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[Investigations on the stability of therapeutic drugs derived from imidazole. XII. Qualitative and quantitative stability evaluation of phentolamine hydrochloride solutions].

Hydrolysis of phentolamine hydrochloride in aqueous solutions, and at pH 1.0 and pH 8.0 was studied by means of thin-layer chromatography. A spectrophotometric method for quantitative assessment of phentolamine hydrochloride hydrolysis has been elaborated, and thermodynamic parameters of this reaction were determined.

Chromatography, Thin Layer↗

[Evaluation of the stability of biological specimens used for monitoring of occupational exposure. Studies of the stability of phenol and trichloroacetic acid in urine].

The paper presents results of studies on phenol and trichloroacetic acid concentration in urine samples stored for 30 days at + 5 degrees C and + 20 degrees C. It has been checked whether the addition of sulphuric acid as a conservant to urine can affect changes in phenol concentration in the samples stored. The results obtained did not indicate any significant changes in concentrations of phenol or trichloroacetic acid in the urine samples. It has been recommended that due to bacterial processes the material studied should be kept in refrigerator (+ 5 degrees C).

Chemical Industry↗