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PubMed1986

Predictive tests for Meniere's disease.

The prognostic value of electrocochleography and of the glycerol dehydration test in Meniere's disease is well recognized. Abnormal electrocochleographic waveforms carry a poorer prognosis. After adequate dehydration, significant threshold changes for better or worse predict the likely course of events following endolymphatic sac surgery. Meniere's disease frequently becomes bilateral. Vestibular aqueduct tomography in patients with Meniere's disease gives very different results, in both ears, compared with those in control patients. The acetazolamide cochlear hydration test can help detect latent hydrops. Plasma osmolality studies are an essential part of all these tests. Otoadmittance investigations show significantly higher baseline values in fluctuant endolymphatic hydrops compared with nonfluctuant Meniere's disease or control subjects. When the hearing improves after dehydration there is a paradoxical increased resistance to the flow of sound energy through the inner ear. Reduced hearing after glycerol is associated with an increase in maximum conductance or a decreased cochlear resistance. Otoadmittance studies on the "normal" ear of patients with "unilateral" Meniere's disease show similar abnormalities and changes. A study of serum levels of immune complexes and complement in patients with Meniere's disease shows elevated levels compared with controls. As yet the significance of this finding is unclear, though it may be related to disease activity.

Acetazolamide↗
PubMed1995

A comparison of transcranial magnetic stimulation with electroneuronography as a predictive test in patients with Bell's palsy.

The aim of this study was to examine the neuronographic findings of electrical and transcranial magnetic stimulation of the facial nerve and to compare their ability to predict clinical recovery from idiopathic facial nerve palsy (Bell's palsy). Eighty-six patients were examined clinically and neurophysiologically immediately on presentation to Tampere University Hospital. Electroneuronography (ENoG) and transcranial magnetic stimulation (TMS) were performed 1-6 times for each patient. The time interval between each examination varied from 2 to 7 days. Seventy-eight patients were followed for a median period of 13 months after the onset of palsy. Facial nerve function was graded according to the House-Brackmann grading system. Relative amplitude differences of ENoG and TMS during the acute phase were then correlated with clinical outcome. Statistical analysis of the results showed that a TMS response elicitable during the first 5 days of the palsy was correlatable with a good prognosis. ENoG results correlated with clinical outcome at a later time from onset of symptoms. TMS was well tolerated and no adverse effects were seen. These results indicate that TMS is a useful method for the early prediction of outcome in patients with Bell's palsy.

Acute Disease↗
PubMed1991

Genetic predictive testing and private insurances.

Genetic information is a potential tool for selection of job applicants and of candidates for insurance. Social implications of genetic information may represent a threshold for the access to health care facilities. Some of the issues related to the use of predictive genetic information by private life and health insurance companies are discussed. They include the potential threat for the privacy of the individual and his relatives, the pressure to undergo genetic testing and the social consequences of the use of genetic information by private insurance companies. The justified financial interests of insurance companies and the interests of the individual to have his privacy protected and to be able to partake in social attainments have to be brought into balance. A ban on genetic testing in connection with access to insurances and a limitation to the use of existing genetic information have been suggested by the Dutch Health Council. This approach to the problem should be adopted throughout the European Communities, so that medical progress does not turn out to be against the interests of the consumer.

AIDS Serodiagnosis↗
PubMed2006

The Assessment of Basic Learning Abilities (ABLA) test predicts the relative efficacy of task preferences for persons with developmental disabilities.

BACKGROUND: Prior studies have showed that presentation methods could affect the accuracy of a choice assessment. METHODS: In the current study, high- and low-preferred work tasks were identified in nine adults with developmental disabilities. Both tasks were then introduced in pairs within a choice assessment using the actual tasks, pictures of the tasks and spoken descriptions of the tasks. Participants were also given the Assessment of Basic Learning Abilities (ABLA) test that evaluated their discrimination skills. RESULTS: For five of the participants, their consistent choice of preferred task was predicted by their discrimination skills as assessed by the ABLA. CONCLUSIONS: These findings extend that of Conyers et al. whereby the systematic assessment of discrimination skills could predict the effectiveness of different presentation methods in this population.

Adult↗
PubMed1987

Intravenous ritodrine as a possibly provocative predictive test in gestational diabetes. A case report.

A 24-year-old, nonobese, gestational diabetic woman developed diabetic ketoacidosis while receiving intravenous ritodrine therapy to suppress premature labor. This case emphasizes the necessity for close observation of any gestational diabetic during intravenous ritodrine tocolysis and suggests the possibility of predicting diabetes in pregnant patients exhibiting marked glucose intolerance during therapy.

Adult↗
PubMed1982

Nonstress test prediction of fetal status.

Eighty-six patients were selected from the high-risk group delivered at Lincoln Hospital in New York City, constituting 22% of the total of 3,500 patients delivered. All of them underwent a nonstress test (NST) and oxytocin challenge test (OCT) antepartally and were also monitored during labor. Sixty-six of them had reactive nonstress patterns, all associated with a negative OCT. Three of them who had reduced variability developed late decelerations in labor; only one had a low Apgar score. Nineteen patients had absence of unequivocal accelerations, five associated with a negative OCT. Of these, only one developed late decelerations in labor. Of 14 others with nonreactive or combined positive OCT patterns, 9 developed late decelerations in labor. Two of them who also had reduced variability developed severe late decelerations in early labor, were delivered by cesarean section and had severe perinatal asphyxia. One case of baseline bradycardia was observed, and the patient did well. When reactive, NST appears to be as reliable as a negative OCT as an indicator of antepartum fetal well-being. Labor may be a life-threatening stress for fetuses displaying nonreactive positive OCT patterns with diminished variability.

Female↗
PubMedDate not supplied

The disulfiram-alcohol reaction: factors determining and potential tests predicting severity.

13 ambulatory alcoholics (3 women, 10 men) who consented to alcohol-aversive treatment with disulfiram were subjected to detailed investigations before, during, and after the disulfiram-alcohol reaction (DAR). The studies included quantitative estimation of liver function (aminopyrine breath test, ABT; galactose elimination capacity, GEC) prior to the DAR, measurement of alcohol and acetaldehyde plasma levels together with pulse rate and blood pressure during the DAR, and the effects of disulfiram on erythrocyte acetaldehyde-oxidizing capacity (AOC). As expected, the severity of the DAR showed considerable interindividual variation. However, the maximal fall in diastolic blood pressure was closely (r = 0.83; p less than 0.001; n = 13) related to peak acetaldehyde plasma level (AAPL). The decrease in systolic blood pressure was age dependent, individuals greater than 40 years exhibiting a larger drop for a given AAPL. The dependence of acetaldehyde formation on liver function was suggested by a significant correlation (r = 0.88; p less than 0.01; n = 8) between ABT and AAPL; this relationship was influenced by the prior intake of enzyme-inducing drugs. Measurements of AOC indicated that a disulfiram-induced maximal suppression is achieved already after 6 days of treatment reaching levels of 0.7 +/- 0.6 nmol/ml/min (SD) (compared to pretreatment values of 4.1 +/- 0.9). Mean values in untreated alcoholics and in subjects with alcoholic or nonalcoholic liver disease were not significantly different from controls.(ABSTRACT TRUNCATED AT 250 WORDS)

Acetaldehyde↗
PubMed1985

Predictive testing of vulvar and cervical cancers to chemotherapy by the subrenal capsule assay.

The 6-day subrenal capsule assay (SRCA) in normal immunocompetent mice was used to assess response of vulvar and cervical cancers to chemotherapy. Twenty-five out of 31 assays (81%) were evaluable. The previously treated tumors tended to be less sensitive than the untreated tumors (20 vs 33%). Three to five cytotoxic drugs or drug combinations were tested against each individual tumor. In the whole material the combination of cisplatin and etoposide (VP-16) was significantly more effective than bleomycin (P less than 0.01, chi 2 test). The combinations adriamycin + cyclophosphamide + cisplatin and cyclophosphamide + methotrexate were also rather effective. Preliminary clinical correlations were positive. The reliability of the SRCA was discussed, and it was concluded that the assay is a promising predictive method for individualizing chemotherapy.

Adult↗
PubMed1982

The monitoring of environmental mutagens/carcinogens. A perspective on tests predicting chemical mutagens/carcinogens in man.

The current interest in the subject of environmental mutagenesis/carcinogenesis has prompted much investigation into ways of identifying chemicals which may pose a genotoxic risk to man and his progeny. Various systems have been developed which measure gene mutation, chromosome damage and DNA repair. The main test systems are briefly discussed as well as their usage and limitations.

Animals↗
PubMed1985

Dinitrochlorobenzene skin testing predicts response to hepatitis B vaccine in dialysis patients.

The pattern of seroconversion and anti-HBs titres after 3 doses of hepatitis B vaccine was studied in 40 haemodialysis patients who had been grouped on the basis of their cell-mediated immune (CMI) response into strong or weak reactors. CMI response was determined by means of a dinitrochlorobenzene (DNCB) skin test. Titres of anti-HBs were comparable to those in healthy controls in 13 of 14 (93%) strong reactors but in only 9 of 26 (35%) weak reactors. Strong reactors had an equally satisfactory seroconversion rate with either 20 micrograms or 40 micrograms of vaccine whereas weak reactors had a negligible seroconversion rate with the 20 micrograms dose. In terms of hepatitis B prophylaxis, haemodialysis patients with a well preserved CMI response require only 20 micrograms of vaccine, with a consequent saving in cost. In contrast, it will be necessary to devise more effective immunisation schedules for most patients with a poor CMI response.

Adult↗