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At least 397 records · Page 22Linked to original sources
PubMed1997

Stimulation of endosteal bone formation by local intraosseous application of basic fibroblast growth factor in rats.

We investigated the effects of local intraosseous application of basic fibroblast growth factor under physiologic conditions. An aqueous solution containing 0 (vehicle), 25, 100, or 400 micrograms of basic fibroblast growth factor was injected via a needle into the ilium of rats. Two weeks later, bone mineral density of the ilium was significantly increased (P < 0.01) with all three doses, and a dose-effect relationship was apparent. Light microscopy revealed proliferation of undifferentiated mesenchymal cells on the endosteal and trabecular surfaces, as well as apposition of newly formed bone on existing trabeculae. Intraosseous injection of basic fibroblast growth factor may be of use for the treatment of osteoporosis.

Administration, Topical↗
PubMed1998

Unclassified sclerosing bone dysplasia with osteopathia striata, cranial sclerosis, metaphyseal undermodeling, and bone fragility.

Sclerosing bone dysplasias are diagnosed on the basis of a characteristic pattern of osteosclerosis and clinical manifestations; in many of them, cause and pathogenesis are still unknown. A 33-year-old man had five fractures of the humerus, tibiae, and femur as a result of mild traumatic incidents that occurred between the ages of 18 and 33 years as well as a remnant of rib fractures without apparent trauma on radiographs. His height was 158 cm (-2.2 SD). Radiographic evaluation showed cranial sclerosis, longitudinal striations in the metaphyses of the femur and tibia, fan-like striation in the ilium, metaphyseal widening in the femur and tibia, and sclerosis of the ribs. The blood chemistry findings, including serum calcium, phosphorus, and alkaline phosphatase, were normal. Biopsy from the ilium showed thick trabeculae composed of woven bone. The coexistence of osteopathia striata, cranial sclerosis, metaphyseal undermodeling, and bone fragility has not been recognized previously. Our case appears to represent a new form of sclerosing bone dysplasia.

Abnormalities, Multiple↗
PubMed1998

Anatomic basis of Tönnis' triple pelvic osteotomy for acetabular dysplasia.

Dysplasia of the hip in adults can be treated by a pelvic osteotomy. In order to assess pelvic anatomy in relation to surgical approach and osteotomy sites, 12 cadaver hips were studied. A triple pelvic osteotomy as described by Tönnis [6] through ilium, pubis and ischium was performed, followed by an intrapelvic and anterior and posterior dissection of the hip. At the ischium, the pudendal and inferior gluteal neurovascular bundles are most at risk medially and proximally respectively. Much less in danger is the sciatic n. as it runs 1 to 3 cm lateral to the osteotomy site. At the pubis osteotomy the femoral v. lies close on the bone and is prone to damage. The artery lies further off the bone. The ilium osteotomy starts just proximal to the anterior inferior iliac spine and exits posteriorly at the sciatic notch. Here the sciatic n. and the superior gluteal neurovascular bundle may be damaged. The practical surgical implications of these three osteotomies are discussed, especially with respect to the requirement of meticulous subperiostal dissection and accurate placement of retractors.

Acetabulum↗
PubMed1998

Heterochronic processes in human evolution: an ontogenetic analysis of the hominid pelvis.

Changes in pelvic shape in human ontogeny and hominid phylogeny suggest that the heterochronic processes involved differ greatly from the neotenic process traditionally described in the evolution of the skull. The morphology of 150 juvenile and adult pelves of African apes, 60 juvenile and adult pelves of modern humans, two adult pelves and a juvenile hip bone of australopithecines (Sts 14, AL 288, MLD 7) was studied. Multivariate results, ontogenetic allometries, and growth curves confirm that the pelvic growth pattern in humans differs markedly from those of the African apes. The results permit the following conclusions. First, the appearance of a new feature (acetabulo-cristal buttress and cristal tubercle) at the time of human birth allows the addition of traits, such as the attainment of a proportionally narrower pelvis, with more sagittally positioned iliac blades. Pelvic proportions and orientation change progressively in early childhood as bipedalism is practiced. Other changes in pelvic proportions occur later with the adolescent growth spurt. Second, comparison of juvenile and adult australopithecines to modern humans indicates that 1) some pelvic traits of adult Australopithecus resemble those of neonate Homo; 2) the pelvic growth of Australopithecus was probably closer to that of apes, than to that of humans; and 3) prolonged growth in length of hindlimb and pelvis after sexual maturity seems to be a unique feature of Homo. The position of the acetabulo-cristal buttress and of the cristal tubercle on the ilium are similar in adult Australopithecus and neonate Homo suggesting that this feature may have been displaced later during hominid evolution. Progressive displacement of the acetabulo-cristal buttress on the ilium occurs both during hominid evolution (from Australopithecus to Homo sapiens) and human growth (from neonate to adult). This suggests peramorphic evolution of the pelvic morphology of hominids combining three processes of recapitulation (pre-displacement, acceleration and time hypermorphosis). The results lend credence to the hypothesis that no single heterochronic process accounts for all human evolutionary change; rather this reflects a combination of relative changes in growth rhythm and duration, including other perturbations, such as the appearance of new morphological features.

Adolescent↗
PubMedDate not supplied

Malignant pelvic tumors: limb-sparing resection and reconstruction.

Limb salvage of malignant pelvic tumors should be considered when the tumor can be resected with a satisfactory surgical margin or when tumor location is such that amputation would not provide a better margin. Local recurrence rates approximate 17%, with higher recurrence rates in patients with positive microscopic resection margins. Skeletal reconstruction is not necessary following resection of the anterior pelvis or incomplete removal of the ilium because pelvic stability is maintained. In patients with resection of the ilium and loss of pelvic stability, iliosacral arthrodesis provides good function. Reconstruction following periacetabular resections remains extremely challenging. Options include iliofemoral arthrodesis or pseudarthrosis, massive allograft or autoclaved autograft with hip arthroplasty, and pelvic or saddle prosthesis. We favor iliofemoral arthrodesis in the young, active patient because it provides good function with a durable, stable limb.

Adolescent↗
PubMed1984

Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved.

Prostatic cancer in 1885 autopsy cases was classified according to the number of organs involved in metastasis, and a comparison was made concerning the frequency of metastasis to the various organs. The frequencies of metastasis to the lungs and para-aortic lymph nodes were low in cases with single-organ involvement (4.6% and 2.3%, respectively), but increased rectilinearly in accordance with the number of organs involved and became high in cases with metastasis to three or more organs (49.1% and 21.8% in total, respectively). On the other hand, the frequencies of local extension to the bladder and invasion of the pelvic lymph nodes were high even in cases with single-organ involvement (34.5% and 9.2%, respectively) and were not significantly changed regardless of the number of organs involved. No significant correlation was seen between pelvic and para-aortic lymph node involvement. In cases with single-organ involvement, metastasis to the lumbar spine occurred frequently, but those to the ribs, sternum, and ilium occurred less frequently. There may be multiple metastases in cases with metastases to the para-aortic lymph nodes, sternum, and ilium. The number of metastatically involved organs is useful in analyzing the mode of metastasis.

Aged↗
PubMed1988

Gluteus maximus muscle function and the origin of hominid bipedality.

Bipedality not only frees the hands for tool use but also enhances tool use by allowing use of the trunk for leverage in applying force and thus imparting greater final velocity to tools. Since the weight and acceleration of the trunk and forelimbs on the hindlimbs must be counteracted by muscles such as m. gluteus maximus that control pelvic and trunk movements, it is suggested that the large size of the cranial portion of the human gluteus maximus muscle and its unique attachment to the dorsal ilium (which is apparent in the Makapan australopithecine ilium) may have contributed to the effectiveness with which trunk movement was exploited in early hominid foraging activities. To test this hypothesis, the cranial portions of both right and left muscles were investigated in six human subjects with electromyography during throwing, clubbing, digging, and lifting. The muscles were found to be significantly recruited when the trunk is used in throwing and clubbing, initiating rotation of the pelvis and braking it as trunk rotation ceases and the forelimb accelerates. They stabilize the pelvis during digging and exhibit marked and prolonged activity when the trunk is maintained in partial flexion during lifting of heavy objects.

Adult↗
PubMed1982

Abnormal development of vertebrae in paralyzed chick embryos.

Ventral bars, cartilaginous projections from the ventral aspect of the synsacrum that contact and form a joint with the ilium, were found in all normal chick embryos of age E9 and older. Bars were absent in a number of embryos which had been paralyzed from age E4 by the use of the acetylcholine receptor blocker alpha-bungarotoxin. They were also absent in some embryos that had been paralyzed between ages E4 and E10 but allowed to move thereafter. The bars, already formed, remained present in a third group of embryos in which paralysis was initiated age E10. Apparently, normal embryonic movements induce the formation of bars. In support of this conclusion is the observation that two of three embryos which had had their hindlimb buds amputated at age E3 lacked bars. In these embryos with amputations, the ilium was present at least in part, but the forces exerted on the region where the bars develop would have been greatly reduced because of the lack of hind limb musculature. It is concluded that the bars, which form part of the iliosynsacral joint, are induced epigenetically by normal embryonic movements.

Animals↗
PubMed1992

Changes in bone mineralization, architecture and mechanical properties due to long-term (1 year) administration of pamidronate (APD) to adult dogs.

The goal of this study was to evaluate the effect of 1 year of APD administration on bone mineralization and bone mineral chemistry in the dog. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5 and 25.0 mg/kg per day (0.1% concentration for 12 months) as part of a long-term toxicity study. The os ilium and a vertebra were used to determine the mineralization profile and, subsequently, each density fraction was analysed chemically. The ribs were used to determine lattice parameters of the apatite crystal size using X-ray diffraction. The sternum was used to determine selected morphometric parameters using image analysis of specimen X-ray films and subsequently to determine mechanical properties using velocity-of-sound techniques. We found that for both the ilium and the vertebrae there was a significant shift of the mineralization profile towards greater density in a dose-related manner. This effect levelled off with the highest dose because the shift in mineralization profile correlated better with the square root of the dose than with the dose. Together with data on crystal size, which show an increase in lattice parameters and a decrease in crystal size with dose, our data lead us to believe that long-term administration of APD leads to an increase in bone mineralization without major changes in bone chemistry of Ca, Mg, and P and with a decrease in bone apatite crystal size. The image analysis shows a dose-related increase in trabecular bone volume and thickness.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2004

A relict trematosauroid (Amphibia: Temnospondyli) from the Middle Jurassic of the Junggar Basin (NW China).

A temnospondyl ilium from the uppermost Toutunhe Formation (Middle Jurassic, Callovian) of the southern Junggar Basin is described. Among the known temnospondyls it is very unusual in morphology because of its very long and slender shaft. It compares closely only to the ilium of one of the latest known trematosaurids from the Ladinian of southern Germany. The Toutunhe Formation has also yielded vertebrae and skull fragments of temnospondyls which belong to the brachyopid Gobiops from the Upper Jurassic of Mongolia. Brachyopoid ilia do not, however, display a morphology similar to that of the new specimen. It is therefore concluded that this specimen represents a second taxon of temnospondyl from the Toutunhe Formation, which probably represents the latest surviving trematosauroid. The Trematosauroidea, which was hitherto exclusively known from the Lower to early Upper Triassic, therefore joins the Brachyopoidea--and possibly the Capitosauroidea --as another group of temnospondyls which survived the end--Triassic mass extinction.

Amphibians↗
PubMed2000

Multifocal osteogenic sarcoma in Paget's disease.

The most serious complication of Paget's disease is sarcomatous degeneration of pagetic bone. Multifocal sarcomatous degeneration occurs mainly in polyostotic Paget's disease. Multifocal Paget's sarcoma is uncommon and can arise in any site. We report two cases of synchronous multifocal sarcomatous degeneration. The two patients were elderly women (aged 77 and 86 years, respectively) who developed sarcomatous lesions concomitantly, in the first case report in left ilium, left tibia, and first lumbar vertebra and in the second case report in the skull, right ilium, and sacrum. Whether these cases are due to the simultaneous development of several primaries or to metastases from a single primary remains unclear.

Aged↗
PubMed2001

Revision acetabular arthroplasty using a pedestal cup in patients with previous congenital dislocation of the hip - four case reports and review of treatment.

Despite extensive acetabular bone defects as found in revisions of total hip arthroplasty for high hip dislocation, the ilium usually still provides secure fixation of the pedestal of the acetabular component. Four cases are presented in which reconstruction was performed using a newly developed, conical, titanium, ribbed shaft socket designed for cementless press-fit into the dorsocranial ilium to obtain primary stability. In each case the pedestal cup allowed restoration of the original centre of rotation. There were no complications. A Harris hip score of 85 points was achieved after an average of 28.5 months. All components were radiologically stable. While the findings demonstrate the short-term efficacy of the procedure, longer follow-ups and a larger number of patients are needed before the durability of this reconstructive technique can be assessed.

Adult↗
PubMed2000

A multidisciplinary approach to the treatment of malignant pelvic bone tumors: results with eight consecutive patients.

The prognosis for malignant pelvic bone tumors is worse than that for malignant bone tumors of the extremities because definitive surgery in the pelvis is often difficult to accomplish. The results for eight patients who were treated consecutively with a multidisciplinary approach, from 1990, were analyzed. The histologic diagnosis was osteosarcoma in five patients, chondrosarcoma in two, and Ewing's sarcoma in one. Five lesions arose in the ilium and three in the pubis. The extraosseous tumors decreased in size and/or were encapsulated as a result of preoperative chemotherapy in six patients, four of these achieving a wide surgical margin. With respect to tumor location and surgical margin, all five lesions in the ilium involved the sacrum, four of these being resected with an inadequate margin. The three lesions in the pubis were resected with an adequate margin. Local recurrence was observed in two patients who had been treated with an inappropriate margin. During the period between 18 and 57 months after the first operation, five patients were continuously free of disease and one was still alive but had lung metastases. Our results indicate that a patient's chances of definitive surgery may be enhanced by a multidisciplinary approach, although the management of sacroiliac involvement remains challenging.

Adult↗
PubMed1986

Pelvic stresses in vitro--I. Malsizing of endoprostheses.

Seven embalmed human cadaveric hemi-pelves have been stripped of all soft tissues except the articular cartilage and instrumented with 25 strain-gauge rosettes on both the medial and lateral surfaces. Loads up to 2.5 kN were applied, without simulated muscle forces, to mimic the line-of-action of the resultant joint-force in a single-legged stance. In this parametric study, endoprostheses were studied at the 'correct' size and in sizes of 1 and 2 mm above and below the correct size. The correct size of endoprosthesis produced similar periacetabular stress data to those obtained with the normal femoral head; however, significant changes in stress on the medial and lateral aspects of the ilium suggested the correctly-sized spherical endoprosthesis had a different moment arm than its anatomical counterpart. Endoprostheses of 1 mm greater than the correct size caused major increases in the magnitude of both periacetabular and medial-wall stresses, while prostheses of +2 mm created dramatic and significant increases in magnitudes of these stresses. Endoprostheses smaller than the correct size caused only small but significant changes in the pattern of stresses up to -2 mm malsizing and, in particular, were associated with the disappearance of all periacetabular tensile stresses; however, stress data on the medial and lateral aspects of the ilium were more closely matched to the 'normal' for this -2 mm of undersizing.

Hip Prosthesis↗
PubMed1989

Normal pelvic strain pattern in vitro.

Four cadaver pelves were dissected of soft tissue and each of the eight hemipelves instrumented with ten rosette strain gauges. Static loading was conducted to simulate single leg stance, and applied through the intact hip joint. The medial portion of the pelvis was under tension directed vertically and the lateral ilium was in compression. This strain pattern is consistent with bending applied to the ilium from the action of the abductor and joint reaction forces.

Biomechanical Phenomena↗
PubMedDate not supplied

Interactive effects of ethanol intake and maternal nutritional status on skeletal development of fetal rats.

Skeletal development on gestation day 21 was examined in fetuses of alcohol-consuming (A), pair-fed (PF) and ad lib-fed (C) Sprague-Dawley females. Ethanol (36% ethanol-derived calories) was administered in liquid diets that were marginal (Diet A1) or optimal (Diet A2) in terms of pregnancy requirements (18% vs. 25% total calories as protein, respectively). For each bone studied, a lengthwise measurement was made of the whole bone and of the ossified portion(s), and percent ossification was calculated. Number of sternebral ossification centers present was also determined. Alcohol-exposed fetuses showed retarded ossification of the tibia and radius, regardless of maternal protein intake. Increasing the protein content of the alcohol diet from 18% (Diet A1) to 25% (Diet A2) significantly increased ossification of the ulna, sternum, humerus and ilium-ischium. For the ulna, A2 fetuses showed greater ossification than A1 fetuses but were still retarded compared to PF and C fetuses. For the sternum, humerus and ilium-ischium, however, ossification in A2 fetuses increased to the levels observed in the PF and C groups. In addition, number of sternebral ossification centers present was significantly increased in A2 compared to A1 fetuses. These data indicate that skeletal development provides a sensitive index of ethanol-induced developmental delay as well as interactive effects of ethanol and nutrition.

Animals↗
PubMedDate not supplied

Influence of lumbar flexion on the position of the intercrestal line.

BACKGROUND AND OBJECTIVES: This study was performed to ascertain whether the position of the intercrestal line changes as a result of flexion of the lumbar spine. METHODS: Previously taken lumbar spine x-rays of 103 patients in the neutral and full-flexed positions were reviewed. In the lateral flexion images to compensate for the sagittal rotation of the pelvis during lumbar flexion and for the possible difference in the level between the two sides of the ilium when taking the lateral images, the intercrestal line was drawn as follows: a potential line, crossing the midpoint of the highest points of both iliums, should be perpendicular to the tangential line at the point of intersection of the potential line with the skin. The position of the intercrestal line in relation to the spinous process was determined on an imaginary line moved 1 cm toward the vertebral body from the tangential line on the 2 successive spinous processes, and the interspinous distance of L3-4 was measured on this imaginary line. RESULTS: With full-flexion of the lumbar spine, the position of the intercrestal line in relation to the spinous process [median (25th to 75th percentiles)] changed slightly from L4 (L4-L4-5) into L4-5 (L4-L4-5) (P <.001), but it remained at the same level in 58.3% of the patients (60/103). In no case was a change of more than 1 level observed. The interspinous width (mean +/- SD) of L3-4 increased from 6.5 +/- 2.4 mm to 13.2 +/- 4.4 mm (P <.001). CONCLUSION: When compared with the neutral position, the position of the intercrestal line usually does not change with full flexion of the lumbar spine, and even in cases in which change occurs, it does not move beyond the next level.

Adult↗
PubMed1993

High failure rate of bulk femoral head allografts in total hip acetabular reconstructions at 10 years.

The authors evaluated the radiographic appearance and functional performance of 30 cemented total hip arthroplasty acetabular reconstructions in 28 patients in whom bulk, weight-bearing, femoral head allografts were used to augment severe acetabular bone deficiency with a mean follow-up period of 10 years (range, 8-13.3 years). The average age of the patients was 51 years. The current study group represents the 10-year subset of a larger series of 38 hip reconstructions previously reported. The graft was bolted within the acetabulum in 12 hips and to the lateral wing of the ilium in the other 18 hips. On average, these grafts supported approximately 60% of the acetabular component. All grafts united. Failure of fixation of the acetabular component occurred in 47% of the acetabular reconstructions (14 hips in 14 patients). Four were diagnosed as loose on the basis of radiographic criteria alone and the other 10 hips had a loose acetabular component at reoperation. Loosening occurred in 58% (7 of 12) of the sockets with intraacetabular graft and in 40% (7 of 18) of those bolted to the lateral ilium. The failure rate of 47% in these reconstructions at 10 years is in sharp contrast to high success rates at less than 5 years and argues against the use of bulk weight-bearing allografts for most situations unless the only alternative is resection arthroplasty.

Acetabulum↗