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At least 397 records · Page 22Linked to original sources
PubMed1985

Cell surface alterations in murine leukaemia P388 adriamycin-resistant cells: studies on lectin-induced agglutination and rearrangement of lectin receptors.

Cell surface alteration was studied in a subline of murine lymphocytic leukaemia resistant to the broad-spectrum anticancer agent adriamycin (P388/ADR) employing concanavalin A(Con A)-induced agglutination and rearrangement of lectin receptors. Con A induced more agglutination of P388/ADR when compared to the drug-sensitive parental cell line (P388/S). Studies on the redistribution of Con A and Ricinus communis agglutinin-I revealed a high percentage of P388/ADR showing internalized fluorescence, while a majority of P388/S displayed a uniform distribution of fluorescence on the cell surface.

Animals↗
PubMed1983

Lectin-dependent and lectin-independent activities of human mononuclear cells that modulate the growth of human synovial cells.

Human peripheral mononuclear cells (MC) secrete 2 soluble activities that modulate the growth of human synovial fibroblastic cells. A growth-suppressive, lectin-dependent activity is elaborated by the non-adherent population and its secretion begins before DNA synthesis is initiated in concanavalin-stimulated MC cultures. The elaboration of this activity is partially dependent on the presence of serum and it appears to be distinct from virus-induced human leukocyte interferon. The second activity is secreted spontaneously by the MC, under a variety of culture conditions including supplementation with homologous human plasma, and it enhances the growth of synovial fibroblasts. The rate of secretion of the growth-enhancing activity by the nonstimulated MC approximately parallels that of the inhibitory activity from the stimulated MC cultures. MC from patients with rheumatoid arthritis and from nonaffected individuals secrete similar concentrations of growth-stimulatory activity for the synovial fibroblasts.

Arthritis, Rheumatoid↗
PubMed1993

The use of lectins identified with specific antibodies in lectin histochemistry of NZB/W F1 mouse kidney.

The affinity of Helix pomatia, peanut, Pisum sativum, soy bean, and wheat germ agglutinins to various nephron parts of NZB/W F1 mice was different and is assumed to be age dependent. The affinity of Pisum sativum agglutinin to basal membranes of small renal vessels increased with the age of NZB/W F1 mice. The wheat germ agglutinin bound to structures with alkaline phosphatase activity.

Animals↗
PubMed1984

Lectins from indigenous Australian wildflowers--detection of lectins from Bauhinia carronii, Hardenbergia comptoniana, Ptilotis obovatus and Rhadogia crassifolia.

Extracts from 21 indigenous Australian plant species, representing eight genera, were tested for haemagglutinating activity to human and animal erythrocytes. Extracts from Bauhinia carronii, Hardenbergia comptoniana, Ptilotis obovatus and Rhadogia crassifolia agglutinated at least one of the erythrocyte types tested. The extracts from B. carronii and R. crassifolia contained mitogens for human lymphocytes. Both the haemagglutinating and mitogenic activity of the B. carronii extract were inhibited by lactose. Both the haemagglutinating and mitogenic activity of R. crassifolia were inhibited by maltose and alpha-methyl-glucoside. The haemagglutinating activity of H. comptoniana was inhibited by raffinose and the haemagglutinating activity of P. obovatus by maltose and alpha-methylglucoside.

Animals↗