Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Osteogenesis, Distraction”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 397 records · Page 22Linked to original sources
PubMedDate not supplied

Distraction osteogenesis versus autogenous onlay grafting. Part I: outcome of implant integration.

PURPOSE: The primary goal of this study was to compare bone-to-implant contact (BIC) in alveolar bone augmented by distraction osteogenesis with BIC in alveolar bone augmented by onlay iliac crest grafting. MATERIALS AND METHODS: Alveolar bone defects were created bilaterally in 5 American foxhounds, and after healing, bone augmentation was accomplished using distraction osteogenesis on 1 side of the jaw and onlay grafting on the other. Twelve weeks after consolidation, implants were placed in augmented and control sites. The animals were sacrificed and the jaws harvested for histologic analysis after an additional 8 weeks. RESULTS: The mean BIC was 54.7% +/- 14.6% for implants placed in distracted sites, 53.8% +/- 11.8% for sites where an onlay graft was used, and 51.2% +/- 14.4% for control sites. Significant differences in BIC were noted between experimental and control sites only at the apical third of the implant (19.8 +/- 1.8 for distracted sites; 15.5 +/- 1.5 for grafted sites; 8.0 +/- 0.5 for control sites; P < .05). DISCUSSION: The data showed that both distraction osteogenesis and onlay grafting produce sufficient bone for implant placement. There were no differences between procedures in regard to BIC after 8 weeks. CONCLUSION: These data suggest that both onlay grafting and vertical distraction are appropriate methods for bone augmentation prior to implant placement.

Alveolar Ridge Augmentation↗
PubMed1996

Simultaneous distraction osteogenesis and microsurgical reconstruction for facial asymmetry.

Restoring facial balance in patients with severe facial asymmetry is a challenging problem for the craniofacial team. Attention to bony reconstruction as well as soft-tissue contouring is required for patients with moderate to severe deformities. Traditionally, facial skeletal reconstruction was performed with osteotomies and bone grafting. More recently, distraction osteogenesis has proven to be successful in achieving bone lengthening. For select cases, distraction osteogenesis has lessened the need for major skeletal procedures and has allowed earlier surgical intervention. The reconstruction of the soft tissues in facial asymmetry has generally been performed as a second-stage procedure after skeletal reconstruction. The disadvantage of these traditional approaches is that it requires two separate major operative procedures, with the accompanying increased morbidity, hospital stay, and cost. We present a patient with hemifacial microsomia and a grade III mandibular deformity, in whom both the hard- and soft-tissue deficiencies were corrected in one surgical procedure with mandibular distraction osteogenesis and soft-tissue augmentation with a vascularized parascapular osteocutaneous flap. The technique and results at 1-year follow-up are presented.

Adolescent↗
PubMed2002

Distraction osteogenesis for augmentation of the deficient alveolar ridge.

Distraction osteogenesis is a technique in which new bone generation and soft tissue proliferation are achieved by means of distraction or lengthening of the preexisting native bone. This technique has its origins in orthopedic surgery and has been used more extensively in the craniofacial region over the past few years. It has been successfully used to treat patients with mandibular, maxillary, and midface deficiencies, and its use for augmentation of the resorbed or atrophic dento-alveolar ridge is currently being explored. In this report, the technique of alveolar distraction is discussed and two cases are presented in detail.

Adult↗
PubMed2006

Axial shortening during distraction osteogenesis leads to enhanced bone formation in a rabbit model through the HIF-1alpha/vascular endothelial growth factor system.

Axial micromotion of bone fragments enhances callus formation during fracture repair or limb lengthening. To examine this, we used an axial-shortening model of the tibial callus in rabbits and performed histological analyses. After 10-mm lengthening of the left tibia with an external fixator, we shortened the callus by 2 mm. Radiographs and quantitative evaluation of corrected bone mineral density showed a significant increase in mineralization in the shortened callus (57.3 vs. 36.2%, p = 0.001). Histologically, greater osteoblast proliferation and more vigorous trabecular bone formation were noted in the shortened calluses than in the controls. Around the front of membranous bone formation in the shortened callus, there was a significant decrease in mean percentage area of vascular lumens (1.8 vs. 4.5%, p = 0.009), which seemed attributable to compressive force, and a significantly increased production of vascular endothelial growth factor (VEGF; 422.5 vs. 142.7 pg/mg protein, p = 0.007) and its receptors. There were also increased numbers of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts and proliferating cell nuclear antigen (PCNA)-positive cells. A marked increase of hypoxia inducible factor-1alpha (HIF-1alpha) expression in osteoblasts was also observed in this area. Thus, enhancement of membranous bone formation by static compression or axial dynamization may be at least partly attributable to HIF-1alpha-mediated VEGF induction following the local hypoxia caused by collapse of vascular lumens.

Alkaline Phosphatase↗
PubMed2005

Correction of severe post-traumatic deformities in the distal femur by distraction osteogenesis using Taylor Spatial Frame: a case report.

A case of deformity and shortening after post-traumatic growth arrest treated using the Taylor Spatial Frame (Smith & Nephew, Tennessee, USA) is presented. This is the first report showing the application of the frame for post-traumatic deformity in the distal femur, and successful outcomes promise utilization of the frame even for correction of severe deformity in the distal femur.

Adult↗