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PubMed1969

Adverse effect of topical fluorinated corticosteroids in rosacea.

Fourteen patients suffering from rosacea treated by prolonged topical applications of fluorinated steroids showed adverse effects. Aggravation and extension of telangiectasia occurred in all, and in most cessation of the treatment was followed by severe rebound inflammatory oedema and acute pustular eruption. The telangiectasia cleared or was much improved within three months of cessation of the use of fluorinated steroids. Hydrocortisone did not produce the same effect, and hence it was used, together with oral tetracycline, for treatment.

Administration, Topical↗
PubMed2004

Low genetic diversity among Frankia spp. strains nodulating sympatric populations of actinorhizal species of Rosaceae, Ceanothus (Rhamnaceae) and Datisca glomerata (Datiscaceae) west of the Sierra Nevada (California).

Frankia spp. strains typically induce N2-fixing root nodules on actinorhizal plants. The majority of host plant taxa associated with the uncultured Group 1 Frankia strains, i.e., Ceanothus of the Rhamnaceae, Datisca glomerata (Datiscaceae), and all actinorhizal members of the Rosaceae except Dryas, are found in California. A study was conducted to determine the distribution of Frankia strains among root nodules collected from both sympatric and solitary stands of hosts. Three DNA regions were examined, the 5' end of the 16S rRNA gene, the internal transcribed spacer region between the 16S and 23S rRNA genes, and a portion of the glutamine synthetase gene (glnA). The results suggest that a narrow range of Group 1 Frankia spp. strains dominate in root nodules collected over a large area of California west of the Sierra Nevada crest with no apparent host-specificity. Comparisons with Group 2 Frankia strain diversity from Alnus and Myrica within the study range suggest that the observed low diversity is peculiar to Group 1 Frankia strains only. Factors that may account for the observed lack of genetic variability and host specificity include strain dominance over a large geographical area, current environmental selection, and (or) a past evolutionary bottleneck.

California↗
PubMed1990

Rosacea-like angiosarcoma of the face.

We present an 84-year-old white male patient who, during a 2-year period, developed successively tumor infiltrations of an angiosarcoma in his face. The tumor started at the right lower eyelid, later appeared on the nose, the front, the cheeks and the earlobes. The first clinical impression was that of a rosacea. The tumors where successfully treated by soft X-rays, the total doses ranging from 4,800 to 5,600 cGy.

Aged↗
PubMed1976

The treatment of steroid-induced rosacea and perioral dermatitis.

Description of adverse effects of strong corticosteroids in rosacea. Perioral dermatitis also seems to be caused by treatment with strong corticosteroids. The rebound effect after weaning the patient from strong corticosteroids might be obviated by hydrocortisone 17-butyrate or hydrocortisone 21-acetate. Continued oral tetracycline treatment is recommended.

Adolescent↗
PubMedDate not supplied

Pharmaco-toxicological study of Kageneckia oblonga, Rosaceae.

The probable antipyretic, antiinflammatory, analgesic and antioxidant properties of Kageneckia oblonga, Rosaceae, were investigated and the major compounds of its active extracts were isolated. The study comprised the acute toxicity of the extracts of global methanol, hexane, dichloromethane and methanol. The cytotoxicity of global methanol extract was studied in three tumoral cell lines. All the extracts exhibited the pharmacological activities under study. Methanol and dichloromethane were the most toxic extracts. From the global methanol extract, isolations were performed of prunasin, 23,24- dihydro-cucurbitacin F, and a new cucurbitacin, 3beta-(beta-D-glucosyloxy)-16alpha,23alpha-epoxycucurbita-5,24-diene-11-one. The cytotoxicity of both cucurbitacins on human neutrophils at the assayed concentrations was not statistically significant. In-vitro assays showed that both cucurbitacins can be partly responsible for the analgesic, antipyretic, and anti-inflammatory activities. Evaluation was done of the cytotoxicity of global methanol extract, 23, 24-dihydrocucurbitacin F, aqueous extracts and prunasin against P-388 murine leukaemia, A-549 human lung carcinoma and HT-29 colon carcinoma. Since global methanol extract presented a strong cytotoxicity against P-388 murine leukaemia, A-549 human lung carcinoma, and HT-29 cell lines, it is highly probable that this extract contain one or more cytotoxic compounds that could be investigated for their potential use as an agent against cancer.

Analgesics, Non-Narcotic↗
PubMedDate not supplied

Cytotoxic, hypoglycemic activity and phytochemical analysis of Rubus imperialis (Rosaceae).

Rubus imperialis, Artemia salina, 3-O-methylellagic-4'-O-alpha-rhamnose Acid Screening of different extracts, fractions and compounds from Rubus imperialis Chum. Schl. (Rosaceae) has been conduced using the brine shrimp microwell cytotoxicity assay. Three parts of the plant (methanolic extract from leaves, roots and stems), three fractions from roots (hexane, ethyl acetate and butanol) and three isolated compounds (niga-ichigoside F1, 23-hydroxytormentic acid, ellagic acid derivative) were tested. The most promising material (LC50 <1000 microg/ml) were the methanolic extract and ethyl acetate fraction from roots. However, there was little correlation observed in the degree of toxicities observed between the isolated compounds. On the other hand, the cytotoxicity and in vivo assays confirmed the hypoglycemic activity of methanolic extract and validated the Brazilian popular use of R. imperialis as an antidiabetic agent.

Animals↗
PubMed1999

Recognizing rosacea.

Rosacea is a common disorder of the facial skin that tends to become apparent after age 30. Symptoms are usually progressive, but early diagnosis and appropriate management can alleviate patient discomfort and psychological distress as well as prevent serious long-term complications.

Anti-Infective Agents↗
PubMed2000

Rosacea: an update.

Rosacea is a common inflammatory skin disease affecting the central face of adults. Its etiology is unknown. Early diagnosis and appropriate treatment, usually with topical or systemic antibiotics or both, minimizes symptoms and helps to prevent complications.

Adult↗
PubMed1999

[Rosacea, vinegar and lemon, dysuria and Helicobacter pylori].

A 52 year old male consulted his clinician because of dysuria, difficulty in voiding and cutaneous lesions that were cured with high daily ingestion of acid substances (vinegar and lemon). For the last 20 years he had made several consultations without finding any solution to his problem. The patient was advised to stop acid ingestion after which he presented disuria and skin lesions compatible with rosacea. Due to the known association between this skin disorder and gastric colonization with H. pylori an upper gastrointestinal endoscopy was performed and the presence of the bacteria was confirmed. The patient received specific treatment with permanent resolution of the symptoms. We repeated the endoscopy with biopsy that did not show the presence of H. pylori. It is suggested that gastric colonization with H. pylori could be related to irritative symptoms of the lower urinary tract that are not due to other disease processes.

Acetic Acid↗
PubMed2000

[Rosacea, acne and other diseases of the seborrheic spectrum].

Diseases of seborrhoic origin include rosacea, acne, gram-negative folliculitis, demodex-folliculorum, perioral dermatitis as well as seborrhoic dermatitis. An important prerequisite for adequate therapy is the knowledge of these different diseases. Unfortunately, topic steroids are often applied, resulting in well known corticosteroid side-effects like skin atrophy and teleangiectasias. The different clinical diseases of seborrhoic origin are reviewed here and a treatment guide is presented.

Acne Vulgaris↗
PubMed2001

Recurrent phlyctenular keratoconjunctivitis: a forme fruste manifestation of rosacea.

BACKGROUND: Phlyctenular keratoconjunctivitis represents a delayed type hypersensitivity response to a systemic antigen within the body. METHODS: We present a case of symptomatic, recurrent, phlyctenular keratoconjunctivitis in an 8-year-old child. The patient's inflammation responded favorably to topical steroids at each episode, but no specific antigen could be identified. CONCLUSION: After observing the father's erythematous facial lesions, we attributed the child's ocular inflammation to rosacea (as a forme fruste manifestation) and treated her with systemic erythromycin. The symptoms were rapidly relieved and the disease process was arrested.

Child↗
PubMed2001

Microfungi on Rosaceae in eastern Westphalia (Sauerland, North Rhine-Westphalia, Germany).

Microfungi occuring on Rosaceae in the Sauerland were examined. 38 microfungi from 27 different genera were found, including Ascomycetes of the orders Erysiphales, Helotiales, Hypocreales and Taphrinales and Basidiomycetes of the order Uredinales as well as mitosporic fungi. The examined samples have been collected in the period of march to september 2000. New hosts could be found for the following species: Discosia potentillae Lib., Phragmidium acuminatum (Fr.) Cooke, Stigmina carpophila (Lev.) M.B. Ellis, Seimatosporium pestalozzioides (Sacc.) B. Sutton, Septocyta ruborum (Lib.) Petr. and Zythiostroma mougeotii (Fr.) Höhn. Discosia potentillae Lib. is recorded for the first time for Germany and Cercospora potentillae Chupp & Greene for the first time for Europe.

Fungi↗
PubMed2002

Polyphenols of Egyptian Rosaceae plants--two new flavonoid glycosides from Sanguisorba minor Scop.

Two new flavonol glycosides, 8-methoxyquercetin-3-O-beta-glucosyl-(1'"-2")-O-beta-glucoside and kaempferol-3-O-[2'"-galloyl-O-beta-glucosyl-(1'"-2")-O-beta-glucoside)], together with five known quercetin and kaempferol 3-O-mono-glycosides, were isolated and identified from the aerial parts of Sanguisorba minor Scop. (Rosaceae). All structures were determined by routine methods of analysis and confirmed mostly by negative ESI-MS, 1H- and 13C NMR.

Flavonoids↗
PubMed2003

Is permethrin 5% cream effective for rosacea?

Permethrin 5% cream is a safe alternative for the topical treatment of papulopustular rosacea. Permethrin 5% cream is superior to metronidazole 0.75% gel and placebo in decreasing Demodex folliculorum, and is as effective as metronidazole 0.75% gel in treating erythema and papules.

Animals↗
PubMed1992

Management of rosacea.

Rosacea is a skin dysfunction affecting a large number of individuals. The cause is unknown and there is no known cure. Once the condition is recognized, however, much can be done to reduce the extent and impact of this disease.

Humans↗
PubMed1992

Flushing and rosacea: overview and nursing interventions.

Rosacea is a dynamic facial dermatosis characterized by exacerbations and remissions which affects middle-aged men and women, most of whom flush easily. It is a conspicuous, yet treatable condition. Oral and topical antibiotics, as well as changes in lifestyle and elimination of aggravating factors, are necessary for control. Nurses facilitate compliance with the treatment regimen and optimize patient self-esteem.

Female↗