[Antibiotics and the lymphatic system; experiments and clinical suggestions].
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An original method of studying the functional state of the lymphatic system-lymphotachoradiography, elaborated in the Institute of Experimental and Clinical Oncology of the USSR Acadeny of Medical Sciences, was found to be rather effective in estimating metastatic spread of the uterine cervix and body cancer. The coefficients of phagocytosis of colloid particles by lymphoid tissue are determined. Normal coefficients are equal for inguinal, iliac and paraaortic groups of lymph nodes to 1.60+/-0.05; 1.40+/-+/-0.04; 1.10+/-0.10 accordingly. In some pathological changes in lymph nodes these coefficients are changed: 0.41+/-0.01; 0.48+/-0.01; 0.24+/-0.05, correspondingly.
Suspensions, emulsions, solutions, and liposomes were used as carriers to deliver drugs endolymphatically in animals. The purpose was to find which preparation was best tolerated by lymph tissue while slowly releasing the highly concentrated drugs out of nodal depots. Large unilamellar liposomes manufactured by detergent dialysis yielded the best results.
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