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Cough induced by low pH.

Citric acid has been used as a tussive agent in the investigation of the cough reflex. The mechanism of cough stimulation remains unclear. We conducted studies to compare the cough response of citric acid to an organic (acetic acid) and an inorganic acid (phosphoric acid). We also compared the cough response of citric acid to capsaicin, a non-acid tussive stimulus. In study 1, 26 subjects inhaled equimolar concentrations of citric and acetic acid. In study, 2, 22 subjects inhaled citric acid and phosphoric acid in concentrations of similar pH. Eighteen subjects from study 2 completed a capsaicin cough challenge test. The cough response was recorded and the concentration causing two coughs, the cough threshold, calculated (D2). The correlation of cough thresholds between both citric and acetic acid (r = 0.79, 95% CI 0.37-0.90, P < 0.0001) and citric acid and phosphoric acid (r = 0.68, 95% CI 0.37-0.86, P = 0.0005) were significant. There was no correlation between the citric acid and capsaicin cough thresholds. These results show that an individual's cough response to acetic and phosphoric acid are similar to that caused by citric acid. Thus these acids may cause cough by a common mechanism such as disturbance of the pH of the airway surface liquid. Capsaicin does not appear to share this common pathway.

Acetic Acid↗

Evaluation of cyclonic ash, commercial Na-silicates, lime and phosphoric acid for metal immobilisation purposes in contaminated soils in Flanders (Belgium).

In order to reduce the health risks associated with historically enriched metal smelting sites in Flanders (Belgium), the capacities of a non-beringite cyclonic ash and commercial Na-silicates to fix metals and create conditions to restore vegetation cover were evaluated and compared to lime and H(3)PO(4). All tested amendments reduced Ca(NO(3))(2)-extractable soil metal concentrations and reduced metal uptake in Agrostis capillaris seedlings. Sodium released by Na-silicates was possibly toxic to bean plants while an isotopic dilution technique revealed that metals were only weakly sorbed by silicates (i.e. reversible sorption). Cyclonic ash appeared more efficient than lime in both reducing oxidative stress in beans and Zn, Cu and Pb uptake in grasses. The metal fixing mechanism for both amendments appeared similar (i.e. irreversible fixation at constant pH), in contrast to H(3)PO(4) where at least part of the immobilised Cd was irreversibly fixed across a range of pH.

Adsorption↗

Moving single bubble sonoluminescence in phosphoric acid and sulphuric acid solutions.

The phenomenon of sonoluminescence still presents some unsolved aspects. Recently [Y.T. Didenko, K. Suslick, Molecular Emission during Single Bubble Sonoluminescence, Nature 407 (2000) 877-879.], it was found that a single cavitating air bubble in polar aprotic liquids (including formamide and adiponitrile) can produce very strong sonoluminescence while undergoing macroscopic translation movements in the resonator, a condition known as moving single bubble sonoluminescing (MSBSL). Here we describe some experiments conducted in aqueous solutions of phosphoric and sulphuric acid. In these liquid media, it is possible to reproduce MSBSL and luminescence is emitted even if a trapped bubble is subjected to a strong shape instability, named in the literature "jittering phase". When a moving and luminescing bubble was present and the acoustic pressure gradually increased, we observed the generation of a discrete lattice of trapped bubbles. The bubbles in the lattice emit very intense light flashes and can change their position while maintaining the overall spatial distribution in time. Some preliminary results, obtained from Mie-scattering and measurements of relative light intensity, are reported.

Journal Article↗

Preparation and characterization of polyalkene membranes modified with four different ion-exchange groups by radiation-induced graft polymerization.

Three different cation-exchange membranes with carboxylic acid, phosphoric acid, and sulfonic acid groups, and one anion-exchange membrane with a triethylamine group were prepared by radiation-induced graft polymerization. The maximum capacities of the carboxylic acid, phosphoric acid, sulfonic acid, and triethylamine groups were 3.0, 2.30, 2.43, and 1.42 mmol/g, respectively. The physico-chemical properties of the polyalkene non-woven fabric membrane with four different ion-exchange groups were examined by thermogravimetric analysis, X-ray photoelectron spectrometry (XPS), and scanning electron microscopy. The prepared ion-exchange membrane was applied to the removal of terephthalic acid in dyeing wastewater.

Carboxylic Acids↗

Variations in acid-etch patterns with different acids and etch times.

Research has shown that mandibular premolars have the highest rate of orthodontic bracket bond failure. Bond strength is thought to depend on the quality and quantity of enamel etch produced by the acid. Phosphoric acid is the most commonly used acid for etching before bonding. Nitric acid is also commercially available for etching enamel; however, it has not been studied specifically for etching in orthodontic bonding. This ex vivo study compared the enamel etch patterns achieved on the orthodontic bonding area of extracted mandibular premolars treated with 37% wt/wt phosphoric acid and 2.5% wt/wt nitric acid applied for 15, 30, or 60 seconds. The etch patterns were viewed with a scanning electron microscope and assessed with a 5-point etch scale. Statistical analysis showed that increasing the duration of acid application (irrespective of acid type) significantly increased the amount of better quality etch. Phosphoric acid at 37% concentration was more effective at producing a good-quality etch than was nitric acid at 2.5% for all 3 application times. The quantity of good-quality etch produced by phosphoric acid at 37% was time specific, with 15 seconds being significantly less effective than 30 or 60 seconds. However, 60 seconds was not significantly better than 30. Comparing the upper half of the orthodontic bonding area with the lower half showed no statistically significant differences for either acid type or length of application (P >.005). These findings support the use of 37% wt/wt phosphoric acid and indicate an optimum application time of 30 seconds.

Acid Etching, Dental↗

Electrical Conductivity of Water/Sodium Bis(2-ethylhexyl) Sulfosuccinate/n-Heptane and Water/Sodium Bis(2-ethylhexyl) Phosphate/n-Heptane Systems: The Influences of Water Content, Bis(2-ethylhexyl) Phosphoric Acid, and Temperature.

Conductance behaviors of reverse micelles/microemulsions have been investigated by means of electrical conductometry, with em-phasis on the influences of water content, bis(2-ethylhexyl) phos-phoric acid (HDEHP) content, and temperature. Two systems were prepared and studied, i.e., sodium bis(2-ethylhexyl) sulfosuccinate (AOT) in n-heptane (H(2)O/AOT/n-heptane) and sodium bis(2-ethylhexyl) phosphate (NaDEHP) in n-heptane (H(2)O/NaDEHP/ n-heptane). The conductance behaviors of AOT+HDEHP and NaDEHP+HDEHP systems are dependent upon water content (W(0), expressed as the molar ratio of solubilized water and surfactant(s)), HDEHP content, and temperature. With an increase of water content, the conductivity-W(0) curves of the AOT+HDEHP system show maximum conductivity and no percolation conductance, different from that of the AOT system. The conductivity of the NaDEHP+HDEHP system varies with the NaDEHP to HDEHP ratio. For the systems with the NaDEHP to HDEHP ratios of 80 : 20 and 70 : 30, both maximum conductivity and percolation phenomenon can be observed, while for the system with the NaDEHP to HDEHP ratio of 90 : 10, neither maximum conductance nor percolation conductance occurs. With varying temperature, markedly different conductance behaviors were observed in AOT+HDEHP and NaDEHP+HDEHP systems. Percolation conductance occurs in the AOT+HDEHP system and the onset temperature for percolation conductance decreases with increasing water content and/or HDEHP content. In the H(2)O/(NaDEHP, HDEHP)/n-heptane system, however, the conductivity decreases markedly with increasing temperature until a minimum, followed by a slow recovery of the conductivity. These phenomena could be attributed to the different aggregation states of the surfactants and the different transition mechanisms of charge carriers in respective systems at different water contents, HDEHP contents, and temperatures. Copyright 2001 Academic Press.

Journal Article↗