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PubMed1995

Starting a neuroscience research laboratory in a developing country: a Fulbright experience in Honduras.

The first laboratory of neurophysiology was installed in the medical school of the University of Honduras during the 1992-1993 academic year. The goal of the project was to improve the teaching of physiology in the medical curriculum and to establish a neuroscience research laboratory able to address Honduran needs. In addition to a computer learning facility and wet labs in neurophysiology for medical students, an independent research program that focused on social problems in the country (for example, the effects of malnutrition on the developing central nervous system) was developed, paving the way for the first graduate program in physiology in Honduras. Funded by a Fulbright Lectureship Grant, the shoe-string budget was augmented by donations of equipment by colleagues. This first-hand account describes the planning and implementation of the project, covering both expected and unexpected problems and successes. An update on the progress of the lab after two years of independent operation is also described.

Budgets↗
PubMedDate not supplied

The challenge of neuroscience: psychiatry and phenomenology today.

The paper illustrates the present role of phenomenological psychopathology by outlining its methods and focusing on some of its major issues: embodiment or body scheme, intentionality, time consciousness and intersubjectivity. The application of these categories to the analysis of psychotic disorders is demonstrated. Special emphasis is given to the relationship between phenomenology and cognitive neuroscience, a relationship that has been variously viewed as 'mutual constraint' or as 'mutual enlightenment'. This is where a new cooperation linking phenomenology, psychopathology and cognitive science begins to emerge. Phenomenology offers a methodically developed theory of human subjectivity that is indispensable to any attempt to understand, explore and treat psychiatric disorders.

Forecasting↗
PubMedDate not supplied

Genetics, neuroscience and psychiatric classification.

Some psychiatrists anticipate a revolution in psychiatric nosology, on the basis of emerging data from genetics and genomics. There are, however, good empirical and conceptual reasons to resist any such revolution. Basing an understanding of psychiatric entities on one of multiple biological (not to mention sociocultural and psychological) considerations is a specious method of approaching the project of psychiatric taxonomy. A classification system that lacks sufficient consensus on the phenomenology of those classified cannot be adequately buttressed by exclusively genetic accounts. This paper advocates a more diversely informed nosology that, in turn, fosters attention to broader diagnostic considerations. We explore more plausible ways in which genetics and genomics, in conjunction with neuroscience and other biological disciplines, can help to shape diagnostic classification in psychiatry. There are, of course, differing views on the degree of prominence that genetics should take in psychiatric diagnosis and classification. We outline these accounts in illustration of this continuum. Drawing on Wimsatt's work on robustness analysis, we dismiss optimistic scenarios about the potential nosological advantages of psychiatric genetics and genomics, and offer a novel defense of realism about psychiatric entities. We also briefly sketch an integrative methodology for psychiatric research and classification.

Diagnosis, Differential↗
PubMedDate not supplied

Space vestibulo-neuroscience in the new century: why proceed in semi-darkness?

With advancing technology, neuroscientists have explored vestibular transducer microstructure and molecular processes, neural pathways of interaction between vestibular visual and proprioceptor systems and neurochemical processes of adaptive change. Progress in space vestibulo-neuroscience will be fostered by focus on interactions among the systems involved in whole-body movement relative to the earth. Description of perceptual and sensorimotor reactions to complex accelerative stimuli during goal-directed and passive movement is crucial to conceptualizing the functional significance of various interactions and viable theory. The vestibulo-ocular reflex is now quantifiable in three dimensions, but description of the dynamics of spatial orientation perception has progressed very little in the 20th century. Much is known about perception of static body tilt, but the dynamics of tilt and movement perception (beyond rotation about an earth-vertical axis) remains relatively unexplored. Innovative procedures and departure from accepted psychophysics are needed. Models developed to predict the dynamics of spatial orientation under complex conditions must be consistent with information at all levels (neural, sensorimotor, and perceptual). To close our eyes to any one aspect of the spatial orientation reaction is to proceed in semi-darkness unnecessarily.

Animals↗
PubMed2002

The integration of neurology, psychiatry, and neuroscience in the 21st century.

OBJECTIVE: This article examines the historical basis for the divergence of neurology and psychiatry over the past century and discusses prospects for a rapprochement and potential convergence of the two specialties in the next century. METHOD: The author presents a brief historical overview of developments in neurology and psychiatry from the late 19th century. The histories of research and prevailing scientific opinion on two neuropsychiatric disorders, Alzheimer's disease and Tourette's syndrome, are compared to illustrate the effects of viewing a disease process from, respectively, the neurologic/organic and psychiatric/functional perspectives. RESULTS: Research on Alzheimer's disease, because of its early pathologic demonstration, moved rapidly toward identification of associated synaptic abnormalities and genetic mutations. In Tourette's syndrome, the absence of evident brain pathology resulted in vacillation between organic and functional explanations and persistent controversy about the nature of the illness. CONCLUSIONS: Neurology and psychiatry have, for much of the past century, been separated by an artificial wall created by the divergence of their philosophical approaches and research and treatment methods. Scientific advances in recent decades have made it clear that this separation is arbitrary and counterproductive. Neurologic and psychiatric research are moving closer together in the tools they use, the questions they ask, and the theoretical frameworks they employ. The interests of neurology and psychiatry converge within the framework of modern neuroscience. Further progress in understanding brain diseases and behavior demands fuller collaboration and integration of these fields. Leaders in academic medicine and science must work to break down the barriers between disciplines.

Alzheimer Disease↗
PubMed1990

The psychotherapies in the context of new developments in the neurosciences and biological psychiatry.

We are in an era when the common denominators accounting for the major favorable effects of the different psychotherapies merit further clarification. At the same time, definite progress has been made in determining those specific psychotherapeutic techniques and methods that produce the desired results most efficiently with particular types of patients with specific types of problems. Continuing psychotherapy research will be required, and such research will need to be linked and co-ordinated with the new scientific progress being made in biological psychiatry and the neurosciences.

Humans↗
PubMed2002

Developments in cognitive neuroscience: II. Implications for theories of transference.

An integration of psychoanalytic theory with contemporary developments in cognitive neuroscience offers a useful perspective on long-standing controversies about the nature of transference, and a better understanding of the precise mechanisms by which transferential processes occur. Contemporary psychoanalytic views of transference are reviewed, and the many processes that constitute transference are described. Two issues that have emerged in different guises for several decades-the role of the analyst in eliciting transference, and the nature of "real" and "transferential" components of the therapeutic relationship-are reconsidered in the light of concepts such as connectionist networks. Although a useful analytic stance is one that allows the patient's enduring dynamics to dominate the analytic field, it is suggested, anonymity is neither a cognitive possibility nor the driving force behind most transference reactions, and the distinction between "real" and "transferential" perceptions is one of therapeutic interest, not of mechanism. Certain features of the analytic situation make some dynamics more likely than others to enter the treatment relationship, notably those related to authority, intimacy and attachment, and sexuality. Transference reactions are best understood as constructed from a combination of the patient's enduring dispositions to react in particular ways under particular conditions; features of the analytic situation and of the analyst; and interactions between patient and analyst. These reactions do not unfold ineluctably from the patient's mind in the consulting room, nor are they cognitive constructions of the patient-analyst dyad or co-constructions of relatively equal partners exerting their influence on the analytic field.

Adult↗
PubMed2003

On the astonishing clinical irrelevance of neuroscience.

The clinical work of psychoanalysts can be thought of in both a narrow and a broad sense. In the narrow sense, it refers to what is commonly thought of as psychoanalytic technique, the methods analysts use to understand their patients and to convey that understanding to them. In the broad sense, it refers to the entirety of their work as clinicians: the content of understanding, as well as such things as diagnosing, estimating analyzability, recommending therapy, and prescribing medication. The current enthusiastic expectation that neuroscience will have an immediate and direct impact on clinical work in the narrow sense is misguided, but neuroscientific discoveries, it is argued, will have a major impact on psychoanalytic theory in the not too distant future. The resulting changes in metapsychology will ultimately have reverberations on clinical work in the broad sense, although psychoanalytic technique, the analyst's basic approach to patients, will remain essentially the same.

Curriculum↗
PubMed1987

Undergraduate clinical neurosciences programme development: a consumer-based evaluation.

Intern responses to a questionnaire were used to evaluate an undergraduate clinical neurosciences programme. The data obtained were judged an authentic measure of instructional efficacy. Most interns rated themselves competent in performing the neurological examination but ill-equipped to interpret their findings and to manage effectively common problems, especially emergencies. Neurological diseases and the non-biomedical aspects of patient care were identified relatively infrequently as matters needing greater emphasis. Explanations for these findings may include a curriculum of traditional format, differences in teaching and assessing theoretical and practical competence, and the typical responsibilities of interns in an academic hospital. Intern evaluation of undergraduate clinical programmes can provide data useful to their development.

Clinical Competence↗
PubMed2001

Voxels in the brain: neuroscience, informatics and changing notions of objectivity.

In the 1990s, the 'Decade of the Brain', a number of digital and electronic resources have been created to enable the rationalization and integration of the various sub-fields of neuroscience. This approach has been described as 'neuroinformatics'. An important subset of tools (atlases of the brain) developed in the Human Brain Project is examined in detail in order to understand how the use of these tools changes the practice of science. In the course of the development of atlases, what constitutes 'objective' neuroscientific knowledge is redefined in important ways, according to both technological possibilities built into these tools and to the constraints of standardization inherent in projects that involve multiple measurements. The constitution of objectivity is examined across a number of levels (ontological, epistemic, pragmatic) and the concept of 'digital objectivity' is suggested as a label for a particular configuration of ideals, techniques and objects of knowledge in cyberscience.

Brain↗
PubMed2001

Neuroscience and morality.

Humans are social animals who use specialized brain mechanisms to assess the actions of others. This system for social cognition can be studied by imaging techniques, and its damage can lead to inappropriate social and moral behavior. Neuroscience can thus enrich our understanding of behaviors traditionally thought to be outside the province of science.

Brain↗
PubMed2002

Do you know your brain? A survey on public neuroscience literacy at the closing of the decade of the brain.

What does the public know about the developments offered by brain research? What factors influence public neuroscience literacy? What issues need to be emphasized to the public? To address these questions, a survey was conducted using a questionnaire with 95 assertions, answered by indicating yes, no, or I don't know. The opinions of 35 senior neuroscientists and 2158 members of the public of Rio de Janeiro were heard on issues such as the mind-brain relationship, the senses, learning, and memory. The incidence of "correct" answers among the public improved the most with schooling, followed by reading of popular science magazines and of newspapers. An analysis of the responses to each assertion revealed which themes are well- or poorly known to the public. The results attest for the importance of popular scientific communication and indicate issues on which communication efforts should be concentrated in order to increase public awareness about the brain.

Adolescent↗
PubMed2006

From neuroscience to application in neuropharmacology: A generation of progress in electrophysiology.

A continuum from neuronal cellular/subcellular properties to system processes appears to exist in many instances and to allow privileged approaches in neuroscience and neuropharmacology research. Brain signals and the cholinergic and GABAergic systems, in vivo and in vitro evidence from studies on the retina, or the "gamma band" oscillations in neuron membrane potential/spiking rate and neuronal assemblies are examples in this respect. However, spontaneous and stimulus-event-related signals at any location and time point reflect brain state conditions that depend on neuromodulation, neurotransmitter interaction, hormones (e.g., glucocorticois, ACTH, estrogens) and neuroendocrine interaction at different levels of complexity, as well as on the spontaneous or experimentally-induced changes in metabolism (e.g., glucose, ammonia), blood flow, pO2, pCO2, acid/base balance, K activity, etc., that occur locally or systemically. Any of these factors can account for individual differences and/or changes over time that often are (or need to be) neglected in pharmaco-EEG studies or are dealt with statistically and by controlling the experimental conditions. As a result, the electrophysiological effects of neuroactive drugs are to an extent non-specific and require adequate modeling and precise correlation with independent parameters (e.g., drug kinetics, vigilance, hormonal profile or metabolic status, etc.) to avoid biased results in otherwise controlled studies.

Brain↗
PubMed2006

Development of a neuroscience-oriented "methods" course for graduate students of pharmacology and toxicology.

To provide graduate students in pharmacology/toxicology exposure to, and cross-training in, a variety of relevant laboratory skills, the Duquesne University School of Pharmacy developed a "methods" course as part of the core curriculum. Because some of the participating departmental faculty are neuroscientists, this course often applied cutting-edge techniques to neuroscience-based systems, including experiments with brain G protein-coupled receptors. Techniques covered by the course include animal handling and behavioral testing, bacterial and mammalian cell culture, enzyme-linked immunosorbent assay, western blotting, receptor binding of radioligands, plasmid DNA amplification and purification, reverse transcriptase-polymerase chain reaction, gel electrophoresis, and UV-visible and fluorescence spectroscopy. The course also encompasses research aspects such as experimental design and record keeping, statistical analysis, and scientific writing. Students were evaluated via laboratory reports and examinations, and students in turn evaluated the course using a detailed exit survey. This course introduces the graduate student to many more techniques and approaches than can be provided by the traditional graduate "rotation" format alone and should serve as a template for graduate programs in many basic research disciplines.

Adult↗
PubMed2006

Using literature and innovative assessments to ignite interest and cultivate critical thinking skills in an undergraduate neuroscience course.

Science education reform initiatives emphasize 1) the value of concepts over facts; 2) the benefits of open-ended, inquiry-based problem-solving rather than protocols leading to a single correct answer; and 3) the importance of a multidisciplinary approach to teaching that is not confined by departmental boundaries. Neuroscientists should be at the forefront of this movement by the very nature of the discipline we study. Neuroscience is a relatively new field that integrates diverse subjects (anatomy, physiology, pharmacology, molecular biology, computer science, and psychology) and experimental advances are constantly changing and expanding our understanding of brain function. How can we convey this excitement in the classroom? The project described in this article uses nonscientific literature to introduce a scientific topic of study. In addition, the multitask assignment requires the acquisition of content knowledge and the development of critical thinking skills. As students explore the topic from multiple perspectives, they recognize the interconnectedness of science and society and confront ethical and moral issues related to science. A comparison of exam scores, essay responses, engagement level, as well as students' own reflections, demonstrates that inclusion of the project does not sacrifice content knowledge, rather it enhances the overall learning process.

Adult↗
PubMed2004

Integrating research on developmental psychopathology and neuroscience in the study of adolescence: introduction to part II.

This chapter introduces three papers that summarize research findings in clinical and basic neuroscience. They integrate prior research on clinical aspects of developmental psychopathology, basic research on brain development in nonhuman primates, and neuroimaging research on both normal and abnormal human development. From the clinical perspective these papers call attention to the unique relationship between adolescence and psychopathology. From the basic science perspective they call attention to the sequence of events that culminates in a fully mature central nervous system.

Adolescent↗
PubMed2006

Microfluidic chambers for cell migration and neuroscience research.

This chapter describes the fabrication and use microfluidic chambers for cell migration and neuroscience research. Both microfluidic chambers are made using soft lithography and replica molding. The main advantages of using soft lithography to create microfluidic chambers are reproducibility, ease of use, and straightforward fabrication procedures. The devices can be fabricated in biology and chemistry laboratories with minimal access to clean-room facilities. First, a microfluidic chemotaxis chamber, which has been used in investigating chemotaxis of neutrophils, human breast cancer cells, and other cell types, is described. Precise and stable gradients of chemoattractants with arbitrary shapes can be generated for different applications. Second, a multicompartment culture chamber that can fluidically isolate neuronal processes from cell bodies is described. The design of this chamber is such that only neurites grow through a series of microgrooves embedded in a physical barrier. Both devices are compatible with phase, differential interference contrast, and fluorescence microscopy.

Animals↗
PubMed2004

The contribution of small animal positron emission tomography to the neurosciences--a critical evaluation.

This article presents an overview of those animal studies which so far have been performed with dedicated small animal positron emission tomographs in the field of the neurosciences. In vivo investigations focus on energy metabolism, perfusion and receptor/transporter binding in rat models of reinforcement, learning and memory, traumatic brain injury, epilepsy, depression, cardiovascular diseases--such as ischemia and focal stroke--and neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's disease. In the majority of studies, important novel aspects arise from the fact that the investigators made use of an option inherent to in vivo studies, namely to conduct longitudinal investigations on the same animals. Relevant findings pertain to the relationship of brain metabolism/perfusion and the cholinergic system, the regulation state of dopamine receptors upon cocaine administration and withdrawal, the regulation state of dopamine receptors and transporters in animal models of Parkinson's and Huntington's disease, and potential treatments of progressive dopaminergic depletion with adenoviral vectors, embryonic grafts, stem cells and nerve growth factors.

Animals↗