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PubMed1998

Early developmental modulation of GABAA receptor function. Influence on adaptive responses.

If GABA is serving a trophic role during early brain development, before taking on its function as a neurotransmitter, interference with the function of GABA during this period should have a profound influence on neural organization. We have addressed this hypothesis by evaluating the effects of exposing rat fetuses to diazepam (DZ), a positive modulator of GABA at the GABAA receptor, over gestation days 14 to 20. Studies have shown that adult rats exposed in utero to DZ over this developmental period make inappropriate behavioral responses and have altered neural and hormonal responses to environmental stimuli that threaten the organism's stability and homeostasis. Thus, the early exposure led to altered adaptive responses. These effects of the early exposure did not become apparent until late in adolescent development. Furthermore, specific behavioral and neural responses to environmental challenges normally emerge over adolescent development. Other studies have shown that the GABAA receptor in adult brains is responsive to environmental challenges. Thus, we hypothesize that early modulation of the action of GABA mediated via the GABAA receptor interfered with the neural organization of adaptive responses.

Adaptation, Physiological↗
PubMed2005

Case study: the internet as a developmental tool in an adolescent boy with psychosis.

The Internet has become an increasingly important part of teen culture; however, there still remains little in the medical/psychiatric literature pertaining to the impact of the Internet on adolescent development. Despite the potential problems associated with communication online, the Internet offers a variety of positive opportunities for teens. In this report, we present a case study that illustrates the Internet as a helpful tool in a 15-year-old adolescent boy with a history of chronic neurological illness accompanied by refractory psychosis. Although the case emphasizes some of the ways in which the Internet may have a positive impact on adolescent development, further research is indicated to evaluate the contexts in which the Internet serves healthy developmental processes and those in which its influence is potentially deleterious.

Adolescent↗
PubMed1999

Psychosocial predictors of cigarette smoking among adolescents living in public housing developments.

BACKGROUND: Adolescents residing in low-income public housing developments in inner-city regions may be particularly vulnerable to a variety of risk factors associated with cigarette smoking. OBJECTIVE: To elucidate the aetiology of cigarette smoking among adolescents living in public housing developments. DESIGN, SETTING, AND SUBJECTS: We examined predictors of smoking from four domains: background characteristics, social influences, behavioural control, and psychosocial characteristics using a sample of seventh graders (mean age 12.9 years) who reside in public housing developments in New York City (n = 624). The addresses of participants in a larger investigation of the aetiology and prevention of smoking were checked to determine if they lived in one of 335 public housing developments in New York City. All participants living in public housing developments were included in the current study. MAIN OUTCOME MEASURES: African-American and Hispanic students completed questionnaires about their cigarette use, social pressures to smoke, smoking attitudes, smoking knowledge, and smoking resistance skills. Students also provided information on demographic and behavioural control (such as church and school attendance). RESULTS: Logistic regression analyses indicated that social influences from friends and family members predicted smoking. Psychosocial characteristics such as advertising resistance skills, anti-smoking attitudes, and refusal skills lowered the odds of smoking. CONCLUSIONS: These findings suggest that smoking prevention approaches targeted at these young people should increase their awareness of social pressures to smoke, correct misperceptions about the prevalence of smoking among friends, and teach relevant psychosocial skills.

Adolescent↗
PubMed1991

Object relations in childhood and adolescence: the development of working representations.

This article describes two studies based on an integration of theory and research in object relations and developmental social cognition. The following four dimensions were assessed in 2nd and 5th graders and in 9th and 12th graders using Thematic Apperception Test (TAT) responses and Ss' descriptions of meaningful interpersonal episodes: complexity of representations of people, affect-tone of relationship paradigms, capacity for emotional investment in relationships and moral standards, and understanding of social causality. In both studies, developmental differences emerged on all measures except affect-tone, as expected. Results document object-relational development beyond the preoedipal years and suggest the diagnostic importance of distinguishing multiple dimensions of object relations rather than considering object relations as a single or unitary developmental line.

Adolescent↗
PubMed2001

Psychosocial development in adolescents with Turner syndrome.

Turner syndrome is a genetic condition in which part or all of the second X chromosome is missing. Our goal in this study was to examine the psychosocial adjustment of a sample of adolescent girls with Turner syndrome. Subjects included 122 girls with a diagnosis of Turner syndrome (TS) and a control group of 108 girls with no genetic disorder or chronic illness. Subjects were 13 to 18 years of age. A battery of questionnaires assessing social, academic, school, and behavioral functioning was administered. TS girls were seen as having significantly more problems in terms of social relationships and school progress and were more likely to meet criteria for attention-deficit hyperactivity disorder than control girls. The TS girls were also rated by a parent as less socially competent (e.g., fewer friends, less time with friends) than the control group. Social difficulties appear to be an area of vulnerability for TS girls. Counseling individuals with Turner syndrome and their families about the need to carefully develop and nurture social skills and relationships may prove useful in advancing the social adaptation of these young women.

Adaptation, Psychological↗
PubMed1984

Adolescents and their experience of parental divorce.

This paper describes the results of an interview-based study of the reactions of 64 adolescents to the separation and divorce of their parents. The results of the interviews suggest that parental divorce does not necessarily interfere with adolescent development. They also suggest that adolescents would prefer to live in a one-parent home than a two-parent home which is fraught with conflict, and that it is preferable for parents who are unable to resolve such conflict in any other way to separate rather than allow it to persist. Further, the results of the interviews provide some suggestions as to the way divorcing parents should behave if they are to facilitate the adjustment of their adolescent children to the divorce process. In particular, attention is drawn to the extent to which they need to keep their children informed about their intentions, their conduct towards each other following the separation and their conduct in forming and maintaining new relationships.

Adolescent↗
PubMed1993

Social changes among youth: the United States experience.

The tremendous increase in research on adolescence over the past 20 years, and especially the last decade, has produced a great deal of knowledge about adolescent development and the development of problems during adolescence. This new knowledge should lead to more effective interventions. Although more research is needed on basic developmental processes and context influences, this is especially the case in the area of effective interventions. The next decade may bring significant new knowledge that will dramatically improve the lives of young people in the United States. This is desperately needed as the current status of youth must change.

Adolescent↗
PubMed1996

The development of adolescent idiopathic scoliosis.

There are many conflicting actiological theories for adolescent idiopathic scoliosis. We present a simple new model of scoliosis and a mechanism by which it is initiated and progresses. This mechanism provides a final common pathway for the multiple aetiological factors. A simple model of the spine, incorporating its fundamental mechanical features, was constructed. The model consisted of interconnected anterior compression and posterior tension columns. It allowed normal spinal movements, with flexion limited by the posterior column and rotation centered around the anterior column. It also allowed deformities to develop. The ends of the model were fixed in the position of the vertebrae they represented. Overgrowth of the anterior column relative to the posterior column caused the model to take up the shape of an idiopathic scoliosis. The greater the overgrowth, the more marked the deformity. Normally anterior and posterior column growth are coupled. During the growth spurt the thoracic kyphosis flattens indicating that anterior growth temporarily exceeds posterior growth. If this over-growth is marked a scoliosis will develop, as demonstrated by the model. Once this occurs the coupling is lost, anterior growth further outstrips posterior growth and the deformity progresses. Not all scolioses worsen, as the tendency to progress is balanced by neuromuscular factors and remodelling. Factors that increase the growth rate, induce asymmetry or decrease the inherent stability of the spine all encourage the development and progression of a scoliosis. This explains the complex biomechanics of scoliosis and provides a final common pathway by which the multiple aetiological factors can induce idiopathic scoliosis. It has important implications for the understanding and treatment of this condition.

Adolescent↗
PubMed2006

Risk and protection in the development of problem behaviors in adolescents.

The development of problem behaviors among adolescents is affected by complex interactions between risk and protective factors. This study was designed to determine whether selected risk and protective factors described among participants in the National Longitudinal Study of Adolescent Health predicted problem behavior cluster membership. Approximately, 13,000 adolescents from the Add Health study were examined. Three clusters of adolescents (exhibiting normal, problem, and deviant behaviors) and changes in cluster membership over 1 year were examined for relationships to specific risk and protective factors. Findings revealed that factors for current behavior problems differ from those for changes in cluster membership. These results suggest that approaches to preventing problems may differ from those required to help adolescents who are already manifesting problems.

Adolescent↗
PubMed1995

Developmental issues influencing guidelines for adolescent health research: a review.

Adolescent development brings many opportunities to adolescents as research participants. They may be enthusiastic participants, especially if the focus of the research is of interest to the adolescents. Their increasing sense of self and development of autonomy may yield open, thoughtful responses less likely with older research participants. At the same time, the researcher must be aware of particular vulnerabilities of adolescents. Cognitive and reasoning capacity emerges gradually over the adolescent decade, making younger adolescents less capable than older adolescents of effective reasoning. The researcher can adjust materials to be understandable to the younger adolescent but should also recognize that inexperience could increase anxiety or emotionality about an issue not problematic to an older adolescent or adult. Making clear the right of the adolescent to refuse to discuss particular issues usually permits more honest responses, and increases the likelihood of consent to research or parts of research. Especially stressful circumstances may cause degradation of reasoning capacity suggesting that the researcher needs to assess whether the adolescent is able to make a wise decision about participation, as well as about particular responses. The researcher can usually identify ways to alleviate stress in the study situation and should take all steps necessary to obtain both informed consent and valid responses. Existing research provides clear evidence that most adolescents, at least past age 14 or 15 years, are able to function as well as adults research participants under most circumstances. With younger adolescents and under stressful situations, the researcher can find ways to minimize risk from research and increase the likelihood of valid responses.

Adolescent↗
PubMed1996

Sex and strain differences of acoustic startle reaction development in adolescent albino Wistar and hooded rats.

Acoustic startle responses (ASR) were studied in 12 young Wistar albino and in 15 hooded rats of both genders. The six week old animals were first exposed to a 6.9 kHz tone pair of 2 ms pulses of 120 db intensity with the inter-stimulus interval (ISI) between 2 and 11 ms. ASR amplitudes and latencies as a function of the ISI, animal strain and gender were recorded and analyzed for ten consecutive weeks. No differences in the ASR amplitude between Wistar and hooded rats were found. ASR amplitude increased during the experimental period and followed body weight increase. Significant differences were also observed between male and female rats in their startle responses to acoustic stimuli. Generally, male subjects responded with a greater ASR amplitude than females, and the changes may be attributed to the difference in neuromuscular development between genders. This experiment sets a background for further developmental studies.

Acoustic Stimulation↗
PubMed2003

Pubertal timing, sexual behaviour and self-reported depression in middle adolescence.

The associations between pubertal timing, sexual activity and self-reported depression were analysed in a population sample of 17,082 girls and 15,922 boys aged 14-16 as a par of a classroom survey. Pubertal timing was assessed by age at onset of menstruation (menarche) or ejaculations (oigarche). Sexual experiences elicited included kissing, light petting, heavy petting and intercourse. Self-reported depression was measured by the 13-item Beck Depression Inventory. Among girls, self-reported depression was associated with early puberty and intimate sexual relationship. Among boys depression was associated with very early and late puberty and experience of intercourse. Early puberty is a risk factor for self-reported depression. Intimate sexual relationships in middle adolescent are likely to indicate problems in adolescent development rather than successful adolescent passage.

Adolescent↗
PubMed2001

Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers.

BACKGROUND: Human exposure to chemicals is normally monitored by measurement of environmental pollutants in external media. We investigated whether biomarkers in adolescents can show exposure to, and health effects of, common environmental pollutants. METHODS: We recruited 200 17-year-old adolescents (120 girls) from a rural control area and from two suburbs polluted by a lead smelter and two waste incinerators. We measured biomarkers of exposure and of effect in blood and urine samples, and obtained questionnaire data. School doctors measured testicular volume and staged sexual maturation. FINDINGS: Internal exposure was mostly within current standards. Concentrations of lead and cadmium in blood, PCBs (polychlorinated biphenyls) and dioxin-like compounds in serum samples, and metabolites of VOCs (volatile organic compounds) in urine were higher in one or both suburbs than in the control area. Children who lived near the waste incinerators matured sexually at an older age than others, and testicular volume was smaller in boys from the suburbs than in controls. Biomarkers of glomerular or tubular renal dysfunction in individuals were positively correlated with blood lead. Biomarkers of DNA damage were positively correlated with urinary metabolites of PAHs (polycyclic aromatic hydrocarbons) and VOCs. Interpretation Biomarkers can be used to detect environmental exposure to pollutants and measure their biological effects before overt disease develops. Our findings suggest that current environmental standards are insufficient to avoid measurable biological effects.

Adolescent↗
PubMed2001

A case of anterior open bite developing during adolescence.

Imaging studies have reported on the relationship between temporomandibular joint (TMJ) degeneration and facial deformity. These studies have suggested that mandibular growth is affected by TMJ degeneration, resulting in altered skeletal structure as mandibular retrusion. However, there are very few longitudinal case reports on TMJ osteoarthrosis (OA). Progressive open bite occurred in an adolescent patient with TMJ OA. Cephalometric analysis showed a downward and backward rotated mandible, and a labial inclination of the upper incisor. Magnetic resonance imaging showed internal derangement without reduction and erosion in the right and the left condyles. Although the cause of open bite is unclear in this case, tongue thrusting, and internal derangements in the temporomandibular joint were suspected as causes of the open bite.

Bone Resorption↗
PubMed2003

Personality differences in childhood and adolescence: measurement, development, and consequences.

Child psychologists and psychiatrists are interested in assessing children's personalities. This interest is fueled by the practical desire to identify differences between children that have predictive utility, and by recognition that future advances in developmental theory, especially in relation to gene-environment interplay, can only be as good as the measures on which they rely. The aim of this article is to facilitate these practical and theoretical advances. First, we delineate a taxonomy of measurable individual differences in temperament and personality in childhood, and point the reader to proven and/or promising measuring instruments. Second, we describe the processes through which early temperament differences may become elaborated into adult personality structure and lifelong adaptation, and identify gaps in the empirical research that need to be filled. Third, we explore the various connections between temperament/ personality traits and psychopathology, and direct attention to promising questions and strategies.

Achievement↗
PubMed1997

Genetics and developmental psychopathology: 1. Phenotypic assessment in the Virginia Twin Study of Adolescent Behavioral Development.

We introduce an overlapping cohort sequential longitudinal study of behavioral development and psychopathology in a representative sample of 1412 pairs of twins aged 8 through 16 years. Multiple phenotypic assessments involve a full psychiatric interview with each child and each parent, and supplementary parental, teacher, and child interview material and questionnaires. For the first wave of assessments, the numbers of reported DSM-III-R symptoms of Major Depressive Disorder (MDD), Separation Anxiety Disorder (SAD), Overanxious Disorder (OAD), Oppositional Defiant Disorder (ODD), Conduct Disorder (CD), and Attention Deficit Hyperactivity Disorder (ADHD), assessed through interviews, confirm patterns of age and sex trends found in other epidemiological samples, but underscore their dependence on whether the child or the parent is the informant. Correlations across domains for symptoms reported by the same informant are often as large as correlations across informants for the same domain of symptoms. Factor analyses of these symptom counts, taking account of informant view and unreliability of assessment, show the high degree of correlation between SAD and OAD, between MDD and OAD, and between CD and ODD. ADHD symptoms are relatively independent of the other domains, but show moderate correlations with CD, ODD, and MDD. Factorially derived dimensional questionnaire scales, based on child, parental, and teacher reports, show patterns of relationship to symptom counts consistent with both convergent and discriminant validity as indices of liability to clinical symptoms. Across informants, questionnaire scales provide as good a prediction of symptoms as do clinical interviews. Multitrait-multimethod confirmatory factor analysis reveals the patterns of relationship between symptoms of psychiatric disorder in children taking due account of informant and unique sources of variance. Gender differences are consistent within the correlated clusters of ODD/CD and MDD/SAD/OAD, although there are disorder-specific age trends. There are large informant-specific influences on the reporting of symptoms in clinical interviews. Dimensional questionnaire scales provide a useful source of additional information. In subsequent analyses of genetic and environmental etiology of childhood psychopathology we must expect that results may differ by informant and method of assessment. Multivariate and developmental analyses that explore the sources of these differences will shed new light on the relationship between genetic and environmentally influenced vulnerability and the manifestation of psychopathology in specific circumstances.

Adolescent↗