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PubMed2004

[Preserved ability to read aloud kanji idioms in left handed alexia].

We report a 69-year-old left-handed man, who developed alexia after a right medial occipito-temporal lobe infarction. On admission to the rehabilitation department two months after the onset, neurological examination showed left hemianopia, left hemiparesis, decreased deep sensation on the left side, and alexia. A brain MRI demonstrated infarcts in the right medial occipito-temporal lobe and the splenium of the corpus callosum. Detailed neuropsychological examination was performed two months after the onset. The patient was alert and cooperative. His speech was fluent with some word-finding difficulty. Comprehension for spoken materials, repetition, and naming abilities were all preserved. Systematic examination for reading revealed that reading aloud was disturbed in both kanji and kana words. Reading comprehension was significantly better for kanji words than kana words. First, we examined the effects of number of characters in a word. The number of characters in a word didn't affect his reading performance. Second, his performance on reading aloud of usual kanji words was compared with that of kanji words representing idioms. A kanji idiom is different from usual kanji words, in which pronunciation of each character is selected from several options. Reading aloud kanji idioms was significantly better than usual kanji words. In addition, reaction time to complete reading a word was much shorter for kanji idioms than usual kanji. An analysis of qualitative features of errors revealed that most errors in kanji idiom reading were semantically similar to the correct answers, while many errors in usual kanji word reading were classified into "don't know" responses. These findings suggested that a kanji idiom was tightly connected to its pronunciation, which resulted in his much better performance for kanji idiom reading. Overlearning of a unique relationship between a kanji idiom and its pronunciation might modify neuronal organization for reading.

Aged↗
PubMed2005

Predicting reading fluency in patients with macular disease.

PURPOSE: Difficulty in reading is the most frequent complaint of patients with macular disease (MD). This article assesses whether clinical variables measured at the onset of MD can be used to predict patients' future reading ability. METHODS: Twenty-five patients with MD were recruited within 4 weeks of the onset of symptoms in their second affected eye. Clinical and demographic features were recorded at baseline and at the exit point of the study 3 to 12 months later. Odds ratios (OR's) were constructed to assess the predictive value of these variables in terms of reading fluency and any change in reading speed at the exit point of the study. RESULTS: Baseline contrast sensitivity was associated with future fluent reading (OR, 2.40; interval size, 0.15; 95% confidence interval, 1.13 to 5.07). Age, sex, scotoma size, disease type, visual acuity, and reading speed were not statistically significant predictors of future fluent reading. It was not possible to predict fully in which patients reading speed improved or deteriorated. CONCLUSIONS: Contrast sensitivity can predict the likelihood of future fluent reading in patients with MD. Baseline reading speed, visual acuity, age, disease type, and scotoma size are poor predictors of future reading performance.

Contrast Sensitivity↗
PubMed1995

DH element reading frame selection is influenced by an Ig heavy chain transgene, but not by bcl-2.

Mouse B cell precursors containing Ig DHJH junctions in one particular reading frame are selectively lost during B cell development. In this register, arbitrarily referred to as reading frame 2, DHJH junctions give rise to an open reading frame starting upstream of the DH element and including the DHJH-peptide fused to the constant region of IgM. Expression of this protein, called D mu, has been strongly implicated in the loss of B cell precursors containing reading frame 2 DHJH junctions. In an attempt to elucidate the means of D mu counterselection, we have examined the reading frame distribution of DHJH junctions in peripheral B cells from mice transgenic for either the human bcl-2 oncogene or for a functionally rearranged Ig mu heavy chain. In bcl-2 transgenic mice, reading frame 2 accounted for < 5% of the DHJH junctions in peripheral B cells, a value not significantly different from controls. Reading frames 1 and 3 were equally represented among the remaining junctions. By contrast, the reading frame distribution of endogenous DHJH junctions in splenic B cells from Ig mu heavy chain transgenic mice showed no evidence of bias against D mu encoding DHJH junctions. Reading frames 2 and 3 accounted for 27% and 30% of the sequenced DHJH junctions, respectively, and the remaining 43% were reading frame 1. Thus although the presence of BCL-2 cannot prevent the selective loss of reading frame 2 DHJH B cells, a functional mu heavy chain can. These results suggest that D mu-expressing B cell precursors may be selectively lost because of the premature and inappropriate cessation of heavy chain gene rearrangement rather than because of the induction of an apoptotic process which can be blocked by BCL-2.

Animals↗
PubMed1996

Fundus-controlled examination of reading in eyes with macular pathology.

The ability to read is an important parameter for the optical rehabilitation of visually handicapped patients. For the choice of the best therapy, more detailed knowledge of the physiology of reading is required. We evaluated reading velocity as well as the number of saccades in and against the direction of reading for reading plates with different character sizes (10 steps from a letter height of 3-0.25 degrees) using the scanning laser ophthalmoscope in 20 healthy eyes and 30 eyes with central and paracentral scotomas. The number of characters read during each fixation increased with decreasing size of characters from 3.2 to 4.4 in normals. However, the reading velocity decreased from 14 to 11 digits/s when digits became very small. In patients' eyes the greatest reading velocity was reached at 6.1 digits/s for a 1 degree size, and the maximal number of digits read during one rest phase was 3.2 for a 0.75 degree size. In patients we observed a high number of saccades against the reading direction and different loci of fixation. Fundus-controlled examination allows for new insights into the physiology and pathophysiology of reading. Loss of the central visual field leads to an increase in the number of saccades because the number of digits perceived during each fixation decreases. The high number of regressions may be caused by the typical shift of the center of fixation following paracentral scotoma. Saccades directed toward the scotoma have to be corrected due to failure of exact positioning.

Adult↗
PubMed1997

Transient and sustained processing: effects of varying luminance and wavelength on reading comprehension.

BACKGROUND: Reading disability (RD) is a serious epidemiologic problem and may affect up to 15% to 20% of elementary school children. This study addresses whether the reading comprehension skills of children with RD improve as wavelength and contrast of light are altered. METHODS: Fifty-six children, identified as either normal or reading disabled, were required to read a series of standardized 300-word passages under four conditions: no filter (baseline); light gray filter, dark gray filter, and blue filter. Each reading selection was timed, reading comprehension was measured, and data were processed. RESULTS: Initial standardized reading comprehension test scores significantly differentiated average from poor readers. Using reading selection levels consonant with each subject's ability, no significant differences were measured in baseline comprehension scores between good and poor readers. Comprehension scores of poor compared to good readers were significantly better using blue filters (p < 0.01). CONCLUSIONS: Our study suggests an association between wavelength of light, luminance, and reading performance. Blue filters were found to improve reading comprehension in poor readers. The results support the concept of a transient system deficit involving wavelength of light and reading performance.

Child↗
PubMed2000

Spoken language correlates of reading impairments acquired in childhood.

This study reports the reading difficulties of five children following unilateral left hemisphere stroke sustained either before or during the early stages of literacy acquisition. Although each of the children experienced a period of disturbed language processing in the initial stages postonset, at the time of testing none of the children were considered to be clinically aphasic. Yet, on a standardized test of oral reading each of the children achieved a reading age that lagged behind chronological age and marked reading impairments were disclosed in four of the five children. A set of standardized and nonstandardized tests, aimed at measuring aspects of cognitive and spoken language processing that are considered to be important for normal reading acquisition, was administered. Where nonstandardized tests were used, performance of each of the stroke children was compared to that of groups of normally developing control children, closely matched for chronological age. A range of residual deficits in cognitive and spoken language processing was disclosed among the five brain-damaged children that appeared to be associated with their reading impairments. Two children had expectedly poor reading due to a selective impairment in verbal IQ; a specific phonological reading disorder was revealed in two children, each of which had a residual impairment to phonological awareness; and delayed reading acquisition was observed in one child with a general language deficit. It is suggested that when a child suffers damage to the left hemisphere in the early stages of reading acquisition, difficulties with learning to read are likely to ensue and may arise as a consequence of an underlying cognitive or linguistic deficit.

Brain↗
PubMed2006

Reading impairment and visual processing deficits in schizophrenia.

Individuals with schizophrenia show magnocellular visual pathway abnormalities similar to those described in dyslexia, predicting that reading disturbance should be a common concomitant of schizophrenia. To date, however, reading deficits have not been well established, and, in fact, reading is often thought to be normal in schizophrenia based upon results of tests such as the WRAT, which evaluate single word reading. This study evaluated "real world" reading ability in schizophrenia, relative to functioning of the magnocellular visual pathway. Standardized psychoeducational reading tests and contrast sensitivity measures were administered to 19 patients and 10 controls. Analyses of between group differences were further refined by classification of participants into reading vs. non-reading impaired groups using a priori and derived theoretical models. Patients with schizophrenia, as a group, showed highly significant impairments in reading (p<0.04-p<0.001), with particular deficits on tests of rate, comprehension and phonological awareness. Between 21% and 63% of patients met criteria for dyslexia depending upon diagnostic model vs. 0-20% of the controls. The degree of deficit correlated significantly with independent measures of magnocellular dysfunction. Reading impairment in schizophrenia reaches the level of dyslexia and is associated with compromised magnocellular processing as hypothesized. Findings related to symptoms, functioning and recommendations for reading ability assessment are discussed.

Adolescent↗
PubMed2001

Effectiveness and cost-effectiveness of double reading of mammograms in breast cancer screening: findings of a systematic review.

There is a lack of direct evidence on the effectiveness of double reading of breast screening mammograms within the context of national screening programmes even though about half of the countries that use mammography screening have implemented double reading. A systematic review was conducted to compare double reading with single reading of mammograms for screening accuracy, patient outcomes and costs. We searched an extensive range of electronic databases, bibliographies of studies were scanned and experts were contacted. Data extraction and quality assessment was undertaken independently by two reviewers. Estimates of the diagnostic accuracy were calculated for those studies with follow-up to identify interval cancers. Only 10 cohort studies met the inclusion criteria with reported extractable data on the effectiveness of double compared to single reading. The mix of methodologies meant that few conclusions could be drawn about the effect of double reading independent of number of views, or effects on size and type of tumours detected. Overall, double reading increases the cancer detection rate by 3-11 per 10,000 women screened and has a double impact on recall rates depending on the recall policy used. The benefit could be mainly in the detection of small cancers, and could be greatest where two readers have different strengths and weaknesses, or where readers are less experienced. Double reading can improve accuracy as compared with single reading. In particular, double reading by consensus or arbitration achieves an increase in cancer detection rate together with a reduction in the rate of women recalled for assessment. Further research should quantify the relative benefit from double reading according to recall policy and number of mammographic views, and estimate the impact on patient outcome.

Journal Article↗
PubMed1975

Relationship of early readings of minimal inhibitory concentrations to the results of overnight tests.

Broth dilution minimal inhibitory concentration (MIC) readings were compared after different incubation periods and with different inoculum concentrations. The purpose was to determine the best conditions for obtaining early results as close as possible to overnight readings. Initially, 76 antibiotic-organism combinations were tested using the International Collaborative Study technique and inoculum and were read after 3, 8, and 18 h of incubation. Approximately 28% of tests showed fourfold or greater increases in MICs after 18 h of incubation compared with the 3-h readings. No overnight MICs were lower than early readings. MICs of single antibiotics against seven organisms were also read with an automatic particle counter to confirm the validity of the visual readings. Experiments were made to determine whether inoculum manipulation could reconcile the differences between 3- and 18-h MIC results. One hundred and eight organism-antibiotic combinations were tested comparing 3-h MIC readings using an inoculum of 10(7) organisms per ml with overnight readings using 10(5) per ml. In 71 cases, readings with both inocula were within the range tested and 57 (86%) were within +/-1 log(2) of each other and followed an approximately normal distribution. Improved comparability between early read and overnight MICs thus may be achieved by inoculum manipulation, and this may be a suitable approach in the future development of automated procedures.

Anti-Bacterial Agents↗
PubMed1999

Reading numbers aloud: a measure of the limiting effect of breathlessness in patients with cancer.

BACKGROUND: Progress in the treatment of breathlessness at rest or on minimum exertion in patients with cancer requires a practical and valid method of measuring symptoms. A study was undertaken to explore the practicality, repeatability, and sensitivity of reading numbers as a form of exercise test in this group of patients. METHODS: Thirty patients with cancer and 30 age matched healthy subjects read numbers aloud as quickly and clearly as they could for 60 seconds. After five readings the maximum number of numbers read and the number read per breath was noted. This procedure was carried out twice in one day and one week later to assess within and between day repeatability. The sensitivity of the test was assessed by making measurements in 13 patients with cancer before and after drainage of their pleural effusion. RESULTS: The concept was easily understood by all subjects. Twelve patients were unable to complete five readings in all tests due to tiredness. Compared with control subjects patients read fewer numbers in the three tests (87-89% of control) and fewer numbers per breath (59-60% of control). Repeatability was good both within and between days. After drainage of their effusion all patients were less breathless and there was an increase in both the maximum number of numbers read (23%) and the number read per breath (60%). CONCLUSIONS: The number of numbers read and the number read per breath over 60 seconds was practical, easy to carry out, showed good repeatability within and between days and was sensitive to the improvement seen following drainage of a pleural effusion. It may be a useful measure of the limiting effect of breathlessness in this group of patients.

Aged↗
PubMedDate not supplied

The role of environment in the development of reading skills: a longitudinal study of preschool and school-age measures.

The purpose of this study was to extend previous studies on the influence of environmental measures on intelligence scores by examining how proximal and distal measures of children's environments in the preschool period and in the primary-grade period are related to their performance on reading achievement tests. Reading performance was explored using two approaches. The first approach involved the identification of children within a longitudinal sample who had poor reading skills at 8 years of age. The second approach used the full range of reading scores to explore whether factors influencing poor reading were different from those influencing good reading. Participants were 113 children, including 35 children with poor reading skills, who were part of a longitudinal study of cognitive development. Socioeconomic status (SES), Home Observation for Measurement of the Environment (HOME) scores at 3 and 10 years of age, and school-administered and individually administered reading achievement scores were obtained. Both SES and HOME scores were found to be related to reading abilities, but preschool environment measures were more strongly and consistently related to and predictive of reading scores. Differences in the patterns of correlations and the results of the predictive models were found between the full sample and the poor readers. Variables other than proximal and distal measures of the environment are involved in the development of reading skills.

Achievement↗
PubMedDate not supplied

The role of IQ in a component model of reading.

The purpose of this study was to test the role of visual processing speed and IQ in a model of reading. This study investigated whether the processes involved in reading differ between a group of children with and a group without reading disability. These two groups of children completed tests of reading comprehension, listening comprehension, decoding, processing speed, and intelligence. The results indicated that processing speed explains a significant amount of variance in reading comprehension over that accounted for by the simple view of reading. Also, IQ accounts for a significant amount of variance in reading over that accounted for by the simple view of reading and processing speed. Path analyses indicated that the effect of IQ on reading is partially mediated by decoding in the children with reading disability. The results point to the importance of the role of IQ in predicting reading comprehension.

Achievement↗
PubMed2003

Double reading of barium enemas: is it necessary?

OBJECTIVE: The purpose of our study was to determine the effectiveness, clinical impact, and feasibility of double reading barium enemas. MATERIALS AND METHODS: Independent double readings of 1,003 consecutive barium enemas (822 double- and 181 single-contrast examinations) were prospectively performed. From this pool of 1,003 examinations, 994 were included in our study. Examinations showing at least one polyp or carcinoma 5 mm or larger were considered to have positive results. For combined readings, results were considered positive if either of the two interpreters reported finding a polyp or carcinoma. A McNemar test was used to compare the first reader's results with the combined results of the first and second readers. Results were retrospectively correlated with endoscopic or surgical results in 360 patients, and agreement between first and combined readings and endoscopic results was determined. RESULTS: Adding a second reader increased the number of positive results on examinations from 249 to 315 (p < 0.0001) and resulted in potential alteration of clinical treatment in 98 patients (9.9%). Sensitivity of the first and combined readings for detection of all lesions was identical, 76.3% (95% CI, 65.4-87.1%). Specificity decreased from 91.0% (95% CI, 87.9-94.3%) for the first reading to 86.4% (95% CI, 82.2-90.0%) for the combined reading. The overall measurement of agreement decreased from a kappa value of 61.8 (95% CI, 51.2-72.4%) for the first reading to 52.9 (95% CI, 42.2-63.6%) for the combined reading. The second reading required an average of 3.3 min. Sensitivity for the detection of adenocarcinomas was 100%. CONCLUSION: Although feasible, double reading of barium enemas does not improve sensitivity for detection of polyps and produces a higher false-positive rate.

Adult↗
PubMed2000

[The scenes of doctor-patient meeting in the contemporary Korean novels: chiefly on the basis of doctor's reading on patients].

"Medicine as an art" implies that there is something in medicine beyond the limit of science. The practice of medicine is far more than the simple application of scientific principles to a particular biologic aberration. The communication between a doctor and a patient is the core component of medical practice, but little attention has been generally drawn to it. This study shows three types of doctor's reading on 'patient' as an alternative model to see the doctor-patient communication on the basis of the concept of 'patient as a text' and Bakhtin's narrative theory. They are monologic, dialogic, and discontinuous readings. In monologic reading, the doctor has one - sidedly the whole power in communication and it reflects only the doctor's point of view. The doctor mainly concerns for the disease and its treatment. In the dialogic reading, the power of doctor-patient is shared and their views are reflected each other The doctor should consider the patient as a human and understand his social and psychological surroundings. If the patient refuses to be treated, especially in the case of terminal cancer patient, he has nothing to do with his doctor. Therefore, the discontinuous reading can be applied and in result, no communication takes place between them. To evaluate the proposed types of the doctor's reading on patient, the three types can be applied to the scene of doctor-patient meeting in the novels. The meetings of lieutenant Sung and medical officers in Sending Back by Jung - In Suh are in accordance with the type of monologic reading. In Wan - Seo Park's Three Days in the Fall, the type of dialogic reading can be applied to that of the doctor I's lives with her patients. In Yong - Moon Chun's The Days of Dead Doctors, the type of discontinuous reading can be applied to the events between Haeng - Oh Kim and doctors in ICU. And the 3 parts of whose figure and relationship with Sorok Island have changed throughout the work. The doctors should have abundant experiences of life to make the dialogic reading possible. The dialogic reading can be realized, in its true sense, only if they see the patient not as a disease, but as a man and only if they make efforts to understand his circumstances.

History, 20th Century↗
PubMed1999

Simultaneous activation of reading mechanisms: evidence from a case of deep dyslexia.

We report the performance of LC, a deep dyslexic. We investigated extensively her errors according to serial cognitive neuropsychological models of oral reading. Initial evaluation of her reading suggested impaired access to the phonological output lexicon (POL). Impaired grapheme-to-phoneme conversion (GPC) and semantic errors in reading suggested that LC read via an impoverished semantic route. However, a serial model of oral reading could not explain error differences in reading, picture naming, spontaneous speech, and repetition. Neologisms occurred in oral reading but not in spontaneous speech and repetition. Semantic errors in naming exceeded those in oral reading. To account for these different error patterns we propose that the semantic route, the direct route from the orthographic input lexicon to the POL, and GPC activate simultaneously during reading, converging at the POL to constrain phonological selection. These routes are modular but not functionally encapsulated. For LC, the POL receives ambiguous information due to degradation of all routes, causing reading errors.

Adult↗
PubMed2005

Sensory input from the moving hand influences saccadic eye movements during reading.

Reading involves saccadic eye movements. Measured reading time and the number of mistakes made while reading reflect the speed and accuracy of the saccades in target localization, if all other factors influencing these parameters are kept constant. The observed phenomenon that reading a book is easier when it is held in an individual's hand than when it is not, especially when movement of the reading text occurs while travelling in a vehicle, raises the question of the role of sensory input from the moving arms in guiding saccades in the direction in which the text is moved. To address this question, 12 healthy subjects (6 males and 6 females), aged 19-21 years took part in this study where reading time and the number of mistakes made while reading a non-moving standardized printed text was noted. Similar printed texts were read by the subjects while mechanically moving them at different fixed speeds in the horizontal plane, with and without the subject's arms moving with the text. At each speed, the reading time recorded when the subject's arms moved with the text was significantly lesser than when they did not (P<0.05). The number of mistakes made were significantly more when not moving the arms than when moving them with the text, at higher speed of text movement (P<0.05). The results indicate that sensory input from the passively moving arms guided saccades in the direction of movement of the text during reading.

Adult↗
PubMed2002

The validity and reliability of short German sentences for measuring reading speed.

PURPOSE: To investigate whether short German sentences that have been developed to be highly comparable in number and length of words, as well as in difficulty and construction, are reliable and valid test items for measuring reading speed in order to use them for measuring simultaneously reading acuity and speed with the "Radner Reading Charts". METHODS: Tests were performed in 198 persons: 99 university students (average age 23.6+/-2.8 years) and blue-collar apprentices (average age 18.4+/-2.5 years). Reading speed and the number of errors were determined first with 24 sentences for our recently developed German reading charts (14 words equal in difficulty, length and construction) and secondly with long paragraphs of the "Zuercher Reading Test" (ZRT; paragraphs 3-5, 261 words). RESULTS: The overall mean reading speed obtained with short sentences was 209.6+/-41.0 words per minute (wpm), compared with 169.2+/-35.0 wpm for the ZRT ( P<0.001). The correlation between the short sentences and the ZRT was high ( r=0.9). Students read faster and made fewer errors than did the apprentices. Reliability analyses yielded an overall Cronbach's alpha coefficient of 0.98. The coefficient of selectivity of the 24 sentences (test items) varied from 0.75 to 0.88. CONCLUSION: The present study indicates that the 24 short single sentences we have tested are highly comparable in terms of both lexical difficulty and reading length, and it has demonstrated the validity and reliability of such sentences as test items for determining reading speed.

Adolescent↗
PubMed2005

Differences in reading performance of patients with Drusen maculopathy and subretinal fibrosis after CNV.

PURPOSE: To evaluate differences in reading performance and contrast sensitivity on patients with drusen maculopathy and subretinal fibrosis after CNV (choroidal neovascularisation). METHODS: 136 patients (60 with drusen (D), 76 with fibrosis (F)) were studied. Patients were classified according to type of maculopathy and best-corrected visual acuity into groups D1 and F1 (LogMAR 0.2-0.4), groups D2 and F2 (LogMAR>0.4-0.7), and group F3 (LogMAR>0.7-1.3). Reading acuity (in LogRAD) and speed were examined with the Radner Reading charts and compared to the reading speed measured with the long paragraphs of the Zuercher Reading Test. Contrast sensitivity was measured with Pelli-Robson charts. RESULTS: The patients' distance visual acuity was comparable between the drusen and fibrotic CNV groups (D1 versus F1, D2 versus F2). The reading acuity of the corresponding groups D1 and F1 was also comparable, but F2 patients showed a statistically lower reading acuity than D2 patients (P=0.03). All reading speed measurements of the groups F1 and F2 were significantly worse than those of the corresponding groups D1 and D2 (P-values: 0.0005-0.02). The correlation of reading speed between the Radner and Zuercher texts was very high (r=0.73-0.94). The contrast sensitivity was significantly lower in all groups compared with group D1 (P<0.001), but comparable for groups F1, F2, and F3. CONCLUSIONS: Despite comparable results in distance visual acuity, patients with subretinal fibrosis after CNV had a greater reduction in reading ability than the patients with drusen. The distance visual acuity measurements alone, therefore, underestimate the real-life conditions and impact of AMD.

Aged↗