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PubMed2000

[A case study of Woringer-Kolopp disease. Immunohistochemical study].

Woringer-Kolopp disease is a localized epidermotropic T cell lymphoma with good prognosis. We describe a 79-year-old man with an erythematous scaly plaque of the foot. Clinical diagnosis of psoriasis, parapsoriasis and fungal infection were proposed. Histopathological and immunohistochemical findings were characteristic of Woringer-Kolopp disease. We observed an immunohistochemical positivity of tumour cells for the anti-CD103 antibody (alphaEB7 integrin) according to the epidermotropism of this localized cutaneous T cell lymphoma.

Aged↗
PubMed2001

Cutaneous T-cell lymphoma at a young age.

A case of cutaneous T-cell lymphoma (CTCL) in a 22-month-old patient is discussed, emphasizing the importance of screening for CTCL even in very young patients with atypical symptoms of eczema, atopic dermatitis, or parapsoriasis. The clinical, histologic, and immunologic diagnostics can now be supported by molecular methods; therefore, patients at the earlier stages of CTCL can be diagnosed and treated with good results.

Adolescent↗
PubMed1975

Tryptophan metabolism in skin diseases.

In a number of skin disturbances conditioned or aggravated by sunlight and/or mainly diffused to the cutaneous connective tissue (present acquired pellagra, lupus erythematosus, porphyria cutanea tarda, actinic reticuloid, Rothmund-Thomson syndrome, lymphocytoma cutis, scleroderma, dermatomyositis, burns, linphomas, parapsoriasis, acrodermatitis enteropathica) excretive changes were found only in the "via kynurenine" metabolites. As a rule kynureniase activity was reduced and tryptophan-pyrrolase activity was increased. In the epidermis tryptophan leads to niacin pathway was found to be present and sometimes autonomous.

Animals↗
PubMed1977

[Utilisation of photochemotherapy by UVA and locally applied psoralens (author's transl)].

In the Skin Clinic of Neurnberg about 1,500 patients have been treated since 1972 with blacklight and 8-methoxypsoralen, approximately 120-150 every day. This new therapy has proved very good in psoriasis, acne, bacterial disseminated eczema, parapsoriasis and mycosis fungoides. The technique and the rate of relapses, the side effects and their endogenous as well as exogenous causes will be discussed.

Acne Vulgaris↗
PubMed1977

[Treatment of inflammatory and proliferative skin diseases].

Treatment of inflammatory and proliferation dermatoses can now be accomplished with pharmacologic agents which inhibit production of mediators or their actions. The immune system can be stimulated by thymosin, imidazo drugs, BCG, corynebacterium parvum and idoxyuridine. Immune complex diseases may be treated with corticosteroids, clofazimine, sulfonamides, antimalarial drugs, and nicotinic acid. Low dose, safe immunosuppressive therapy can successfully control scleromyxedema, guttate parapsoriasis, histiocytosis X, Kaposi's sarcoma, and Sézary syndrome.

Adrenal Cortex Hormones↗
PubMed2003

Morphometric study of lymphoid cells in mycosis fungoides and its simulators.

The distinction of early stages of mycosis fungoides from benign lymphoid disorders of skin is difficult by conventional histological techniques. We studied 10 cases of mycosis fungoides, 10 cases of large plaque parapsoriasis, 10 cases of other benign lymphoid disorders of skin and 5 cases of lymph nodes. Nuclear area, perimeter of the nucleus, nuclear contour index, cytoplasmic area, form factor and nuclear cytoplasmic ratio as well as DNA-ploidy were determined by image analysis. There were statistically significant difference (P value < 0.05) between all parameters except nuclear cytoplasmic ratio of the lymphoid cells of Mycosis Fungoides and benign lymphoid disorders of skin. Aneuploidy was found in 50% cases of Mycosis Fungoides. Histopathological parameters like epidermotropism pautrier micro-abscess and atypical lymphocytic infiltrate in both epidermis and dermis were more marked in aneuploid than diploid cases. So, the determination of nuclear contour index and DNA-ploidy is of importance to differentiate between Mycosis Fungoides and benign lymphoid disorders of skin.

Adult↗
PubMed2006

Expression of the CD1a molecule in B- and T-lymphoproliferative skin conditions.

The skin immune system is characterized by the presence of two types of CD1a expressing cells: langerhans cells and dermal dendritic cells, which are professional antigen processing and presenting cells. It is well established that several dermatoses are associated with T-cell mediated immune responses. In these pathological skin conditions, T-cells are activated by professional antigen presenting cells and dendritic cells are the most potent antigen presenting cells for both T-helper cells and T-cytotoxic cells. Therefore, it is plausible that dendritic cells are crucially involved in the pathogenesis of lymphoproliferative skin conditions characterized by the presence of a T-cell infiltrate. In this study, we examined the frequency and distribution of CD1a expressing cells and CD3+ cells in both the dermal and epidermal compartment in a wide range of lymphoproliferative dermatoses with a T-lymphoid infiltrate. In the skin conditions investigated, the CD1a molecule was highly expressed in mycosis fungoides, T-cutaneous lymphoid hyperplasia, lymphomatoid papulosis and parapsoriasis, whereas few CD1a-positive cells were observed in cutaneous B-cell lymphomas. Our study demonstrates a distinct pattern of CD1a staining in the infiltrates of cutaneous lympho-proliferative disorders which may reflect different immunoregulatory events involving T-lymphocytes and CD1a-positive dermal and epidermal dendritic cells.

Antigens, CD1↗
PubMed1991

Soluble IL2 receptor serum levels and epidermal cytokines in mycosis fungoides and related disorders.

We examined the immune activation in 20 patients with mycosis fungoides, 6 patients with erythrodermia of unknown origin (Pré-Sézary's syndrome), 5 with lymphomatoid papulosis, 4 with parapsoriasis, 2 with Sézary's syndrome, and 2 with actinic reticuloid, by measuring soluble interleukin-2 receptor levels in serum. In Mycosis fungoides we observed normal levels in 3 patients (less than 500 units/ml), between 500 and 1000 units/ml in 9 patients, and greater than 1000 units/ml in 5 patients. Four of these 5 patients died within one year after this observation, as did 2 patients with Pré-Sézary and Sézary's syndrome, respectively, who had a similarly large increase in sIL2R. Although sIL2R is not a specific parameter for cutaneous T-cell lymphoma, a value above 1000 units/ml is correlated with clinical disease activity and is a serious prognostic parameter. We also studied cytokine activity in epidermal homogenates from 9 patients with Mycosis fungoides and one patient with Sézary's syndrome. We observed interleukin-1-like activity within the normal range for healthy skin. However, we also observed in the same epidermal homogenates a T-lymphocyte chemotactic activity in patients with stage II, but not in stage I. The nature of this activity is not yet fully elucidated, but it may be an important biological factor for the epidermal T-cell accumulation in this disorder.

Aged↗
PubMedDate not supplied

[Lymphatoid papulosis. Ultrastructural study. Review of the literature].

The authors report a case of lymphomatoid papulosis with an ultrastructural study, and review 84 cases which they found in the literature. They recall the clinical and histological signs and the course of this disease which usually has a benign prognosis. The classification and relationship with varioliform parapsoriasis of Mucha-Habermann and the hematodermias remain debated.

Aged↗
PubMedDate not supplied

[Skin cancer in general practice].

33 cancer-like skin changes were observed during a four year period from April 1985 to April 1989: 14 basaliomas, 8 squamous carcinomas, 1 mixed type, 2 morbus Bowen, 2 cornua cutanea with malignant change, 1 parapsoriasis en plaques, 3 keratosis, 1 malignant melanoma and 1 lentigo malignant melanoma. The skin changes were biopsied with a biopsy punch (3, 4, 6 mm diameter) or excised with safety-distance, the histological investigations were done at the Pathological Institute of the University of Münster, radiation therapy until 1987 at the Urban Hospital Bielefeld and since 1988 at the Urban Hospital Gütersloh.

Aged↗
PubMed1985

HLA-DR-antigen bearing keratinocytes in various dermatologic disorders.

In normal human epidermis HLA-DR-antigen is only present on Langerhans' cells and the acrosyringeal epithelium. We investigated the distribution of HLA-DR-antigen in 78 specimens of various skin diseases by an immunoperoxidase method using a monoclonal anti-HLA-DR antibody. HLA-DR-antigen bearing keratinocytes were not only found in lichen planus and mycosis fungoides, as it has been referred previously, but were also observed in some cases of cutaneous B-cell lymphoma, pseudolymphoma, lupus erythematosus, parapsoriasis en plaque, bullous pemphigoid, drug reaction, contact dermatitis, actinic keratosis and verrucous carcinoma. Direct contact of lymphoid cells with keratinocytes was not necessary for Ia-antigen expression.

Antibodies, Monoclonal↗
PubMed1988

Chronic fixed drug eruption caused by acetaminophen.

A case of chronic fixed drug eruption resembling parapsoriasis en plaques is reported, which presented with persistent, stable lesions that were present for seven months before the diagnosis was established. The patient's skin cleared totally with avoidance of acetaminophen and flared prominently with re-exposure. Distribution of the recurrence was different: some previous sites had apparently become refractory and remained clear, some involvement had recurred in the same site, and new areas of involvement had appeared, causing the eruption to "wander," as is often seen in acute fixed drug eruption due to acetaminophen.

Acetaminophen↗
PubMed1978

Mycosis fungoides-like cells. Their presence in a case of pityriasic dermatitis with a comment on their significance as an indicator of primary T-cell dyscrasia.

A case of pityriasic dermatitis in which the histologic findings mimicked mycosis fungoides was examined ultrastructurally. Large numbers of mycosis-like cells were found in the dermis and within epidermal spongiotic vesicles. Such cells occur in the epidermal and dermal infiltrates of primary T-lymphocyte disorders, notably in mycosis fungoides, the Sézary syndrome, and parapsoriasis en plague. However, they have also been found in the dermal infiltrates of benign dermatoses, in some skin tumors, and occasionally in normal controls. They share ultrastructural features with transformed T lymphocytes. It is emphasized that cells with this morphology may be found in the skin in any condition involving T-cell transformation or dysplasia. The mere presence of cells with this morphology within skin infiltrates is insufficient evidence for the diagnosis of primary T-cell dyscrasia.

Diagnosis, Differential↗
PubMed1977

[Lichenoid pityriasis. Clinical study of 13 cases].

13 patients with Pityriasis Lichenoides are studied clinical and histologically, showing a clinical polymorphism of the lesions, mainly in the papulous, vesiculous, and necrotic ones. The data about age, sex, evolution and response to the treatment in the present study are similar to those found by other authors. Constantly, we found, a variable degree of vasculitis. In almost all the cases there was a damage of the epithelium --exoserosis and exocytosis--, as well as presence in some cases, of red cells extravasated within the epidermis. In upper dermis we found in all biopsies, divers degrees of perivascular cell infiltration mainly composed of lymphocytes and histiocytes with predominance of the last ones, in five cases. In the majority of our cases, there was a strong relationship between the clinical and the histological aspects, but in some cases, mild lesions showed an acute microscopical picture. We are of the opinion that Pityriasis Lichenoides must be considered as a different entity from Parapsoriasis. In addition, we think that PL, is a clinical picture that manifests itself as a chronic or an acute form, and both types can be seen in the disease evolution. Finally, we could not find an evident influence and a positive response to the treatment in our patients with the classical therapeutics.

Adult↗
PubMed1979

Photochemotherapy for mycosis fungoides: long-term followup study.

A 3-year followup on ten of 12 patients with mycosis fungoides (MF) treated with photochemotherapy (PUVA; psoralens + ultraviolet light) reveals eight patients whose diseases have remained clear while receiving maintenance PUVA. An additional 35 patients with MF have been successfully treated with PUVA. Eight cases of parapsoriasis en plaque have cleared with PUVA. PUVA is indicated in early eczematous and plaque stages of MF. It may be used as adjunctive therapy in tumor-stage MF treated with X-ray therapy or chemotherapy.

Humans↗
PubMed1984

Lymphomatoid papulosis: a follow-up study.

A follow-up study has been performed on 16 patients with lymphomatoid papulosis diagnosed at the Finsen Institute during the years 1970-81. In none of the patients did malignant lymphoma develop during the observation period (7 months to 22 years). During this period the nature of the lesions and the tendency to recurrence were unchanged in 11 patients, spontaneous remission took place in 4, and 1 patient went into complete remission after PUVA treatment (8-methoxsalen followed by UVA). The histological material (32 punch biopsies) could be divided into two major groups diagnosed as either typical (16 biopsies) or consistent with lymphomatoid papulosis (16 biopsies). Based on our present knowledge, we suggest the following classification of lymphomatoid papulosis: 1) "classical" lymphomatoid papulosis, 2) lymphomatoid papulosis associated with parapsoriasis en plaque or mycosis fungoides and 3) primary cutaneous T-cell lymphoma.

Adult↗
PubMed1981

[Disseminated type of pagetoid reticulosis? Mycosis fungoides?].

We present a case of a 69 year old man who died with a progressive systemic disease. This case demonstrated a multiple clinical evidence with aspects of psoriasis, parapsoriasis en plaques, mycosis fungoides, lymphogranulomatosis and finally of the disseminated type of pagetoid reticulosis. The last biopsies always demonstrated the typical histology of pagetoid reticulosis. The earlier biopsies revealed findings similar to mycosis fungoides and even in part similar to lymphogranulomatosis.

Aged↗
PubMed1981

Staging laparotomy in cutaneous T-cell disease.

Staging laparotomy performed in 13 patients with various forms of cutaneous T-cell disease (mycosis fungoides, Sézary syndrome, cutaneous lymphoma, atrophic parapsoriasis, and alopecia mucinosa) showed evidence of visceral or lymph node involvement in three (23%) patients; in two of these patients, noninvasive investigations and staging procedures did not disclose any abnormalities. All three patients were alive after a mean follow-up period of 3 1/2 years. In the ten patients with normal findings at laparotomy, the presence of intra-abdominal lymphoma was suggested in six by noninvasive staging procedures (lymphangiogram, spleen or liver-spleen scan, and computerized tomographic scan of the abdomen). Five of these ten patients died; four of the five patients died after relentless progression of the disease and visceral involvement. Staging laparotomy may have a role in the management of cutaneous T-cell disease because noninvasive investigations may be poor indicators of the presence or absence of intra-abdominal disease. The course of these patients, even those in whom laparotomies did not show any abnormalities, emphasizes the progressive potential of cutaneous T-cell disease.

Adult↗