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[Dynamics of the intake and utilization of orally administered 1,2-propanediol in glycogen synthesis in the rat liver].

The possibility of an isocaloric substitution of 1,2-propandiol for carbohydrates in the food ration of rats was investigated. The inclusion of propandiol as a synthetic source of food energy in the alimentation in an amount comprising 20 per cent of the overall calorific value of carbohydrates does not affect adversely the growth intensity, nor does it produce any materials upsets in the metabolism of test animals. With its oral introduction in a dose of 1 g per 100 g of weight 1,2-propandiol is quickly absorbed, its level reaching the maximum in the blood and liver after a lapse of 1 hour with complete metabolization in the organism over a period of 12 hours. In fasting rats 1,2-propandiol is utilized as a precurser in the synthesis of glycogen and when introduced by the intraperitoneal route it does not influence the rate of the liver glycogen synthesis from glucose. Daily oral introduction of 2 g of 1,2-propandiol per 100 g of body weight for a space of three and seven days, superimposed upon a carbohydrate-rich diet, brings about a fall of the liver reserve glycogen level.

Administration, Oral↗