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At least 415 records · Page 23Linked to original sources
PubMed1988

[Axillary blockade of the brachial plexus. A prospective evaluation of 1133 cases of plexus catheter anesthesia].

UNLABELLED: The results of 1133 axillary catheter brachial blocks are reported. Effectiveness and side-effects were monitored in a prospective manner over a period of 1 year. METHOD: The puncture was performed with an 18-gauge plastic cannula fitted with a solid steel stylet. The stylet has a 45 degrees, short bevel with rounded edges. When puncturing the axillary neurovascular sheath, no attempt was made to elicit paresthesias with the needle. A distinct "click" and very easy advancement of the plastic cannula were signs of being well inside the neurovascular sheath. To confirm the correct positioning, 0.5-3 ml refrigerated saline solution were injected. If no paresthesias could be produced, a new puncture was performed using a nerve stimulator. The plastic cannula was fixed to the skin. For long-lasting operations or if postoperative analgesia or sympatholysis was required, a more flexible catheter was introduced through the plastic cannula. As an initial dose 40 ml 1% mepivacaine was injected via the cannula. If there was an insufficient block after 20 min, another 20 ml 1% mepivacaine was given. For long-lasting operations, 40 ml 1% mepivacaine was injected every 2 h. RESULTS: Surgery was completed in 72% of patients; 24% required some form of supplementation including 17.2% of patients who received a "top-up" after 20 min (Table 1). In 3.8% of cases the technique was considered to be a complete failure, meaning that patients needed some type of general anesthesia including the use of i.v. ketamine.(ABSTRACT TRUNCATED AT 250 WORDS)

Axilla↗
PubMed1986

Human adenine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme.

We defined the amino acid sequence of adenine phosphoribosyltransferase isolated from human erythrocytes. Peptide fragments formed by cleavage at arginine, lysine, glutamic acid, and methionine were purified by high pressure liquid chromatography and sequenced by manual Edman degradation. The complete primary structure of human adenine phosphoribosyltransferase was established by sequence analysis of 19 peptide fragments. Presumed homology between the human and rodent enzymes was used to order fragments that had inadequate overlapping sequences. The enzyme has 179 residues with a calculated subunit molecular weight of 19,481. Mass spectrometry indicated that the NH2-terminal residue is acetylated. Human adenine phosphoribosyltransferase has sequence homology with xanthine-guanine phosphoribosyltransferase from Escherichia coli in 110-amino acid region encompassing the NH2-terminal section of the enzyme.

Adenine Phosphoribosyltransferase↗
PubMedDate not supplied

[Regional adenitis following BCG vaccination (author's transl)].

During a period of time close to four years, 239 children with regional lymphadenopathy following BCG vaccination have been treated. Early neonatal vaccination, individual sensitivity and possible mistakes in the dose of vaccine administered may all influence the development of pathological regional lymphadenopathy. In advanced cases, surgery is proposed as the most effective treatment for a rapid recovery. No cases of recurrence or fistulization appeared in our series.

BCG Vaccine↗
PubMed1984

Human adenosine deaminase. cDNA and complete primary amino acid sequence.

A previously cloned partial adenosine deaminase cDNA insert (0.8 kilobase) was used to clone additional nucleotide sequences from human HPB ALL cDNA libraries. cDNA encompassing the entire coding, and 3'-untranslated regions as well as nearly all of the 5'-untranslated region was obtained. The complete amino acid sequence of the enzyme deduced from the cDNA sequence and protein sequencing consists of 362 amino acids, excluding the initiator Met, and accounts for Mr = 40,638. Secondary structure predictions assign adenosine deaminase to the alpha/beta class of proteins. Northern blot analysis with a cDNA probe showed adenosine deaminase mRNA to be present in normal to above normal amounts in B-lymphoblasts derived from adenosine deaminase-deficient patients with severe combined immunodeficiency disease. Knowledge of the cDNA and primary amino acid sequence of adenosine deaminase will be pivotal in further defining the genetic abnormality and its functional consequences in adenosine deaminase expression defects.

Adenosine Deaminase↗
PubMed1983

Nucleotide and amino acid sequence comparisons of preprosomatostatins.

The amino acid and nucleotide sequences have been aligned for five preprosomatostatins: two from catfish, two from anglerfish, and one from rat. The physical characteristics of the aligned residues as well as substitutions in the nucleotide sequences suggest considerable mutability in one of the catfish and anglerfish precursors while three of the preprohormones which give rise to somatostatins-14 are closely related. Although there is a considerable number of amino acid substitutions within the aligned somatostatin-14 precursors, there is a high degree of structural relatedness among them. These results suggest that additional physiological roles for the amino acid sequences outside of the hormone region are likely. The predicted secondary structures of the three somatostatin-14 precursors are dominated by helical and turn configurations which are correlated with observed co- and post-translational processing of the preprohormones.

Amino Acid Sequence↗
PubMed1983

A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases.

Comparison of the primary structures of three phosphoribosyltransferases (human hypoxanthine-guanine, Salmonella typhimurium ATP, and Escherichia coli glutamine) showed no significant amino acid sequence homology except for a 35-residue span in hypoxanthine-guanine and glutamine phosphoribosyltransferases. However, comparison of smoothed plots of amino acid physical characteristics thought to control protein folding with amino acid sequence number resulted in a substantial correlation for a 120-residue stretch in each of the phosphoribosyltransferases. A secondary structure prediction analysis of the regions indicated a dinucleotide-binding fold with its characteristic beta alpha beta secondary structural pattern. Furthermore, the physical parametric correlation analysis suggested a common catalytic domain fold for hypoxanthine-guanine and glutamine phosphoribosyltransferases which was consistent with the register of the sequence homology. A possible binding mode of the phosphoribosyltransferase substrates is discussed. The physical parametric approach to protein sequence comparison may be generally applicable for distantly related proteins which maintain similar structural folds without any apparent sequence homology.

ATP Phosphoribosyltransferase↗
PubMed1984

[A technic to avoid postoperative intestinal hypodynamia].

The hypodynamic postoperative ileus in children, has as main cause the circle gastric distension-reflex intestinal ileus, produced by the swallowed air. The gastric emptying system-through a Levin tube from the stomach is not usually sufficient to get off all the swallowed air. Nevertheless, a continuous suction from the lower third of oesophagus, through a double lumen sump tube is twelve times more effective in the getting off de air before it comes into the stomach, without need of a nasogastric tube.

Abdomen↗
PubMed1984

A computer-managed clinical evaluation system: implications for competency-based dietetic education programs.

Instruments for evaluating clinical performance of students were developed, tested, and designed for a computer-managed evaluation system for the competency-based dietetic internship program at Emory University, Atlanta. The development, evaluation, and utilization of the instruments are described. The method of development included: (a) analysis of validated competencies and performance criteria to determine aspects of behavior appropriate to measure in clinical settings, (b) specification of major areas to be evaluated, (c) specification of component behaviors within each of the major areas, (d) specification of criteria to be used in evaluating component behaviors, and (e) definition of the rating continuum. Validation of the instruments consisted of determinations of content validity, interrater reliability, and practicality. Results of the use of the computer-managed evaluation system indicated that the instruments were valid, reliable, and practical to use for evaluating students' clinical performance.

Computers↗
PubMed1984

[Pheochromocytomas in children].

Three cases of pheochromocytoma in children are presented. Diagnosis was made by selective adrenal arteriography, ultrasound examination and catecholamines urinary levels. The surgical treatment consisted in exeresis of the tumor in all cases. In one case familial incidence was found. The postoperative course has been normal in all cases.

Adrenal Gland Neoplasms↗
PubMed1982

A model for competency-based, computer-managed instruction in allied health.

A competency-based, computer-managed instruction model was developed and used in revising and managing the curricula of dietetic internship and physical therapy certificate programs. Use of the model resulted in identification and validation of program competencies and performance criteria, revision of curricula, and implementation of a computer-managed instructional support system to record, store, and provide feedback to students and instructors about performance on the competency measures. Improvements in the quality of the curricula and in the ability to manage student performance information have resulted from these efforts. The computer-managed instruction system has been well received by instructors and students. The most obvious benefits include savings in time for instructors and immediate feedback on performance for students. Results indicate that a competency-based, computer-managed approach to curriculum development and implementation is desirable and practical and has the potential for effectively serving future developments in allied health education.

Allied Health Personnel↗
PubMed1981

Structural prediction of sugar-binding proteins functional in chemotaxis and transport.

Comparisons of the D-galactose- and D-ribose-binding protein amino acid sequences and secondary structure predictions with the known primary and three-dimensional structure of L-arabinose-binding protein suggest that the three proteins have similar molecular structures. These studies also indicate an evolutionary relationship among the proteins. One region of striking homology between the galactose- and ribose-binding proteins suggests that this may be th protein-protein contact site for interaction with the membrane-bound chemotaxis receptor. The ligands and the geometry of the galactose binding site are also predicted.

Amino Acid Sequence↗
PubMed1981

A computer-managed instruction system applied to dietetic education.

The emergence of competency-based programs in dietetic education has introduced the need for a systematic method of managing student performance information. A computer-managed instruction system which performs many of the routine clerical tasks usually assumed by instructors is being utilized in Emory University's Dietetic Internship Program. Preliminary use of the system indicates that it was well received by both instructors and students. Its most obvious benefits were the immediate feedback on performance and decreased demands on faculty time for evaluation and record-keeping processes.

Computer-Assisted Instruction↗
PubMed1982

A structural model for maize zein proteins.

With the knowledge of the amino acid sequences of two maize zein proteins (apparent molecular weights of 19,000 and 22,000), a structural model is proposed for their molecular conformation. The circular dichroic spectrum taken in the 190-240 nm range for a zein protein mixture in methanol solution showed the zein secondary structure to be largely helical. The polar, hydrophobic, and turn characteristics of the zein residues, as well as the homologous repeat units in their primary sequences, suggested a structure with nine adjacent, topologically antiparallel helices clustered within a distorted cylinder. Polar residues distributed along the helical surfaces allowed intra- and intermolecular hydrogen bonding such that the zein molecules could be arranged in planes. The proposed glutamine-rich turns located between the helices and at the cylindrical caps would favor side chain interactions resulting in stacking of the molecular planes. Physical properties observed for the zein proteins are explained by the model.

Amino Acid Sequence↗