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PubMed1979

Audiovisuals and non-print learning resources in a health sciences library.

The MD undergraduate program at McMaster University, based entirely on self-instruction, requires the provision of all kinds of learning resources. How these are assembled and made available is described. Emphasis is placed on the practical library problems of cataloging, shelving, maintenance, and distribution of audiovisual materials including pathology specimens and 'problem boxes' as well as the more usual films, videotapes and slide/tape sets. Evaluation is discussed briefly.

Audiovisual Aids↗
PubMed1980

Education and training for computer-based reference services: review of training efforts to date.

This article raises several questions regarding training for computer-based reference services, including who is to be trained and who is responsible for training. It discusses these issues and then provides a summary of the training provided to date by search service suppliers, database suppliers, library schools and extension programs, library cooperatives, and professional organizations. The available training materials are also discussed. Some projections are made of likely future activities.

Information Systems↗
PubMed2001

Hospitals and consumer health information in New Zealand: the role of the library.

A research project was conducted with the primary objective of finding out what New Zealand hospitals are doing about providing consumer health information to patients, and specifically, the role played by hospital libraries. A database was compiled of all New Zealand hospitals, both public and privately funded. An individual responsible for consumer health information was identified at each hospital and a questionnaire sent directly to them. A 64% response rate was achieved, representing 196 hospitals. Fifty-four hospitals reported having an in-house Library or Information Centre for patients, but the materials and services provided varied widely. Results from this survey show that the provision of consumer health information in the hospital sector in New Zealand is ad hoc, and libraries are not necessarily involved.

Humans↗
PubMed2006

A pilot project of a cancer patient library in Italy: results of a customer-satisfaction survey and its products.

AIMS: The purpose of this study is to determine the degree of satisfaction of users of the Cancer Information Point section of the Library for Patients (CIP-LP), active since 1998 at the National Cancer Institute of Aviano, Italy. The CIP-LP is based on a skilled intermediary, adequate informative material and a specific location, within the Scientific Library of the Institute. PATIENTS AND METHODS: A survey was developed to assess service functionality and quality from the users' viewpoint. During a 6-month period, a questionnaire was mailed to 194 patients and relatives who previously used the CIP-LP; 113 (58%) were returned and processed. RESULTS: Of the respondents, 91% were pleased with the CIP-LP and 95% would recommend the service to other people. The information obtained contributed to a clearer understanding of the illness and treatment (45% as first answer) and a better control of the situation (33%). Fifty-one per cent evaluated the information received as 'good', 42%'excellent' and 4%'of sufficient quality'. CONCLUSION: This survey shows the appreciation and usefulness in the users' perception of a specific hospital library for cancer patients and their relatives, providing an information service supplementary to doctor-patient communication.

Adult↗
PubMed2006

EST analysis of cDNA libraries from the entomopathogenic fungus Beauveria (Cordyceps) bassiana. II. Fungal cells sporulating on chitin and producing oosporein.

In the accompanying paper [Cho, E.-M., Liu, L., Farmerie, W. & Keyhani, N. O. (2006). Microbiology 152, 2843-2854], the analysis of expressed sequence tag (EST) libraries derived from homogeneous single-cell populations of aerial conidia, in vitro blastospores and submerged conidia of the entomopathogenic fungus Beauveria (Cordyceps) bassiana has been reported. Here an extended EST analysis is presented of complex cell mixtures derived from fungal cells sporulating on chitin or grown under culture conditions inducing the production of the B. bassiana secondary metabolite, oosporein. Fungal material used for the construction of the libraries included germinating conidia and blastospores, mycelia, as well as cells in various developmental stages. Approximately 2,500 5' end sequences were determined from random sequencing of clones from each library, and were clustered into 277 contigs with 1,069 singlets, and 306 contigs with 1,064 singlets, for the chitin and oosporein libraries, respectively. Almost half (45-50 %) of the sequences in each library displayed either no significant similarity (e value >10(-4)) or similarity to hypothetical proteins found in the NCBI database. Approximately 20-25 % of the sequences in each library could be annotated by gene ontology terms. A comparative analysis between the two libraries, as well as the libraries in the accompanying paper, is presented. A set of 4,360 clustered and unique sequences was characterized. The data are indicative of a highly plastic gene expression repertoire being available to B. bassiana for growth during different environmental and developmental conditions, and provides a dataset for gene discovery and genome annotation.

Benzoquinones↗
PubMed2001

Application of an automated synthesis suite to parallel solution-phase peptide synthesis.

An in-house developed automated synthesis suite was used to prepare a library of 72 tetrapeptide derivatives, the starting materials for pharmaceutically attractive pentapeptides, employing a convergent strategy. An initial set of 18 dipeptides were synthesized on a large-scale (100-1000 g) using automated synthesis workstations, and then 72 tetrapeptides were synthesized on a medium scale (5-10 g) using an automated system. Each di- or tetrapeptide was prepared in a single operating cycle using a modified methanesulfonic acid method, then a sub-library of 56 pentapeptides were synthesized in parallel, on a small-scale (100 mg-1 g) using a robotic workstation.

Carboxylic Acids↗
PubMed1997

Synthetic strategies in combinatorial chemistry.

Different synthetic strategies are required for the two kinds of libraries being developed for combinatoral chemistry. Preparation of a 'focused' library involves conversion of a known synthetic route to the solid-phase or automated format, whereas generation of a 'prospecting' library is driven more by availability of input materials and considerations of structural novelty. While both types can be identified over the history of combinatorial chemistry, elaborating syntheses of novel, nonoligomeric, 'drug-like' molecules for use in prospecting libraries is a relatively recent development.

Chemistry, Organic↗
PubMed1966

Topics in library technology: copying techniques.

Photocopying applications in the library include the combining of previously separate material, the separation of a single item into two or more of its parts, and the selection of parts of existent material by the use of overlays. The production of catalog cards, the creation of sheet material (new book lists, reference bibliographies) from card-form materials, an Index Medicus-derived alerting service, and overdue notices copied from charge cards are among the applications exemplifying these general types. Larger-scale operations employing microfilm are noted. The distinction between copying and printing, in the light of equipment advances, is discussed.

Copying Processes↗
PubMed1994

Providing consumer health information through institutional collaboration.

In the past several years, The Claude Moore Health Sciences Library of the University of Virginia Health Sciences Center (HSC) has noted a growing demand for consumer health information. However, because the primary role of the library is to provide information services to health professionals at the HSC, questions have been raised as to the amount of time, energy, and money that should be expended to provide health care information to consumers. The library staff, because it can provide special expertise regarding the availability and utilization of consumer health materials, has felt the responsibility to participate in HSC initiatives that reach a broad audience. Library efforts in that regard include assisting with inventory and management of patient education materials, participating in a community health promotion task force, collaborating with hospital departments in planning a consumer health information center, establishing a consumer health information reference section in the library, and obtaining a grant to offer a networked health information system to local public and community college libraries. Consumers of health information benefit from the enhanced services that result from combining the expertise of health professionals and patient educators with the information management skills of library staff.

Consumer Advocacy↗
PubMed1990

Streamlined approach to creating yeast artificial chromosome libraries from specialized cell sources.

The study of tumor-specific chromosomal abnormalities has been severely impeded by an inability to link cytogenetic to molecular data. Restriction fragment length polymorphism mapping of any particular chromosomal rearrangement to the resolution limit of genetic methodology generates sets of probes that frequently are still too widely spaced to render the rearrangement breakpoints accessible to molecular isolation. The stable propagation of genomic fragments of up to one million base pairs in size as yeast artificial chromosomes (YACs) represents an important development in this regard. However, existing YAC libraries have been made from karyotypically normal sources making the localization and cloning of specific rearrangement breakpoints much more difficult. As a solution to this problem, we present an improved method for creating YAC libraries that can utilize specialized tumor-derived materials and that can be executed effectively in a small laboratory setting. Procedures that enabled more consistent DNA insert size selection and enhanced yeast transformation frequency were employed to generate a human YAC library from a neuroepithelioma cell line containing a characteristic t(11;22) chromosomal translocation. Approximately 40,000 colonies with an average insert size of 330 kilobase pairs were created. This library was screened with two single-copy probes that bracket the translocation breakpoint. YAC clones ranging from 370 to 550 kilobase pairs that were specific for each single-copy probe were identified. Specialized YAC libraries will make many more tumor-specific chromosomal abnormalities accessible to molecular isolation.

Cell Line↗
PubMed1998

Gene VIII-based, phage-display vectors for selection against complex mixtures of ligands.

Selection of shotgun phage-display libraries against complex mixtures of components, such as cells or sera, may result in a high number of nonspecifically binding phage. Consequently, correct interactions may be difficult to identify. To enable discrimination between faithful and nonspecific interactions, a set of eight different gene VIII-based, phage-display vectors were constructed. All vectors contain a "universal" screening tag positioned in such a way that it is only expressed when the inserted DNA encodes an open reading frame, which corrects a shift of reading frames in the vector. A Staphylococcus aureus shotgun phage-display library was made in a stoichiometric mixture of all vectors. After affinity-selection against IgG, one vector completely outcompeted the others. This vector contains the promoter and signal sequence from the gene encoding staphylococcal protein A and one suppressible stop codon immediately upstream of gene VIII. An increase in the frequency of clones expressing the affinity tag in all pannings correlated with selection for ligand-binding clones. This enables detection of putatively correct clones after selection of a shotgun phage-display library both against purified ligands and more complex materials like calf serum.

Bacterial Proteins↗
PubMed1992

Rapid isolation of desired sequences from lone linker PCR amplified cDNA mixtures: application to identification and recovery of expressed sequences in cloned genomic DNA.

A simple and efficient method for the rapid isolation of specific sequences from PCR-amplified cDNA mixtures has been developed. cDNA mixtures obtained using lone linker PCR (Ko et al. 1990) appeared to be highly representative even though the starting material, 100 ng-2 micrograms of total RNA, is much less than is required for making an ordinary cDNA library. With this method, cDNA mixtures were obtained from limited materials, including early mouse embryos and primordial germ cells. For selective enrichment of desired cDNAs, biotinylated probe was hybridized with the lone linker-linked cDNA in solution and the resulting probe-cDNA hybrid was captured by Streptavidin-coated magnetic beads. After appropriate washing, cDNA was released from the beads and subjected to amplification followed by cloning into a vector. Using genomic fragments isolated during chromosomal walking in the T/t complex of mouse Chromosome (Chr) 17, cDNAs encoding novel germ cell specific genes have been readily isolated by the above procedures. The method, termed random access retrieval of genetic information through PCR (RARGIP), will streamline the entire process from RNA to cDNA greatly. Its application potentials in various areas of molecular genetics will be discussed.

Animals↗
PubMedDate not supplied

The legalities and practicalities of developing a course-specific electronic reserve room.

This article discusses important issues related to maintaining the currency of readings in a nursing course. The development of a course-specific electronic reserve room is offered as a methodology for achieving both timeliness and simplified distribution of course readings. The article reviews legal issues related to the development of an electronic reserve room for internet access. In addition, hardware and software issues related to the transference of paper materials to a digital format are considered.

Copyright↗
PubMed2003

Application of multivariate curve resolution for analysis of FT-IR microspectroscopic images of in situ plant tissue.

The chemometric techniques of multivariate curve resolution (MCR) are aimed at extracting the spectra and concentrations of individual components present in mixtures using a minimum set of initial assumptions. We present results from the application of alternating least squares (ALS) based MCR to the analysis of hyperspectral images of in situ biological material. The spectra of individual pure components were mathematically extracted and then identified by searching the spectra against a commercial library. No prior information about the chemical composition of the material was used in the data analysis. The spectra recovered by ALS-MCR analysis of an FT-IR microspectroscopic image of an 8-micron-cornkernel section matched very well the spectra of the corn storage protein, zein, and starch. Through the application of MCR, we were able to show the presence of a second spectrally different protein, which could not be easily seen using univariate analysis. These results demonstrate the value of multivariate curve resolution techniques for the analysis of biological tissue. The value of principal components analysis (PCA) for hyperspectral image analysis is also discussed.

Algorithms↗
PubMed1964

HELPING THE SMALLER LIBRARY.

On invitation, we approach, as consultants, the problem of helping a smaller library. Once we are certain we are qualified for the assignment, we arrange to visit the library and see its problems of personnel, space, and book collection. Talking with personnel operating the library may indicate appropriate courses of action. We recommend library procedures and systems commensurate with the present needs and future growth of a given institution or organization. We appreciate the quantity and quality of services rendered by small libraries. We learn who the readers are and what material is available locally before making recommendations concerning budgets or purchases. Our suggestions on technical matters include either work samples or references. We do not confuse library personnel with great detail. We tell them about local and nearby resources, services of the National Library of Medicine, and the Medical Library Association. We make them feel free to request further information as needed.

Book Collecting↗
PubMed1984

Integrating library services and continuing education.

This paper presents an innovative integration of library services and continuing education (CE). While print material is an important continuing education information source for physicians, its volume is overwhelming. Librarians have developed the use of a variety of methods, including online data bases such as MEDLINE, to simplify and expedite access to printed information. Combining a library information delivery system with formal continuing education course activities can enhance the educational potential of two popular learning methods.

Data Collection↗
PubMed1993

Collaboration in support of curriculum media: educational media and video production services.

Video Production Services and the Educational Media Department of the St. Louis University Health Sciences Center Library have an interrelated working relationship serving the schools of medicine, nursing, and allied health by providing videotaped instructional material. This paper details the various processes involved from the time a faculty member approaches the librarian in search of a specific subject video to the completion of an original production by the video professional, with both professionals playing an integral role in the provision of high quality curricular material. Our experience in the evolution of the process provides other medical libraries or biomedical communications units with a framework for successful production delivery.

Curriculum↗
PubMed1993

Chromosome painting using FISH (fluorescence in situ hybridization) with chromosome-6-specific library demonstrates the origin of a de novo 6q+ marker chromosome.

We report the application of chromosome painting using FISH (fluorescence) in situ hybridization) to demonstrate the origin of a de novo 6q+ marker chromosome. A girl with a mental retardation/multiple malformation syndrome was shown to have the karyotype 46,XX, 6q+. Banding analysis could not determine the origin of the extra chromosomal material. Using FISH with a chromosome-6-specific library we showed that the marker chromosome was completely painted, indicating an origin from chromosome 6. The child's phenotype was compared with previously reported cases with partial chromosome 6 trisomy. A clinically recognized syndrome emerged, although she apparently also demonstrated novel features.

Abnormalities, Multiple↗