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408 records · Page 23Linked to original sources
PubMed1991

Spatially localized magnetic resonance spectroscopy of the brains of normal and asphyxiated newborns.

Phase-modulated rotating frame imaging is a modification of magnetic resonance spectroscopy, which uses a linear radiofrequency field gradient to obtain spatially localized biochemical information. Phase-modulated rotating frame imaging was used to study regional cerebral energy metabolism in the brains of 9 normal newborns and 25 newborns after birth asphyxia. Relative concentrations of phosphorus-containing metabolites and intracellular pH were determined for brain tissue at three specified depths below the brain surface for all neonates. Wide variations in metabolite ratios were seen among normal neonates, and considerable metabolic heterogeneity was demonstrated in individual neonates by depth-resolved spectroscopy. Asphyxiated neonates with severe hypoxic-ischemic encephalopathy and a poor neurodevelopmental outcome showed the expected rise in inorganic orthophosphate and fall in phosphocreatine concentrations in both global and spatially localized spectra. Phase-modulated rotating frame imaging showed that metabolic derangement was less in superficial than in deeper brain tissue. The inorganic orthophosphate-adenosine triphosphate ratio from 1 to 2 cm below the brain surface was more accurate than any global metabolite ratio for the identification of neonates with a poor short-term outcome. These data are consistent with the known vulnerability of subcortical brain tissue to hypoxic-ischemic injury in the full-term neonate.

Adenosine Triphosphate↗
PubMed1990

[The evaluation of an anti-leprosy program in Uélés (1975-1989)].

Foperda, who took over and continued the work initiated in 1924 by the Congo Red Cross, is responsible for the programme of fight against leprosy in the Ueles region (Zaire). Important results have been obtained since 1975 in the framework of a specialised medical service. These results are exposed and discussed herebelow. The evolution of the endemic leprosy in the region under survey allows to contemplate new trends for the pursuit of the programme in the coming years (controlled integration within polyvalent health services).

Democratic Republic of the Congo↗
PubMed1979

Biochemical assessment of the nutritional state of gravida of different socio-economic classes at the Wesley Guild Hospital, Ilesha, Nigeria.

Non-pregnant women from the low socio-economic class were found to have significantly lower haemoglobin, plasma transferrin and retinol-binding protein concentrations than those from the upper classes. Pregnancy in these poor women resulted in a further significant lowering of these constituents. Children born to such mothers had significantly lower birthweights and plasma transferrin concentrations. A highly significant positive correlation was found between maternal serum transferrin concentration and birthweight, suggesting that this protein is a sensitive index of nutritional state in pregnancy.

Birth Weight↗
PubMed1995

Electrocardiogram monitoring at rest and during exercise in 31P magnetic resonance spectroscopy studies of the human heart at 1.9 tesla.

An electrocardiogram (ECG) monitoring system has been developed and evaluated in normal volunteers (n = 7) and patients with various cardiac diseases (n = 24) in a 1.9 tesla magnet during magnetic resonance spectroscopy studies. To minimize an ECG signal path, and thus to reduce motion-related artifacts on the ECG during a dynamic exercise test, one coaxial cable was used to obtain the ECG signal from two electrodes placed parallel to the longitudinal body axis on the left side of the chest. A fiber optic link and an inductor-capacitor low-pass filter were used to remove extraneous radiofrequency (RF) noise and RF pulse artifacts respectively, and the examination bed was solidly supported on the base of the magnet. The ECG monitoring system provided a useful means for continuous recording of the ECG independently of the R-R interval in the high magnetic field, and permitted reliable monitoring of the QRS complex of the subject at rest and during exercise.

Atrial Fibrillation↗