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Subcapsular hemorrhage of the liver in the newborn.

Infants with large subcapsular hemorrhages of the liver may have signs that mimic hypovolemic shock commonly seen with intraventricular hemorrhage. A retrospective clinicopathologic study of 783 neonates spanning ten years disclosed an incidence of 15% for subcapsular hemorrhage of the liver. Infants at risk were not clearly distinguishable clinically from control cohorts, but tended to be premature male infants with chronic problems during gestation and more complications during labor and delivery. Physical manipulations including umbilical venous catheter placement, tracheal intubation, and chest tube placement were typically seen in the affected neonates.

Adult↗

[Acid-base balance in capillary blood of newborns with perinatal hypoxemia symptoms].

The purpose of the study was to compare acid-base parameters in capillary blood of newborns from groups with hypoxaemia symptoms and from the control group (physiological deliveries). 111 newborns were divided into 8 groups. Group I consisted of 33 newborns from uncomplicated labour while groups II-VIII involved newborns from complicated labor with symptoms of hypoxaemia. Capillary blood was taken in the 10th and 60th minute and after 24 hours of newborn's life. In newborns with pathological CTG, green amniotic fluid and prolonged first stage of labour--higher duration of acidosis was observed.

Acid-Base Equilibrium↗

Multicystic encephalopathy: review of eight cases with etiologic considerations.

Multicystic encephalomalacia (MCE) is a rare lesion that arises during the perinatal period. Although hypoxic-ischemic insults may be responsible for this lesion, recent evidence suggests that herpesviruses may represent another etiologic agent. To elucidate the pathogenesis of MCE, eight cases collected over a 34-year period were evaluated for destructive lesions in gray and white matter. Immunocytochemical methods, in situ hybridization and polymerase chain reaction (PCR) methodology were employed to search for herpes simplex viruses types 1 and 2 (HSV1 and HSV2), cytomegalovirus (CMV), varicella zoster virus (VZV), Epstein-Barr virus (EBV) and JC variant of papovavirus (JCV). Review of the clinical histories revealed that there had been a complicated labor and delivery in 6/7 cases. Neuropathological lesions consisted of extensive tissue destruction, neuronal loss and gliosis in hemispheric white matter, cerebral cortex, basal ganglia, thalamus, cerebellum and brainstem tegmentum. Only one case showed evidence of latent HSV infection by PCR. CMV, VZV, JCV and EBV were not detected. Arteriopathy was noted in one case. The widespread nature of the lesions and their association with perinatal ischemia suggest that severe hypoxia may be the more common etiology of MCE. Term infants appear especially susceptible to this type of cerebral damage.

Autopsy↗

[Evaluation of indications for cesarean section. Comparison of two decades. Preliminary results].

We have retrospectively analysed the incidence of cesarean section during the periods 1970-79 and 1981-90 and the evolution, if any, of the principal indication over time. The average incidence of cesarean section was 9.01% in the seventies and 11.63% in the eighties: the difference was statistically significant. Four classes of indication show significant differences between the periods considered: previous cesarean, feto-pelvic disproportion, anomalous presentation, gestosis. An evolution of cesarean section indications is shown: minus parity, better health, sanitary and environmental conditions, better physiopathological and clinical knowledge of pregnancy complication and labor seem to be causes of that evolution.

Cesarean Section↗

Maternal, perinatal and infant health in Bedouin and Jews in southern Israel.

A study has been made of 3,745 Bedouin and 9,422 Jewish babies born in 1972-73 to residents of the Beersheba district of southern Israel (the Negev). Newborn infants weighing less than 1 kg were excluded. Thirty-seven percent of the Bedouin babies were born at home; their mothers tended to be older and of higher parity than those choosing to deliver in hospital. Less than 6% of Bedouin mothers had been to school, compared with 90% of the Jews; 30% were aged under 20 or over 34 years, compared with 18% of the Jews, and 23% were having their seventh or later baby, compared with 12% of the Jews. Mean birth weight of babies born in hospital was about 200 g lower in Bedouin than in Jews, and 11.4% of Bedouin and 6.5% of Jewish infants weighed less than 2.5 kg. There was little variation in complications of labor between the 1,959 Bedouin and 8,877 Jewish women delivered in Beersheba's Soroka Medical Center. The cesarean section rate was 1.8% in Bedouin and 4.3% in Jews, while in 0.3% of Bedouin and 1.4% of Jews labor was induced. Monozygous twinning rates were similar in the two ethnic groups (4.8 and 4.5 sets/1,000 deliveries, respectively) but dizygous twinning was twice as common among the Bedouin as among the Jews (13.0 vs 6.0 sets/ 1,000). Male births accounted for 0.526 and 0.512 of the total in Bedouin and Jews, respectively. Perinatal mortality rates for hospital births were 31.1 and 18.3/1,000 in Bedouin and Jews, respectively. Infant deaths among Bedouin (31.0/1,000) were underreported; the rate was 16.8/1,000 for Jewish infants. Although rates of all specific causes of death were higher in Bedouin than in Jews, patterns of mortality in subgroups based on birth weight, sex, twinning and maternal age were quite similar in the two ethnic groups. There were six reported deaths from tetanus among Bedouin babies. For the cohort of babies born in 1972, admissions to the Soroka Medical Center pediatric wards were recorded in 366 (195.5/1,000) Bedouin and 787 (174.3/1,000) Jewish babies younger than the age of one year. Bedouin admission rates were higher than those of Jews for gastroenteritis (119.1 and 64.5/1,000 respectively), infectious and parasitic diseases (29.4 and 21.9), malnutrition (25.6 and 8.0) and external causes (10.1 and 4.4). Admission rates for bronchitis and pneumonia were, however, lower among Bedouin than Jews in the first six months of life.

Birth Order↗

Safety of nonsteroidal antiinflammatory drugs in pregnant patients with rheumatic disease.

OBJECTIVE: To determine whether active arthritis in pregnant patients can be safely treated with nonsteroidal antiinflammatory drugs (NSAID) without harm to the neonate or longterm adverse effects in the offspring. METHODS: Patients were recruited from a prospective study on pregnancy and rheumatic disease. A cohort of 88 pregnant patients with inflammatory rheumatic disease was divided into 2 groups, 45 who were treated 43 not treated with NSAID during pregnancy. Possible longterm effects of NSAID on physical and mental development of the offspring were evaluated by telephone interview. RESULTS: Groups did not differ with regard to demographic data. Fourty-nine pregnancies had been exposed to standard doses of NSAID for a mean duration of 15.3 weeks. A comparison of pregnancies exposed with those not exposed to NSAID revealed no differences in pregnancy outcome, duration of labor, complications at delivery, or neonatal health. No significant differences were found between the groups with respect to health and development of offspring at followup. CONCLUSION: This study of a limited number of pregnancies in rheumatic patients showed no teratogenicity or adverse effects of NSAID on the neonate, nor did it reveal harmful longterm effects caused by intrauterine exposure to these drugs.

Adolescent↗

Pregnancy complicated by malaria, precipitate labor and uterine rupture.

A case of Plasmodium falciparum malaria is reported in a 25-year-old pregnant woman with a history of three previous cesarean sections. She developed premature precipitate labor which was complicated by stillbirth, uterine rupture, bladder and vaginal tears necessitating hysterectomy.

Adult↗

Birth weight, Apgar scores, labor and delivery complications and prenatal characteristics of Southeast Asian adolescents and older mothers.

The study population included 337 adolescents and 876 mothers who delivered live-born, singleton infants in the Maternity and Infant Care Program at the Minneapolis Health Department between 1980-1982. Whites and blacks on the average experienced menarche 1-2 years earlier than the Southeast Asians although age of first pregnancy was 2 years later for the Southeast Asians. In spite of the significantly later ages of entry into prenatal care, lower weight gains, and hematocrits among the Southeast Asians, compared to the white and black populations, overall height-weight status on admission compared favorably with whites and blacks. The virtual absence of alcohol and tobacco consumption among the Southeast Asians may in fact contribute to the generally favorable Apgar scores, length of gestation, and birth weights. The high frequencies of alcohol and tobacco consumption among white adolescents during pregnancy suggest the need for more intervention to discourage smoking in this population. Further, the potential adoption of these substances needs to be discouraged among the Southeast Asian adolescents. While 2-4% of the whites, blacks and Hmong adolescents experienced eclampsia, 1% of the older Hmong mothers and none of the other Southeast Asians experienced eclampsia. The most frequent complication for all groups was perineal laceration.

Adolescent↗

Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor.

BACKGROUND & AIMS: Hepatitis A virus (HAV) infection is the most common cause of acute hepatitis but is rarely reported during pregnancy. Our aim was to evaluate the impact of acute HAV infection on pregnancy outcome. METHODS: Consecutive admissions of 79,458 pregnant females during a 25-year period were retrospectively reviewed. RESULTS: Thirteen cases of second and third trimester HAV infection were found and evaluated. Nine of the 13 patients (69%) developed gestational complications, including premature contractions (n = 4), placental separation (n = 2), premature rupture of membranes (n = 2), and vaginal bleeding (n = 1). In 8 of these patients, complications led to preterm labor, at a median of 34 gestational weeks (range, 31-37 weeks). Delivery was vaginal in 12 of the 13 cases; fetal distress was noted in a single case, and meconium in amniotic fluid in 2 cases. Median birth weight was 1778 grams and 3040 grams in preterm and term deliveries, respectively (P < .05). Child outcome was favorable in all cases. In 4 cases, neonatal serum HAV RNA levels were measured and found negative. The presence of fever and hypoalbuminemia were associated with delivery at an earlier gestational week. There was a positive relation between gestational week at diagnosis of HAV infection and birth week (r = 0.68, P = .02), suggesting a causality relationship. All mothers featured full recovery from HAV infection. CONCLUSIONS: Acute HAV infection during pregnancy is associated with high risk of maternal complications and preterm labor. HAV serology and maternal vaccination during prepregnancy evaluation should be considered in areas of the world in which susceptible adult populations exist.

Acute Disease↗

Uterine and fetal blood flows in pregnancies complicated by preterm labor.

Flow velocity waveforms were recorded by Doppler ultrasonography from the uterine arteries, umbilical artery, thoracic descending aorta, renal artery and middle cerebral artery in fetuses of 57 pregnancies complicated by preterm labor with intact membranes. The uterine artery resistance index was significantly increased in patients with preterm labor when compared to reference limits for gestation, but no relationship was found with the time interval between Doppler recordings and delivery. The group of fetuses (n = 15) delivered within 48 h from entry to the study showed significantly reduced pulsatility index values from the middle cerebral artery when compared to fetuses delivered later or to the normal reference limits for gestation. No significant differences were found in the other vessels studied. In conclusion preterm delivery is associated with alterations in fetal cerebral waveforms and knowledge of these changes may prove useful in the evaluation of patients with preterm labor.

Adult↗

[Clinical condition of the newborns and the type of labor and pregnancy complications in cases of meconium in the amniotic fluid].

The studied material comprised 36 newborns and their mothers, among them 12 newborns had meconium in the amniotic fluid (study group) and 24 newborns with clear amniotic fluid served as controls. The fluids were studied biochemically. In both compared groups the analysed factors were: 1) week of labour, 2) body weight and length, 3) clinical condition of the newborn by the Apgar score, 4) type of labour, 5) type of pregnancy complications in mothers. The results were subjected to statistical analysis. It was found that meconium presence in the amniotic fluid correlated with the presence of clinical symptoms suggesting intrauterine asphyxia of the fetus, and the number of caesarean sections was greater in this group. A correlation was noted between the presence of meconium in the amniotic fluid and worse clinical condition of the newborn.

Amniotic Fluid↗

Vaginal and cervical pH in normal pregnancy and pregnancy complicated by preterm labor.

A prospective study was performed in order to determine vaginal and cervical pH in pregnancy. In normal pregnancy vaginal pH (using a pH meter with connected glass electrode) was found to be between 3.8 and 4.0 (1 SD +/- 0.3) at the introitus, mid-vaginal, and at the anterior and posterior fornix. In patients with preterm labor (n = 50) or prolonged rupture of the membranes (PROM, n = 35) pH was increased significantly to 4.2-4.5 (1 SD +/- 0.7) resp. to 5.2-6.1 (1 SD +/- 0.8). Cervical pH ranges between 6.5 and 7.0 in all groups studied. Elevated pH values are due to disturbed vaginal flora. We recommend vaginal pH measurement for an quick detection of infection in cases with preterm labor and for clarifying PROM in suspicious cases.

Bacterial Infections↗

Complications in pregnancy, labor, and delivery with uterine leiomyomas: a population-based study.

OBJECTIVE: To determine the extent to which uterine leiomyomas are associated with characteristics of pregnancy, labor, and neonatal outcome recorded on birth certificates. METHODS: In a population-based series of women who delivered singleton live infants in Washington state from 1987-1993, we linked computerized birth certificates and hospital discharge records to investigate the relationship between uterine leiomyomas and complications in pregnancy and delivery. Subjects were 2065 women with uterine leiomyomas noted on computerized hospital discharge records. From the remaining records, a comparison group of women without uterine leiomyomas diagnoses were selected at random and frequency-matched by birth year to women with leiomyomas. We used unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of pregnancy or delivery complications in relation to uterine leiomyomas after multivariate adjustment. RESULTS: Women with leiomyomas were more likely than controls to be over age 35 at delivery, nulliparous, or black. We observed independent associations between uterine leiomyomas and abruptio placentae (OR 3. 87, 95% CI 1.63, 9.17), first trimester bleeding (OR 1.82, 95% CI 1. 05, 3.20), dysfunctional labor (OR 1.85, 95% CI 1.26, 2.72), and breech presentation (OR 3.98, 95% CI 3.07, 5.16). The risk of cesarean was also higher among women with uterine leiomyomas (OR 6. 39, 95% CI 5.46, 7.50), but a portion of the excess risk might have been due to biased detection of leiomyomas at cesarean delivery. CONCLUSION: Leiomyomas appear to increase likelihood of complications during pregnancy, labor, and delivery.

Adult↗