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Results for “COCARBOXYLASE”

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PubMed1980

[Experiences with cocarboxylase treatment of alcoholics in ambulatory care].

A report is given on a treatment carried out in 1971 in 20 adults alcoholic outpatients by means of intravenously administered carboxylase and vitamin B injections. Under abstinence, a reduction in the addiction, psychic activation and physical recuperation without withdrawal symptoms occurred within a few days. Absolute permanent abstinence, which was aimed at, was observed in seven patients, lasting over a period of three to five years. In another six patients is lasted for several months up to two years. In two alcoholics, an improvement of the condition without a longer lasting abstinence was obtained; five patients could hardly be influenced. A subsequent treatment might probably improve the rate of success obtained with this method. The disturbance of the pyruvate metabolism in chronic alcoholism as a cause of the addiction is discussed.

Adolescent↗
PubMed1982

Growth requirements of Haemophilus somnus.

The growth factor needs of Haemophilus somnus, which have not been defined to date, were found to be provided by 1% IsoVitaleX (IVX; BBL Microbiology Systems) in tryptose broth. Some growth, however, occurred in unsupplemented tryptose broth. Of the ingredients of IVX, cocarboxylase was found to stimulate growth to about the same degree as the total supplement. Cocarboxylase was without direct effect in 2% peptone broth, which supported no growth of 25 H. somnus strains until supplemented with IVX, optimally at the 10% level. This could be substituted for by proportional amounts of cysteine or cystine, but by no other IVX ingredient. Cysteine-cystine and IVX but not cocarboxylase supplementation allowed H. somnus to grow in Eagle minimal medium, a completely synthetic medium, but attempts at serial passage were unsuccessful.

Culture Media↗
PubMedDate not supplied

[The influence of modulators of enzyme activity on the pharmacological effect of thiopental sodium and ketamine and on the pharmacokinetics of thiopental sodium].

The rat experiments studied the impact of inductors and inhibitors of enzymatic activity of xenobiotic metabolism on the pharmacological activity of sodium thiopental and ketamine and on the pharmacokinetics of sodium thiopental. Cocarboxylase, cobalt chloride and cimetidine enhanced the pharmacological action of sodium thiopental, but failed to exert any action on the effect of ketamine. The preparations of vitamin K, particularly vikasol and menadione sodium bisulfite, and phenobarbital attenuated the effects of these anesthetics, but tocopherol unchanged it. Phenobarbital and vikasol accelerated blood elimination of sodium thiopental, whereas cimetidine and cocarboxylase slowed down this process.

Animals↗