Recalcitrant endocarditis successfully treated by heart transplantation.
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Endocarditis, Bacterial↗
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Twelve years' experience with the St. Jude Medical valve prosthesis.
Since July 1978, 1,284 patients have received the St. Jude Medical prosthesis (425 aortic, 636 mitral, and 223 double aortic-mitral), and the results in these patients were reviewed according to guidelines of the Society of Thoracic Surgeons. Follow-up was complete in 98%. Of 80 late deaths, 29% were valve related. The actuarial survival rate, including operative deaths, at 12 years was 81.7% and 87.1%, respectively, for aortic and mitral valve replacement, and it was 82.6% at 11 years after double valve replacement. All patients were anticoagulated with warfarin to maintain the thrombotest value between 10% and 25%, which is equivalent to between 2.8 and 1.6 times the control according to the international normalized ratio of the prothrombin time. The linearized rate of complication for aortic, mitral, and double valve replacement, respectively (expressed as the percent per patient-year), was as follows: structural deterioration, 0; non-structural dysfunction, 0.16, 0.30, and 0.20; valve thrombosis, 0.05, 0.09, and 0; thromboembolism, 1.35, 1.63, and 0.79; anticoagulant-related hemorrhage, 0.10, 0.18, and 0.10; and prosthetic valve endocarditis, 0.21, 0.06, and 0.20. Reoperation was performed in 16 patients. The freedom from reoperation rate at 12 years was 99.5% and 98.0% for aortic and mitral valve replacement, respectively, and it was 99.1% at 11 years for double valve replacement. Thus, during the 12-year follow-up in patient who received the St. Jude Medical prosthesis, the valve performed satisfactorily and with an acceptable risk of late complication even though patients were anticoagulated using a lower dose of warfarin.
Actuarial Analysis↗
Results of represervation of the chordae tendineae during redo mitral valve replacement.
BACKGROUND: Previous studies have shown that preservation of the chordae tendineae improves early and late postoperative left ventricular function after mitral valve replacement. This report describes the results of represervation of the chordae tendineae during redo mitral valve replacement in patients who had their chordae tendineae preserved during their initial operation. METHODS: Fifty-four patients undergoing reoperative mitral valve replacement with preservation of their chordal annular attachments (chordae group) were compared with 187 patients who had redo mitral valve replacement without preservation of the chordae (nonchordae group). The interval between the initial operation and the reoperation was 8.7 +/- 4.4 years in the chordae group and 8.6 +/- 4.9 years in the nonchordae group (p = 0.315). Seventy-three patients underwent aortic valve replacement during their redo mitral valve replacement compared with 168 patients who had mitral valve replacement alone. There were 15 patients who had their chordal attachments represerved during redo double-valve replacement. RESULTS: In the chordae group, intraoperative assessment revealed excellent chordal connection between the preserved papillary muscles and the mitral annulus in all patients. One patient had adhesions between the preserved chordae and the stent of the tissue valve. The chordal attachments were preserved during insertion of the second valve in all patients. The incidence of low output syndrome and operative mortality in the chordae group was 16.7% and 7.4%, respectively. In the nonchordae group, the incidence of low output syndrome was 27.3% (p = 0.112 compared with the chordae group) and the operative mortality was 13.4% (p = 0.236 compared with the chordae group). In patients with double-valve replacement, represervation of the chordae was associated with a reduction in low output syndrome (0% versus 24%; p = 0.034) and mortality (6.7% versus 15.5%; p = 0.374). CONCLUSIONS: Preservation of the chordal attachments between the papillary muscles and the mitral annulus can be accomplished during reoperative mitral valve replacement. Represervation of the chordae tendineae may reduce postoperative low output syndrome, especially in high-risk patients undergoing redo double-valve replacement.
Aortic Valve↗
Diagnosing functional complete denture fractures.
Many factors can contribute to the fracture of complete dentures. This article has identified some of these factors and presented some methods that can greatly reduce or eliminate functional complete denture base fractures when used with a thorough diagnosis and treatment plan.
Denture Bases↗
Treatment outcome with implant-retained overdentures: Part I--Clinical findings and predictability of clinical treatment outcome.
This nationwide study was conducted to clinically evaluate treatment with implant-retained overdentures when applied on a large scale and to determine to what degree treatment results could be predicted from patient and treatment characteristics at baseline. A total of 429 patients who had received implant overdenture treatment were clinically investigated by two dentists. Implant survival was high, especially for implants placed in the mandible. Results for the maxilla appeared far less promising. Complications that were observed predominantly concerned inflammation of the peri-implant tissues and poor oral hygiene. The quality of the overdentures, as assessed on three conventional prosthetic parameters, was generally good. Nevertheless, overdentures on oral implants appear to require considerable maintenance. No statistically significant correlation could be found between patient and treatment characteristics at baseline and the clinical treatment outcome. So, although treatment outcome with implant-retained overdentures appeared favorable, clinical results were not individually predictable.
Dental Health Surveys↗
Salvage for failed implant arthroplasty of the wrist.
We have had to revise 19 wrist arthroplasties--seven silicone implants and 12 metal-on-plastic total wrist arthroplasties. Each of the seven silicone implants was successfully revised in one operation; the four fusions and three total wrist implants were functioning 6 or more years after surgery. Nineteen operations were needed to revise the total wrist implants. Four had failed because of loosening, six had become unbalanced, and two had become infected. All of the loose prostheses eventually required fusion. Four of the unbalanced wrists were rebalanced, but two of these patients have pain; the other two cases required fusion. One infected wrist required fusion, and one is stable with an implant.
Arthritis, Rheumatoid↗
Hancock II porcine bioprosthesis: excellent durability at intermediate-term follow-up.
OBJECTIVES: This study aimed to assess the clinical performance and durability of a new generation of porcine valve, the Hancock II bioprosthesis, at intermediate-term follow-up. BACKGROUND: Standard porcine bioprostheses undergo progressive structural deterioration, mainly due to cusp and commissural calcification, affecting durability and requiring reoperation. The Hancock II bioprosthesis, which is currently undergoing clinical investigation, is made from a porcine aortic valve treated with a calcium-retarding agent (sodium dodecyl sulfate [T6]), which should delay onset of calcification and increase durability. METHODS: From May 1983 to December 1992, we used the Hancock II bioprothesis in aortic (59 patients), mitral (101 patients) and mitral-aortic (25 patients), valve replacement procedures. Postoperative follow-up ranged from 0.1 to 8.7 years (mean [+/- SD] 4.5 +/- 2.6 years) and was 100% complete. Freedom from major postoperative events was calculated at 7 years for patients with aortic valve replacement and at 8 years for those with mitral and mitral-aortic valve replacement. RESULTS: The actuarial survival rate was 48 +/- 10%, 76 +/- 3% and 63 +/- 6%; freedom from valve-related mortality was 91 +/- 4%, 94 +/- 2% and 89 +/- 6%; freedom from thromboembolism was 80 +/- 11%, 90 +/- 2% and 79 +/- 7%; and freedom from reoperation was 100%, 97 +/- 1% and 89 +/- 6% after aortic, mitral and mitral-aortic valve replacement, respectively. No structural valve deterioration occurred. CONCLUSIONS: At intermediate-term follow-up the Hancock II bioprosthesis showed excellent durability in all positions. However, the effectiveness of anticalcification treatment must be assessed with longer follow-up studies.
Actuarial Analysis↗
Acute disruption of polytetrafluoroethylene grafts adjacent to axillary anastomoses: a complication of axillofemoral grafting.
PURPOSE: Acute disruption at or adjacent to axillary anastomoses of axillofemoral grafts has been sporadically reported. We have recently reported the patency and limb salvage results of a large number of axillofemoral grafts. In this report we describe a series of axillary artery-graft disruptions that occurred in these patients. METHODS: Beginning in 1983, axillofemoral bypass was performed by the authors using standardized operative technique and a single prosthetic graft material (8 mm externally supported polytetrafluoroethylene). Axillary anastomoses were placed on the first portion of the artery and were performed with the arm abducted and with the graft redundant. The records and operative reports of all patients with disruption were reviewed for findings and subsequent hospital course. RESULTS: Two hundred two axillofemoral grafts were performed from 1983 to 1993. Ten patients (5%) had axillary disruption at intervals ranging from 1 to 46 days (mean 21 days) after operation. Ischemia was the indication for operation for seven of the patients and infected aortic prostheses for three. Infection did not occur in any of the axillary wounds and was not the cause of any of the disruptions. Four disruptions occurred with arm abduction/shoulder elevation movements; three awakened patients from sleep, and one occurred while the patient was sitting quietly. For the other two patients, preceding activity was unknown. Brachial plexus deficit was present in one patient. Four of the 10 disrupted grafts were also acutely occluded. Operative findings included sutures pulling out of the artery in four cases, tearing or sutures pulling out of the graft in four cases, and cause unknown in two cases. Treatment included arterial ligation in one patient, and restoration of circulation through revision of the axillofemoral grafts in the other nine patients. There were no operative deaths. One patient had a prolonged hospital course followed by nursing home placement and died 9 months later. The brachial plexus deficit did not resolve. There have been no repeat disruptions. CONCLUSIONS: We conclude that axillofemoral grafting includes the potential for disruption of the proximal anastomosis, which has occurred in 5% of our patients. Although multiple steps have been recommended to avoid this complication, occasional cases continue to occur despite observing all precautions.
Acute Disease↗
Pasteurella multocida infection of a total hip arthroplasty. A case report.
The authors report a case history of a diabetic woman requiring revision hip arthroplasty of a Charnley total hip prosthesis that was infected with Pasteurella multocida. The infection of the loose prosthesis followed a cat bite to the same leg. Advice is given on the management of patients with infection following animal inoculations, and the subject of increased risk with a loose prosthesis is discussed.
Animals↗
Bone scan, gallium scan, and hip aspiration in the diagnosis of infected total hip arthroplasty.
The difficulty in differentiating aseptic loosening from infection in painful total hip arthroplasty is well recognized. This prompted a review of the efficacy of the preoperative investigations used at the authors' institution. One hundred forty-four patients who underwent revision hip arthroplasty were reviewed. Seventy-two had sequential bone-gallium scan, and/or hip aspiration, and intraoperative Gram stain. These were compared to intraoperative culture as the gold standard. Twenty infected hips were detected on culture. For prediction of infection, the bone-gallium scan had a sensitivity of 38% and a specificity of 100%. Hip aspiration had a sensitivity of 57% and a specificity of 97%. The investigations combined gave a sensitivity of 64% and a specificity of 95%. Intraoperative Gram stain compared with subsequent culture yielded a sensitivity of 23% and a specificity of 100%. Uncemented hips were infected more frequently (47%) than cemented hips (9%), significant at P < .0001. It was concluded that bone-gallium imaging is not an effective method for investigating painful hip prostheses for sepsis and offers no additional advantage over hip aspiration. Intraoperative Gram stain also missed a large number of infections. Other modalities, such as indium-labeled-leukocyte imaging and capsular histologic examination, may be more efficacious. A significant difference in the number of infections found in cemented versus uncemented hips was shown, hence greater vigilance for infection is required when patients present with painful uncemented hip arthroplasties.
Adult↗
Primary total knee arthroplasty in the elderly.
In a retrospective study, the authors investigated the outcome of primary total knee arthroplasty in patients aged 75 years or older. There is an increased risk of perioperative mortality and medical morbidity, but not surgical morbidity. The results were equal to the younger control group in terms of patient satisfaction, pain relief, stability, range of motion, residual degree of flexion contracture, and extension lag. Mobility was less impressive in the elderly group; factors included were ability to walk, use of walking aids, gait, ability to get out of a chair, and ability to climb stairs.
Age Factors↗
Prosthetic valve endocarditis: analysis of risk factors for mortality.
Between 1975 and 1990, 70 episodes of prosthetic valve endocarditis (PVE) were diagnosed in 65 patients at Leiden University Hospital. The overall mortality rate was 27%. Antecedent endocarditis attributable to the same micro-organism (mortality 63%, P = 0.02) and Staphylococcus aureus as the causative micro-organism (mortality 100%, P = 0.001) were significant predictors for mortality. Sex, type and position of the valve and therapy had no significant influence on the mortality. All patients infected with S. aureus died, irrespective of whether they received medical treatment alone or in combination with surgery. None of the patients with streption, endocarditis had abscesses at reoperation; the mortality rate for this group was 14%. Abscess formation, especially in aortic valves, was the most important finding at reoperation and corresponded with a mortality rate of 55%. Ring abscesses occurred equally in patients with mechanical and bioprosthetic valves. Seven of the 15 patients (47%) with significant prosthetic valve dehiscence died. In patients with mitral valve endocarditis, localized dehiscence of the valve was observed. In conclusion a previous endocarditis attributable to the same micro-organism and the causative micro-organism (S. aureus) were important risk factors for mortality due to PVE.
Adolescent↗
Posterior cruciate ligament-substituting total knee arthroplasty in young rheumatoid patients with advanced knee involvement.
The integrity and strength of the posterior cruciate ligament (PCL) in the rheumatoid knee are known to be suboptimal. However, the results of PCL-substituting total knee arthroplasty in rheumatoid patients are not well documented. We reviewed 86 PCL-substituting total knee arthroplasties in 52 rheumatoid patients with grade IV or V radiographic disease. The mean age at surgery was 41.9 years. All patients underwent follow-up evaluation for an average of 7.8 years. Revision was performed for 1 knee because of aseptic loosening of the tibial component, and for 3 knees because of deep infection. An isolated insert exchange was performed on one knee. Using revision of any component for aseptic loosening or radiographic loosening as the end point, the mean 10-year survival rate was 94.0%.
Actuarial Analysis↗
Intraoperative frozen section for detecting active infection in failed hip and knee arthroplasties.
The authors reported the result of 40 sessions of intraoperative frozen section on polymorph count in 33 patients undergoing exploration or revision hip and knee surgery to detect active infection. The correlation rate between frozen section and permanent section was 0.95 to 1.00. If the polymorph count more than 5 per high-power field (40 X) was chosen as positive, the sensitivity, specificity, positive predictive value, and negative predictive value would be 0.93, 0.77, 0.68, and 0.95, respectively. Taking polymorph count of more than 10 as positive, the sensitivity, specificity, positive predictive value, and negative predictive value would then be 0.86, 0.85, 0.75, and 0.92, respectively. The authors concluded that intraoperative frozen section is an inexpensive, rapid, and helpful adjunct to detect active infection. A polymorph count of lower than 5 highly suggests the absence of active infection.
Aged↗
Optimal timeframe for reporting short-term complication rates after total knee arthroplasty.
This study attempts to identify the optimal follow-up period to report short-term complication rates after primary total knee arthroplasty. Discharge data from 1991 through 2001 was obtained from California and linked to state death records. Rates of mortality, infection, and pulmonary embolism were determined at 30-day intervals for up to 1 year postoperatively. An analysis of 222,684 primary total knee arthroplasties was performed. The peak rate and a large proportion of the complications that occurred during the first year after surgery were seen within the initial 30-day postoperative period. Regression analyses demonstrated that the patient and hospital characteristics predictive of outcome differed when comparing the results at 1 year postoperatively to shorter-term follow-up periods. The findings of this study indicate that 30- and 60-day follow-up periods provide an adequate accounting for adverse events related to mortality, infection, and pulmonary embolism. However, the regression results highlight the continued importance of reporting long-term outcomes.
Aged↗
Femoral revision with a fluted, tapered, modular stem seventy patients followed for a mean of 3.9 years.
Fluted tapered revision femoral stems have been used successfully in Europe. Modularity makes these implants more versatile, but outcomes of modular designs have not been reported. We report a retrospective review of 70 such stems with a mean follow-up of 47 months. Combined metaphyseal/diaphyseal bone loss was present preoperatively in 36 (51%) of 70 hips. Three hips (4.3%) were re-revised or in need of re-revision, and worst-case survival was 87%. The mean postoperative patient-assessed Oxford Hip Score was 21.1. Restoration of proximal bone was noted in 56%. Complications included mean subsidence of 9.9 mm, dislocation in 7 (10%) of 70 hips, and fracture or cortical perforation in 17 (24.2%) of 70. These results are equivalent to, or better than, reported results of other types of cementless revision femoral stems.
Adult↗
The role of macrophages in osteolysis of total joint replacement.
The osteolysis associated with conventional polyethylene on metal total joint replacements is associated with the formation of an inflamed periprosthetic membrane rich in macrophages, cytokines and implant-derived wear particles. There is a wealth of evidence to indicate that the presence and activation of macrophages in the periprosthetic tissues around joint replacements is stimulated by UHMWPE particles. Particles within the size range 0.1-1.0 microm have been shown to be the most reactive. Animal studies have provided increasing evidence that, of the milieu of cytokines produced by particle-stimulated macrophages, TNF-alpha is a key cytokine involved in osteolysis. Recent advances in the understanding of the mechanisms of osteoclastogenesis and osteoclast activation at the cellular and molecular level have indicated that bone marrow-derived macrophages may play a dual role in osteolysis associated with total joint replacement. Firstly, as the major cell in host defence responding to UHMWPE particles via the production of cytokines and secondly as precursors for the osteoclasts responsible for the ensuing bone resorption.
Animals↗
Stimulation of bone formation by zoledronic acid in particle-induced osteolysis.
We investigated the effect of a single subcutaneous dose of zoledronic acid on particle-induced osteolysis and observed excessive regional new bone formation. We utilized the murine calvarial osteolysis model and polyethylene particles in C57BL/J6 mice. Twenty-eight mice were used, seven per group. Specimens were stained with Giemsa dye. The osteoid tissue area was determined. Bone thickness was measured as an indicator of bone growth. Net bone growth was significantly increased in animals with zoledronic acid treatment: 0.02 mm(2)+/-0.03 mm(2) in animals with particle implantation only (group 2), 0.25 mm(2)+/-0.08 mm(2) with particle implantation and zoledronic acid treatment directly after surgery (group 3; p=0.0018), and 0.21 mm(2)+/-0.11 mm(2) with particle implantation and zoledronic acid treatment on the fourth postoperative day (group 4; p=0.0042). The mean bone thickness was 0.2 mm+/-0.04 mm (range 0.17 mm-0.31 mm) in group 1 (sham controls) and 0.16 mm+/-0.02 mm (range 0.14 mm-0.19 mm) in group 2, 0.31 mm+/-0.04 mm (range 0.28 mm-0.39 mm) in group 3, and 0.29 mm+/-0.02 mm (range 0.28 mm-0.34 mm) in group 4. Student's t-test revealed a statistically significant difference between groups 2 and 3 (p=0.00042), and groups 2 and 4 (p=0.0019). In conclusion, our observational study suggests that zoledronic acid may stimulate bone apposition locally in the process of particle-induced osteolysis.
Animals↗