time was 18.1 +/- 5.7 seconds. None of the patients in this study experienced complications from this marking technique. MCDS allows accurate identification of tumor sites. This method may be useful for tumor-site identification during laparoscopic gastrectomy.

Aged↗

Non-clip laparoscopic colectomy using electrothermal bipolar vessel sealer clinical experiences.

BACKGROUND/AIMS: An electrothermal bipolar vessel sealer (EBVS) has been developed as an alternative to suture vessels, hemostatic clips, staplers and ultrasonic coagulators for ligating vessels and tissue bundles. To leave the artificial material in the abdominal cavity, such as hemostatic clips or staplers, is undesirable because some complications have been reported and their long-term effects are not well known. We have performed laparoscopic colectomy without any metastatic clips using EBVS to divide all vessels. METHODOLOGY: From 2001 through 2002, ten consecutive patients underwent laparoscopic colectomy for colon cancer and ulcerative colitis with non-use of hemostatic clip technique in Kobe University Hospital, Kobe, Japan. RESULTS: All procedures were performed successfully without any kind of trouble. The average blood loss was 103.1 +/- 42.6mL. The average operation time was 234.0 +/- 11.1 min. There were no postoperative complications or death. In addition to the minimal blood loss and procedure time, the merit of EBVS is to leave no artificial material behind in contrast to the application of hemostatic clips or staplers. CONCLUSIONS: The use of EBVS is safe and easy in laparoscopic colectomy. This non-clip technique using EBVS will reduce the opportunity to leave artificial materials in the abdominal cavity.

Aged↗

A monoclonal antibody directed against CLIP (ACTH 18-39). Anatomical distribution of immunoreactivity in the rat brain and hypophysis with quantification of the hypothalamic cell group.

After the recent demonstration of the facilitatory effect exerted by corticotropin-like intermediate lobe peptide (CLIP or adrenocorticotropic hormone (ACTH) 18-39) on paradoxical sleep in the rat (Chastrette and Cespuglio, 1985), we undertook the production of monoclonal antibodies against this peptide. Wistar rats were immunized against CLIP and their spleen cells fused with mouse myeloma cells. After recloning, 25 supernatants were found to give positive immunohistochemical reactions in the rat brain. In immunohistochemical tests performed by preabsorption, the 25 supernatants presented similar properties, i.e. recognized CLIP, ACTH (1-39) and ACTH (25-39), but not ACTH (1-24) and the C-terminal fragment (34-39). We assume that the epitope(s) recognized by the 25 supernatants is (are) located between the amino-acids Asn25 and Ala34 of the CLIP molecule. The immunoreactivity observed in the rat brain and hypophysis with this antibody was distributed with a pattern quite similar to that described for anti-ACTH antibodies. A main group of immunoreactive cell bodies was located in the mediobasal hypothalamus and a small group in the nucleus of the solitary tract. Immunoreactive fibres were distributed from the olfactory nucleus to the spinal cord and formed particularly rich networks in the hypothalamus and preoptic area. Among other locations, immunoreactive axons were also present in the brainstem centres involved in the control of the sleep-waking cycle, which is in accordance with the influence of CLIP on paradoxical sleep. Using Abercrombie's formula, the number of immunoreactive cells in the mediobasal hypothalamus was estimated at about 3000 neurons. We conclude that our monoclonal anti-CLIP antibody can be considered as a good marker of proopiomelanocortin neurons.

Adrenocorticotropic Hormone↗

Chronic administration of ketanserin and the development of two-kidney-two-clip Goldblatt renovascular hypertension in the rat.

The effect of ketanserin (Kt) has been analyzed during the development of two-kidney-two-clip (2k-2c) renovascular hypertension in the rat. Male Wistar rats were divided into four experimental groups: (1) clip Kt (ClKt) (n = 12)--A silver clip (0.25 mm width) was placed in each renal artery 3 days after beginning the administration of Kt (10 mg/kg/day) in the drinking water; (2) sham Kt (ShKt) (n = 13)--Similar to group 1, but the clips were placed in, and immediately removed from, the renal arteries; (3) untreated clip (UCl) (n = 10)--Similar to group 1, but the rats drank water; (4) untreated sham (USh) (n = 10)--Similar to group 2, but the rats drank water. Blood pressure (BP) was measured before surgery and was followed weekly for 7 weeks. At the end of this period, blood and cerebrospinal fluid (CSF) samples were obtained in all the animals. Plasma renin activity (PRA) and plasma and CSF angiotensinogen concentration (AoC) were evaluated. The results have shown that Kt partially inhibited the increase in BP induced by bilateral renal ischemia (BP: UCl rats 180.5 +/- 12.4 versus ClKt rats 149.8 +/- 5.1 mm Hg; p less than 0.01; USh rats 116.7 +/- 3.7; ShKt rats 114.4 +/- 5.0 mm Hg). PRA was similar in hypertensive and control rats whether or not they had received Kt. AoC in plasma was decreased in clipped treated and untreated rats.(ABSTRACT TRUNCATED AT 250 WORDS)

Angiotensinogen↗

[A case of ruptured middle cerebral artery aneurysm with acute subdural hematoma after clipping of the aneurysm nine years previously].

It is known well that acute subdural hematoma develops most frequently after head injury, and secondly from pathological lesions such as intracranial ruptured aneurysm or AVM. A case of ruptured middle cerebral artery aneurysm which was clipped nine years before resulting in acute subdural hematoma is reported. At 6 pm on July 21, 1988, a 53-year-old woman with severe headache starting at 4:20 pm was transferred to our hospital. She suffered from herniated signs; Conscious disturbance; anisocoria; positive OCR; decerebrate posture. An emergency CT showed right acute subdural hematoma with severe midline shift. Following a decompressing craniotomy at 9 pm, the subdural clot was evacuated. It measured 90g in volume and the underlying cortex was normal. There was no evidence of SAH. Right carotid angiography three weeks after the first operation showed a middle cerebral artery aneurysm at the site of a clip which had been applied nine years ago. A second operation was performed on August 30, 1988. Via the right pterional route, the middle cerebral artery aneurysm was clipped successfully with a Sugita's clip replacing the first clip. We concluded that the regrowth and rebleeding of the middle cerebral artery aneurysm which had been clipped nine years before was most probable. She was discharged with slightly decreased consciousness and right motor weakness, on November 13, 1988.

Acute Disease↗

MR imaging in patients with intracranial aneurysm clips.

Four patients with intracranial aneurysm clips made from a variety of alloys were studied without incidence by MR imaging at field strengths ranging from 0.35 to 0.6 T. Knowledge of the type of alloy used in the manufacturing of an aneurysm clip is important in determining whether the clip will or will not deflect in a magnetic field. Ferromagnetic clips show deflection and torque in a magnetic field and have the potential to dislodge from the aneurysm. Nonferromagnetic or weakly ferromagnetic aneurysm clips such as the Sugita (Elgiloy), Yasargil (316 LVM stainless steel), Heifetz (Elgiloy), Yasargil (Phynox), and Vari-Angle McFadden (MP35N) do not deflect or deflect weakly in the magnetic field and therefore would not be expected to dislodge during MR. The option of imaging many patients with intracranial aneurysm clips with MR extends the usefulness of the technique to a previously excluded population.

Adult↗

[Metallurgical study on Heifetz clip failure (author's transl)].

A metallurgical study on a fractured aneurysm clip (Heifetz) was described. The conclusion can be summarized by the following: 1) Metallurgical data clearly indicate that the mode of failure is intergranular creacking--probably form a stress-corrosion mechanism. 2) Surgically used aneurysm clip is always in corrosive environments form the metallurgical points of view. Apart from inadequate sterilization was well as mishandling, therefore, corrosion of a metal clip is unavoidable. 3) A clip with multiple parts and made from different alloys may have a greater tendency to corrode than a clip of the one-piece variety. In this meaning Yasargil's clips without strut may be most useful.

Corrosion↗

[Partial occlusion of the inferior vena cava by clips. Indications and results about 95 cases (author's transl)].

Vena cava clips were applied in 95 patients between October 1975 and October 1979, without mortality directly related to the surgical intervention. One patients died early after operation due to an associated thoracic aorta aneurysm. The 10 deaths occurring at a later stage were not related to the insertion of the clips or its consequences. One patient developed a pulmonary embolism during operation, as a result of a concomitant juxtarenal thrombectomy. Postoperative extension of a femoropopliteal thrombosis or bilateralization of an iliac phlebitis was observed in 31 p.cent (30 out of 95) of cases. Permeability of the inferior vena cava was confirmed in 32 patients, 65 p. cent of the clips remained patent. Lower limb venous sequelae, related to the insertion of the clip or its consequences, were noted in 34 p.cent (24 of 69) but caused little inconvenience. Severe venous disorders, due to the thrombo-embolic disease, were always present before the insertion of the clips. Postoperative morbidity was low, the clip causing extension of previously existing venous thrombosis, without significant distal sequelae. The absence of recurrence of pulmonary embolism demonstrates the efficacy of this method. The employ of a caval filter to preserve improved permeability of the inferior vena cava (IVC) is discussed.

Adolescent↗

[Clip migration in the common bile duct and consecutive calculus formation after laparoscopic cholecystectomy].

In 1991 a 64-year old woman underwent laparoscopic cholecystectomy for symptomatic gallstones. The follow-up was uneventful. Two years later a painless obstructive jaundice appeared. Endoscopic retrograde cholangio-pancreatography revealed a freely floating surgical clip within the common bile duct. It was a FILSHIE-Clip, commonly used to ligate the cystic duct. The endoscopic extraction of the foreign body was unsuccessful because the clip slipped into a small intrahepatic bile duct. Smaller gallstones that had probably crystallized around the clip could be extracted. Finally the clip itself disappeared spontaneously after endoscopic sphincterotomy through the papilla. It is discussed why movement of a surgical clip into the common bile duct appears after laparoscopic cholecystectomy.

Cholecystectomy, Laparoscopic↗

A comparative study of spring-loaded clips and electrocoagulation for female sterilization.

The surgical, immediately postoperative and delayed postoperative complications and complaints associated with spring-loaded clips and electrocoagulation as techniques of tubal sterilization at laparoscopy were evaluated in a comparative study. Each of the two techniques was randomly assigned to 150 subjects. All sterilizations were performed as outpatient procedures. Subjects were followed-up during the first six weeks and again at about six months after sterilization. Rates of complications (surgical and early postoperative) were similar for the two procedures. None of the subjects required subsequent hospitalization. Technical difficulties at surgery were more frequent with the spring-loaded clip technique, principally as a result of mechnical problems with the prototype laparoscope and clip applicator. Postoperative pelvic and abdominal pain were reported by a significantly higher proportion of the patients when the spring-loaded clip was used (spring-loaded clips, 43.6%; electrocoagulation, 31.5%). At the six-month follow-up examination, rates of abnormal pelvic findings and changes in menstrual cycle formation were similar for the two techniques of tubal occlusion. There was one procedure failure among the electrocoagulation patients and none among the spring-loaded clip patients.

Adult↗

Spontaneous vaginal expulsion of Hulka clips.

BACKGROUND: Laparoscopic Hulka clip application is a common method of outpatient sterilization in women. We present a patient who experienced spontaneous expulsion of two Hulka clips. CASE: A 21-year-old woman was seen 17 months after sterilization because of spontaneous, asymptomatic passage of two Hulka clips into the vagina. The passage of one clip went unnoticed by the patient. Radiographic studies confirmed the migration and absence of two Hulka clips previously placed on the left fallopian tube. CONCLUSION: In rare circumstances, Hulka clips can migrate from the abdominal cavity and be expelled spontaneously, possibly by transuterine passage. This migration may occur without the patient's knowledge.

Adult↗

Role of dopamine in the striatum, renin-angiotensin system and renal sympathetic nerve on the development of two-kidney, one-clip Goldblatt hypertension.

PURPOSE: The possible role of the striatum and renin-angiotensin (R-A) system for the development of two kidney-one clip (2K-1C) Goldblatt hypertension is examined. MATERIALS AND METHODS: Monoamine contents of the striatum were determined by brain dialysis techniques, and plasma and kidney levels of the R-A system were measured by radioimmunoassay in sham-operated rats (experiment 1), 2K-1C hypertension (experiment 2), left renal denervation only (experiment 3), renal denervation of left clipped-kidney (experiment 4) and left renal artery clipping with renal denervation of right nonclipped kidney (experiment 5) in the acute phase. RESULTS: Plasma angiotensin I (ANG I) and plasma angiotensin II (ANG II) were initially increased between the first day and the first week, were suppressed at the second week, then increased again at the third week. Renal denervation of clipped or nonclipped kidneys did not influence the plasma R-A system in 2K-1C rats. The levels of striatum dopamine (DA), dihidroxyphenylacetic acid (Dopac) and homovanillic acid (HVA) in hypertensive 2K-1C rats were higher than those in normotensive sham-operated rats. There were significant positive relationships between these monoamines and systolic blood pressure. Renal levels of ANG I, II and angiotensin I converting enzyme activity (ACE) in the clipped-kidney were significantly higher than in sham-operated and nonclipped kidneys of 2K-1C rats. CONCLUSION: The enhanced R-A system in clipped-kidney and high levels of monoamines described above in the striatum appear to participate in the development of 2K-1C hypertensive rats.

3,4-Dihydroxyphenylacetic Acid↗

[Bleeding from unruptured dissecting aneurysm in the vertebral artery after proximal clipping].

This is a case report of a patient with unruptured dissecting aneurysm in the vertebral artery that bled after being treated by proximal clipping. A 53-year-old male was admitted to our hospital due to transient right hemiparesis which occurred 20 days prior to his admission. He had been medicated for hypertension for the previous 33 years. CT scan and MRI showed lacunar infarction in the left corona radiata, and an aneurysm was accompanied with clot in the prepontine cistern. Angiography revealed a dissecting aneurysm in the right intracranial vertebral artery. His right hemiparesis was derived from infarction in the left corona radiata. It was likely that the dissecting aneurysm might rupture in the future. Proximal clip ping was performed to prevent rupture of the aneurysm. After clipping of the right vertebral artery distal to the PICA, the wall of the aneurysm appeared to be drawn toward the clip blades and to be tensed by the blades. Four hours after the operation, he complained of severe headache, and experienced a sudden loss of consciousness and the immediate development of a deep comatose state. CT scan disclosed massive SAH in the right cerebellopontine and basal cistern. Repeat angiography demonstrated that the aneurysm was not visualized and the right vertebral artery distal to the aneurysms was opacified through the left vertebral artery. Ventricular drainage was performed, but the patient died on the 20th day after bleeding. It was suspected that the aneurysmal clip might have produced shear force on the weak adventitia of the dissecting aneurysms and that the intra-aneurysmal pressure might have increased because of blood back-flow via the contralateral vertebral artery after the proximal clipping.

Aortic Dissection↗

Aneurysm clips made of titanium: magnetic characteristics and artifacts in MR.

PURPOSE: To evaluate the magnetic characteristics, artifact formation, and implant safety of titanium aneurysm clips for use in MR imaging. METHODS: Aneurysm clips made of titanium alloy TiAl6V4 were tested in a magnetometer to determine their magnetic susceptibility and in a 1.5-T MR imager using both a geometric phantom and an animal model. A commercially available alpha-Phynox clip served as the reference standard. RESULTS: We found minimal magnetization and a significant reduction in image artifacts with the titanium clip as compared with the Phynox clip. CONCLUSION: The titanium clips improve image quality, biocompatibility, and patient safety in medical MR applications.

Aneurysm↗

Randomised trial of subcuticular suture versus metal clips for wound closure after thyroid and parathyroid surgery.

A randomised trial was conducted to compare the results of neck wound closure using metal (Michel) clips or subcuticular suture. All operations were performed using a standardised technique, which included wound infiltration with 10 ml bupivacaine and adrenaline solution, no strap muscle division and the use of suction drains. All the collar incisions and wound closures were performed by the same surgeon. At the end of each operation patients were randomised to wound closure by either metal clips (n = 38) or a continuous 3/0 prolene subcuticular suture (n = 42). Daily postoperative pain scores and the discomfort caused by clip/suture removal were recorded. The cosmetic appearance of each wound was scored by the patient, the surgeon, and an independent observer using verbal response and linear analogue scales. The two study groups were well matched for age, sex, indication for surgery and operation performed. There were no differences in postoperative pain scores between clips and sutures. Removal of subcuticular sutures was performed more quickly (P < 0.0001) and caused less pain (P < 0.0001, visual analogue scale; P = 0.0042, verbal response scale) than the removal of clips. At the time of discharge, the cosmetic appearance scores generated by the surgeon, patient and independent observer were higher for suture closed wounds than clips. However, by 3 and 6 months follow-up there were no differences in cosmetic appearance between the two methods of closure. Only very short-term cosmetic results are influenced by the type of wound closure in thyroid and parathyroid surgery, but sutures are quicker and less painful to remove than Michel clips.

Adult↗

Marker clip placement following directional, vacuum-assisted breast biopsy.

The purpose of this study was to evaluate the accuracy of marker clip placement after 11-gauge directional, vacuum-assisted breast biopsies. During a 9-month period, 150 stereotactic breast biopsies were performed using a directional, vacuum-assisted device and an 11-gauge probe. In 114 cases, a marker clip was deployed at the biopsy site using the through-probe method. In 94 cases, stereotactic coordinates of the clip were obtained and were available for retrospective review. Comparing the coordinates of the lesion with those of the clip, placement errors were calculated. Overall, clip placement was within 5 mm of the lesion in 81 per cent of cases, within 5-10 mm of the lesion in 17 per cent of cases, and >10 mm from the lesion in 2 per cent of cases. Mean total placement error was 4.5 mm. The mean z axis error was 3.2 mm, compared with 0.88 and 2.0 mm for the x and y axes, respectively. Marker clip placement after vacuum-assisted biopsy is an accurate method of localizing the biopsy site should subsequent surgery be required.

Adult↗

An evaluation of the Filshie clip for postpartum sterilization in Austria.

Voluntary sterilization is a popular method of family size limitation. Among other techniques for surgical induction of female sterility, the application of various kinds of clips to the Fallopian tubes has been introduced. The Filshie clips consist of rubber-lined titanium and their use for interval sterilization has been repeatedly published. So far, there are only a few reports regarding the use of Filshie clips during the postpartum period, when tubes are edematous and more friable. Therefore, 300 women voluntarily requesting postpartum surgical sterilization for the purpose of family size limitation were enrolled into a prospective trial. Within 72 h of delivery, 282 women were sterilized under general anesthesia using a subumbilical minilaparotomy approach and Filshie clip application. Of these women, 251 were available for follow-up examination at 6 weeks, 240 at 6 months, 234 at 12 months, and 209 at 24 months after the sterilization procedure. Complication rates were low, and there were no pregnancies during the follow-up period. These results indicate that the application of Filshie clips is a safe and efficacious method of surgical female sterilization in the postpartum period.

Adult↗