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At least 397 records · Page 22Linked to original sources
PubMed1979

[New possibilities in diagnosis and therapy of renal carcinoma (author's transl)].

A brief discussion of the aetiology and epidemiology of renal carcinomas is followed by a description of the clinical features. Attention is drawn to the significance of symptoms emphasizing the importance of early diagnosis. Intravenous urography still remains as the most important diagnostic procedure. It is pointed out that sonography and computer-tomography are now established as newer diagnostic methods, i.e. in distinguishing between cyst and tumor, in renal masses. Therapy, is still based upon surgical treatment. Transperitoneal, radical tumornephrectomy as compared with simple lumbar nephrectomy, has improved 5-year survival rate up to 16% especially in stage III tumors. Extracorporeal surgery for single kidney patients as hyperthermic surgery constitute new surgical methods, but only for specifically equiped urologic clinics. Embolisation of renal cell carcinoma is also used as therapeutic management in largely progressed tumors, and also used, as a preoperative measure, for the reducement of tumor size. Irradiation, before and after surgical treatment, as well as cytostatic therapy, revealed no significant improvement. We have reason to hope that progress in the research of hormonal- and immunotherapy will improve 5-year survival rate, in renal cell carcinoma.

Adolescent↗
PubMedDate not supplied

Computer analysis of defined populations of lymphocytes irradiated in vitro: I. Evaluation of murine thoracic duct lymphocytes.

Computer-assisted morphometric analysis of murine lymphocytes obtained by thoracic duct cannulation demonstrates two populations of cells; the larger population (73 percent) appears to be thymus-derived and the remaining 27 percent is of bone marrow origin. Following exposure to varying amounts of x-radiation, morphologic alterations in both populations are evident. The smaller cell populations are evident. The smaller cell population exhibits some of these changes at lower dose levels than does the larger population. In addition, the character of the radiation-induced changes appears to be different for the two populations of lymphocytes. After 500 rad, the nuclei of the larger population appears unchanged; the nuclei of the population representing 27 percent of the cells have become enlarged and vacuolated and are thought to be edematous. After 2000 rad, the nuclei of the larger population appear pyknotic with coarsely clumped chromatin. In the examined set of cells, the smaller population could no longer be detected after 2000 rad. Such disparate responses to radiation-induced injury may correlate with known differences in immunologic function which serve to distinguish thymic-dependent and bone marrow-derived small lymphocytes.

Animals↗
PubMed1975

Adrenocortical postirradiation fibrosis.

At autopsy, the adrenal zona reticularis showed linear hyaline fibrosis in 19 cases of cancer, after averages of six months and 5,000 roentgens of irradiation to the abdominal, lumbar, or pelvic regions. The associated roentgen dose was significantly greater than when postirradiation adrenal fibrosis was absent. Primary radiation damage to the reticular vascular plexus is suspected.

Adrenal Cortex↗