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Genetic factors in reproduction and their evolutionary significance.

PROBLEM: The reproductive process is a major driving force in human evolution. An evolutionary perspective was brought to bear on some aspects of reproduction and its aberrations, and, conversely, some of the insights of modern reproductive genetics were used to investigate problems in evolution. METHOD: The data used were obtained from the literature in evolution, anthropology, archeology, linguistics, and genetics. RESULTS: The evolutionary line leading to modern humans diverged from that leading to the chimpanzees approximately 5-7 million years ago (Mya). Archaic Homo sapiens emerged ca. 0.3 Mya, and modern Homo sapiens and the development of language ca. 0.1 Mya; thus, modern humans occupy approximately 2% of the evolutionary history of the hominid line. During all of this time, the ancestors of modern humans were migratory hunter-gatherers. It was only during the Neolithic transition ca. 0.01 Mya (approximately 0.2% of hominid evolutionary history) that agriculture was developed, and with it a settled lifestyle that allowed a more stable existence and the development of a different reproductive pattern. Various estimates indicate that the human population increased from 0.05 million at the time of the emergence of modern Homo sapiens to 6,000 million at the present time (120,000-fold increase). CONCLUSIONS: These evolutionary considerations were used to explore three areas: (1) the extinction of the Neanderthals, who coexisted for ca. 65,000 years with modern humans; (2) the relatively low and stable rate of human conceptions (20-35% of ova fertilized naturally or fertilized in vitro); and (3) the long postnatal period required for the full maturation of the immune response. From these considerations, a broad view of the human reproductive process was obtained that may provide some insight into the rationale for the development of effective reproductive technologies.

Animals↗

Psychology and rural America. Current status and future directions.

Rural people constitute about one fourth of the U.S. population, and their special mental health needs have been largely neglected. For a variety of reasons psychologists have focused little attention on this group. Recent economic developments affecting agriculture, farm families, and rural communities have increased awareness of problems facing rural areas. Psychologists can respond to the unique challenges created by rural mental health needs through research on stress, psychopathology, and community well-being. Training programs should be encouraged to recognize rural concerns. Psychologists are needed to practice in rural areas and to help develop effective rural service models. They can also support the development of state and federal policies that address rural needs.

Community Mental Health Centers↗

In silico encounters: harnessing metabolic modelling to understand plant-microbe interactions.

Understanding plant-microbe interactions is vital for developing sustainable agricultural practices and mitigating the consequences of climate change on food security. Plant-microbe interactions can improve nutrient acquisition, reduce dependency on chemical fertilizers, affect plant health, growth, and yield, and impact plants' resistance to biotic and abiotic stresses. These interactions are largely driven by metabolic exchanges and can thus be understood through metabolic network modelling. Recent developments in genomics, metagenomics, phenotyping, and synthetic biology now enable researchers to harness the potential of metabolic modelling at the genome scale. Here, we review studies that utilize genome-scale metabolic modelling to study plant-microbe interactions in symbiotic, pathogenic, and microbial community systems. This review catalogues how metabolic modelling has advanced our understanding of the plant host and its associated microorganisms as a holobiont. We showcase how these models can contextualize heterogeneous datasets and serve as valuable tools to dissect and quantify underlying mechanisms. Finally, we consider studies that employ metabolic models as a testbed for in silico design of synthetic microbial communities with predefined traits. We conclude by discussing broader implications of the presented studies, future perspectives, and outstanding challenges.

Plants↗

Reading between the lines: societal norms in Sierra Leonean readers.

A content analysis of primary school readers in Sierra Leone revealed that the particular modern and traditional normative aspirations expressed in the National Development Plan for 1974/5-1978/9 were also generally reflected in the children's readers. Compared to the 1964 readers, the 1st indigenous readers developed circa 1977 contained markedly greater emphasis on traditional norms, though modernity norms continued to dominate, and substantially less emphasis on Efficacy (a central aspect of modernity) and on Nonparochial Affiliation. This closely corresponded with the intent of the National Plan to continue on a modernizing course employing the traditional norms of Manual Labor and Social Cohesion in a grassroots effort to develop the agricultural sector, with nationalism in a less important role. Apart from lesser emphasis on Efficacy and underemphasis on the Value of Education, both discordant with national goals, the 1977 readers seem to provide children and teachers with a fairly accurate image of the national ethos. This may help to account for the generally positive relationship that has been found between schooling and economic development.

Africa↗

[Unique ecosystem characters and ecological principles for development in the ecotones between agriculture and pasture in north China].

Based on the fact that its ecological deterioration, a rethinking on the former definition of 'transitional zone between agriculture and grassland' was proposed. It was recognized that this zone has been gradually and dynamically formed under the specific circumstances of history and anthroponomy in China. It should thus be re-defined as 'ecotone between agriculture and pasture', instead of just focusing on its features of geography, ecology, and vegetation separately, as well as its character of transition. More attention should be put on its nature of complex system of ecology, society and economy, and then, derive relevant abating measures. Boreal ecotone has the functions of life support for a relatively dense population, as well as ecosystem services. Under the premise of unable copying the models for arid and semiarid areas in abroad, in particular developed countries, an unique strategy of capable of compromising both above-mentioned functions, as well as ecological reconstruction, which is embodied in readjusting agro-structure, rationally utilizing and conserving resources, and establishing 'polar' industries, such as grasses and livestock, should be the center of an interdisciplinary study approach.

Agriculture↗

Vicissitudes of benefit sharing of crop genetic resources: downstream and upstream.

In this article, we will first give a historic overview of the concept of benefit sharing and its appearance in official agreements, particularly with respect to crop genetic resources. It will become clear that, at present, benefit sharing is primarily considered as an instrument of compensation or exchange, and thus refers to commutative justice. However, we believe that such a narrow interpretation of benefit sharing disregards, and even undermines, much of its (historical) content and potency, especially where crop genetic resources are concerned. We argue that benefit sharing should not be based merely on commutative justice but rather on a broader model that is also grounded in the concept of distributive justice. This has repercussions for the application of benefit sharing, which we try to clarify by distinguishing between downstream and upstream benefit sharing. Upstream benefit sharing is not so much inspired by compensation for actions done, or the distribution downstream of benefits developed, but by the idea of shared decision-making on the research and development of resources fundamental to human welfare. Going upstream in the research process of crop genetic resources, and determining research agendas and improving crops according to the needs of the poor, benefit sharing may well be a tool to contribute to world food security and global justice. We concretize our ideas on upstream benefit sharing by introducing a set of criteria that determine the success of consultations on agricultural research agenda setting.

Biodiversity↗

A tiered approach to life stages testing for agricultural chemical safety assessment.

A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk assessment. The ACSA Life Stages Task Force proposes a tiered approach to toxicity testing that assesses a compound's potential to cause adverse effects on reproduction, and that assesses the nature and severity of effects during development and adolescence, with consideration of the sensitivity of the elderly. While incorporating many features from current guideline studies, the proposed approach includes a novel rat reproduction and developmental study with enhanced endpoints and a rabbit development study. All available data, including toxicokinetics, ADME data, and systemic toxicity information, are considered in the design and interpretation of studies. Compared to existing testing strategies, the proposed approach uses fewer animals, provides information on the young animal, and includes an estimation of human exposure potential for making decisions about the extent of testing required.

Agrochemicals↗

Mendelism and medicine: controlling human inheritance in local contexts, 1920-1960.

The rise of Mendelism has often been associated with the development of agricultural sciences and the attempts to improve varieties and select new plants. In contrast, historians have tended to stress the tensions between Mendelism and medicine originating in the influence of eugenicists. The use of Mendel's laws in the context of discussing human inheritance and the transmission of pathologies was nonetheless pervading the medical literature from the 1920s onwards. This paper investigates the dynamics of medical Mendelism by comparing developments in France and in Britain. In contrast to reluctant botanists and zoologists, the elite of the French medical profession was often 'Mendelian'. Mendel's laws have accordingly been integrated into a complex approach to the familial transmission of pathologies, into a theory of pathological inheritance, which combined genetics, germ theory and hygiene. This approach was widely accepted among the paediatricians and obstetricians active in both the eugenics movement and the natalist movement. The career of the pediatrician R. Turpin is a good example of the visibility of this form of medical Mendelism and of its long-lasting impact on genetic research in the country. In Britain, where the social basis of eugenics was not the medical profession, eugenics' claims often clashed with public health and hygiene priorities. Medical Mendelism was in the first place supported and advanced by doctors and scientists participating in the public debates about the care of 'feeble minded' and the classification of social groups. As revealed by the trajectory of L. Penrose this context favoured the linkage between statistics and pedigree analysis, thus leading to the 'Mendelization' of human pathologies. After the war, this Mendelization in turn facilitated the rise of medical genetics as a speciality focusing on genetic counselling and on the management of computable hereditary risks. This comparative analysis thus highlights: a) the influence of local medical cultures on the fate of Mendelism; b) the continuities between the pre-war studies of pathological inheritance and the post-war rise of medical genetics.

Animals↗

Undernutrition in Nigeria: dimension, causes and remedies for alleviation in a changing socio-economic environment.

Undernutrition in Nigeria is a long standing problem which has persisted since the 1960s and whose magnitude is on the increase. This is because food consumption, both in quality and quantity, has decreased appreciably, especially with the commencement of the structural adjustment programme (SAP) in 1986. Available studies from limited data have indicated that the introduction of economic reforms more than anything else has contributed to reduced food intake and the near collapse of nutrition oriented health delivery services. Since the economic reforms may continue into the next decade and beyond, sustainable remedies for alleviation of the problem are urgently needed. Suggested remedial programmes include increased support for the rural farmers, strengthening of the rural credit schemes that are specifically targeted at the poor, distribution of vitamin A and iron supplements in rural health centres, encouraging production of low cost weaning diets and integrating nutrition education in primary health care schemes and in educational curricula.

Adolescent↗

Food for all.

Ensuring food for all requires an interdisciplinary approach, an evaluation of all sectors of the economy and the formulation of objectives which include proper nutrition in overall development plans. It is my contention that the introduction of nutrition priorities at this level, complemented with the traditional immediate and short-term measures of food aid, nutrition programmes, health campaigns and nutrition education will do much to alleviate the world's food problems. Priorities must be defined, planning structures strengthened, and politicians convinced that objectives can be reached. Otherwise, meagre resources will continue to give low priority to agriculture and social reform and we will have accomplished little toward our objective of food for all.

Agriculture↗

The better use of food resources for infants and mothers.

The nutritional and food safety characteristics of the foods customarily eaten by infants and mothers in The Gambia are discussed. Special emphasis is placed on their low energy and nutrient density and the consequent difficulty of meeting internationally recommended levels of intake. The consequences of an inadequate diet during pregnancy and lactation are considered in terms of their effect on the size of the baby at birth, the mother's lactational performance, and the growth and development of the baby. The microbiological contamination of locally introduced weaning foods is also highlighted. Suggestions are made concerning the desirable characteristics of new foods that need to be introduced to overcome these problems. Attention is paid to a more rational distribution and use for aid foods.

Agriculture↗

Health, population, and economic development. International health programs have an important role in promoting economic development and population control.

Health as a basic human value is particularly important to people in the developing world. Rates of economic development lower than had been hoped for and ever more steeply rising population growth have precipitated a reaction against public health programs. Among economists, agriculturalists, and even health professionals the philosophy arose that one should "hold back" on using modern weapons against disease because they are "too effective." To satisfy the recognized popular demand, simple and relatively ineffective measures of curative medicine could be substituted. It was said that the emphasis should be, instead, on agriculture, community development, education, and industrialization and that family planning should be pushed as a separate program. Documentation presented here sharply challenges such a point of view. No segment of the total development process can be effective without the other sectors.

Demography↗

Specific Conductance and pH as Indicators of Watershed Disturbance in Streams of the New Jersey Pinelands, USA.

/ We used linear regression to independently and jointly relate specific conductance and pH measured at New Jersey Pinelands stream sites to the percentage of altered land in a watershed. Percentage altered land included developed and agricultural land uses and represented watershed disturbance for a given site. Median values calculated for a 2-year period (September 1992 through August 1994) characterized pH and specific conductance at the study sites. We found the relationships between the median values for both water-quality measures and percentage altered land for a site to be consistent across subregion and dominant altered-land use. Our results also demonstrated that the water-quality/altered-land relationships developed using median values were similar to relationships developed using data from any single-sample period within the entire study period. Individually, pH and specific conductance explained 48% and 56%, respectively, of the variability in watershed disturbance among study sites. The joint use of pH and specific conductance explained 79% of the watershed disturbance variability among sites. The joint use of these easily obtained water-quality measures can provide a quick assessment of instream water-quality impacts from upstream watershed disturbance at any Pinelands stream site. Additionally, a range in pH and specific conductance, and hence a range in ambient water quality, can be predicted for a given altered-land percentage or a change in existing altered-land conditions.

Journal Article↗

Current and future prospects for control of ostertagiasis in northern Europe--examples from Denmark.

This review primarily discusses the status and prospects for control of bovine ostertagiasis in northern Europe, with examples from Denmark. There are different ongoing developments in agricultural systems and practices, and methods and possibilities for practical control depend on the intensity and specialisation of these; the modern dairy farm remains at highest risk of parasitism, owing to increasing stocking densities and limited natural control elements at hand. Epidemiology and course of infections are significantly influenced by the gradual build-up of acquired immunity, which usually contributes to prevent loss-producing effects in second season and older animals. It may be of doubtful value to exaggerate worm control in first season animals, because this may reduce development of immunity with the risk of translocating parasite problems from the young to the older, economically more important age categories of animals. A number of reasons for adopting an overall consideration on worm control and performance throughout adolescence is emphasised. Control by management relies on a fairly detailed insight into local transmission factors of Ostertagia ostertagi and related trichostrongyles. No doubt future investigations will provide important additional knowledge in this area. Anthelmintics will continue to constitute a major control measure, but it is unlikely that there will be any acceleration in the rate of commercial release of new compounds. However, ongoing modifications and new formulations of existing anthelmintics will continue to be produced, and implementation at the farm level of the proper use of anthelmintics and other control measures will be one of the important tasks of the coming century. Until now, the development of anthelmintic resistance in cattle has been negligible, but it may possibly pose a potential risk over the coming decades. With regard to some new anthelmintics that have environmental concerns related to their faecal excretion, this should be carefully examined in the future. Control in the form of vaccination or biological control by microfungi or others would be attractive alternatives that should be given a high research priority. Yet, at present it is not easy to predict which of these may lead to feasible, practical control.

Agriculture↗