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PubMed2000

[Phenotypic and genotypic variability in signs of productivity of a new Siberian type of the Sovetskaya meat-wool species of sheep].

The heritability of major productivity traits in the new Siberian type of mutton-wool sheep was estimated by different methods. The repeatability of these traits was analyzed. The correlation between various productivity traits and the change in correlation throughout the formation of the new Siberian type of mutton-wool sheep were studied. The traits studied were demonstrated to be important for estimation of the efficiency of selection for commercially important traits and for predicting and planning their development.

Animals↗
PubMed2001

Dustiness of different high-temperature insulation wools and refractory ceramic fibres.

Recent regulations are encouraging the replacement of older types of man-made mineral fibre by more soluble and, thus, less biopersistent compositions. In order for there to be any health benefits from this policy and to gain maximum benefit from such substitutions, the use of the new materials should not increase exposure. The work reported here was undertaken to investigate the use of new high-temperature glass insulation wools in place of refractory ceramic fibres (RCF). Airborne fibre levels occurring during the manufacture of both RCF and calcium magnesium silicate wools (CMS) were compared using measurements of genuine workplace exposure from a routine monitoring operation on the same plant. Exposures during use were compared in one customer facility where RCF and CMS blankets were used for the same task. Further comparisons were made in a laboratory test of dustiness using a "shaking box test". For some manufacturing tasks there are only a few workplace samples and there are few opportunities for genuine comparisons with both RCF and CMS in identical uses. However, both materials produced very similar exposure levels during manufacture, use and in the laboratory test. The novel magnesium silicate fibre was significantly dustier in the laboratory test.

Asbestos, Amphibole↗
PubMed2005

[A linkage map of mirosatellite on chromosome 1 in Liangshan semi-wool sheep].

The 9 microsatellite markers on Chromosomes 1 were used to construct a linkage map of Liangshan semi-wool sheep with a 387 members half-sib pedigrees after paternity testing. The results were as follows: the number of alleles for 9 markers was from 5 to 15; the heterozygosity was from 0.202 to 0.831, the average heterozygosity was 0.617 and the polymorphic information content (PIC) was 0.604. Length of the linkage map of chromosome 1 we built was 311.0 cM which is in consistent with the sheep linkage map of USDA and IMF, and can be used in Quantitative Trait Loci searching in Liangshan semi-wool sheep.

Alleles↗
PubMed2006

[A new purification methods of small DNAs--the purification methods with silica wool].

The principal purpose of this study is to set up efficient purification techniques of small DNAs which are suitable for isolation of from tens to three hundred bases of genes. On the bases of the technique, purification methods for big DNA fragments are established. In the experiment, the DNA bands were cut after agarose gel electrophoresis and put into 0.5 mL of tubes with silica wool, glass wood, absorbent cotton and cotton at the bottom. And then 10 000 r/min for 2 min, the liquid was collected. The results indicated that silica wool was the best of the materials. The recovery rate for DNAs below 200bp was over 90%, 85% to approximately 90% for 300bp. And the technique can be applied to purify bigger DNA fragments. The kits for DNA purification hardly recovered DNA below 150bp. The recovery rate for 150bp of DNA was 5%, 60% even for 300bp. The efficiencies of enzymic digestion and enzymic connection for the DNAs purified by the technique were the same as those for the DNAs isolated by the kits. So, the technique is obviously superior to kit purification methods.

DNA↗
PubMed1989

[The effect of glass wool filtration on human spermatozoa--a comparison with the swim-up technic].

20 fresh human ejaculates (6X normozoospermia, 7X oligozoospermia and 7X asthenozoospermia) were prepared either with the swim-up-method as with the glass wool filtration. After both techniques the motility of the spermatozoa improved markedly. In cases of asthenozoospermia and oligozoospermia the motility increased significantly compared with the value of the ejaculate. From the motile spermatozoa of the ejaculate 45-60% were detectable in the filtrat after glass wool filtration or in the upper fluid after swim-up-procedure.

Female↗
PubMed1989

Retinal cotton-wool-like spots: a marker for AIDS?

The prognostic value of ocular manifestations and its correlation with immune changes in HIV-infected subjects was studied longitudinally with an average follow-up of one year (3-22 months). The most common ocular manifestations were retinal cotton-wool-like spots, observed in 58.8% of AIDS patients and in 76.9% of those with ocular involvement. Two of three ARC cases with cotton-wool-like spots developed Pneumocystis carinii pneumonia a few weeks after ophthalmoscopic examination. A close correlation between ocular changes and decrease of CD4+ lymphocytes was observed. In our opinion, these ocular manifestations are as useful as opportunistic infections or AIDS-related neoplasias in the natural history of HIV infection.

AIDS-Related Complex↗
PubMed1988

Retinal cotton-wool-like spots: a marker for AIDS?

The prognostic value of ocular manifestations and their correlation with immune changes in HIV-infected subjects (75 PGL, 23 ARC, and 17 AIDS) have been longitudinally studied with an average follow-up of one year (3 to 22 months). The most common ocular manifestations were retinal cotton-wool-like spots, observed in 58.8% of AIDS patients and in 76.9% of those with ocular involvement. Two of three ARC patients who showed cotton-wool-like spots developed PCP a few weeks after ophthalmoscopic examination. A close correlation between ocular changes and decrease of CD4+ lymphocytes was observed. In our opinion, these ocular manifestations are as useful an indicator as opportunistic infections or AIDS-related neoplasias in the prognosis of HIV infection.

AIDS-Related Complex↗
PubMed1986

Influence of smoking habits and place of residence on the risk of lung cancer among workers in one rock-wool producing plant in Denmark.

Cancer incidence was studied among 5,317 employees in one rock-wool production plant in Denmark. During the period 1943--1982 a marginally significant excess of 240 cancer cases was observed versus 211.0 cases expected. Among the subgroup of male workers an increasing risk with time since first employment was observed for cancer of the buccal cavity and pharynx, cancer of the respiratory system, and cancer of the bladder, of which only the excess of the first-mentioned reached significance. The increased risk of lung cancer among male workers with 20 or more years since first employment, which was not significantly in excess of 1.0, although still compatible with a two- to threefold increase according to conventional 95% confidence limits, could not be explained by deviations in local lung cancer incidence, place of residence among the rock-wool male workers, or smoking habits prevailing among unskilled workers in the eastern part of Denmark. The number of cases, however, was too small to exclude the effect of chance in this single investigation.

Adult↗
PubMed1986

Mortality of workers in a German rock-wool factory--a second look with extended follow-up.

A cohort of 2,092 workers employed in a German rock-wool factory was followed until the end of 1982, and the mortality experience was compared with the national mortality rates and the rates of an internal reference cohort. This mortality analysis revealed a standardized mortality ratio (SMR) of 110 for overall mortality. Significantly more malignant neoplasms occurred than were expected (SMR 127). The increase in risk for lung cancer (SMR 121), which was not statistically significant, was also not related to time since first exposure or length of employment. The occurrence of an unusually high SMR of 336 for benign and unspecified neoplasms could not be clarified. Most of the excess from other specific causes of death, such as stomach cancer, pancreatic cancer, and alcoholism, appear to be unrelated to the rock-wool production since they occurred either among workers employed for very short periods (less than one year) or as frequently among workers in the reference cohort.

Construction Materials↗
PubMed1982

Effect of antiarrhythmic drugs on In-111-labeled leukocytes: chemotaxis and adherence to nylon wool.

The influence of lidocaine (L) and procainamide (P) on the chemotactic ability and adherence to nylon wool of In-111-labeled human polymorphonuclear leukocytes (PMNs) was investigated. At the normal therapeutic levels of L (0.022 mM whole blood) or P (0.03 mM whole blood) no change in PMN function was observed. However, at and above five times the aforementioned blood levels of L, significant reduction in the chemotactic ability of PMNs was noted (p less than 0.005). The adverse effects of In-111 radiation appeared insignificant at all L or P concentrations during the 3-hr observation period. The labeled PMNs were resistant to the toxic effects of a higher concentration of P than that of L, and the reduction in PMN chemotaxis and adherence to nylon wool was not apparent until the P concentration reached 1.5 mM.

Cell Adhesion↗
PubMed1994

Cotton-wool spots as the initial ocular manifestation in Wegener's granulomatosis.

Various ocular manifestations have been described in Wegener's granulomatosis. Orbital involvement is common and manifestations in the anterior segment of the eye such as keratitis, scleritis, and conjunctivitis may occur. Involvement of the posterior segment presenting with major vascular occlusions or anterior ischemic neuropathy is rare. This case report presents a patient with bilateral cotton-wool spots at the posterior pole associated with histologically proven Wegener's granulomatosis. This finding, as an initial ocular manifestation of the disease, is very uncommon and may be interpreted as focal retinal inflammatory vasculitis. This was supported by the rapid positive response to systemic combined immunosuppressive and steroidal treatment during a 30-month period of review. The presence of cotton-wool spots in association with systemic signs of the disease should be considered in establishing the diagnosis of Wegener's granulomatosis.

Cyclophosphamide↗
PubMed1996

[Clinical and immunological effects of leukapheresis therapy using cotton-wool filter for patients with rheumatoid arthritis].

Remarkable clinical effectiveness of leukapheresis (LP) using a cotton-wool filter as a therapy for patients with rheumatoid arthritis (RA) was previously reported. To study the mechanism and indications for this therapy, 14 patients with RA were treated with this filter 6 times at 2 weeks intervals. The effects on clinical symptoms and subpopulations of peripheral blood mononuclear cells were evaluated on day 0, 3, 7, 14, 42 and 84. The Ritchie articular index, swollen joint counts, Lansbury index and health assessment questionnaire (HAQ), all showed improvements within the first week and the improvements were still observed 3 month later. Improvements in tender joint counts and visual analog pain scale (VAPS) were also observed on day 84. Eight patients showed remarkable improvements (responders) and 6 showed no apparent improvement (non-responders) according to the ACR core set criteria. Responders showed several characteristic features compared to non-responders as follows: the duration of RA was significantly shorter, the anatomical stage was earlier, the positive rate of susceptible HLA-DR4 haplotype associated with Japanese RA (DRB1*0405) was lower, and the proportion of CD4 + Leu8 + lymphocytes and the ratio of CD4+ cells to CD8+ cells (CD+/CD8 ratio) in the peripheral blood were higher throughout the treatment period and increased further even after the course of therapy. The proportion of CD4 + Leu8 + cells was inversely correlated with HAQ and VAPS, suggested that it is critically involved in the mechanism of this therapy. Blood leukocyte analysis at inlet and outlet of the filter showed increase of CD4 +, CD4 + Leu8 + cell percentages and CD4/CD8 ratio. These results suggested that patients with a shorter disease duration, less destruction of the joint, and without susceptible genes were more responsive to this therapy and that the mechanism of clinical improvement of RA by LP with cotton-wool involves immunological modification, such as immunosuppression by CD4 + Leu8 + lymphocytes.

Adult↗
PubMed1981

Detection and quantification of lanosterol and dihydrolanosterol esters by measurements of metastable decompositions. Application to their direct analysis in wool wax.

The fatty acyl moiety in lanosterol and dihydrolanosterol esters was determined by measurement of the metastable transition [M--15]+ leads to [M--15-fatty acid]+ which occurs in the first field free region of a double focusing mass spectrometer. The analysis was made by accelerating voltage scanning. Quantification of the esters was made by single reaction monitoring, using calibration curves measured in the presence of the corresponding matrix. The detection limit for a selected lanosterol ester was below 300 pg. using this technique, each individual lanosterol and dihydrolanosterol ester was detected and quantified in a sample of wool wax. Interference from dihydroagnosterol esters is very likely, but interference from sterol esters which do not have a 4-methyl group is unlikely since the corresponding metastable peak is of very low intensity.

Animals↗
PubMed1996

Investigation of wool protein heterogeneity using two-dimensional electrophoresis with immobilised pH gradients.

The heterogeneity of intermediate filament proteins (IFP) from wool has been investigated using two-dimensional polyacrylamide gel electrophoresis with immobilised pH gradients in the first dimension. The charge heterogeneity has been confirmed with some of the IFP separated as a string of spots with similar molecular weight, but markedly different in isoelectric point (pI). The molecular weight and pI distribution of the string of IFP changed after treatment with alkaline phosphatase, indicating that some of the heterogeneity is caused by phosphorylation.

Alkaline Phosphatase↗
PubMed1980

Mutagenicity tests of fabric-finishing agents in Salmonella typhimurium: fiber-reactive wool dyes and cotton flame retardants.

Thirty-nine fabric-finishing agents were tested for mutagenic activity in Salmonella typhimurium. Twenty-four fiber-reactive wool dyes and three acid dyes (not fiber-reactive) were screened by spot tests in strains TA100, TA98, TA1535, and TA1537. Among these dyes, seven bromoacrylamide dyes and one vinyl sulfone dye were mutagenic. Additionally, one of the three acid dyes was mutagenic in spot tests. The mutagenicity of the acid dye was due to an impurity or breakdown product rather than to the dye itself; the origin of the activities of the other dyes is unknown. No mutagenicity was observed among five chlorotriazine or four sulfonyl-ethane sulfonic acid dyes. Eight phosphorus-containing flame retardants (phosphonium, phosphine, phosphine oxide, and phosphonic acid derivatives) and methyl-N-methylolcarbamate, which is employed to obtain a flame-retardant finish on cotton, were tested for mutagenicity in strains TA100, TA98, TA1535, and TA1537, using quantitative incorporation assays. All were nonmutagenic. Two of three bromoalkyl-substituted triazine flame retardants were mutagenic in strains TA100 and TA1535. It is unknown whether this activity is due to impurities or to the parent compound. The flame retardants tested were either in actual commercial use or in experimental development for potential commercial processes. These results indicate the need for early testing of potential fabric-finishing agents and processes.

Animals↗
PubMed2002

Problems associated with the identification of proteins in homologous families: the wool keratin family as a case study.

The keratin proteins from wool can be divided into two classes: the intermediate filament proteins (IFPs) and the matrix proteins. Using peptide mass spectral fingerprinting it was possible to match spots to the known theoretical sequences of some IFPs in web-based databases, as enzyme digestion generated sufficient numbers of peptides from each spot to achieve this. In contrast, it was more difficult to obtain good matches for some of the lower molecular weight matrix proteins. Relatively few peaks were generated from tryptic digests of high-sulfur proteins because of their lower molecular weight and the absence of basic residues in the first two-thirds of the sequence. Their high sequence homology also means that generally only a few of these peptides could be considered to be unique identifiers for each protein. Nevertheless, it was still possible to uniquely identify some of these proteins, while the presence of two peptides in the matrix-assisted laser desorption/ionization time-of-flight mass spectrum allowed classification of other protein spots as being members of this family. Only one major peptide peak was generated by the high-glycine tyrosine proteins (HGTPs) and there were relatively few sequences available in web-based databases, limiting their identification to one HGTP family.

Amino Acid Sequence↗