Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Metaphysics”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 397 records · Page 22Linked to original sources
PubMed1975

In vitro studies on collagen metabolism in metaphyseal rat bone. A. The effect of pre-treatment with oestradiol-17 beta.

The effect of oestradiol-17 beta treatment on bone collagen metabolism in vitro was studied in metaphyseal rat bone. Rats were oophorectomized and subsequently treated for 3 weeks with different doses of oestradiol-17 beta. Bone pieces were incubated in a modified Krebs-Ringer bicarbonate medium for 6 h. Synthesis of (14c)hydroxyproline from (14C)proline and the incorporation of this amino acid into the bone samples was determined and the collagen synthesis and accretion rates calculated from these data. Collagen resorption rates were calculated from measured release of non-radioactive hydroxyproline to the medium. Castration resulted in an increased rate of accretion and resorption of collagen. All doses of oestradiol tested in this study (1 to 20 mug per animal per day for 3 weeks) decreased both accretion and resorption rates to levels insignificantly different from those of the non-castrated control rats. Only the 2 mug treated group had significantly better collagen balance than the castrated untreated rats.

Animals↗
PubMed1975

In vitro studies on collagen metabolism in metaphyseal rat bone. C. The effect of oestradiol-17 beta in hypophysectomized and in thyro-parathyroidectomized animals.

Oestradiol-17 beta has been administered to hypophysectomized/castrated and to thyro-parathyroidectomized/castrated young mature female rats. Treatment with oestradiol-17 beta 5 mug/day per animal, was continued for 3 weeks. Bone pieces from tibia/femur metaphyses were incubated in vitro for 3 h in order to establish the bone collagen synthesis and resorption rates. The results were compared to results from a previous study on castrated female rats with intact hypophysis, thyroid and parathyroid glands. Bone from the thyro-parathyroidectomized/castrated rats treated with oestradiol-17 beta had a significantly reduced collagen resorption rate in vitro as compared to their paired controls. This is a result consistent with that of castrated female rats with intact thyroid and parathyroid glands treated with oestradiol. Oestradiol-17 beta had no detectable effect upon collagen metabolism in the hypophysectomized/castrated rats. It is concluded that the effect of oestradiol on bone resorption is not exerted via the parathyroid glands or parathyroid hormone. The possibility that oestrogens may act on bone via the hypophysis is discussed.

Animals↗
PubMed1992

Static-dynamic intramedullary nailing (SDIN) in diaphyseal and metaphyseal lower limb fractures.

The authors report their experience with the Grosse-Kempf nail in treatment of diaphyseal and metaphyseal fractures of the femur and tibia. The biological and biomechanical preconditions of the method as well as several details of the surgical technique are discussed, and the results of 70 procedures performed from 1986 to 1989 are evaluated. The outcomes are quite positive and confirm other reports in the literature.

Adolescent↗
PubMed1992

Scanning electron microscopy of proteoglycans in metaphyseal cartilage.

Alcian blue (AB) was used for scanning electron microscope investigations on metaphyseal cartilage. In the pericellular area three-dimensional network connecting the cell membrane surface to the lacunar wall is evident. The network is formed by very long rod-like filaments about 50 nm thick. The segments may be interpreted as the proteoglycans (PGs) of the pericellular area. In the pericellular area in hypertrophic and degenerative zones, the rod-like segments are closely connected to "chain granules" which are the morphological expression of Ca-P non crystalline compounds. The rod-like segments are not at all evident either in glutaraldehyde-osmium fixed fragments or in predigested-(streptococcal hyaluronidase and chondroitinase) AB stained ones. It is concluded that AB is a good method to detect the three-dimensional spatial disposition of cartilage PGs.

Animals↗
PubMedDate not supplied

Variability of the metaphyseal-diaphyseal angle in tibia vara: a comparison of two methods.

Although Levine and Drennan described the metaphyseal-diaphyseal angle (MDA) in tibia vara using the lateral border of the tibial cortex, there is a lack of uniformity in the literature. The authors measured the MDA using both the lateral border and the center of the tibial shaft in 132 knees (66 patients) with bowleg deformity and examined whether there is a significant difference between these two measurements. At angles < or =11 degrees there was significant variance between the two methods. At angles >11 degrees, there was excellent correlation between the two methods and no statistical difference between the two methods. The authors conclude that either method of defining the longitudinal axis is acceptable to measure the MDA for the diagnosis and monitoring of tibia vara.

Bone Diseases, Developmental↗
PubMed2005

[Metaphyseal fibrous defect].

PURPOSE OF THE STUDY: The aim of the study was to identify predisposition to the development of metaphyseal fibrous defect (MFD) on the skeleton and to select appropriate imaging methods and examination for detection of atypically located or larger cortical lesions. MATERIAL: A group of 38 randomly selected patients with MFD was analyzed. It comprised of 27 boys and 11 girls at average ages of 13.7 years and 15.5 years, respectively. The youngest child was 4 and the oldest patient was 30 years old. METHODS: Thirty-two patients with a history of trauma and six patients with problems associated with sports activities were examined by plain radiography. Additional examination included CT scans in eight, MRI in two, scintigraphy in 17, angiography in seven and genetic examination in three patients. Histological evaluation confirming the presence of MFD was carried out in seven patients. RESULTS: The majority of lesions (75.6 %) were found around the knee, 17 in the distal femur and 17 in the proximal tibia. Eight lesions (17.8 %) were present in the distal tibia and three (6.6 %) were at other sites. Multifocal lesions, when detected, were associated with von Recklinghausen's neurofibromatosis, Marfan's disease or familiar occurrence. In most cases the diagnosis was made on the basis of plain radiographic findings. For large lesion in atypical locations, examination by CT, MRI, scintigraphy or biopsy were recommended. DISCUSSION: In this section the authors discussed other pathologic conditions that must be distinguished from MFD. CONCLUSIONS: The bones around the knee were affected most often. Multifocal MFD lesions were associated with von Recklinghausen's neurofibromatosis, Marfan's disease or familiar occurrence. The diagnosis was usually based on plain X-ray examination. To diagnose atypical and large lesions, advanced imaging (CT, MRI), scintigraphy or biopsy were recommended.

Adolescent↗
PubMed1991

[Familial metaphyseal dysplasia: incidental detection of an osteochondroma].

The authors take advantage of an incidental observation of osteochondroma in a patient affected by familial metaphyseal dysplasia to look further into the study of this congenital osteopathy. Examination of the family medical background brings to light the blood-relation of the patient's parents and the presence of the same clinical and radiological features in the patient's sister. Particular attention is given to histological and ultrastructural study of the removed bone tissue.

Adult↗
PubMed1991

Diaphyseal and metaphyseal hemiresection with autograft reconstruction in the treatment of lowgrade tumors of the long bones.

The authors discuss seven cases of parosteal tumors treated conservatively by diaphyseal and metaphyseal hemiresection with cortical autograft reconstruction. This treatment yielded excellent clinical and functional results without having to resort to resection and arthrodesis or prosthetic replacement. The slow growth and low malignancy of these tumors make the use of this technique possible even at the risk of local recurrence, which, if discovered early, can still be treated by further conservative procedures.

Adolescent↗
PubMed1991

Internal and external fixation in complex diaphyseal and metaphyseal fractures of the humerus.

The treatment of diaphyseal and metaphyseal fractures of the humerus is often controversial, especially when these fractures are complex and/or unstable (i.e. comminuted, segmental, or with a butterfly fragment). The authors review the indications, advantages, and disadvantages of various open and closed procedures, concluding that a combination of internal and external fixation is a valid treatment for these fractures. The purpose of the external fixation is immediate stabilization of the fracture, which is difficult if not impossible with intramedullary internal fixation alone. Internal fixation devices (Rush rods or "anchor" nails introduced by closed means) make it possible to align the fracture, facilitating application of the external fixator, and at the same time promote rapid healing. Fractures treated by this method healed in an average of 2 1/2 months, without residual functional limitations of the shoulder or elbow.

External Fixators↗
PubMed1991

[Autosomal recessive metaphyseal chondrodysplasia and Hirschsprung's disease].

Two unrelated patients with Hirschsprung disease and very short stature since birth are reported. Attention is drawn to the early roentgenographic signs of recessive McKusick metaphyseal chondrodysplasia syndrome or cartilage-hair hypoplasia syndrome. Some, but not all, patients with this chondrodysplasia exhibit anomalies of the hair, neutropenia and immune deficiency. Presence of congenital megacolon is apparently not exceptional. Nosologic limits are discussed.

Enchondromatosis↗
PubMed1990

Morphological aspects of rat metaphyseal cartilage pericellular matrix.

In order to verify whether it is possible to observe morphological evidence of a Ca-P amorphous phase (the first step of Ca-P crystalline deposition), the pericellular area of metaphyseal cartilage was investigated. In the pericellular zone of proliferative, maturation, hypertrophic, degeneration and calcification cartilage, many electron-opaque granules, having a very regular diameter of about 12 nm, disposed in closely-packed chains (chain granules) and increasing in number from the proliferation to the calcification zone, are evident. These chain granules, which are closely connected with proteoglycans, disappear after decalcification and are spatially related to ALPase and ATPase activities. They may be the morphological reflection of the Ca-P amorphous phase.

Adenosine Triphosphatases↗
PubMed1990

Surgical management of Rhodococcus equi metaphysitis in a foal.

A chronic Rhodococcus equi metaphysitis involving the distal growth plate of the left third metatarsal bone had induced a longstanding lameness in a young foal. Abnormal hematologic values included mild anemia, hyperfibrinogemia, mild leukocytosis, and neutrophilia. Radiography of the distal portion of MT3 revealed a radiolucent zone on the medial aspect of the growth plate, and small pieces of bone suggestive of sequestra. Treatment with erythromycin estolate and rifampin, aggressive surgical debridement, and cancellous bone grafting helped resolve the bone infection.

Abscess↗
PubMedDate not supplied

Neck metaphyseal angle guidance in proximal femoral varus osteotomy.

An angle within the femoral arch is defined, and its line is described in selecting the osteotomy site and the position of the fixation device in performing a femoral varus osteotomy. This neck metaphyseal angle was measured with varying degrees of rotation on seven pediatric femurs; it was also studied on 283 randomly selected hip radiographs. The angle varied 25-40 degrees in 90% of the patients and was not age related. The angle is stable within 5 degrees as long as the landmarks, base of the great trochanter, and medial metaphysis of the femoral neck are definable (0-30 degrees of rotation).

Adolescent↗
PubMedDate not supplied

Metaphyseal distraction for lower limb lengthening and correction of axial deformities.

Metaphyseal distraction with the Orthofix apparatus was performed on 10 patients (five femora and five tibiae). A retrospective review is presented. The follow-up time was 10-38 months. A satisfactory correction of leg length and axial deformity was achieved in all cases. There was no need for plating or bone grafting. All patients showed solid bony fusion at follow-up. Pin tract infections in seven patients resolved under antibiotic treatment. Problems of pin loosening and mechanical weakness of the distraction device are discussed.

Adolescent↗
PubMedDate not supplied

Metaphyseal osteotomy for the treatment of tailor's bunions.

There have been many surgical approaches described for the surgical treatment of tailor's bunions. The authors have been using a procedure that addresses both an elevated fourth to fifth intermetatarsal angle and an elevated lateral deviation angle, for the past 3 years. The metaphyseal osteotomy provides reliable correction of these two abnormalities and allows for uncomplicated rigid fixation.

Adult↗
PubMedDate not supplied

[2 familial cases of cranio-metaphyseal dysostosis].

The authors describe two familial cases of cranio-metaphyseal dysostosis. The clinical and radiographic features of the cases are analyzed, and the type of treatment used reported.

Abnormalities, Multiple↗