Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Autobiography”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 415 records · Page 23Linked to original sources
PubMed1996

Biological miracles and misadventures: identification of sensitization and asthma in enzyme detergent workers.

The discovery that the enzymes used in biological washing powders were asthma-causing sensitizers derived initially from the concern of an industrial physician as to the possibility of pulmonary damage due to the proteolytic nature of the material. This caused a search for possible cases of enzyme-related illness. Careful history-taking led to a hypothesis concerning sensitization and allergic illness which was supported experimentally by skin prick tests and inhalation challenge tests, and later by radioallergosorbent tests (RAST). It seems that the consequences of handling this potentially allergenic material as a fine powder had not been anticipated; and failure to analyze cases of sickness, to identify asthma, and to consider its workplace source had prevented its recognition elsewhere. Contributing to this failure was the pattern of development and manifestations of allergic illness, which seldom occurred in the workplace and was not confined to enzyme workers or atopics. In some cases the incidence of illness had been suppressed, or investigation prevented.

Asthma↗
PubMed2000

My journey from wool research to insulin.

This paper is an autobiographical study of the author's early work on the chemical cross-linking of proteins as well as on oligomer and peptide synthesis from 1949 in Heidelberg until the synthesis of insulin in 1963 in Aachen.

Animals↗
PubMed1998

Chinese hamster cells meet DNA repair: an entirely acceptable affair.

This personal account relates the advent of mutant isolation and other developments in somatic cell genetics that were critical steps toward isolating DNA repair mutants in mammalian cells. The isolation of auxotrophic and temperature-sensitive mutants in genetically stable Chinese hamster cell during the late 1960s and early 1970s provided a conceptual framework in which to later isolate mutations conferring hypersensitivity to ultraviolet radiation, ionizing radiation, and various chemical mutagens. Complementation group analysis of ultraviolet-sensitive mutants helped identify multiple genes that overlapped with the groups of cancer-prone xeroderma pigmentosum, as well as Cockayne syndrome. The first mammalian cell mutants defective in strand-break repair were also discovered. Subsequent cloning of human genes that corrected CHO-cell mutations in nucleotide-excision repair groups 1-6 later led to identifying the key enzymes in the incision steps of this pathway, as well as the CSB protein, which is involved in coupling excision repair and transcription.

Animals↗
PubMed1999

The first pure embryonic inducing factor.

This is a personal account of the discovery of the mesoderm-inducing activity of fibroblast growth factors. The background is my work on the dorsalising signal in early amphibian embryos that was done at the imperial Cancer Research Fund in London. I became interested in mesoderm induction because of the embryologic work of Nieuwkoop and the partial purification of a "vegetalising factor" by Tiedemann. Although, initially, we expected inducing factors to be novel substances, it gradually became clear that the impure preparations we were studying had properties in common with growth factors. This opened the way to the testing of candidate factors, resulting in the conclusion that some inducing factors and growth factors,in fact, were the same molecules despite being discovered through different routes and assayed using different methods. After a slow start looking at the molecular biology of fibroblast growth factors in Xenopus, we eventually found that their most interesting functions in early development lay not at the stage of mesoderm induction but, rather, in the anteroposterior patterning of the body, which occurs during gastrulation.

Animals↗
PubMed2000

A view on the science: physical anthropology at the millennium

EDITOR'S NOTE The year 2000 marks the onset of the 21(st) century. In this transitional year, prominent physical anthropologists will provide brief reflections on our discipline, including what attracted them to it, and their views on the directions our discipline may pursue as we enter, in January 2001, the third millennium. Copyright 2000 Wiley-Liss, Inc.

Journal Article↗
PubMed1993

The effects of written autobiographical recollection induction procedures on mood.

This study assessed the effects of group induction procedures that are practical in their administration (written format) and also individualized. Fifty-four females and 36 males were assigned randomly to one of three conditions. Conditions One and Two consisted of subjects being asked to think of the two saddest or two happiest events of their lives, respectively. Condition Three consisted of a control condition in which subjects were asked to read a geography article. The procedure produced marked decreases in depression (p < .001) and anxiety (p = .001) as mood states in Condition One (happy events) and marked increases in depression (p < .001) and anxiety (p < .001) in Condition Two (sad events). These procedures are particularly suitable for mood induction in a group setting.

Adolescent↗
PubMed1976

Reflections on a do-it-yourself training program in clinical psychology.

This paper is a somewhat modified version of the inaugural Rapaport--Klein Memorial Lecture at Austen Riggs Center presented June 21, 1974. The author describes the experiences, the series of "apprenticeships" and clinical exposures, which coalesced into his education, from teenage days in the New York Madison House settlement, through Harvard undergraduate and graduate work, to Worcester State Hospital as head of psychological services and research. In conclusion, the author discusses the effects of the kinds of training experiences he has described on the issues that arose in the formulation of formal standards of training in clinical psychology.

Attitude of Health Personnel↗
PubMed1977

Reminiscences of a sociologist: Rudolf Herberle.

The author tells of his drift from law and economics into sociology at a time when this field was not yet institutionalized in his native Germany. He describes his research experiences in European countries and in America. He shows how working on a variety of seemingly disconnected subjects contributed to his education as a sociologist. He also discusses his experiences as teacher and author during the first years of the Hitler regime.

Demography↗
PubMed2000

Fission yeast on the brink of meiosis.

The fission yeast Schizosaccharomyces pombe (S. pombe) is now well established as a versatile genetic model organism. It is widely used to analyse the basic eukaryotic cell cycle during vegetative growth and it is also well suited to studies on the elementary processes of sexual reproduction, including intercellular communication and signal transduction in zygote formation, as well as meiosis before sporulation. Systematic mutant screening has contributed much to our current understanding of unicellular differentiation in S. pombe, and structural analysis has revealed a simplified meiotic prophase with abundant crossing-over but no homologue synapsis. This article is a personal account of how this branch of fission yeast genetics has developed.

Denmark↗
PubMed1985

Twenty-five years of behavioral toxicology within occupational medicine: a personal account.

Decisive for my long-term involvement in behavioral toxicology were the hours spent in interviewing and testing patients with occupational poisonings during the first years of my career as a clinical psychologist within the framework of occupational medicine. Important auxiliary factors were the innovative and inspiring scientific climate at our Institute, and the supportive kind of scientific education provided by this environment during the years. It has been rewarding and exciting to follow the international progress of behavioral toxicology. Advances in this special domain of research were and are partly related to advances in occupational epidemiology and toxicology, in neurotoxicology and other allied disciplines, as well as to advances in other branches of psychology. But the major challenge to behavioral toxicology during the first decades of its existence has been finding its place and role within these disciplines. Important challenges for the next decades are defining further the exposure-effect relationships as a basis for the standard setting, extending the surveillance of neurotoxic hazards to the developing countries, and searching for better understanding of the practical significance o neurobehavioral effects, eg, from the point of view of the afflicted individual. To realize these aims, further efforts are needed to coordinate the field of behavioral toxicology and to augment communication between those immediately involved.

Finland↗