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PubMedDate not supplied

[Tick-borne relapsing fever morbidity in the western Pamirs].

Morbidity with tick-borne recurrent fever in the western Pamirs is compared with that of the 1930s. It reduced considerably though the disease is widespread in the Pandj valley. The majority of patients are earlier resistant local inhabitants. This may be accounted for by vector number decrease to the level causing loss of immunity in the large part of the population. Unlike even distribution of recurrent fever in the western Pamirs in the 1930s, nowadays most cases are detected in the lower parts of the Pandj valley and there are no infection foci in the upper parts, which might be connected with gradual increase in the portion of immune population up the Pandj river and with diagnosis inadequacy. The incidence of recurrent fever in the Pamirs is considerably higher than in other parts of Tajikistan.

Age Factors↗
PubMed2005

Identifying relapsing fever Borrelia, Senegal.

We describe a nested polymerase chain reaction for the identification of Borrelia species from serum of patients with unidentified fevers. This technique, based on single nucleotide polymorphisms of the 16S ribosomal RNA gene, was used to test blood samples from 7,750 patients, 33 of whom were diagnosed with spirochete infections. Borrelia crocidurae was the only species identified.

Adult↗
PubMed1987

Fatal-Jarisch Herxheimer reaction in a case of relapsing fever misdiagnosed as lobar pneumonia.

A fatal Jarisch-Herxheimer reaction developed after treatment with high doses of penicillin in a case of lobar pneumonia caused by Borrelia duttoni. Penicillin given on the first day and tetracycline on subsequent days to avoid severe Jarisch-Herxheimer reactions, has the disadvantage of a longer period of spirochetemia and hypotension as compared with tetracycline on the first day. Treatment may have contributed to the death of this patient.

Adult↗
PubMedDate not supplied

[The effect of the causative agent of tick-borne relapsing fever on the respiration of the vector Ornithodoros papillipes (Birula, 1895) (Ixodoidea, Argasidae)].

A relatively low level of normal respiratory metabolism in O. papillipes has been observed as compared to most other invertebrates and even ixodid ticks. It is connected with biological peculiarities and habitat of this species. Changes in respiratory metabolism under the influence of Borrelia have been revealed. These changes vary at different stages of tick life cycle. In long-fasting infected individuals, respiration is further inhibited, and in nourished ones, is increased as compared to noninfected ticks.

Animals↗
PubMed2002

Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever.

A 14-year-old girl was seen at a community clinic with a chief complaint of abdominal pain and fevers and was treated with oral ciprofloxacin for presumed pyelonephritis. She became tachycardic and hypotensive after her first dose of antibiotic, and she developed disseminated intravascular coagulation. She was admitted to our hospital for presumed sepsis. Her outpatient peripheral blood smear was reviewed, revealing spirochetes consistent with Borrelia sp. To our knowledge this is the first reported case of the Jarisch-Herxheimer reaction to ciprofloxacin.

Adolescent↗
PubMedDate not supplied

[Effect of Borrelia--the causative agent of tick-borne relapsing fever--on the vector].

Direct or indirect evidence of pathogenic effect of Borrelia sogdiana, a tick-borne recurrent fever causative agent, on Ornithodoros papillipes is obtained, pointing to a parasitic character of their relations. Differences between infected and uninfected ticks are revealed both under normal life conditions (lower survival, more intensive process of moult), as well as under the effect of poison. Higher sensitivity of infected ticks to DDT was established experimentally; HCCH effect was determined indirectly by counting ticks after treatment. Authors suggest that the effect of causative agent on ticks' viability is more expressed under the conditions close to emergency.

Animals↗
PubMed2000

Size conversion of a linear plasmid in the relapsing fever agent Borrelia duttonii.

Borreliae have genomes composed of both linear and circular replicons. We have characterized the organization of linear DNA molecules from the Borrelia duttonii strain Ly. It contains a linear one megabase chromosome and 12 linear plasmids of 11 to 200 kb in size. A variant of the strain obtained after successive in vitro cultivation in BSKII medium had a 69 kb molecule instead of the 44 kb linear plasmid. No detectable differences in the growth rates and cellular structures were found. Southern hybridization using the vsp33 gene sequence from Borrelia hermsii as a probe showed that both plasmids (69 and 44 kb molecules) contained a similar part of the sequence. The spirochetes of the parental strain cause erythrocytes to aggregate in mice blood, but the variant did not form such aggregates and seemed to have lost its infectivity in mice. Size conversion of the linear plasmid may be associated with the host-parasite relationship in mammals.

Animals↗
PubMed1985

Neonatal Borrelia species infection (relapsing fever).

Two cases of neonatal Borrelia infection occurred. The first was in a 30-hour-old Bedouin neonate who had been delivered of a febrile mother in a tent. She was admitted to the hospital on the second day of life in a good, general state. Her condition deteriorated a few hours after admission when jaundice, hepatosplenomegaly, and hemorrhage appeared. Borrelia organisms were found on peripheral blood smear. The patient died 16 hours after admission. Findings from the physical examination of the mother were normal, and no Borrelia organisms were seen in her blood smears. The second case was in a 15-day-old male newborn who was admitted to the hospital with severe jaundice, hepatosplenomegaly, bleeding tendency, and evidence of severe acidosis. Multiple spirochetes were found in blood and CSF smears. His clinical course was fulminant, and despite massive antibiotic treatment, he died within 24 hours of admission. Three weeks prior to delivery, the mother had had a febrile illness. Examination of the mother and her blood at the time of the illness of her son did not disclose any abnormalities.

Female↗