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[Relationship between growth and tooth eruption. Relationship between growth and physical development and eruption of first permanent molars in São Paulo students].

In order to verify the relationship between the children's growth and their teeth's emergence the authors surveyed 1278 school children in São Paulo's Ipiranga District, 1024 from government controlled schools and 254 from a private school, finding their weight and height anthropometric measures related to the emergence of permanent molars. Their ages were four (completed) to eight incompleted). It was verified that the children from the private school presented in average higher weight and height than those from government controlled schools as well as higher percentages of first permanent molars erupted, in both the sexes and in all the age groups and that there was a positive association between the children's growth and their teeth's emergence.

Body Height↗

The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat.

Both epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1) have been shown to accelerate eruption of teeth in rodents. We compared the effects of neonatal injections of EGF (1 micrograms/g body weight) and CSF-1 (10(6) units) alone or together on the eruption of incisors and first molars. EGF accelerated the eruption of incisors with no significant effect on first molars. CSF-1, in contrast, accelerated molar eruption more than incisor eruption. CSF-1, but not EGF, increased the numbers of mononuclear cells in the dental follicle and osteoclasts on adjacent alveolar bone surfaces around the first molar and produced enhanced resorption of crypt surfaces as revealed by scanning electron microscopy. These data suggest that during eruption rodent incisors and molars may preferentially respond to different molecular regulators.

Alveolar Process↗

[Guided tooth eruption via serial extraction].

Crowding of teeth is the result of arch length discrepancy (ALD). Minimal crowding can be solved with slice-technique, more severe crowding (ALD > or = 5 mm) can be intercepted with a serial extraction procedure. In this paper a sequence of serial extraction will be explained and illustrated with case reports.

Child↗

Face height and tooth eruption in adults--a 20-year follow-up investigation.

A longitudinal roentgen cephalometric investigation of vertical craniofacial and dentoalveolar changes during 20 years of adulthood, was performed in 15 men and 15 women. Two lateral cephalograms taken at the average ages 25 and 45 years, were available of each subject. Skeletal and dental changes were described by 13 linear and four angular cephalometric measurements. The analysis of the linear variables showed that total anterior face height increased by 1.60 mm on average. Approximately one-fifth of this increase occurred in the upper and four-fifths in the lower face. In the dentoalveolar region, significant increments of all dimensions except overjet and overbite were found, indicating an eruptive movement of the teeth and a vertical development of their investing tissues. The analysis of the angular measurements showed that posterior rotation of the mandible and uprighting of the upper incisors had occurred during the period of investigation.

Adult↗

Sources of variability in rat caries studies: weaning age and diet fed during tooth eruption.

A factorial design (2x2) was used to study the caries effect of two diets (starch based versus stock) fed to rat dams and their litters, and also of variations in the weaning age (19 versus 25 days). Higher and reproducible caries scores were obtained in rats which were fed a purified starch-based diet, weaned at 19 days of age, and subsequently given a cariogenic challenge.

Age Factors↗

[Is the reason for a decrease in dental caries after fluoridation in Basle the delay in tooth eruption?].

In several previous reports it was shown that water fluoridation in Basel has significantly reduced caries frequency in 7--15 year-old schoolchildren. This reduction is only for a small part caused by certain time differences in the eruption of the teeth. Neither can it be explained by instruction and motivation for better nutrition and home care, because mouth hygiene of the Basel schoolchildren has not improved over the last decade. Also, a reduction in sugar consumption could not be observed. Therefore, the conclusion seems justified that water fluoridation is mainly responsible for the reduction of caries.

Adolescent↗

[Chronology of permanent tooth eruption in Argentinian children].

The knowledge of the ages at which individual teeth emerge in a given ethnic group is essential for the planning of preventive measures and the treatment on malocclusion within a population. A number of factor such as sex, ethnic characteristics, etc, have been found to be related to emergence timing of the permanent teeth; however ages assessed in other countries cannot be used because of considerable variation from one country to another. This investigation was performed on a cross-sectional sample of 4735 randomly-selected caucasian and amerindian children from 10 geographic regions of Argentina, including the Federal District. Mean ages of eruption were computed using probit procedure. Mean times of emergence of the permanent (except third molars) showed practically no difference between the two ethnic groups. In both samples all teeth emerged earlier in girls. Since it seems that the mean time of emergence of the permanent teeth occurs at least one year before the commencement of schooling, preventive measures should be applied before that age.

Age Factors↗

Dense incisors (din): a new mouse mutation on chromosome 16 affecting tooth eruption and body size.

Dense incisors (din) is a new autosomal recessive mutation in the mouse that interferes with complete eruption of the incisors. The initial eruption of incisors through the gingiva does not differ in mutants and normal littermates, but subsequent further eruption of incisors is arrested in mutants. Radiographic examinations show that, because the incisors do not erupt, continued dentin formation gradually occludes the pulp chambers of these teeth creating as dense incisor. The arrested eruption of the incisor results in an anterior open bite. The pleiotropic phenotype of din/din mutant mice also includes small body size, reduced ear pinna size, and coat color dilution. The din mutation was mapped to Chr 16 near the pituitary transcription factor gene Pit1, but din is not a mutation in Pit1.

Animals↗

[In the interests of taking one's time even when one reads a scientific article! Critical review of the literature on tooth eruption].

Nowadays everybody has access to the medical literature, not only through the libraries of the universities, but even more conveniently via Medline and Pubmed. It is very tempting only to read abstracts and summaries instead of "wasting time" by reading the whole article. Reading the article itself however enables the reader to select only these articles that have a good methodological and statistical basis. In this contribution several topics will be discussed that may help the reader to read scientific articles with a critical mind: definitions, quality of the data, study concepts, composition of the sample, control group, statistical analysis, sample size and interpretation of the results. Different items are exemplified with articles that deal with the emergence of permanent teeth.

Controlled Clinical Trials as Topic↗

Delayed tooth eruption: association with severity of HIV infection.

PURPOSE: HIV status is monitored by expression of clinical symptoms as well as CD4 lymphocyte counts. The purpose of this study is to assess the relationship between delayed dental eruption (DDE) and the progression of pediatric HIV infection to AIDS. METHODS: A population of 70 perinatally HIV-infected children, aged 5 months to 13 years at their time of entry into the study, received dental examinations. Regression analysis between dental age and chronological age was performed. Subject CDC classification, adjusted for age, was used to determine an association between eruptive delay and severity of disease progression. RESULTS: Data revealed no significant difference in timing of eruption based on severity of CD4 depletion alone (P = 0.09). However, clinical symptom status was strongly associated with DDE (P = 0.003). The relationship between symptoms and DDE persisted after controlling for CD4 depletion. CONCLUSIONS: Our study indicates that there is a correlation between the progression from HIV infection to Pediatric AIDS and DDE and that this delay is most closely linked to severity of symptoms and not CD4 depletion.

Acquired Immunodeficiency Syndrome↗

Comparison of different methods for estimating human tooth-eruption time on one set of Danish National Data.

The prevalence of congenitally missing teeth and the eruption times for the teeth in the human permanent dentition, defined as the mean age at which the teeth emerge in the mouth, were calculated from cross-sectional records of 760,108 children. A computation method based on probit analysis and Kärber's method based on dosage/response curves were compared and their estimates related to figures obtained by direct interpolation in the data. Kärber's method was less precise than probit analysis especially when data were not corrected for frequency of congenitally missing teeth or the number of observation points decreased. As the advantage of the Kärber method of easy computation is now reduced by the use of computers, probit analysis is recommended.

Adolescent↗

Evaluating tooth eruption on sealant efficacy.

For patients aged 5 to 9 and 11 to 14, 100 occlusal surfaces on newly erupting permanent molars were treated with a self-curing pit and fissure sealant. All teeth were categorized according to stage of eruption and sealant thickness of the coating applied. After 36 months, 75 surfaces were examined for a final evaluation; 52 surfaces (70%) did not need retreatment. Of the 23 surfaces retreated as a result of sealant loss or marginal deterioration, 18 were retreated only once in the six recall evaluations. Those molars treated originally with the operculum covering the distal marginal ridge of the occlusal surface had twice the probability for retreatment as teeth not treated until the entire marginal ridge was exposed. The thickness of the sealant coating did not affect the early signs of sealant failure.

Adolescent↗

Tooth eruption: the phase transition theory on biological formation of an orderly structure.

The mechanism of the formation of an orderly structure from random elements in organ development was clarified by studying the maturation of the dental arch in the human mandible. First, an application of methods established in statistical physics to a system of organ development was made possible, and then, the mathematical procedures for quantitative study of the structure and development of the dental arch were established in relation to radiographic data. The experimental results demonstrate that a parallel arrangement of the longitudinal axes of the lateral teeth is formed co-operatively in the dental arch. As formulation of the results to mathematical relations, the regulatory process was expressed by a non-linear Langevin equation of order parameter denoting an angle between longitudinal axes of the individual teeth. It follows that the orderly structure evolves with a change in thermodynamic potential; that is, the establishment of order in a phase transition. We propose the concept that organ differentiation is a phase transition in a dissipative system, with the decrease of gene activity substituted for temperature.

Adolescent↗

Relationships between tooth eruption, occlusion and alveolar bone resorption: cytological and cytochemical studies of bone resorption on rat incisor alveolar bone facing the enamel.

The rat labial incisor alveolar bone facing the enamel and bearing the occlusal force was examined by electron microscopy after being compared with the lingual alveolar bone by histological and scanning electron microscopic (SEM) observations. On the labial side, shallow resorptive lacunae were recognized all over the bone surface; these were mainly covered by osteoclasts and some mononuclear cells. The cement line was absent from the bone matrix. On the lingual side, residues of Sharpey's fibers, the bone formation surface and deep resorptive lacunae were observed by SEM. Histologically, bone remodeling areas showing both osteoclasts and active bone-forming osteoblasts on the bone surface, as well as many cement lines in bone matrix, were recognized. Furthermore, electron microscopic and cytochemical studies demonstrated that mononuclear cells located close to osteoclasts displayed osteoblastic characteristics such as alkaline phosphatase activity, a developed Golgi apparatus, and a rough endoplasmic reticulum. These findings indicate that continuous bone resorption occurs on the labial bone surface, while active bone remodeling occurs on the lingual surface. Even on the labial surface, osteoblastic cells close to osteoclasts seem to play an important role in the differentiation and or activation of osteoclasts.

Acid Phosphatase↗

Epithelial alpha-naphthyl acetate esterases in the green vervet monkey gingiva before and after periodontal surgery and during tooth eruption.

To provide enzymatic information on de novo formed junctional (JE) and sulcular epithelium (SE), we performed periodontal surgery on 24 teeth. Ten to 14 days postoperatively, all experimental and 16 control teeth were extracted with adjacent buccal gingiva. In addition, specimens from unerupted and partly erupted teeth containing enamel epithelium (EE) were examined. Fixed cryostat sections were cut in series, stained with HE, or incubated with and without substrate for demonstration of alpha-naphthyl acetate esterase activity and for control purposes, respectively. The distribution and intensity of the alpha-naphthyl acetate esterase activity of newly reformed JE and SE was identical to that of the original JE and SE, i.e. suprabasal and very strong. In contrast, both the oral gingival epithelium (OGE) and the EE displayed a very weak enzyme reaction. These observations indicate that the presence of alpha-naphthyl acetate activity of original and reformed JE and SE is probably site specific and of nondevelopmental origin. Heavy inflammation after healing was associated with enhanced epithelial proliferation of OGE and, in addition, marked esterase activity of these proliferations and corresponding OGE. This points at a possible inflammatory induction of the marked esterase activity seen in JE and SE as well as site-specific, connective tissue influences. Further investigation is needed to elucidate the effect of inflammation on the esterase activity.

Animals↗